Probable graft-vs-graft reaction in an infant after exchange transfusion and marrow transplantation.

Abstract:

:A newborn with graft-vs-host (GVH) disease following an exchange transfusion was treated by attempting to eradicate the incompatible graft and to reconstitute the child hematologically and immunologically with a bone marrow transplant. The patient was a female term infant (blood group B, Rh+ Coombs test positive) who received a one-unit group O, Rh- exchange transfusion from an unrelated female donor for hyperbilirubinemia due to ABO incompatibility on day 2. Signs of acute GVH disease began on day 8 and the clinical diagnosis was supported by skin biopsy. With antithymocyte globulin and high dose dexamethasone, the GVH reaction improved somewhat. Cyclophosphamide, 200 mg/kg total dose, was given over four days followed by a marrow graft from a brother who was HLA-A, B identical, and probably also D locus compatible in mixed lymphocyte culture. All signs of GVH resolved with cyclophosphamide treatment and hematologic reconstitution was evident by 14 days after transplant. Two weeks later the GVH reaction and aplastic anemia recurred and Y chromatin was detected in only 6% of marrow cells. The infant died on day 80. Autopsy showed disseminated candidiasis, disseminated cytomegalovirus infection, thymic dysplasia, hypoplastic marrow, and other histopathologic changes consistent with GVH disease. The persistence of female cells in blood and bone marrow and the destruction of the reconstituted marrow suggest that the original incompatible transfusion-derived graft was not eliminated and that it ultimately rejected the histocompatible marrow graft.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Lauer BA,Githens JH,Hayward AR,Conrad PD,Yanagihara RT,Tubergen DG

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

43-7

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

70

pub_type

杂志文章
  • A national survey of pediatrician knowledge and attitudes regarding human papillomavirus vaccination.

    abstract:OBJECTIVE:A human papillomavirus vaccine was licensed in June 2006. The vaccine is quadrivalent, protecting against 2 human papillomavirus strains that cause cervical cancer and 2 that cause genital warts. The objective of this study was to determine physician characteristics, knowledge, and attitudes associated with a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1946

    authors: Daley MF,Liddon N,Crane LA,Beaty BL,Barrow J,Babbel C,Markowitz LE,Dunne EF,Stokley S,Dickinson LM,Berman S,Kempe A

    更新日期:2006-12-01 00:00:00

  • Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development.

    abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Koopman-Esseboom C,Weisglas-Kuperus N,de Ridder MA,Van der Paauw CG,Tuinstra LG,Sauer PJ

    更新日期:1996-05-01 00:00:00

  • The triple risk hypotheses in sudden infant death syndrome.

    abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.110.5.e64

    authors: Guntheroth WG,Spiers PS

    更新日期:2002-11-01 00:00:00

  • Simulation in Pediatric Emergency Medicine Fellowships.

    abstract:BACKGROUND AND OBJECTIVES:Graduate medical education faces challenges as programs transition to the next accreditation system. Evidence supports the effectiveness of simulation for training and assessment. This study aims to describe the current use of simulation and barriers to its implementation in pediatric emergenc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-4158

    authors: Doughty CB,Kessler DO,Zuckerbraun NS,Stone KP,Reid JR,Kennedy CS,Nypaver MM,Auerbach MA

    更新日期:2015-07-01 00:00:00

  • Parental knowledge, attitudes, and practices associated with not receiving hepatitis A vaccine in a demonstration project in Butte County, California.

    abstract:OBJECTIVE:To determine hepatitis A vaccination coverage and factors associated with not receiving hepatitis A vaccine among children. METHODS:A random cluster sample survey was conducted of parents of children who attended kindergarten in Butte County, California, in 2000. Because of a history of recurrent epidemics, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.e269

    authors: Bardenheier B,González IM,Washington ML,Bell BP,Averhoff F,Massoudi MS,Hyams I,Simard EP,Yusuf H

    更新日期:2003-10-01 00:00:00

  • Osteomyelitis and sepsis: severe complications of fetal monitoring.

    abstract::Sophisticated modern methods of fetal monitoring during labor have improved the prognosis for high-risk infants, but the possible adverse side effects have not yet been fully documented. One infant with osteomyelitis and one with streptococcal sepsis are reported. In the future, greater attention should be paid to suc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Overturf GD,Balfour G

