Efficacy of continuous intercostal bupivacaine for pain relief after thoracotomy.


:We studied 20 patients undergoing thoracotomy, in a double-blind, placebo-controlled crossover trial of intercostal bupivacaine. Bupivacaine 0.25% was infused at 5 ml h-1 through each of two catheters placed in the intercostal space at operation. Mean (95% confidence limits) 24-h requirements for morphine from a patient-controlled analgesia device were 29 (22-37) mg during bupivacaine infusion and 44 (32-57) mg during saline infusion (P = 0.04). Patients also recorded significantly smaller visual analogue scores for pain during bupivacaine infusion. There were no adverse effects related to the intercostal infusion of bupivacaine. We conclude that bupivacaine, infused through catheters placed during thoracotomy in the adjacent intercostal spaces, is a useful adjunct to systemic opioid analgesia.


Br J Anaesth


Dryden CM,McMenemin I,Duthie DJ




Has Abstract


1993-05-01 00:00:00














  • Components of the inspiratory-arterial isoflurane partial pressure difference.

    abstract::We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Landon MJ,Matson AM,Royston BD,Hewlett AM,White DC,Nunn JF

    更新日期:1993-06-01 00:00:00

  • Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery.

    abstract:Background:Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Methods:Cardiac surgery patients at increased risk of large-volume RBC ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wozniak MJ,Sullo N,Qureshi S,Dott W,Cardigan R,Wiltshire M,Morris T,Nath M,Bittar N,Bhudia SK,Kumar T,Goodall AH,Murphy GJ

    更新日期:2017-05-01 00:00:00

  • Cumulation of neomycin and its residual potentiation of tubocurarine in the cat.

    abstract::Cumulation and interaction of neuromuscular blocking effects of neomycin and tubocurarine were determined on responses of the tibialis anterior muscle of the anaesthetized cat to indirect stimulation. Neuromuscular block produced by neomycin was cumulative despite rapid and apparent full recovery of twitch tension and...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Durant NN,Lee C,Katz RL

    更新日期:1981-06-01 00:00:00

  • Descending aortic blood flow during aortic cross-clamp indicates postoperative splanchnic perfusion and gastrointestinal function in patients undergoing aortic reconstruction.

    abstract:BACKGROUND:The purpose of this observational study was to investigate the relationship between splanchnic and renal blood flow during infrarenal aortic cross-clamp (XC) and postoperative gastrointestinal perfusion and function. METHODS:Descending aortic blood flow (DABF) was continuously monitored with an oesophageal ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Kotake Y,Yamada T,Nagata H,Takeda J,Shimizu H

    更新日期:2012-06-01 00:00:00

  • Comparative study of topical anaesthesia with lidocaine 2% vs levobupivacaine 0.75% in cataract surgery.

    abstract:BACKGROUND:This study compared the efficacy of topical anaesthesia with levobupivacaine 0.75% vs lidocaine 2% during cataract surgery by phacoemulsification. METHODS:A prospective, randomized, double-blind study comparing two agents for topical anaesthesia in cataract surgery. Two hundred and forty-six consecutive pat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Fernández SA,Dios E,Diz JC

    更新日期:2009-02-01 00:00:00

  • Effects of cardiopulmonary bypass on neurocognitive performance and cytokine release in old and diabetic rats.

    abstract:BACKGROUND:Age and diabetes mellitus have been identified as independent risk factors for cognitive decline after cardiac surgery with cardiopulmonary bypass (CPB). We tested the effects of CPB on cognitive function in aged and diabetic rats utilizing the Morris water maze (MWM). METHODS:Aged rats (26 months) were ran...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: de Lange F,Dieleman JM,Jungwirth B,Kalkman CJ

    更新日期:2007-08-01 00:00:00

  • Evaluation of postural stability after low-dose droperidol in outpatients undergoing gynaecological dilatation and curettage procedure.

    abstract:BACKGROUND:Low-dose droperidol is suggested to be cost-effective in preventing nausea and vomiting after ambulatory surgery. This clinical study evaluated patient postural stability using a computerized force platform after an i.v. dose of droperidol 0.625 mg in outpatients undergoing gynaecological dilatation and cure...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Song D,Chung F,Yogendran S,Wong J

    更新日期:2002-06-01 00:00:00

  • Nausea and vomiting after fast-track cardiac anaesthesia.

    abstract:BACKGROUND:The aim of this study was to determine the prevalence of postoperative nausea and vomiting (PONV) after fast-track cardiac anaesthesia, risk factors for PONV and its influence on the length of stay in the intensive care unit (ICU). METHODS:A prospective study was performed in the cardiothoracic ICU (CTICU) ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章


    authors: Kogan A,Eidelman LA,Raanani E,Orlov B,Shenkin O,Vidne BA

    更新日期:2003-08-01 00:00:00

  • Transoesophageal echocardiographic monitoring of pulmonary venous obstruction induced by sternotomy closure during infant heart transplantation.

