Influence of oral clonidine on the ventilatory response to acute and sustained isocapnic hypoxia in human males.

Abstract:

:Animal studies suggest that alpha 2 agonists inhibit the chemoreceptor response to hypoxia. We have examined the effect of oral clonidine on the ventilatory response to sustained, isocapnic hypoxia (SpO2 79.7% (SD 1.1%) for 20 min) in eight male subjects. The hypoxic ventilatory response was measured before and after both clonidine and placebo. Clonidine had no significant effect on baseline ventilation or gas exchange. After clonidine, the acute hypoxic response (AHR) (mean 5.81 (95% confidence limits 1.94, 9.68) litre min-1) was significantly less than control (10.40 (5.97, 14.83) litre min-1) and hypoxic ventilatory decline (HVD) (3.42(2.35, 4.49) litre min-1) was also significantly less than control (6.49(3.92, 9.06) litre min-1) (P < 0.05). After placebo, AHR was similar to control but HVD was significantly larger (6.82(5.28, 8.36) litre min-1) than control (4.79(3.03, 6.55) litre min-1) (P < 0.05). Thus clonidine reduced both AHR and HVD but the absolute level of ventilation at the end of hypoxia was unchanged.

journal_name

Br J Anaesth

authors

Foo IT,Warren PM,Drummond GB

doi

10.1093/bja/76.2.214

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

214-20

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)43893-1

journal_volume

76

pub_type

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