Impact of protease inhibitor-containing combination antiretroviral therapies on height and weight growth in HIV-infected children.

Abstract:

OBJECTIVE:To examine beneficial or detrimental effects of protease inhibitor (PI)-containing antiretroviral regimens on height and weight growth in children with human immunodeficiency virus (HIV) infection. METHODS:A prospective cohort study was conducted of 906 HIV-infected children, from pediatric research clinics in the United States, who were between 3 months and 18 years of age and who had height and weight assessed in 1995 (before introduction of PIs in this population) and at least once more through 1999. Changes in age- and gender-adjusted height and weight growth associated with PI use were assessed. RESULTS:Compared with a healthy reference population, children were more affected in height (mean z score: -0.90 [18th percentile]) than in weight (mean z score: -0.42 [34th percentile]) at baseline (1995). Two thirds of children received at least 1 PI during 1996 to 1999. In the multivariate mixed effects regression models adjusted for baseline log(10) CD4 cell count, baseline age, gender, and race/ethnicity, the use of PIs was associated with per-year gains of 0.13 z scores in height and 0.05 z scores in weight relative to the expected growth with non-PI-containing regimens (eg, after 1 year of PI use, a representative 6-year-old boy in our study would be approximately 0.7 cm taller and 0.1 kg heavier than if he had not received PIs). No significant differential effects of PIs on height or weight growth according to specific agents or children's sociodemographic or clinical characteristics were found. CONCLUSIONS:Although the use of PI-containing regimens was not associated with growth retardation, it was associated with only small annual increments in height and weight growth in HIV-infected children.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Buchacz K,Cervia JS,Lindsey JC,Hughes MD,Seage GR 3rd,Dankner WM,Oleske JM,Moye J

doi

10.1542/peds.108.4.e72

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

E72

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

108

pub_type

杂志文章
  • Nosocomial transmission of group B Streptococci in a newborn nursery.

    abstract::Group B streptococcal colonization of normal newborn infants increased from 22.5% within 20 hours of birth to 65.4% at the time of hospital discharge (P less than .001). In contrast, colonization in mothers did not change significantly between the time of admission to labor and delivery (27.7%) and the time of dischar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Paredes A,Wong P,Mason EO Jr,Taber LH,Barrett FF

    更新日期:1977-05-01 00:00:00

  • Probable graft-vs-graft reaction in an infant after exchange transfusion and marrow transplantation.

    abstract::A newborn with graft-vs-host (GVH) disease following an exchange transfusion was treated by attempting to eradicate the incompatible graft and to reconstitute the child hematologically and immunologically with a bone marrow transplant. The patient was a female term infant (blood group B, Rh+ Coombs test positive) who ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lauer BA,Githens JH,Hayward AR,Conrad PD,Yanagihara RT,Tubergen DG

    更新日期:1982-07-01 00:00:00

  • Carbamate poisoning: the 'other' insecticide.

    abstract::A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) were also adm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garber M

    更新日期:1987-05-01 00:00:00

  • Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy.

    abstract:OBJECTIVE:To identify possible causes of suboptimal glycemic control (ascertained by hemoglobin A1c [HbA1c] level) in youths using insulin pump therapy. METHODS:Forty-eight youths who were receiving insulin pump therapy for > or =6 months, and who were using insulin pumps and blood glucose meters with data that could ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.3.e221

    authors: Burdick J,Chase HP,Slover RH,Knievel K,Scrimgeour L,Maniatis AK,Klingensmith GJ

    更新日期:2004-03-01 00:00:00

  • Primary Care-Based Interventions to Promote Positive Parenting Behaviors: A Meta-analysis.

    abstract:CONTEXT:Utilization of primary care settings offers a promising approach to enhance parenting practices that are critical for promoting early childhood development. Determining the impact of existing primary care interventions on key parenting behaviors will aid providers and policy makers as they seek strategies to im...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2015-3393

    authors: Shah R,Kennedy S,Clark MD,Bauer SC,Schwartz A

    更新日期:2016-05-01 00:00:00

  • Effect of antibiotic therapy and etiologic microorganism on the risk of bacterial meningitis in children with occult bacteremia.

