Abstract:
:Different electrodes and stimulus protocols commonly used for electroretinography in rodent eyes were compared for convenience of use, degree of damage to corneal epithelium, and for magnitude of amplitude, reproducibility, left versus right eye accuracy, and reliability of recorded parameters of the flash electroretinogram (ERG). Adult C57BL/6 pigmented mice and albino Wistar rats were used to determine scotopic ERGs in response to Ganzfeld or strobe-light stimulation and light-adapted (photopic) ERGs recorded from both eyes at the same time. Test-retest data were used for statistical analyses to compare a monopolar gold-wire contact lens electrode (CLE), a cotton-wick silver-silver chloride electrode (CSCE), a DTL fiber electrode (DTLE), and a circular stainless steel wire electrode (SSE). Corneas were evaluated for abrasion after ERG recordings using fluorescein staining and also for the time taken, ease of insertion, and re-insertions required for the different electrodes. Compared to CSCE, DTLE, and SSE, the ERG potentials recorded by CLE had significantly larger scotopic amplitudes and oscillatory potentials under strobe or Ganzfeld stimulation and for light-adapted ERG b-wave amplitudes in both mice and rats. In analyzing test-retest data of scotopic ERG a-wave and b-wave amplitudes, the intraclass correlation coefficient showed the best agreement for the CLE (range 0.61-0.94) compared to the SSE (0.13-0.77), DTLE (0.02-0.69), and CSCE (0.12-0.51). In mice and rats, logistic regression analyses revealed significant correlations for amplitudes of most scotopic ERG parameters between contralateral eyes obtained with CLE and for some ERG components recorded by SSE. When comparing ERG amplitudes for stimulation by strobe or Ganzfeld, the difference was least with the CLE compared to DTLE, CSCE, or SSE. The time taken to insert the four different electrodes was greatest for the CLE in both mice and rats. The extent of corneal abrasion resulting from electrode use in mice was largest for the SSE followed by the CLE. However, in rats there was almost no corneal damage after ERG recordings with the CLE. Because of the stability of eye contact, the CLE allows ERGs to be determined over a longer recording session. Recording of scotopic and photopic (light-adapted) ERGs in rodents with monopolar gold-wire contact lens electrodes provides greater amplitudes and higher reproducibility when compared to other commonly used corneal electrodes. These electrodes are significantly better overall than others that were evaluated and should be considered for a standard protocol to monitor retinal function in rodent eyes.
journal_name
Vision Resjournal_title
Vision researchauthors
Bayer AU,Cook P,Brodie SE,Maag KP,Mittag Tdoi
10.1016/s0042-6989(01)00103-1subject
Has Abstractpub_date
2001-08-01 00:00:00pages
2173-85issue
17eissn
0042-6989issn
1878-5646pii
S0042-6989(01)00103-1journal_volume
41pub_type
杂志文章相关文献
VISION RESEARCH文献大全abstract::In this work we report on a unique and ancient type of eye, in which the lower surface of the upper calcite lens units possessed an enigmatic central bulge making the dioptric apparatus similar to a bifocal lens. This eye belonged to the trilobite Dalmanitina socialis, which became extinct several hundred million year...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(99)00216-3
更新日期:2000-01-01 00:00:00
abstract::An outline drawing often serves as an excellent depiction of a visual scene. Somehow, our visual system can form two- and three-dimensional percepts solely from one-dimensional contour information. In mathematics, contour closure plays a key role in bridging this dimensional gap, however in perception the link between...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(93)90080-g
更新日期:1993-05-01 00:00:00
abstract::A series of multiple regression analyses was conducted on a corpus of eye movement data to examine whether the influence of properties of words n-1 and n+1 on the time spent fixating word n changes as a function of whether word n is associated with a punctuation mark (i.e., whether or not a punctuation mark separates ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.12.006
更新日期:2007-04-01 00:00:00
abstract::The absorption of a photon by a photoreceptor triggers a small voltage fluctuation termed the 'bump'. Here, in the housefly, I introduce the bispectrum of photoreceptor noise to characterise the bump under dim light. The bispectrum provides explicit phase information and is not contaminated by Gaussian background nois...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2005.09.020
更新日期:2006-03-01 00:00:00
abstract::Visual performance is greatly impaired when tested with heterochromatic isoluminant stimuli. It is thus concluded that the chromatic system contribution to many visual tasks is limited. We suggest that unless color and luminance are shown to be processed independently, such experiments do not demonstrate shortcomings ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(92)90220-d
更新日期:1992-07-01 00:00:00