    更新日期:1975-02-01 00:00:00

  • The mononuclear phagocyte system: role in expression of immunocompetence in neonatal and adult life.

    abstract::The cells of the mononuclear phagocyte system are critical elements in host defense. They are essential to many specific immune processes in addition to their well-recognized role in nonspecific resistance. In this report we describe studies of the influence of the maturation of this system of cells on the capacity of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blaese RM,Poplack DG,Muchmore AV

    更新日期:1979-11-01 00:00:00

  • Evaluation of community-based health projects: the healthy tomorrows experience.

    abstract:OBJECTIVES:To address the "millennial morbidities," pediatricians must partner with community-based organizations to develop interventions. Little is known about the capacity of the resulting programs for program evaluation or the importance of evaluation in project success and sustainability. The objective of this stu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3273

    authors: Ruch-Ross H,Keller D,Miller N,Bassewitz J,Melinkovich P

    更新日期:2008-09-01 00:00:00

  • Corneal abrasions in young infants.

    abstract:OBJECTIVES:We sought to determine the prevalence of corneal abrasions and possible associations with fingernail length, demographic information, sleeping, and crying among young infants. METHODS:Parents of 1- to 12-week-old infants without symptoms who were presenting for well-child visits completed a brief questionna...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2023

    authors: Shope TR,Rieg TS,Kathiria NN

    更新日期:2010-03-01 00:00:00

  • Recommendations for influenza immunization of children.

    abstract::Epidemiologic studies indicate that children of all ages with certain chronic conditions and otherwise healthy children younger than 24 months of age are hospitalized for influenza infection and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is recommended fo...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.113.5.1441

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2004-05-01 00:00:00

  • Heterogeneity of diagnoses presenting as cyclic vomiting.

    abstract:OBJECTIVE:To establish the diagnostic profile in children who present with cyclic vomiting. METHODS:We studied 225 children < 18 years of age who presented to our pediatric gastroenterology service from 1986 to 1997 with at least three discrete episodes of vomiting between which they were well. To determine the diagno...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.3.583

    authors: Li BU,Murray RD,Heitlinger LA,Robbins JL,Hayes JR

    更新日期:1998-09-01 00:00:00

  • Involuntary smoking and incidence of respiratory illness during the first year of life.

    abstract::A prospective study of 1,144 infants and their families was performed. Smoking and family histories were evaluated with respect to the incidence of lower respiratory disease during the first year of life. It was found that (1) tracheitis and bronchitis occurred significantly more frequently in infants exposed to cigar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pedreira FA,Guandolo VL,Feroli EJ,Mella GW,Weiss IP

    更新日期:1985-03-01 00:00:00

  • Comparison of rifampin and ampicillin in day care center contacts of Haemophilus influenzae type b disease.

    abstract::A prospective, randomized, crossover trial was conducted comparing therapy with rifampin to therapy with ampicillin in eradicating Haemophilus influenzae type b carriage. Twenty-eight carriers were identified in a day care center following exposure to a patient with H influenzae type b meningitis; 26 children were ran...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gessert C,Granoff DM,Gilsdorf J

    更新日期:1980-07-01 00:00:00

  • Contraceptive Provision to Adolescent Females Prescribed Teratogenic Medications.

    abstract:BACKGROUND AND OBJECTIVES:Rates of adult women receiving contraceptive provision when simultaneously prescribed a known teratogen are alarmingly low. The prevalence of this behavior among pediatric providers and their adolescent patients is unknown. The objective of this study was to describe pediatric provider behavio...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-1454

    authors: Stancil SL,Miller M,Briggs H,Lynch D,Goggin K,Kearns G

    更新日期:2016-01-01 00:00:00

  • Validity of Newborn Clinical Assessment to Determine Gestational Age in Bangladesh.

    abstract:BACKGROUND:Gestational age (GA) is frequently unknown or inaccurate in pregnancies in low-income countries. Early identification of preterm infants may help link them to potentially life-saving interventions. METHODS:We conducted a validation study in a community-based birth cohort in rural Bangladesh. GA was determin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3303

    authors: Lee AC,Mullany LC,Ladhani K,Uddin J,Mitra D,Ahmed P,Christian P,Labrique A,DasGupta SK,Lokken RP,Quaiyum M,Baqui AH,Projahnmo Study Group.

