Abstract：
BACKGROUND AND OBJECTIVE:Some oral bacteria are susceptible to killing by red light after their sensitization with toluidine blue O (TBO). The photochemotherapy of periodontal disease in vivo would require a therapeutic window where bacteria could be killed without adjacent normal tissue damage. STUDY DESIGN/MATERIALS AND METHODS:The laser-induced effects of TBO on normal human gingival keratinocytes and fibroblasts have been studied in vitro. For the assessment of viability, the CellTiter 96TM AQueous Non-Radioactive Cell Proliferation Assay was used. RESULTS:TBO was cytotoxic at low concentrations (5.0 micrograms/ml). Sensitization of keratinocytes and fibroblasts with 2 and 5.0 micrograms/ml TBO, respectively, for 5 min and exposure to light from a 7.3 mW Helium/Neon (HeNe) laser for up to 2 min (0.876J) did not reduce cell viability. However, killing of Streptococcus sanguis was achieved following exposure to HeNe light for 75 sec (0.547J) in the presence of TBO at a concentration of 2.5 micrograms/ml. CONCLUSION:The development of a system for the lethal photosensitization of bacteria responsible for periodontal disease may be possible.
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Soukos NS,Wilson M,Burns T,Speight PMdoi
10.1002/(SICI)1096-9101(1996)18:3<253::AID-LSM6>3.subject
Has Abstractpub_date
1996-01-01 00:00:00pages
253-9issue
3eissn
0196-8092issn
1096-9101pii
10.1002/(SICI)1096-9101(1996)18:3<253::AID-LSM6>3.journal_volume
18pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:The identification of parathyroid glands can be a major problem in parathyroid surgery. The purpose of this study was to evaluate the feasibility of optical coherence tomography (OCT) in distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue. METHODS:Ex vivo...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22195
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Riehl's melanosis is a chronic acquired hyperpigmentation disorder that causes significant cosmetic problems for patients with this condition. Several treatment options, including low-fluence Q-switched Nd:YAG (QSNY) 1064-nm laser treatment, have been attempted with inconsistent results. We ai...
journal_title：Lasers in surgery and medicine
pub_type：
doi：10.1002/lsm.23214
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In a previous study, the possibility of removal of dog gingival melanin pigmentation with CO(2) laser therapy was reported. The present study was designed to investigate the effect of the CO(2) laser on human gingival pigmentation and evaluate the clinical outcome. STUDY DESIGN/MATERIALS AND M...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(sici)1096-9101(1999)25:2<140::aid-lsm7>3.
更新日期：1999-01-01 00:00:00
abstract：:Laser physiology has shown that while wound healing is generally excellent after laser impaction, it nevertheless is delayed. It is thought that this factor may be important in the treatment of hypertrophic and keloid scars. These scars have been treated in a variety of ways with the laser, and the results, which have...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900030402
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The difficulties typically encountered in studying the effects of restorations on tooth reinforcement are often due to the 3-dimensional (3D) nature of deformation. Therefore, electronic 3D-Speckle-Interferometry (3D-ESPI) was used to assess the impact of different restorative materials on the...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20036
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of laser monotherapy on quality of life in breast cancer patients with chronic radiation dermatitis. STUDY DESIGN:A prospective, IRB-approved study was conducted at Memorial Sloan Kettering Cancer Center. Breast cancer patients with chronic radiation dermatitis completed health-relate...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22780
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Variable square pulse (VSP) Er:YAG laser should be quicker than older Er:YAG lasers. The objectives were: (1) comparison of VSP laser and mechanical handpiece efficacy for apicectomy and (2) determination of optimal pulse width/energy/frequency combination. STUDY DESIGN/MATERIALS AND METHODS:...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20168
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Oral mucositis is a dose-limiting and painful side effect of radiotherapy (RT) and/or chemotherapy in cancer patients. The purpose of the present study was to analyze the effect of different protocols of laser phototherapy (LPT) on the grade of mucositis and degree of pain in patients under RT....
