Covariate adjusted mixture models and disease mapping with the program DismapWin.

abstract：:In this paper, we develop a method for the simultaneous estimation of spectral density functions (SDFs) for a collection of stationary time series that share some common features. Due to the similarities among the SDFs, the log-SDF can be represented using a common set of basis functions. The basis shared by the colle...

journal_title：Statistics in medicine

authors： Maadooliat M,Sun Y,Chen T

更新日期：2018-12-30 00:00:00

abstract：:Log-linear models for capture-recapture type data are widely used for estimating sizes of populations. Log-linear methods model conditional interactions between the sources. Often, however, the marginal associations are more appropriate and easier for the practitioner to conceptualize. Analyses here of previously publ...

journal_title：Statistics in medicine

authors： Regal RR,Hook EB

更新日期：1998-01-15 00:00:00

abstract：:Health authorities are often alerted to suspected cancer clusters near the vicinity of potential point sources by members of the public. A surveillance system, where administrative regions around the potential point sources are regularly monitored for high disease rates, would allow for responses which are easier to o...

journal_title：Statistics in medicine

authors： Le ND,Petkau AJ,Rosychuk R

更新日期：1996-04-15 00:00:00

abstract：:A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial stu...

journal_title：Statistics in medicine

authors： Lindsey JK,Jones B

更新日期：1996-02-28 00:00:00

abstract：:Assessing the calibration of methods for estimating the probability of the occurrence of a binary outcome is an important aspect of validating the performance of risk-prediction algorithms. Calibration commonly refers to the agreement between predicted and observed probabilities of the outcome. Graphical methods are a...

journal_title：Statistics in medicine

authors： Austin PC,Steyerberg EW

更新日期：2019-09-20 00:00:00

abstract：:Blinded estimation of variance allows for changing the sample size without compromising the integrity of the trial. Some of the methods that estimate the variance in a blinded manner either make untenable assumptions or are only applicable to two-treatment trials. We propose a new method for continuous endpoints that ...

journal_title：Statistics in medicine

authors： Xing B,Ganju J

更新日期：2005-06-30 00:00:00

abstract：:Technologic advances give rise to new tests for detecting disease in many fields, including cancer and sexually transmitted disease. Before a new disease screening test is approved for public use, its accuracy should be shown to be better than or at least not inferior to an existing test. Standards do not yet exist fo...

journal_title：Statistics in medicine

authors： Alonzo TA,Pepe MS,Moskowitz CS

更新日期：2002-03-30 00:00:00

abstract：:Regression to the mean arises often in statistical applications where the units chosen for study relate to some observed characteristic in the extreme of its distribution. Gardner and Heady attribute the effect of regression to the mean to measurement errors. They assume the model Yi = U + ei, where U is a fixed withi...

journal_title：Statistics in medicine

authors： Johnson WD,George VT

更新日期：1991-08-01 00:00:00

abstract：:This work is motivated by a longitudinal study of women and their ectopic pregnancy outcomes in Lund, Sweden. In this article, we review and apply the Liang-Zeger methodology to the Lund ectopic pregnancy data set. We further analyse the ectopic pregnancy data using conditional modelling approaches suggested by Rosner...

journal_title：Statistics in medicine

authors： Hadgu A,Koch G,Westrom L

更新日期：1997-11-15 00:00:00

abstract：:Combining multiple markers can improve classification accuracy compared with using a single marker. In practice, covariates associated with markers or disease outcome can affect the performance of a biomarker or biomarker combination in the population. The covariate-adjusted receiver operating characteristic (ROC) cur...

journal_title：Statistics in medicine

authors： Kim S,Huang Y

更新日期：2017-07-10 00:00:00

abstract：:We propose the use of Gaussian mixed models to analyse statistically 24 hour ambulatory blood pressure data from clinical trials. We develop specific models and apply them to data from a clinical study that compares two angiotensin-converting enzyme inhibitors. We investigate and discuss computing issues related to th...

journal_title：Statistics in medicine

authors： Selwyn MR,Difranco DM

更新日期：1993-09-30 00:00:00

abstract：:We develop analysis methods for clinical trials with time-to-event outcomes which correct for treatment changes during follow-up, yet are based on comparisons of randomized groups and not of selected groups. A causal model relating observed event times to event times that would have been observed under other treatment...

journal_title：Statistics in medicine

authors： White IR,Babiker AG,Walker S,Darbyshire JH

更新日期：1999-10-15 00:00:00

abstract：:Effective statistical help to biological and medical research demands thorough involvement of the statistician. The breadth of his activities can be illustrated by considering the questions he needs to discuss with his scientific colleagues in the course of planning a comparative experiment. The paper presents and com...

journal_title：Statistics in medicine

authors： Finney DJ

更新日期：1982-01-01 00:00:00

abstract：:Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Although most previous works on adaptive designs and mid-course sample size re-estimation have focused on two-stage or group-sequential designs ...

journal_title：Statistics in medicine

authors： Bartroff J,Lai TL

更新日期：2008-05-10 00:00:00

abstract：:I reflect on the statistical methods of the Christakis-Fowler studies on network-based contagion of traits by checking the sensitivity of these kinds of results to various alternate specifications and generative mechanisms. Despite the honest efforts of all involved, I remain pessimistic about establishing whether bin...

journal_title：Statistics in medicine

authors： Thomas AC

更新日期：2013-02-20 00:00:00

abstract：:Hypothesis testing, in which the null hypothesis specifies no difference between treatment groups, is an important tool in the assessment of new medical interventions. For randomized clinical trials, permutation tests that reflect the actual randomization are design-based analyses for such hypotheses. This means that ...

