Abstract：
:Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, which, if sustained, induces widespread endothelial damage and MODS. Immunomodulating therapies, at present, have proven ineffective in reducing morbidity and mortality, presumably because of the heterogeneous nature of sepsis and septic shock and the reciprocating and redundant nature of this inflammatory cascade. Organ-specific therapies can support life but impair both organ-specific function and remote organ function. Novel therapies aimed at minimizing further organ dysfunction may improve outcome in a cost-effective fashion by preventing both further primary organ dysfunction or remote organ dysfunction secondary to the subsequent activation of the inflammatory response.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Pinsky MRdoi
10.1016/s0883-9441(96)90024-6subject
Has Abstractpub_date
1996-06-01 00:00:00pages
95-107issue
2eissn
0883-9441issn
1557-8615pii
S0883-9441(96)90024-6journal_volume
11pub_type
杂志文章,评审abstract：PURPOSE:To identify elements which enable patient and family centred care (PFCC) in the intensive care unit (ICU) and priorities for PFCC research. MATERIALS AND METHODS:We engaged a panel of multidisciplinary stakeholders in a modified Delphi process. Items generated from a literature review and panelist suggestions ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.08.008
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:To describe the associations between right ventricular (RV) function and outcomes of patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). METHODS:This is a retrospective study, conducted 2006-2015 at an academic hospital in USA. We included patients with AKI requirin...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2020.11.022
更新日期：2020-11-30 00:00:00
abstract：PURPOSE:The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC). MATERIALS AND METHODS:This is a 4-year ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the causes, incidence, and impact on outcome of admission hyperlactatemia in patients admitted to a general medical intensive care unit (ICU). METHODS:A retrospective cohort study was done in an 8-bed general ICU of tertiary care hospital over 15 months. Data regarding pat...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.11.009
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:Early markers of oxygenator dysfunction during prolonged use of extracorporeal membrane oxygenation (ECMO) are important for timely exchange to avoid sudden loss of function due to clot formation within the system. The measurement of D-dimers (DDs) in plasma might be a marker for early diagnosis of thrombus for...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2013.12.008
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:Arterial blood gas measurement is frequently performed in critically ill patients to diagnose and monitor acute respiratory failure. At a given metabolic rate, carbon dioxide partial pressure (PaCO2) is entirely determined by CO2 elimination through ventilation. Transcutaneous partial pressure of carbon dioxide...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.09.014
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:To evaluate mortality, length of stay, and inter-hospital transfer in the Veteran Health Administration (VHA) among low complexity Intensive Care Unit (ICU) patients. MATERIALS AND METHOD:Retrospective study of adult ICU admissions identified in VHA Medical SAS®; 2010-2015 at Veterans Affairs (VA) Medical Cent...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.10.013
更新日期：2019-02-01 00:00:00
abstract：:Patient ventilatory dyssynchrony (PVD) is a mismatch between the respiratory drive of the patient and ventilatory assistance. It is a complex event seen in almost all ventilated patients and at any ventilator mode, with uncertain significance and prognosis. Due to its different pathophysiological mechanisms, there is ...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2020.07.016
更新日期：2020-12-01 00:00:00
abstract：HYPOTHESIS:As vasopressin is a small peptide, its sieving coefficient (SC) and clearance (CL) during continuous renal replacement therapy may be intermediate to those for urea and β2 microglobulin (commonly used markers for small- and middle-molecular weight solutes, respectively). METHODS:A prospective, minimal-risk ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.03.005
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:Analgesia and sedation protocols (ASPs) reduce duration of mechanical ventilation (MV) in the medical intensive care unit (ICU), but data in the surgical ICU (SICU) are limited. The objective of this study was to determine the impact of a nursing-driven ASP with criteria for infusion initiation in the SICU. MA...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.11.029
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Platelets play a key role in the genesis of thrombosis. Plateletcrit (PCT) provides complete information on total platelet mass. The relationship between PCT values and long-term outcomes in patients with ST-segment elevation myocardial infarction (STEMI) who undergo primary angioplasty is not known. We sought ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2014.07.001
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Low tidal volume (LTV) ventilation reduces mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This study investigates adherence of intraoperative LTV and whether patient outcomes were different with or without continued intraoperative LTV ventilation in patients wi...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.08.002
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:The objective of this study is to correlate the levels of satisfaction of family members, with their perception of the way information was offered and assistance delivered during the patient's stay in the intensive care unit (ICU). MATERIALS AND METHODS:This is a prospective study conducted in a 13-bed mixed I...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2007.04.004
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:The Competency Based Training in Intensive Care Education (CoBaTrICE) programme developed common standards of ICM training by describing competencies of an intensivist. Entrustable Professional Activities (EPAs) of Intensive Care Medicine (ICM) (EPAsICM) are presented as a new workplace-based assessment to...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.09.012
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Dynamometry is an objective tool for volitional strength evaluation that may overcome the limited sensitivity of the Medical Research Council scale for manual muscle tests, particularly at grades 4 and 5. The primary aims of this study were to investigate the reliability, minimal detectable change, and time to ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2012.03.001
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:During intracranial aneurysm surgery, numerous factors may alter cerebral blood flow and oxygen supply-demand balance. Continuous monitoring of jugular bulb venous oxygen saturation (SvjO2) may help in the anesthetic management of such procedures. MATERIALS AND METHODS:Fiberoptic SvjO2 was continuously monitor...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/s0883-9441(97)90040-x
更新日期：1997-09-01 00:00:00
abstract：:Integral to the management of the neurocritically injured patient are the prevention and treatment of hypotension, maintenance of cerebral perfusion pressure, and occasionally blood pressure augmentation. When adequate volume resuscitation fails to meet perfusion needs, vasopressors are often used to restore end-organ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.04.004
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:We sought to examine variation in long-term acute care hospital (LTACH) quality based on 90-day in-hospital mortality for patients admitted for weaning from mechanical ventilation. METHODS:We developed an administrative risk-adjustment model using data from Medicare claims. We validated the administrative mode...
journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrc.2018.03.022
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The maintenance of patient-specific optimal cerebral perfusion pressure (CPPopt) is crucial for patients with traumatic brain injury (TBI). The goal of the study was to explore the influence of CPP declination from CPPopt value on the TBI patients' outcome. METHODS:The CPP and cerebrovascular autoregulation (C...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.04.029
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:Liquid perfluorochemicals reduce the production of reaction oxygen species by alveolar macrophages. We sought to determine whether the use of liquid perfluorochemicals in vivo during liquid ventilation would attenuate oxidative damage to the lung. MATERIALS AND METHODS:Healthy infant piglets (n = 16) were inst...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/s0883-9441(99)90004-7
更新日期：1999-03-01 00:00:00
abstract：PURPOSE:The purpose of this study is to examine the impact of hypernatremia acquired after intensive care unit (ICU) admission on mortality and length of stay (LOS). MATERIALS AND METHODS:Data for this observational study were collected from patients admitted between January 1, 2008, and September 30, 2010 to 344 ICUs...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2012.11.013
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:The purpose of the study is to describe the role of human metapneumovirus (hMPV) infection in critical illness and acute respiratory distress syndrome (ARDS). MATERIALS AND METHODS:We collected clinical and demographic information from a retrospective chart review, comparing patients with and without an intens...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.09.035
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics of individualized amikacin single-dosage regimens targeting low peak serum concentrations in a population of intensive care unit (ICU) patients, and to describe the outcomes associated with this dosing strategy. MATERIALS AND METHODS:In this prospective,...
journal_title：Journal of critical care
pub_type： 临床试验,杂志文章
doi：10.1053/jcrc.2003.50003
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:The objective of this study is to explore the attitudes, knowledge, and behavior of house staff physicians regarding the use of ultrasound guidance (UG) during central venous catheter placement (CP). MATERIALS AND METHODS:A questionnaire-based study was used to survey house staff in multiple training programs ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.06.005
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the role of inflammatory biomarkers and total bile acid (TBA) in oral secretions in the development of ventilator-associated pneumonia (VAP). MATERIALS:This prospective study was conducted in an intensive care unit. Oral secretions were collected from mechanically venti...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2011.12.008
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:In certain populations, social, legal, and religious factors may influence end-of-life decisions in ventilator-dependent patients. This study aims to evaluate attitudes of first-degree relatives of chronically ventilated patients in Israel, toward end-of-life decisions regarding their loved ones, themselves,...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2009.01.011
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:There is a paucity of literature to support undertaking emergency laparotomy when indicated in patients supported on ECMO. Our study aims to identify the prevalence, outcomes and complications of this high risk surgery at a large ECMO centre. MATERIALS AND METHODS:A single centre, retrospective, observational ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.06.021
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Alcohol-use disorders (AUDs) have been associated with increased sepsis-related mortality. As patients with AUDs are often thiamine deficient, we investigated practice patterns relating to thiamine administration in patients with AUDs presenting with septic shock and explored the association between receipt of ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.08.022
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:We investigated whether a critical rise of intracranial pressure (ICP) leading to a loss of cerebral perfusion pressure (CPP) could serve as a surrogate marker of brain death (BD). MATERIALS AND METHODS:We retrospectively analyzed ICP and CPP of patients in whom BD was diagnosed (n = 32, 16-79 years). Intracra...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.03.009
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:A retrospective analysis of critically-ill patients with hypoxic hepatitis (HH) to characterize the biochemical profile and to identify predictors of mortality using the Medical Information Mart for Intensive Care III database. METHODS:HH was defined as a rapid increase in AST/ALT≥800IU/L after exclusion of ot...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.04.040
更新日期：2017-10-01 00:00:00
