Effects of glutamine on tumor growth and apoptosis of hepatoma cells.

abstract：AIM:The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. METHODS:Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA...

journal_title：Acta pharmacologica Sinica

authors： Zhao WJ,Ma YH,Fei J,Mei ZT,Guo LH

更新日期：2003-10-01 00:00:00

abstract：AIM:Our previous study demonstrated an siRNA-mediated, allele-specific silencing of mutant genes that cause amyotrophic lateral sclerosis. To improve siRNA design for better therapeutic use of RNA interference, we systematically tested the base-pairing mismatch strategy in the design of asymmetric siRNA. METHODS:A nat...

journal_title：Acta pharmacologica Sinica

authors： Geng CM,Ding HL

更新日期：2008-02-01 00:00:00

abstract：AIM:To investigate the effects of chronic ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats. Simultaneously, the effects of nonselective opioid antagonist (naloxone) on the CaM kinase IV expression in the NAc ...

journal_title：Acta pharmacologica Sinica

authors： Li J,Bian WL,Xie GQ,Cui SZ,Wu ML,Li YH,Que LL,Yuan XR

更新日期：2008-06-01 00:00:00

abstract：:Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and "polypills", as the frontier in new drug development. A trad...

journal_title：Acta pharmacologica Sinica

authors： Zhang JH,Zhu Y,Fan XH,Zhang BL

更新日期：2015-06-01 00:00:00

abstract：AIM:To examine the protective effect of propofol in renal ischemia/reperfusion (I/R) injury and the role of heme oxygenase-1 (HO-1) in this process. METHODS:Sprague-Dawley rats were randomly divided into 3 groups: (i) sham-operated group; (ii) I/R group; and (iii) propofol group. Bilateral renal warm ischemia for 45 m...

journal_title：Acta pharmacologica Sinica

authors： Wang HH,Zhou HY,Chen CC,Zhang XL,Cheng G

更新日期：2007-08-01 00:00:00

abstract：AIM:Oral risedronate is effective in the treatment of postmenopausal osteoporosis when administered daily, weekly, or monthly. In this 1-year, randomized, double-blind, multicenter study we compared the weekly 35-mg and daily 5-mg risedronate dosing regimens in the treatment of Chinese postmenopausal women with osteopo...

journal_title：Acta pharmacologica Sinica

authors： Gu JM,Wang L,Lin H,Chen DC,Tang H,Jin XL,Xia WB,Hu YQ,Fu WZ,He JW,Zhang H,Wang C,Yue H,Hu WW,Liu YJ,Zhang ZL

更新日期：2015-07-01 00:00:00

abstract：AIM:To investigate the postantibiotic effects (PAE) of different classes of antimicrobials against five different types of bacteria. METHODS:Minimal inhibitory concentrations (MIC) were determined by twofold macrodilution in broth. The antimicrobial agents were eliminated by washing method after the bacteria were expo...

journal_title：Acta pharmacologica Sinica

authors： Wang MG,Zhang YY,Zhu DM,Zhang J,Shi YG

更新日期：2001-09-01 00:00:00

abstract：AIM:To elucidate inhibition of protein kinase C alpha (PKC alpha) activity by staurosporine on apoptosis of oral cancer cell line tongue squamous cell carcinoma (TSCCa) cells and to clarify the role of survivin and caspase-3 in mediating apoptosis. METHODS:TSCCa cell viability was measured by MTT assay after 100 nmol/...

journal_title：Acta pharmacologica Sinica

authors： Zhang YX,Yu SB,Ou-Yang JP,Xia D,Wang M,Li JR

更新日期：2005-11-01 00:00:00

abstract：AIM:To explore correlation of T helper 1 (Th1) and Th2 cytokine between the cortical layer and pulmonary airway in ovalbumin-induced rat asthma model. METHODS:Aerosol antigen-induced changes of inflammation in bronchoalveolar lavage fluids (BALF) and pulmonary histologic section in sensitized rats were investigated. C...

journal_title：Acta pharmacologica Sinica

authors： Xie QM,Chen JQ,Shen WH,Bian RL

更新日期：2002-03-01 00:00:00

abstract：:The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respir...

journal_title：Acta pharmacologica Sinica

authors： Serebrovska ZO,Chong EY,Serebrovska TV,Tumanovska LV,Xi L

更新日期：2020-12-01 00:00:00

abstract：AIM:To investigate the anticancer mechanism of a methoxyflavanone derivative, WJ9708012, highlighting its role on a crosstalk between endoplasmic reticulum (ER) and mitochondrial stress. METHODS:Cell proliferation was examined using sulforhodamine B assay. Cell-cycle progression, Ca(2+) mobilization and mitochondrial ...