    abstract::A case of an infant receiving orthotopic heart transplantation with over-sized donor heart was reported. Left lower pulmonary venous obstruction after sternotomy closure was detected by transoesophageal echocardiography (TOE) and the decision to delay sternal closure was made and the clinical outcome was very satisfac...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Lin CP,Chan KC,Chou YM,Wang MJ,Tsai SK

    更新日期:2002-04-01 00:00:00

  • Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group.

    abstract::Neurone specific enolase (NSE) and S-100 beta protein have been used as markers of brain damage. We hypothesized that blood concentrations of NSE and S-100 beta protein reflect cognitive dysfunction after abdominal surgery. We studied 65 elderly patients in whom neuropsychological testing was performed before abdomina...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Rasmussen LS,Christiansen M,Rasmussen H,Kristensen PA,Moller JT

    更新日期:2000-02-01 00:00:00

  • Cardiac rate and rhythm during anaesthesia for dental extraction. A comparison of halothane, enflurane and isoflurane.

    abstract::Cardiac rate and rhythm were compared in 60 patients having dental extractions under conventional general anaesthesia using halothane, enflurane or isoflurane to supplement nitrous oxide in oxygen. The incidence of arrhythmia was higher in the halothane group when compared with both the enflurane (P less than 0.05) an...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Casson WR,Jones RM

    更新日期:1985-05-01 00:00:00

  • Impact of balanced tetrastarch raw material on perioperative blood loss: a randomized double blind controlled trial.

    abstract:BACKGROUND:As 6% hydroxyethyl starch (HES) 130/0.40 or 130/0.42 can originate from different vegetable sources, they might have different clinical effects. The purpose of this prospective, randomized, double-blind controlled trial was to compare two balanced tetrastarch solutions, one maize-derived and one potato-deriv...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Joosten A,Tircoveanu R,Arend S,Wauthy P,Gottignies P,Van der Linden P

    更新日期:2016-10-01 00:00:00

  • Surgical/tourniquet pain accelerates blood coagulability but not fibrinolysis.

    abstract::Tissue damage during surgery induces coagulation factors and activates platelets. Surgical pain may provoke release of catecholamines, leading to hypercoagulability. We have investigated the effect of surgical pain on blood coagulability and fibrinolysis in orthopaedic operations using tourniquets in 22 patients under...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kohro S,Yamakage M,Arakawa J,Kotaki M,Omote T,Namiki A

    更新日期:1998-04-01 00:00:00

  • The lumbar extradural structure changes with increasing age.

    abstract::We have examined the extradural space using a flexible extraduroscope in 74 patients undergoing extradural anaesthesia at the L2-3 interspace. Extraduroscopy showed that the extradural space becomes widely patent and the fatty tissue in the extradural space diminishes with increasing age. We postulate that these age-r...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Igarashi T,Hirabayashi Y,Shimizu R,Saitoh K,Fukuda H,Mitsuhata H

    更新日期:1997-02-01 00:00:00

  • Althesin, ketamine and methohexitone at pressure--duration of action of a single i.v. dose.

    abstract::General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Shearer AJ,Ross JA,Manson HJ

    更新日期:1981-05-01 00:00:00

  • Transcutaneous electric acupoint stimulation reduces intra-operative remifentanil consumption and alleviates postoperative side-effects in patients undergoing sinusotomy: a prospective, randomized, placebo-controlled trial.

    abstract:BACKGROUND:Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. We assessed the effect of transcutaneous electric acupoint...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Wang H,Xie Y,Zhang Q,Xu N,Zhong H,Dong H,Liu L,Jiang T,Wang Q,Xiong L

    更新日期:2014-06-01 00:00:00

  • Epidural analgesia in a child with sickle cell disease complicated by acute abdominal pain and priapism.

    abstract::We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Labat F,Dubousset AM,Baujard C,Wasier AP,Benhamou D,Cucchiaro G

    更新日期:2001-12-01 00:00:00

  • Pulmonary thromboendarterectomy in a case of hereditary stomatocytosis.

    abstract::We present a case of pulmonary thromboendarterectomy performed successfully in a patient with stomatocytosis. Stomatocytosis is a rare condition of abnormal erythrocyte morphology in which haemolysis and hyperkalaemia occur at cooler temperatures. A 35-yr-old male with stomatocytosis was referred for pulmonary thrombo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Murali B,Drain A,Seller D,Dunning J,Vuylsteke A

    更新日期:2003-11-01 00:00:00

  • Effect of age, gender and anaesthetic technique on the pharmacodynamics of atracurium.

    abstract::We have measured in 38 patients the plasma concentration profile of atracurium and its effect on the electromyographic first response of the train-of-four. One of three techniques was used to supplement anaesthesia with 66% nitrous oxide in oxygen, 0.9% isoflurane (end-tidal), 0.5% halothane (end-tidal) or midazolam 3...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章


    authors: Parker CJ,Hunter JM,Snowdon SL

    更新日期:1993-01-01 00:00:00

  • Comparison of propofol/remifentanil and sevoflurane/remifentanil for maintenance of anaesthesia for elective intracranial surgery.

