Abstract:
:The phosphatidylinositol-3-kinases (PtdIns-3-kinase) are a family of enzymes involved in the control of cell replication. One member of the family, the mammalian p110/p85 PtdIns-3-kinase, is a potential target for anticancer drug development because of its role as a component of growth factor and oncogene activated signalling pathways. There are a number of inhibitors of this PtdIns-3-kinase, the most potent being wortmannin (IC50 4 nM). Wortmannin inhibits cancer cell growth and has shown activity against mouse and human tumor xenografts in mice. Other inhibitors of the PtdIns-3-kinase are halogenated quinones which also inhibit cancer cell growth and have some in vivo antitumor activity. Some D-3-deoxy-3-substituted myo-inositol analogues and their corresponding PtdIns analogues have been synthesized. They may act as myo-inositol antimetabolites in the PtdIns-3-kinase pathway and they can inhibit cancer cell growth.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Powis G,Berggren M,Gallegos A,Frew T,Hill S,Kozikowski A,Bonjouklian R,Zalkow L,Abraham R,Ashendel Csubject
Has Abstract,Author List Incompletepub_date
1995-01-01 00:00:00pages
395-403issue
4eissn
0001-527Xissn
1734-154Xjournal_volume
42pub_type
杂志文章,评审abstract::Aims. This study aimed to investigate CHRNA3 (rs8040868) and PHACTR2 (rs9390123) single-nucleotide polymorphisms (SNPs) for association with non-small-cell lung cancer (NSCLC) risk in a Chinese population, and whether the environment affects the genetic polymorphisms. Methods. This case and control study included 500 ...
journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2014_926
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journal_title:Acta biochimica Polonica
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abstract::AMP deaminase (EC 3.5.4.6) from anterior lobe of bovine pituitary has been purified for the first time. Six molecular forms of the enzyme were eluted from phosphocellulose P11 with a KC1 concentration gradient. By two stage gel chromatography individual molecular forms were purified to electrophoretic homogeneity. Com...
journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:035001103
更新日期:2003-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:024903703
更新日期:2002-01-01 00:00:00
abstract::We have studied the ability of yeast DNA polymerases to carry out repair of lesions caused by UV irradiation in Saccharomyces cerevisiae. By the analysis of postirradiation relative molecular mass changes in cellular DNA of different DNA polymerases mutant strains, it was established that mutations in DNA polymerases ...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Questions regarding functional markers characterizing injured intestines remain unanswered. Brush border disaccharidases are crucial for the functioning of the intestines. AIMS:The study was designed to assess changes in disaccharidase activity (DA) following intestinal injury and to compare them with morph...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:10.18388/abp.2016_1330
更新日期:2016-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2015_1125
更新日期:2015-01-01 00:00:00
abstract::Sea urchin gonad (roe) is a highly valued food in Japan and North America. Gonad price is strongly influenced by quality, with appearance, especially colour being a major determinant. Previous attempts to extract a carotenoid profile from the New Zealand sea urchin species Evechinus chloroticus have been challenging d...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::One of the most unusual features of RNA viruses is their enormous genetic variability. Among the different processes contributing to the continuous generation of new viral variants RNA recombination is of special importance. This process has been observed for human, animal, plant and bacterial viruses. The collected d...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::The paper relates on the current advancements in the synthesis of complex cyclic terpenoids by superacidic induced cyclization of open chain precursors. It is shown that functional groups disposal in the initial substrate strongly influences the reaction outcome. Possible variations of the investigated compound struct...
journal_title:Acta biochimica Polonica
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doi:
更新日期:2007-01-01 00:00:00
abstract::The biodegradability and biocompatibility properties of ε-caprolactone homopolymers place it as a valuable raw material, particularly for controlled drug delivery and tissue engineering applications. However, the usefulness of such materials is limited by their low hydrophilicity and slow biodegradation rate. In order...
journal_title:Acta biochimica Polonica
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doi:
更新日期:2014-01-01 00:00:00
abstract::In this study we investigated the level of 8-oxo-2'-deoxyguanosine (8-oxodG) in DNA of Cardamine pratensis plants subjected to different growth conditions trying to answer the question whether factors like light and water accessibility or low temperature may have an impact on the total DNA oxidative damage. The level ...
journal_title:Acta biochimica Polonica
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更新日期:1999-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Acta biochimica Polonica
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更新日期:1986-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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更新日期:1978-01-01 00:00:00
abstract::Translation of viral proteins from subgenomic RNAs (sgRNAs) is a common strategy among positive-stranded RNA viruses. Unlike host mRNA, sgRNA of Potato leafroll virus (PLRV) does not possess a cap at its 5' end nor a poly(A) tail at the 3' terminus, both of which are known to be crucial for translation of RNA in eukar...
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更新日期:2009-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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更新日期:1985-01-01 00:00:00
abstract::Calretinin (CR) is a neuronal EF-hand protein previously characterized as a calcium (micromolar affinity) binding protein. CR-containing neurons are spared in some neurodegenerative diseases, although it is as yet unconfirmed how CR plays an active role in this protection. Higher levels of some metal cations (e.g. cop...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It als...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::beta-Secretase, a beta-site amyloid precursor protein (APP) cleaving enzyme (BACE), participates in the secretion of beta-amyloid peptides (Abeta), the major components of the toxic amyloid plaques found in the brains of patients with Alzheimer's disease (AD). According to the amyloid hypothesis, accumulation of Abeta...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00