Bioactivity of serum hCG in preeclampsia.

Abstract:

OBJECTIVE:To compare hCG levels, obtained by biologic and immunologic means, in women with normal pregnancies and women with preeclampsia. METHODS:Peripheral blood samples from women in the third trimester with preeclampsia (n = 30) or normal pregnancies (n = 30) were assayed for immunoactive and bioactive hCG (mouse Leydig cell testosterone production assay). RESULTS:Serum bioactive hCG levels tended to be lower than normal, and immunoactive hCG levels tended to be higher in women with preeclampsia, but the differences were not statistically significant. However, the ratio of bioactive to immunoactive hCG was significantly lower than normal for preeclamptic women (0.70 +/- 0.28 vs. 1.15 +/- 0.35 for normotensive pregnant women [mean +/- standard deviation], P <.001). CONCLUSION:The ratio of bioactive to immunoreactive serum hCG is lower among preeclamptic than among normotensive pregnant women.

journal_name

Obstet Gynecol

authors

Casart YC,Camejo MI,Proverbio F,Febres F

doi

10.1016/s0029-7844(01)01463-6

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

463-5

issue

3

eissn

0029-7844

issn

1873-233X

pii

S0029784401014636

journal_volume

98

pub_type

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