    更新日期:2016-07-01 00:00:00

  • Use of bacterial antigen detection in the diagnosis of pediatric lower respiratory tract infections.

    abstract::Two immunochemical methods were used to identify Haemophilus influenzae and Streptococcus pneumoniae capsular antigens in the urine and serum of 162 children with acute lower respiratory tract infection. These methods were compared with standard bacterial blood culture. Viral and mycoplasma cultures of respiratory sec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ramsey BW,Marcuse EK,Foy HM,Cooney MK,Allan I,Brewer D,Smith AL

    更新日期:1986-07-01 00:00:00

  • Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children.

    abstract:OBJECTIVE:This study evaluated age- and sedative agent-related differences in bispectral index across observed sedation levels in a large sample of children < 18 years of age. PATIENTS AND METHODS:With institutional review board approval and waiver of consent, data from 4 independently conducted studies were combined ...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2006-2577

    authors: Malviya S,Voepel-Lewis T,Tait AR,Watcha MF,Sadhasivam S,Friesen RH

    更新日期:2007-09-01 00:00:00

  • Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea.

    abstract:OBJECTIVE:Methylxanthines are among the most commonly prescribed drugs in neonatal intensive care. This study evaluates the effect of caffeine on oxygen consumption and metabolic rate in premature infants with idiopathic apnea. METHODS:Eighteen preterm infants at gestational ages from 28 to 33 weeks and birth weights ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.4.660

    authors: Bauer J,Maier K,Linderkamp O,Hentschel R

    更新日期:2001-04-01 00:00:00

  • Pacifier use and morbidity in the first six months of life.

    abstract:OBJECTIVE:To assess the prevalence of pacifier use and whether this habit adversely affects the health of 6-month-old infants. DESIGN:Data collected via self-completion questionnaires from mothers forming part of the prospective, population-based Avon Longitudinal Study of Pregnancy and Childhood. METHODS:The mothers...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.e34

    authors: North K,Fleming P,Golding J

    更新日期:1999-03-01 00:00:00

  • Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.

    abstract::Immunodeficiency-centromeric instability-facial dysmorphism syndrome, characterized by variable immunodeficiency, centromeric instability, and facial anomalies caused by epigenetic dysregulation resulting in hypomethylation, is caused in many patients by mutations in DNMT3B, a DNA methyltransferase gene; associated in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0640

    authors: Gennery AR,Slatter MA,Bredius RG,Hagleitner MM,Weemaes C,Cant AJ,Lankester AC

    更新日期:2007-11-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Haemophilus influenzae.

    abstract::Synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible Haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.406

    authors: Feldman WE

    更新日期:1978-03-01 00:00:00

  • The psychological consequences of Turner syndrome and review of the National Cooperative Growth Study psychological substudy.

    abstract:OBJECTIVE:To present longitudinal data on the psychological profile of a cohort of girls with and without Turner syndrome (TS) treated for 3 years with growth hormone (GH). METHODS:Among a sample of 283 children with short stature, 37 girls with TS were recruited at 27 US medical centers. Of the original cohort, 22 gi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Siegel PT,Clopper R,Stabler B

    更新日期:1998-08-01 00:00:00

  • A 17-Year-Old With Chest Pain.

    abstract::A 17-year-old male subject with a history of deep venous thrombosis presented with acute unilateral severe chest pain. His examination was nonspecific, and vital signs were normal. His initial laboratory evaluation revealed mild thrombocytopenia, elevated troponin levels, and critically elevated activated partial thro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-0794

    authors: Shah AY,Jamison M,Otero HJ,Jung L,Frank LH,Guerrera MF,Kirkorian AY

    更新日期:2017-03-01 00:00:00

  • Sleep problems seldom addressed at two general pediatric clinics.