journal_title：Acta pharmacologica Sinica

authors： Kuo TC,Huang WJ,Guh JH

更新日期：2011-01-01 00:00:00

abstract：AIM:To study the effect of E6, a novel calmodulin inhibitor, on the activity of P-glycorprotein (P-gp) in purified primary cultured rat brain microvessel endothelial cells (RBMEC). METHODS:Flow cytometry was used to purify RBMEC from other cell types. Fluorescence of P-gp substrate rhodamine123 (Rh123) in RBMEC was me...

journal_title：Acta pharmacologica Sinica

authors： Zhu HJ,Liu GQ

更新日期：2003-11-01 00:00:00

abstract：AIM:HMGB1 (high-mobility group box-1) is a nuclear protein containing a consensus RB (retinoblastoma)-binding LXCXE motif. In this study, we studied the potential association of HMGB1 and RB and the in vitro and in vivo activities of HMGB1 in human breast cancer cells. METHODS:The protein-protein interaction was deter...

journal_title：Acta pharmacologica Sinica

authors： Jiao Y,Wang HC,Fan SJ

更新日期：2007-12-01 00:00:00

abstract：:Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo efficacies of SHR-A140...

journal_title：Acta pharmacologica Sinica

authors： Yang CY,Wang L,Sun X,Tang M,Quan HT,Zhang LS,Lou LG,Gou SH

更新日期：2019-07-01 00:00:00

abstract：AIM:To evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma. METHODS:Thirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.5/160 μg twice daily for one year. The effect of formoterol-budesonide on air...

journal_title：Acta pharmacologica Sinica

authors： Wang K,Liu CT,Wu YH,Feng YL,Bai HL,Ma ES,Wen FQ

更新日期：2011-01-01 00:00:00

abstract：AIM:To study the protective effect of the polypeptide isolated from Chlamys farreri (PCF) on hairless mice skin damaged by ultraviolet A. METHODS:Enzymes and malondialdehyde (MDA) were determined by biochemical methods; the expressions of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. Th...

journal_title：Acta pharmacologica Sinica

authors： Wang CB,Yao RY,Liu ZT,Zhong WZ,Liu XP,Wang YJ

更新日期：2002-09-01 00:00:00

abstract：AIM:Retinoic acid receptor-related orphan nuclear receptors (RORs) are orphan nuclear receptors that show constitutive activity in the absence of ligands. Among 3 subtypes of RORs, RORc is a promising therapeutic target for the treatment of Th17-mediated autoimmune diseases. Here, we report novel RORc inverse agonists ...

journal_title：Acta pharmacologica Sinica

authors： Wu XS,Wang R,Xing YL,Xue XQ,Zhang Y,Lu YZ,Song Y,Luo XY,Wu C,Zhou YL,Jiang JQ,Xu Y

更新日期：2016-11-01 00:00:00

abstract：:Cocaine is one of the most abused illicit drugs worldwide. It is well known that the dopamine (DA) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nAChRs). In this study, we investigated the effects of cocaine on a special subtype of neuronal nAChR, ...

journal_title：Acta pharmacologica Sinica

authors： Ma ZG,Jiang N,Huang YB,Ma XK,Brek Eaton J,Gao M,Chang YC,Lukas RJ,Whiteaker P,Neisewander J,Wu J

更新日期：2020-02-01 00:00:00

abstract：AIM:To study the effect of Huangqi Jianzhong Tang in reducing fatigue improvement in athletes. METHODS:Twelve athletes were randomly separated into a control group, whose members were administered with placebos, and the experimental group, whose members were administered with Huangqi Jianzhong Tang. During the eight w...

journal_title：Acta pharmacologica Sinica

authors： Chen KT,Su CH,Hsin LH,Su YC,Su YP,Lin JG

更新日期：2002-08-01 00:00:00

abstract：:The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemisinin, displays broad antitumor activity and direct cytotoxicity on va...

journal_title：Acta pharmacologica Sinica

authors： Li Z,Zhu YT,Xiang M,Qiu JL,Luo SQ,Lin F

更新日期：2020-07-23 00:00:00

abstract：AIM:To determine whether ONO-1078 (pranlukast), a potent leukotriene receptor antagonist, has neuroprotective effect on focal cerebral ischemia in the rat. METHODS:Focal cerebral ischemia was induced by 30 min of middle cerebral artery (MCA) occlusion and followed by 24 h reperfusion. ONO-1078 (0.003-1.0 mg/kg) or veh...