    abstract:OBJECTIVE:To quantify the effect of antibiotic therapy on the probability of subsequent bacterial meningitis in children with fever without source treated as outpatients. DESIGN:Bayesian meta-analyses. REPORTS INCLUDED: All reports of the organism-specific prevalence of occult bacteremia in children with fever without...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:

    authors: Baraff LJ,Oslund S,Prather M

    更新日期:1993-07-01 00:00:00

  • RCT of a mentoring and skills group program: placement and permanency outcomes for foster youth.

    abstract:OBJECTIVE:To examine the impact of a mentoring and skills group intervention for preadolescent children in foster care on placement stability and permanence at 1-year postintervention. METHODS:A randomized controlled trial was conducted with 9- to 11-year-old children who were maltreated and placed in foster care (n =...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-3447

    authors: Taussig HN,Culhane SE,Garrido E,Knudtson MD

    更新日期:2012-07-01 00:00:00

  • Overweight among low-income preschool children associated with the consumption of sweet drinks: Missouri, 1999-2002.

    abstract:OBJECTIVE:To examine the association between sweet drink consumption and overweight among preschool children. METHODS:A retrospective cohort design was used to examine the association between sweet drink consumption and overweight at follow-up among 10904 children who were aged 2 and 3 years and had height, weight, an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1148

    authors: Welsh JA,Cogswell ME,Rogers S,Rockett H,Mei Z,Grummer-Strawn LM

    更新日期:2005-02-01 00:00:00

  • Childhood Assets and Cardiometabolic Health in Adolescence.

    abstract:BACKGROUND:Research shows that the development of cardiometabolic disease can begin early in life with risk factors accumulating over time, but less is known about protective pathways to positive health. In this study, we use prospective data to test whether childhood assets predict a greater likelihood of being in opt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2004

    authors: Qureshi F,Koenen KC,Tiemeier H,Williams MA,Misra S,Kubzansky LD

    更新日期:2019-03-01 00:00:00

  • Comparison of outcome measures for a traditional pediatric faculty service and nonfaculty hospitalist services in a community teaching hospital.

    abstract:OBJECTIVE:Several studies have found decreased cost and length of stay for patients who are cared for by pediatric hospitalists compared with traditional faculty models. The objective of this study was to compare cost and length of stay between a faculty group and 2 separate hospitalist groups in a community teaching h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3146

    authors: Boyd J 3rd,Samaddar K,Parra-Roide L,Allen EP,White B

    更新日期:2006-10-01 00:00:00

  • The medical cost of abusive head trauma in the United States.

    abstract:OBJECTIVES:Health consequences of shaken baby syndrome, or pediatric abusive head trauma (AHT), can be severe and long-lasting. We aimed to estimate the multiyear medical cost attributable to AHT. METHODS:Using Truven Health MarketScan data, 2003-2011, we identified children 0 to 4 years old with commercial or Medicai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0117

    authors: Peterson C,Xu L,Florence C,Parks SE,Miller TR,Barr RG,Barr M,Steinbeigle R

    更新日期:2014-07-01 00:00:00

  • Involuntary smoking and incidence of respiratory illness during the first year of life.

    abstract::A prospective study of 1,144 infants and their families was performed. Smoking and family histories were evaluated with respect to the incidence of lower respiratory disease during the first year of life. It was found that (1) tracheitis and bronchitis occurred significantly more frequently in infants exposed to cigar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pedreira FA,Guandolo VL,Feroli EJ,Mella GW,Weiss IP

    更新日期:1985-03-01 00:00:00

  • Bilirubin photoisomerization in premature neonates under low- and high-dose phototherapy.

    abstract::Photoisomerization of native bilirubin to more polar configurational isomers (Z,E-bilirubin) and structural isomers (lumirubin) was studied in 20 premature infants with physiologic jaundice to determine the effect of low-dose (6 microW/cm2/nm) v high-dose (12 microW/cm2/nm) phototherapy. Patients were assigned prospec...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Costarino AT,Ennever JF,Baumgart S,Speck WT,Paul M,Polin RA

    更新日期:1985-03-01 00:00:00

  • Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial.