abstract::Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when co...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.03.031
更新日期:2006-10-01 00:00:00
abstract::We used a tracking method to measure errors in estimating absolute time-to-collision caused by adapting to an expanding target. After adaptation, the estimated time-to-collision was longer than in the baseline condition. This was the case whether estimates were based on binocular information alone or monocular informa...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(99)00065-6
更新日期:1999-10-01 00:00:00
abstract::Visual information is an essential guide when interacting with moving objects, yet it can also be deceiving. For instance, motion can induce illusory position shifts, such that a moving ball can seem to have bounced past its true point of contact with the ground. Some evidence suggests illusory motion-induced position...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2012.03.010
更新日期:2012-05-01 00:00:00
abstract::It has been known for some time that visual acuity in amblyopia is higher for single letters than for letters in a row (termed crowding). Early work showed that this could not be accounted for on the basis of the destructive interaction of adjacent contours (termed contour interaction), which was shown to be, in resol...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(01)00099-2
更新日期:2001-08-01 00:00:00
abstract::Foveal pathway visual function was assessed in 11 patients having tumours extending into the suprasellar region but without evidence of visual impairment as assessed by visual acuity and Bjerrum screen campimetry. Psychophysical and routine visual evoked potential (VEP) measurements were obtained from the eye ipsilate...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00306-9
更新日期:1997-05-01 00:00:00
abstract::Vernier thresholds were measured behaviourally in five cats using offsets in gratings of two spatial frequencies and in single lines. Thresholds ranged from 2.2 to 6.7', and no threshold differences were found across stimuli. These results are discussed in relationships with published spatial resolution data and are r...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(86)90107-0
更新日期:1986-01-01 00:00:00
abstract::In order to assess the contribution of high spatial frequency channels (i.e. local, edge-dependent mechanisms) to the grating induction effect, grating induction magnitude was measured as a function of systematic amounts of blurring of the inducing/test field boundary for four test field heights which spanned a two oc...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(93)90130-o
更新日期:1993-12-01 00:00:00
abstract::A new discrete-time reverse-correlation scheme for the study of visual neurons is proposed. The visual stimulus is generated by drawing with uniform probability, at each refresh time, an image from a finite set S of orthonormal images. We show that if the neuron can be modeled as a spatiotemporal linear filter followe...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00247-7
更新日期:1997-09-01 00:00:00
abstract::Three experiments investigated whether and to what extent increases in age affect the functionality of stereopsis. The observers' ages ranged from 18 to 83 years. The overall goal was to challenge the older stereoscopic visual system by utilizing high magnitudes of binocular disparity, ambiguous binocular disparity [c...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2008.08.008
更新日期:2008-10-01 00:00:00
abstract::The perception of blackness was investigated by measuring spectral efficiency and field additivity under conditions of temporal induction. For both purposes, observers foveally viewed a 0.75 deg, inducing stimulus for 5 sec followed immediately (or 200 msec later) by a broadband (5500 K) reference stimulus of the same...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(89)90197-1
更新日期:1989-01-01 00:00:00
abstract::Retinotopic encoding is preserved in primate visual cortex. However, several physiological and psychophysical studies have revealed that visual processes can be disengaged from retinotopic coordinates. We examined whether this non-retinotopic processing is common to humans and pigeons, two visually dominant vertebrate...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2014.08.007
更新日期:2014-10-01 00:00:00
abstract::Retinal prostheses attempt to restore some amount of vision to totally blind patients. Vision evoked this way will be however severely constrained because of several factors (e.g., size of the implanted device, number of stimulating contacts, etc.). We used simulations of artificial vision to study how such restrictio...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2008.04.027
更新日期:2008-07-01 00:00:00
abstract::Bisection is one of several spatial localization tasks that achieve hyperacuity performance levels. We find that optimal bisection thresholds, and hyperacuity tasks in general, are no better than might be expected from simple contrast detection and discrimination performance. The three-line bisection task can be descr...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(98)00121-7