    abstract:BACKGROUND:Propofol and sevoflurane are suitable agents for maintenance of anaesthesia during neurosurgical procedures. We have prospectively compared these agents in combination with the short-acting opioid, remifentanil. METHODS:Fifty unpremedicated patients undergoing elective craniotomy received remifentanil 1 mic...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sneyd JR,Andrews CJ,Tsubokawa T

    更新日期:2005-06-01 00:00:00

  • Incidence of sub-perineural injection using a targeted intracluster supraclavicular ultrasound-guided approach in cadavers.

    abstract:BACKGROUND:Multi-injection targeted intracluster injection ultrasound-guided supraclavicular brachial plexus block has been advocated to provide a faster onset of anaesthesia compared with a double injection technique. By placing the needle within clusters of hypoechoic structures, corresponding to neural tissue, this ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Retter S,Szerb J,Kwofie K,Colp P,Sandeski R,Uppal V

    更新日期:2019-06-01 00:00:00

  • Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section.

    abstract:BACKGROUND:In a prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of adding meperidine 10 mg to intrathecal bupivacaine on the duration of early postoperative analgesia in 40 patients having elective Caesarean section under spinal anaesthesia. METHODS:Patients received intrath...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yu SC,Ngan Kee WD,Kwan AS

    更新日期:2002-03-01 00:00:00

  • Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits.

    abstract:BACKGROUND:Multiple cognitive and psychiatric disorders are associated with an increased tonic inhibitory conductance that is generated by α5 subunit-containing γ-aminobutyric acid type A (α5 GABAA) receptors. Negative allosteric modulators that inhibit α5 GABAA receptors (α5-NAMs) are being developed as treatments for...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Manzo MA,Wang DS,Li WW,Pinguelo A,Popa MO,Khodaei S,Atack JR,Ross RA,Orser BA

    更新日期:2020-12-30 00:00:00

  • Atropine and glycopyrronium show similar binding patterns to M2 (cardiac) and M3 (submandibular gland) muscarinic receptor subtypes in the rat.

    abstract::Atropine and glycopyrronium are frequently used for premedication to reduce oral and respiratory secretions and prevent bradycardia. Glycopyrronium is said to have similar antisialagogue effects, but is less likely to cause significant tachycardia than atropine. Different antimuscarinic receptor selectivity patterns c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Gomez A,Bellido I,Sanchez de la Cuesta F

    更新日期:1995-05-01 00:00:00

  • Effects of chronic angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor treatments on neurohormonal levels and haemodynamics during cardiopulmonary bypass.

    abstract:BACKGROUND:Chronic treatment with renin-angiotensin system (RAS) antagonists frequently causes deleterious hypotension during anaesthesia. We compared the effects of angiotensin II receptor antagonists (ARA) and angiotensin-converting enzyme inhibitors (ACEI) on neurohormonal levels and haemodynamics during cardiopulmo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Oh YJ,Lee JH,Nam SB,Shim JK,Song JH,Kwak YL

    更新日期:2006-12-01 00:00:00

  • Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine.

    abstract:BACKGROUND:The incidence of pain on injection of propofol remains unacceptably high in children, despite various strategies to reduce it. A new drug formulation of propofol has, in adult studies, been reported to cause less injection pain compared with other propofol solutions. The aim of the present prospective random...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nyman Y,von Hofsten K,Georgiadi A,Eksborg S,Lönnqvist PA

    更新日期:2005-08-01 00:00:00

  • Recovery after total intravenous general anaesthesia or spinal anaesthesia for total knee arthroplasty: a randomized trial.

    abstract:BACKGROUND:This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS:One hundred and twenty subjects were randomly alloca...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Harsten A,Kehlet H,Toksvig-Larsen S

    更新日期:2013-09-01 00:00:00

  • Capnogram slope and ventilation dead space parameters: comparison of mainstream and sidestream techniques.

    abstract:BACKGROUND:Capnography may provide useful non-invasive bedside information concerning heterogeneity in lung ventilation, ventilation-perfusion mismatching and metabolic status. Although the capnogram may be recorded by mainstream and sidestream techniques, the capnogram indices furnished by these approaches have not pr...

    journal_title:British journal of anaesthesia

    pub_type: 评论,杂志文章


    authors: Balogh AL,Petak F,Fodor GH,Tolnai J,Csorba Z,Babik B

    更新日期:2016-07-01 00:00:00

  • Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.

    abstract:BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审


    authors: Fletcher D,Martinez V

    更新日期:2014-06-01 00:00:00

  • Comparison of a new neuromuscular transmission monitor compressomyograph with mechanomyograph.

    abstract:BACKGROUND:We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS:The two monitors ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Dahaba AA,Bornemann H,Holst B,Wilfinger G,Metzler H

    更新日期:2008-03-01 00:00:00