    abstract:OBJECTIVE:The purpose of this work was to evaluate whether education about zinc supplements and provision of zinc supplements to caregivers is effective in the treatment of acute diarrhea and whether this strategy adversely affects the use of oral rehydration salts. PATIENTS AND METHODS:Six clusters of 30,000 people e...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2007-1939

    authors: Bhandari N,Mazumder S,Taneja S,Dube B,Agarwal RC,Mahalanabis D,Fontaine O,Black RE,Bhan MK

    更新日期:2008-05-01 00:00:00

  • Ophthalmia neonatorum: a chart review.

    abstract::Cases of ophthalmia neonatorum diagnosed at Grady Memorial Hospital 1967-1973 were reviewed. Of 302 cases 43 could be diagnosed as gonococcal, 86 chlamydial, 3 gonococcal and chlamydial, 31 staphylococcal, and 5 chemical. Silver nitrate prophylaxis was routinely employed. Gonococcal cases peaked during the third quart...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Armstrong JH,Zacarias F,Rein MF

    更新日期:1976-06-01 00:00:00

  • Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.

    abstract:OBJECTIVE:The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. METHODS:As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal expo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0338

    authors: Rauh VA,Garfinkel R,Perera FP,Andrews HF,Hoepner L,Barr DB,Whitehead R,Tang D,Whyatt RW

    更新日期:2006-12-01 00:00:00

  • Secondhand smoke exposure and neurobehavioral disorders among children in the United States.

    abstract:OBJECTIVES:The association between parent-reported postnatal secondhand tobacco smoke exposure in the home and neurobehavioral disorders (attention-deficit/hyperactivity disorder, learning disabilities, and conduct disorders) among children younger than 12 years in the United States was examined using the 2007 National...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0023

    authors: Kabir Z,Connolly GN,Alpert HR

    更新日期:2011-08-01 00:00:00

  • Self-reported physician practices for children with asthma: are national guidelines followed?

    abstract:OBJECTIVE:To determine self-reported adherence to national asthma guidelines for children by primary care physicians in managed care; and, to analyze sources of variation in these practices by physician specialty and managed care practice type. DESIGN:A survey of 671 primary care physicians (pediatricians and family p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Finkelstein JA,Lozano P,Shulruff R,Inui TS,Soumerai SB,Ng M,Weiss KB

    更新日期:2000-10-01 00:00:00

  • Intrauterine rubella, head size, and intellect.

    abstract::The assumption that congenital rubella is commonly associated with microcephaly and mental retardation was examined. Among a rubella clinic population of 111 children, 92 children had vision sufficient to allow testing by the Leiter International Scale. The mean IQ for this group was 99.46 (SD, 19.5). Head circumferen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Macfarlane DW,Boyd RD,Dodrill CB,Tufts E

    更新日期:1975-06-01 00:00:00

  • Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial.

    abstract:OBJECTIVE:This study compared the effects of immediate (ICC) and delayed (DCC) cord clamping on very low birth weight (VLBW) infants on 2 primary variables: bronchopulmonary dysplasia (BPD) and suspected necrotizing enterocolitis (SNEC). Other outcome variables were late-onset sepsis (LOS) and intraventricular hemorrha...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-1706

    authors: Mercer JS,Vohr BR,McGrath MM,Padbury JF,Wallach M,Oh W

    更新日期:2006-04-01 00:00:00

  • Does bed sharing affect the risk of SIDS? American Academy of Pediatrics. Task Force on Infant Positioning and SIDS.

    abstract::The American Academy of Pediatrics endorses and accepts as its policy the position on bed sharing as articulated below by a panel of experts convened by the National Institute of Child Health and Human Development (NICHD). The Panel attended a conference sponsored by the NICHD entitled "Infant Sleep Environment and SI...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:

    authors:

    更新日期:1997-08-01 00:00:00

  • Are Patients With Loeys-Dietz Syndrome Misdiagnosed With Beals Syndrome?

    abstract::Beals syndrome, also known as congenital contractural arachnodactyly (Online Mendelian Inheritance in Man: 121050), is an autosomal dominant disorder caused by a mutation in FBN2 that is typically characterized by congenital contractures and arachnodactyly. It shares a number of phenotypic features with Loeys-Dietz sy...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1281

    authors: Woolnough R,Dhawan A,Dow K,Walia JS

    更新日期:2017-03-01 00:00:00

  • Systematic review and meta-analysis of therapeutic management of upper-limb dysfunction in children with congenital hemiplegia.