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.20758
更新日期：2009-04-01 00:00:00
abstract：:The use of lasers as surgical tools may open up new possibilities for the treatment of atherosclerotic occlusive vascular disease. However, basic information regarding the effect of laser radiation to the lumen of normal blood vessels is needed prior to clinical application. This work investigates the nature of the CO...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900030308
更新日期：1983-01-01 00:00:00
abstract：:We used a Q-switched Nd:YAG laser with non-linear optical crystals to produce the 5th (213 nm) and the 4th (266 nm) harmonic frequencies. Using these two wavelengths, we ablated fresh porcine corneas and type I collagen synthetic epikeratoplasty lenticules. For the 213-nm ablation, radiant exposure was 1.3 J/cm2. The ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900110610
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:The treatment of acne scars with fractional CO(2) lasers is gaining increasing impact, but has so far not been compared side-by-side to untreated control skin. OBJECTIVE:In a randomized controlled study to examine efficacy and adverse effects of fractional CO(2) laser resurfacing for atrophic acne scars com...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.22048
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Soft tissue sarcomas (STS) are a rare and heterogeneous group of malignant tumors that are often treated through surgical resection. Current intraoperative margin assessment methods are limited and highlight the need for an improved approach with respect to time and specificity. Here we investi...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22564
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22599
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Attempts at using the pulsed dye laser (PDL) operating at 585 nm wavelength and 0.45 milliseconds pulse duration to treat leg veins have been notably unsuccessful. The aim of this study is to evaluate the efficacy and complications of the 595 nm long PDL in the treatment of leg veins. STUDY D...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20035
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:This review has the following objectives: Firstly, it provides an explanation of the evolution of laser/intense pulsed light (IPL) hair reduction modalities from high fluence professional devices to low fluence home-use appliances. Secondly, it summarises published literature reviews on home-use devices (HUD...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,评审
doi：10.1002/lsm.23061
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.5% prilocaine (nanorap-test formulation) compared to placebo (control ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.23071
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Concerning current clinical practice, laser-assisted lipoplasty is still secondary to other procedures. In order to evaluate effects of thermal interaction with fatty-tissue, a near infrared diode laser was examined under reproducible conditions. METHODS:Based on optical spectroscopy of fatty-...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20602
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The effects of Er:YAG laser irradiation on dentin have not been sufficiently investigated. The purpose of this study was to investigate the effects of Er:YAG laser irradiation on dentin. STUDY DESIGN/MATERIALS AND METHODS:After cavities were prepared using Er:YAG laser irradiation or rotary c...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.10061
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The purpose of this in vitro study is to evaluate the use of the KTP (potassium-titanyl-phosphate) 532 nm laser for future use in endovaporization of large choroidal melanomas. STUDY DESIGN/MATERIALS AND METHODS:A KTP 532 nm green laser coupled to a 0.3 mm fiberoptic probe was used to perform...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20121
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:This paper describes the laser techniques available for the treatment of surgical and trauma scars and develops recommendations for an algorithmic-based treatment approach based on extensive clinical experience and published data. STUDY DESIGN/MATERIALS AND METHODS:We reviewed the literature ...
journal_title：Lasers in surgery and medicine
pub_type：
doi：10.1002/lsm.23171
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Enzyme histochemical stains of frozen sections have been used by investigators to assess thermal damage. The assessment of thermal damage to cells in lipid-rich tissues such as subcutaneous tissue and sebaceous glands can be difficult due to the quality of frozen sections of such tissues. The p...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20450
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Pulsed dye laser (PDL) is the first choice for treatment of port wine stains (PWS). However, outcome is highly variable and only a few patients achieve complete clearance. The objective of the study was to compare efficacy and safety of single pass PDL with double pass PDL at a 6 minute interval. METHODS:We...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.22011
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To analyze the impact of humidity and temperature on excimer laser ablation of polyethylene terephthalate (PET), polymethylmethacrylate (PMMA) and porcine corneal tissue, and an ablation model to compensate for the temperature and humidity changes on ablation efficiency. STUDY DESIGN/MATERIAL...
journal_title：Lasers in surgery and medicine
pub_type：
doi：10.1002/lsm.23190
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Interstitial photodynamic therapy (iPDT) of non-resectable recurrent glioblastoma using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has shown a promising outcome. It remained unclear, however, to what extent inter- and intra-tumoural differences of PpIX concentrations influence...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22126
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Helium plasma skin regeneration (PSR) is a novel skin rejuvenation technology with significant differences compared with nitrogen PSR technology but that may exert similar skin tissue effects. Study objectives included a comparison of acute and chronic skin tissue changes among the two plasmas...
journal_title：Lasers in surgery and medicine
pub_type：
doi：10.1002/lsm.23167
更新日期：2020-01-01 00:00:00
abstract：:The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (lambda (max) 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,评审
doi：10.1002/lsm.20352
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22702
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Low-level laser therapy (LLLT) is a noninvasive treatment for a wide-assortment of medical ailments. A recent application is for noninvasive body slimming. A Level 1 clinical study was completed and recorded a significant reduction in circumferential measurements across waist, hips, and thighs compared to pl...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22007
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:A novel, noninvasive technology, utilizing suction-coupled radiofrequency (RF) heating and ultra-short pulse duration, high-voltage electrical pulses was studied for its efficacy and safety on adipose tissue reduction. METHODS:Twenty-one subjects underwent treatment of their abdominal fat once...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22223
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Low-intensity laser irradiation (LILI) has been used to modulate a variety of biological processes, including diabetic wound healing. The mechanism of action is thought to exist primarily with the mitochondria. This study aimed to determine the effect of irradiation on normal, diabetic, and isc...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22027
更新日期：2012-07-01 00:00:00
