Cochlear histopathology of the mutant bustling mouse, BUS/Idr.

Abstract:

:The inner ear of mutant bustling mice, BUS/Idr, was examined histopathologically. LM examinations revealed an age-dependent degeneration of the auditory organ of Corti in BUS homozygotes, but not heterozygotes. Cochlear base-to-apex gradient in severity of the degeneration was noted. First signs of degeneration were found in the outer hair cells of the cochlear basal turn at about 3 weeks of age, followed by degeneration of the spiral ganglion cells which occurred slowly. As examined by SEM, stereociliary derangements of both the inner and outer hair cells were apparent in homozygotes as early as after 10 days. No normal arrays of stereocilia were found in homozygotes examined at 10 days through 6 months. The results of immunohistochemical examinations suggest that the sensory cells of the Corti's organ of homozygotes are structurally once normally innervated. No significant difference was found in the expression of protooncogene c-mos in the CNS between BUS homozygotes and control mice. We propose that BUS mice be categorized as a member of the so-called "waltzer-shaker" mutants group.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Yonezawa S,Nodasaka Y,Kamada T,Fujita SC,Kato K,Yamada Y,Ogasawara N,Shoji R

doi

10.3109/00016489609137865

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

409-16

issue

3

eissn

0001-6489

issn

1651-2251

journal_volume

116

pub_type

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