journal_title：Statistics in medicine

authors： Berger VW

更新日期：2000-05-30 00:00:00

abstract：:Models for infant growth have usually been based on parametric forms, commonly an exponential or similar model, which have been shown to fit poorly especially during the first year of life. An alternative approach is to use a non-parametric model, based on a shape invariant model (SIM), where a single function is tran...

journal_title：Statistics in medicine

authors： Beath KJ

更新日期：2007-05-30 00:00:00

abstract：:The Cardiac Arrythmia Suppression Trial was stopped much earlier than planned. Statistical considerations played a very important role in the decision. Flexible group sequential testing was developed for the trial by implementing a Lan and DeMets procedure with use of the permutation test. We compute P-values from the...

journal_title：Statistics in medicine

authors： Pawitan Y,Hallstrom A

更新日期：1990-09-01 00:00:00

abstract：:Many quantitative assay measurements of metabolites of environmental toxicants in clinical investigations are subject to left censoring due to values falling below assay detection limits. Moreover, when observations occur in both unexposed individuals and exposed individuals who reflect a mixture of two distributions ...

journal_title：Statistics in medicine

authors： Chu H,Kensler TW,Muñoz A

更新日期：2005-07-15 00:00:00

abstract：:In studies with survival or time-to-event outcomes, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. Specialized statistical methods must be used to analyze survival data in the presence of competing risks. We conducted a review of randomized controlled trials wi...

journal_title：Statistics in medicine

authors： Austin PC,Fine JP

更新日期：2017-04-15 00:00:00

abstract：:Clinical trials of treatments for rare or fatal diseases must often use historical rather than randomized concurrent controls. Randomized trials may not be possible if (1) the number of patients available is quite small, (2) ethical considerations discourage the assignment of patients to control treatments known to be...

journal_title：Statistics in medicine

authors： Hoehler FK,Mantel N,Gehan E,Kahana E,Alter M

更新日期：1984-07-01 00:00:00

abstract：:The focus of this paper is dietary intervention trials. We explore the statistical issues involved when the response variable, intake of a food or nutrient, is based on self-report data that are subject to inherent measurement error. There has been little work on handling error in this context. A particular feature of...

journal_title：Statistics in medicine

authors： Keogh RH,Carroll RJ,Tooze JA,Kirkpatrick SI,Freedman LS

更新日期：2016-11-10 00:00:00

abstract：:There has been substantial statistical literature in the last several decades on assessing agreement, and coverage probability approach was selected as a preferred index for assessing and improving measurement agreement in a core laboratory setting. With this approach, a satisfactory agreement is based on pre-specifie...

journal_title：Statistics in medicine

authors： Barnhart HX

更新日期：2016-08-15 00:00:00

abstract：:Cross-sectional designs are often used to monitor the proportion of infections and other post-surgical complications acquired in hospitals. However, conventional methods for estimating incidence proportions when applied to cross-sectional data may provide estimators that are highly biased, as cross-sectional designs t...

journal_title：Statistics in medicine

authors： Fluss R,Mandel M,Freedman LS,Weiss IS,Zohar AE,Haklai Z,Gordon ES,Simchen E

更新日期：2013-06-30 00:00:00

abstract：:In this paper we describe Bonferroni-based multiple testing procedures (MTPs) as strategies to split and recycle test mass. Here, 'test mass' refers to (parts of) the nominal level alpha at which the family-wise error rate is controlled. Briefly, test mass is split between different null hypotheses, and whenever a nul...

journal_title：Statistics in medicine

authors： Burman CF,Sonesson C,Guilbaud O

更新日期：2009-02-28 00:00:00

abstract：:In clinical research, we are often interested in assessing how a biomarker changes with time, and whether it could be used as a surrogate marker when evaluating the efficacy of a new drug. However, when the longitudinal marker is correlated with survival, linear mixed models for longitudinal data may be inappropriate....

journal_title：Statistics in medicine

authors： Deslandes E,Chevret S

更新日期：2007-12-30 00:00:00

abstract：:Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-...

journal_title：Statistics in medicine

authors： Liu JP,Ma MC,Wu CY,Tai JY

更新日期：2006-04-15 00:00:00

abstract：:Multivariate finite mixture models have been applied to the identification of dietary patterns. These models are known to have many parameters, and consequently large samples are usually required. We present a special case of a multivariate mixture model that reduces the number of parameters to be estimated and seems ...

journal_title：Statistics in medicine

authors： Rita Gaio A,Costa JP,Santos AC,Ramos E,Lopes C

更新日期：2012-08-30 00:00:00

abstract：:We studied the problem of testing a hypothesized distribution in survival regression models when the data is right censored and survival times are influenced by covariates. A modified chi-squared type test, known as Nikulin-Rao-Robson statistic, is applied for the comparison of accelerated failure time models. This st...

journal_title：Statistics in medicine

authors： Tahir MR,Tran QX,Nikulin MS

更新日期：2017-05-30 00:00:00

abstract：:Conventional seamless phase 2/3 design with fixed sample size determination (SSD) has gained its popularity in oncology drug development due to attractive features such as significantly shortening the development timeline, minimizing sample size, as well as early decision making. However, this design is not immune to ...

journal_title：Statistics in medicine

authors： Teng Z,Tian Y,Liu Y,Liu G

更新日期：2020-08-15 00:00:00