    abstract:CONTEXT:Rehabilitation for children with congenital hemiplegia to improve function in the impaired upper limb and enhance participation may be time-consuming and costly. OBJECTIVES:To systematically review the efficacy of nonsurgical upper-limb therapeutic interventions for children with congenital hemiplegia. METHOD...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2008-3335

    authors: Sakzewski L,Ziviani J,Boyd R

    更新日期:2009-06-01 00:00:00

  • Out-of-pocket costs of childhood immunizations: a comparison by type of insurance plan.

    abstract:BACKGROUND:The "Guide to Community Preventive Services" strongly recommends reducing out-of-pocket costs to increase vaccination rates among children. Nevertheless, out-of-pocket expenses are still incurred during the receipt of childhood vaccines, vaccine administration, and associated well-child visits. OBJECTIVE:Ou...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3654

    authors: Molinari NA,Kolasa M,Messonnier ML,Schieber RA

    更新日期:2007-11-01 00:00:00

  • Prediction of digoxin treatment failure in infants with supraventricular tachycardia: role of transesophageal pacing.

    abstract::Transesophageal atrial pacing was used to initiate and terminate tachycardia in 24 infants (seven female and 17 male, aged 1 to 34 days) with ECG documentation of supraventricular tachycardia. Six infants received no chronic treatment, and chronic oral digoxin prophylaxis was administered to 18 infants in an effort to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Benson DW Jr,Dunnigan A,Benditt DG,Thompson TR,Narayan A,Boros S

    更新日期:1985-02-01 00:00:00

  • Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection.

    abstract::Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2017-2038F

    authors: Pessoa A,van der Linden V,Yeargin-Allsopp M,Carvalho MDCG,Ribeiro EM,Van Naarden Braun K,Durkin MS,Pastula DM,Moore JT,Moore CA

    更新日期:2018-02-01 00:00:00

  • Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature.

    abstract::Severe methemoglobinemia resulting from the use of topical benzocaine has been reported in adults as a rare complication. Here we report a case of severe acquired methemoglobinemia resulting from topical use of benzocaine spray during diagnostic upper gastrointestinal endoscopy in a 3-year-old boy with repeated episod...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2005-1952

    authors: Dahshan A,Donovan GK

    更新日期:2006-04-01 00:00:00

  • Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections.

    abstract:OBJECTIVES:To determine the association between parenteral antibiotic duration and outcomes in infants ≤60 days old with bacteremic urinary tract infection (UTI). METHODS:This multicenter retrospective cohort study included infants ≤60 days old who had concomitant growth of a pathogen in blood and urine cultures at 11...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-3844

    authors: Desai S,Aronson PL,Shabanova V,Neuman MI,Balamuth F,Pruitt CM,DePorre AG,Nigrovic LE,Rooholamini SN,Wang ME,Marble RD,Williams DJ,Sartori L,Leazer RC,Mitchell C,Shah SS,FEBRILE YOUNG INFANT RESEARCH COLLABORATIVE.

    更新日期:2019-09-01 00:00:00

  • Psychopathology in children and adolescents with migraine in clinical studies: a systematic review.

    abstract:BACKGROUND:In past decades, numerous population- and hospital-based studies have revealed a relationship between migraine or headache and psychopathology in children. OBJECTIVE:To describe and assess all clinical studies on the prevalence and manifestations of psychological functioning and psychiatric comorbidity in c...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-3293

    authors: Bruijn J,Locher H,Passchier J,Dijkstra N,Arts WF

    更新日期:2010-08-01 00:00:00

  • Reducing distress in mothers of children with autism and other disabilities: a randomized trial.

    abstract:BACKGROUND:Compared with other parents, mothers of children with autism spectrum disorder or other neurodevelopmental disabilities experience more stress, illness, and psychiatric problems. Although the cumulative stress and disease burden of these mothers is exceptionally high, and associated with poorer outcomes in c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3164

    authors: Dykens EM,Fisher MH,Taylor JL,Lambert W,Miodrag N

    更新日期:2014-08-01 00:00:00