Fluoxetine in pathologic skin-picking: open-label and double-blind results.

Abstract:

:Various studies suggest that selective serotonin reuptake inhibitors (SSRIs) may be useful in treating pathologic skin-picking. The authors investigated the effectiveness of fluoxetine in treating this behavior. Fifteen subjects with clinically significant skin-picking were recruited by newspaper advertisement. They received 6 weeks of open-label treatment with fluoxetine. Responders were then randomized to 6 weeks of double-blind fluoxetine or placebo. Treatment effect was assessed with standardized rating scales. All 15 subjects completed open-label treatment, and 8 were responders. Of these eight, the four randomized to double-blind fluoxetine maintained clinically significant improvement. The four randomized to placebo returned to their baseline symptom level. Larger studies are needed to determine which individuals are likely to respond to fluoxetine and the relative effectiveness of fluoxetine, other SSRIs, and other forms of treatment.

journal_name

Psychosomatics

journal_title

Psychosomatics

authors

Bloch MR,Elliott M,Thompson H,Koran LM

doi

10.1176/appi.psy.42.4.314

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

314-9

issue

4

eissn

0033-3182

issn

1545-7206

pii

S0033-3182(01)70489-6

journal_volume

42

pub_type

临床试验,杂志文章,随机对照试验
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