    abstract:OBJECTIVE:Sleep disorders can cause substantial morbidity but often remain undiagnosed among adults. We identified a series of children with sleep-related symptoms and reviewed medical chart notes for the previous 2 years to determine how often sleep problems had been addressed. DESIGN:Observational. Setting. Two univ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.1375

    authors: Chervin RD,Archbold KH,Panahi P,Pituch KJ

    更新日期:2001-06-01 00:00:00

  • Rape prevention through empowerment of adolescent girls.

    abstract:BACKGROUND AND OBJECTIVE:Sexual assault is a major cause of injury, unplanned pregnancy, HIV infection, and mental health problems worldwide. In parts of sub-Saharan Africa, sexual assault has reached epidemic proportions. This study evaluated the efficacy of an empowerment and self-defense intervention for adolescent ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2013-3414

    authors: Sarnquist C,Omondi B,Sinclair J,Gitau C,Paiva L,Mulinge M,Cornfield DN,Maldonado Y

    更新日期:2014-05-01 00:00:00

  • Health outcomes of a community-based therapy program for children with cancer--a shared-management approach.

    abstract::Critical to providing cancer therapy to children in rural areas is finding dependable sources of therapy near the patients' homes. In this study, comparison was made of 668 visits by 24 patients to nearby private practitioners, who carried out 70% of the therapy, with 712 visits by 22 other patients for whom all care ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kisker CT,Strayer F,Wong K,Clarke W,Strauss R,Tannous R,Janco R,Spevak J

    更新日期:1980-12-01 00:00:00

  • Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants.

    abstract:BACKGROUND:Low cortisol concentrations in premature infants have been correlated with increased severity of illness, hypotension, mortality, and development of bronchopulmonary dysplasia. A total of 360 mechanically ventilated infants with a birth weight of 500 to 999 g were enrolled in a randomized, multicenter trial ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2006-3158

    authors: Watterberg KL,Shaffer ML,Mishefske MJ,Leach CL,Mammel MC,Couser RJ,Abbasi S,Cole CH,Aucott SW,Thilo EH,Rozycki HJ,Lacy CB

    更新日期:2007-07-01 00:00:00

  • Outbreak of Mycoplasma pneumoniae-Associated Stevens-Johnson Syndrome.

    abstract:BACKGROUND:Stevens-Johnson syndrome (SJS) is an uncommon, sporadic disease and outbreaks are rare. In November 2013, an outbreak of SJS was identified at Children's Hospital Colorado. METHODS:Outbreak cases were children aged 5-21 with a discharge diagnosis of SJS admitted from September 1 to November 30, 2013. Medica...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0278

    authors: Olson D,Watkins LK,Demirjian A,Lin X,Robinson CC,Pretty K,Benitez AJ,Winchell JM,Diaz MH,Miller LA,Foo TA,Mason MD,Lauper UL,Kupfer O,Kennedy J,Glodé MP,Kutty PK,Dominguez SR

    更新日期:2015-08-01 00:00:00

  • The clinical phenotype of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria): case reports of 23 new patients.

    abstract:OBJECTIVES:To further define the clinical spectrum of the disease for pediatric and metabolic specialists, and to suggest that the general pediatrician and pediatric neurologist consider succinic semialdehyde dehydrogenase (SSADH) deficiency in the differential diagnosis of patients with (idiopathic) mental retardation...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.4.567

    authors: Gibson KM,Christensen E,Jakobs C,Fowler B,Clarke MA,Hammersen G,Raab K,Kobori J,Moosa A,Vollmer B,Rossier E,Iafolla AK,Matern D,Brouwer OF,Finkelstein J,Aksu F,Weber HP,Bakkeren JA,Gabreels FJ,Bluestone D,Barron T

    更新日期:1997-04-01 00:00:00

  • Language ability in children with permanent hearing impairment: the influence of early management and family participation.

    abstract:OBJECTIVE:The goal was to examine the relationships between management after confirmation, family participation, and speech and language outcomes in the same group of children with permanent childhood hearing impairment. METHODS:Speech, oral language, and nonverbal abilities, expressed as z scores and adjusted in a re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2116

    authors: Watkin P,McCann D,Law C,Mullee M,Petrou S,Stevenson J,Worsfold S,Yuen HM,Kennedy C

    更新日期:2007-09-01 00:00:00