更新日期:1999-02-01 00:00:00
abstract::Prior studies indicate that postural stability under binocular viewing is not better than under monocular viewing. This was tested at the distances of 145 cm [Fox, C.R. (1990). Some visual influences on human postural equilibrium: binocular versus monocular fixation. Perception and Psychophysics, 47 (5), 409-422] and ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2006.06.018
更新日期:2006-10-01 00:00:00
abstract::The dependence of spatial frequency on accommodation has been investigated extensively. Recently, differences between myopes and emmetropes with respect to accommodative microfluctuations for high spatial frequency targets have been reported. Considering the diversity of accommodative responses (ARs) to sinusoidal gra...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2015.05.020
更新日期:2015-10-01 00:00:00
abstract::We have measured corneal and total astigmatism on 161 eyes of 90 normal infants and young children aged 2 months to 5 years using the techniques of photorefraction and photokeratometry. Both the mean corneal and mean total astigmatism were found to decrease with increasing age. We found large and significant correlati...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(85)90082-3
更新日期:1985-01-01 00:00:00
abstract::In this study, we show that glutamate regulates the viability of cultured retinal cells upon transient glucose deprivation. At low concentrations (10-100 microM) glutamate decreased MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] reduction to about 50% of control and decreased intracellular ATP leve...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(00)00309-6
更新日期:2001-03-01 00:00:00
abstract::Dynamic random dot fusion, stereopsis and stereoacuity were evaluated in 149 healthy, fullterm infants, using both forced-choice preferential looking (FPL) and steady-state visual evoked potential (VEP) protocols. Few infants aged 2-3 months demonstrated fusion or stereopsis in either the FPL or VEP protocol; most inf...
journal_title:Vision research
pub_type: 临床试验,杂志文章
doi:10.1016/0042-6989(95)00183-2
更新日期:1996-05-01 00:00:00
abstract::We have investigated first-order artifacts in second-order motion perception. Subjects were required to identify the orientation and direction of a drifting sinusoidal contrast modulation. When the carrier consisted of static two-dimensional noise, performance often reflected the use of first-order artifacts that aris...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(96)00147-2
更新日期:1997-01-01 00:00:00
abstract::The distributions of dopamine D1 and D2 receptors were studied in intact goldfish retina with in vitro autoradiography. Specific [3H]SCH 23390 binding (D1 receptors) was greatest over the outer plexiform layer (OPL)/horizontal cell bodies and less so over the inner nuclear and inner plexiform layers (IPL). Specific [3...
journal_title:Vision research
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::We describe an architecture for invariant visual detection and recognition. Learning is performed in a single central module. The architecture makes use of a replica module consisting of copies of retinotopic layers of local features, with a particular design of inputs and outputs, that allows them to be primed either...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/s0042-6989(03)00306-7
更新日期:2003-09-01 00:00:00
abstract::A simple electrophysiological method is described for determining the effective optical density of the intracellular pupil mechanism of insect photoreceptor cells. The method depends on the fact that the photoreceptors can not only be illuminated in the normal, orthodromic way, but also antidromically, i.e. from the b...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/0042-6989(90)90178-n
更新日期:1990-01-01 00:00:00
abstract::Observers can better discriminate orientation or direction near the cardinal axes than near an oblique axis. We investigated whether this well-known oblique effect is determined by the physical or the perceived axis of the stimuli. Using the simultaneous tilt illusion, we generated perceptually different orientations ...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2005.05.016
更新日期:2005-12-01 00:00:00
abstract::Glass patterns are randomized dot arrays that generate the perception of a global structure. They consist of correlated dot pairs which are generated by geometric transformations. The present study employed behavioral and event-related brain potential (ERP) measures to characterize the underlying neuronal processing w...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2005.03.015
更新日期:2005-09-01 00:00:00
abstract::Humans use smooth pursuit eye movements to track moving objects of interest. In order to track an object accurately, motion signals from the target have to be integrated and segmented from motion signals in the visual context. Most studies on pursuit eye movements used small visual targets against a featureless backgr...
journal_title:Vision research
pub_type: 杂志文章
doi:10.1016/j.visres.2010.09.034
更新日期:2010-12-01 00:00:00