journal_title：Acta pharmacologica Sinica

authors： Zhang WP,Wei EQ,Mei RH,Zhu CY,Zhao MH

更新日期：2002-10-01 00:00:00

abstract：AIM:To investigate the role of CYP2E1 in isoniazid (INH)-induced hepatotoxicity and the influence of rifampicin (RFP) on INH-induced liver injury. METHODS:Rats were treated with INH alone (100 mg/kg, ip) or co-administered with RFP (100 mg/kg, ig) for 10 d and 21 d. Hepatotoxicity was assayed by plasma enzymes (sALT, ...

journal_title：Acta pharmacologica Sinica

authors： Yue J,Peng RX,Yang J,Kong R,Liu J

更新日期：2004-05-01 00:00:00

abstract：AIM:Catechol estrogens and 16alpha-hydroxy estrogen are important metabolites that cause carcinogenesis. This study was aimed to stud y the role of cytochrome P450 in estradiol metabolism. METHODS:The estradiol metabolites were determined with HPLC-ECD. Correlation of estradiol metabolites production between cytochrom...

journal_title：Acta pharmacologica Sinica

authors： Cheng ZN,Shu Y,Liu ZQ,Wang LS,Ou-Yang DS,Zhou HH

更新日期：2001-02-01 00:00:00

abstract：AIM:To study the effects of dl-praeruptorin A (Pd-Ia) on nucleus factor-kappaB (NF-kappaB) activativity and tumor necrosis factor-alpha (TNF-alpha) expression in ischemia-reperfusion (I/R) myocardium. METHODS:Langendorff's isolated rat heart was subjected to a 10-min ischemia followed by a 30-min reperfusion. NF-kappa...

journal_title：Acta pharmacologica Sinica

authors： Wang C,Chang TH,Zhang XH,Wang HL

更新日期：2004-01-01 00:00:00

abstract：AIM:To study the effects and mechanisms by which hyposmotic challenge modulate function of L-type calcium current (I(Ca,L)) in rat ventricular myocytes. METHODS:The whole-cell patch-clamp techniques were used to record I(Ca,L) in rat ventricular myocytes. RESULTS:Hyposmotic challenge(∼220 mosmol/L) induced biphasic c...

journal_title：Acta pharmacologica Sinica

authors： Luo AT,Luo HY,Hu XW,Gao LL,Liang HM,Tang M,Hescheler J

更新日期：2010-11-01 00:00:00

abstract：AIM:To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA). METHODS:The clinical trials included two phase I open studies: study 1 was an open-label dose-escalation study in 27 ...

journal_title：Acta pharmacologica Sinica

authors： Ma Y,Lin BR,Lin B,Hou S,Qian WZ,Li J,Tan M,Ma J,Li BH,Wang H,Wen AD,Guo YJ

更新日期：2009-03-01 00:00:00

abstract：AIM:To investigate the influence of picroside II on hepatocyte apoptosis and its mechanism. METHODS:Morphological changes and quantification of apoptotic cells were determined under transmission electron microscopy and flow cytometry respectively. DNA fragmentation was visualized by agarose gel electrophoresis. Semi-q...

journal_title：Acta pharmacologica Sinica

authors： Gao H,Zhou YW

更新日期：2005-06-01 00:00:00

abstract：AIM:To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the pharmacokinetics of cyclosporine A (CsA) in Chinese renal transplant patients. METHODS:One hundred and twenty-six renal transplant patients were recruited. Bl...

journal_title：Acta pharmacologica Sinica

authors： Meng XG,Guo CX,Feng GQ,Zhao YC,Zhou BT,Han JL,Chen X,Shi Y,Shi HY,Yin JY,Peng XD,Pei Q,Zhang W,Wang G,He M,Liu M,Yang JK,Zhou HH

更新日期：2012-12-01 00:00:00

abstract：AIM:To study the effect of nociceptin (orphanin FQ), a newly discovered heptadecapeptide, on cholinergic constrictions in isolated trachea and bronchus of rat. METHODS:The electric field stimulation (EFS) induced a monophasic constriction, which was due to an activation of the cholinergic nerves. RESULTS:Nociceptin 0...

journal_title：Acta pharmacologica Sinica

authors： Wu Y,Fang LB,Yang QH

更新日期：2000-10-01 00:00:00

abstract：AIM:To examine the interactions of allopregnanolone and phenobarbital for the protection against seizures. METHODS:The protective activity of allopregnanolone and/or phenobarbital against seizures was studied in the C57 mice, using the maximal electroshock seizure (MES) test. The modulations by allopregnanolone and/or...

journal_title：Acta pharmacologica Sinica

authors： Lu YQ,Yu R

更新日期：2001-04-01 00:00:00