Abstract：
BACKGROUND:Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. METHODS:From January 1, 1992, to September 30, 1999, our center performed 18 renal transplants in previous solid organ recipients. During the same period, 815 total renal transplants were performed. One- and 3-year graft and patient survival, recipient demographics, donor type, and reason for transplantation were compared between these groups. RESULTS:Of the 18 recipients, 7 had prior heart transplants, 4 had prior liver transplants, and 7 had prior lung transplants. Cyclosporine toxicity contributed to renal failure in 17 (94.4%) of the patients-either as a sole factor (11 patients) or in combination with hypertension, renal artery stenosis, or tacrolimus toxicity (6 patients). Kaplan-Meier 1- and 3-year patient survival was 82.9% and 73.7%, compared with 95.5% and 90.7% in all renal transplant recipients. No surviving patient has suffered renal allograft loss. Mean current creatinine level is 1.4 mg/dL. CONCLUSIONS:Renal transplantation is an excellent therapy for ESRF following prior solid organ transplantation. One and 3-year patient and graft survival demonstrate the utility of renal transplantation in this patient population.
journal_name
Surgeryjournal_title
Surgeryauthors
Coopersmith CM,Brennan DC,Miller B,Wang C,Hmiel P,Shenoy S,Ramachandran V,Jendrisak MD,Ceriotti CS,Mohanakumar T,Lowell JAdoi
10.1067/msy.2001.115834subject
Has Abstractpub_date
2001-09-01 00:00:00pages
457-62issue
3eissn
0039-6060issn
1532-7361pii
S0039-6060(01)27592-8journal_volume
130pub_type
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