Abstract：
BACKGROUND:From a post hoc analysis a hypothesis was generated that women deposit more collagen in a surrogate test wound than men. The purpose of this study has been to verify this hypothesis prospectively in a controlled study. METHODS:Post hoc analyses were done on 37 volunteers (study A). The prospective trial included 47 smoking volunteers (study B). Outcome measures were deposition levels of collagen (hydroxyproline) and protein during a period of 10 days in subcutaneously implanted tubes of expanded polytetrafluoroethylene. RESULTS:The mean increments of collagen deposition levels in women as compared with men were 56% (P <.01) in study A and 74% (P <.001) in study B. The mean increase in the ratio collagen/total protein was 74% (P <.001) and 69% (P <.001), indicating that the increase was specific for collagen. CONCLUSIONS:The studies show that deposition in a miniature subcutaneous test wound of collagen, but not noncollagenous protein, is promoted in women as compared to men. These findings may relate to the observation in some reports indicating higher rates of compromised postoperative wound healing in men.
journal_name
Surgeryjournal_title
Surgeryauthors
Jorgensen LN,Sorensen LT,Kallehave F,Vange J,Gottrup Fdoi
10.1067/msy.2002.119986subject
Has Abstractpub_date
2002-03-01 00:00:00pages
338-43issue
3eissn
0039-6060issn
1532-7361pii
S0039606002086221journal_volume
131pub_type
杂志文章相关文献
SURGERY文献大全abstract：:One hundred sixty patients had preoperative mediastinoscopy, resection of the primary tumor, and complete mediastinal lymphadenectomy for non-small-cell carcinoma of the lung. Minimum follow-up was 24 months (mean 40 months). Postoperative staging based on histologic examination of the specimen of the lung and mediast...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:The role of histocompatibility between donor and recipient in liver transplant rejection is unclear because of a paucity of data. The influence of human leukocyte antigen (HLA) type on immunologic graft loss was examined for primary liver transplantations performed at this center. METHODS:Immunologic graft ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:Ischemia and reperfusion (I/R) injury is a major determinant of early graft dysfunction and long-term graft survival in small intestinal transplantation. The cavitary two-layer method (TLM) has been reported to be superior to the University of Wisconsin cold storage method (UWM) in long-term preservation of ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2003.10.013
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Endotoxemia stimulates tumor necrosis factor (TNF) and interleukin-1 (IL-1) production in mucosa of the small intestine, but the effect on IL-6 production is not known. Intestinal IL-6 may be especially important, considering its role in the acute phase response. We tested the influence of endotoxemia and se...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80342-3
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Video review for assessment of surgical performance is gaining popularity but is time consuming for busy expert reviewers, making review delays inevitable. Decreasing review time and including nonexpert reviewers may facilitate more timely reviews. We hypothesized that a shorter duration video clip would not...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2017.11.011
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Identification of recurrent laryngeal nerve (RLN) has decreased the rates of permanent RLN palsy during thyroid operations; however, unexpected RLN palsy still occurs, even though the visual integrity was assured and most nerve injuries were not recognized intraoperatively. The aim of this study is to determ...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2008.02.006
更新日期：2008-06-01 00:00:00
abstract：:The hemodynamic significance of stenosis was defined by intraoperative measurement of pressure and flow across 22 profunda femoris and 44 iliac artery segments. Measurements were taken at rest and during papaverine-induced vasodilation, and the mean pressure gradient across the arterial segment at double resting flow ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Adrenal cortical carcinoma (ACC) is a rare disease in which recurrence after surgery is common. Mitotane is the primary systemic treatment for recurrent ACC; data are limited regarding the impact of mitotane on recurrent ACC. METHODS:We reviewed the records of all patients who underwent surgery for ACC eval...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.09.006
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Major hepatic resection in patients with unrelieved obstructive jaundice carries an increased risk of postoperative liver failure. We hypothesized that cholestasis induces hepatocyte apoptosis and impairs hepatic regeneration by inhibiting up-regulation of the known immediate-early response genes, nuclear fa...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.122375
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:There has been increasing uptake of minimally invasive pancreatoduodenectomy during the past decade, but it remains a highly specialized procedure as benefits over open pancreatoduodenectomy remain contentious. This study aimed to evaluate current evidence on minimally invasive pancreatoduodenectomy versus o...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：10.1016/j.surg.2020.09.019
更新日期：2020-11-09 00:00:00
abstract：BACKGROUND:Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remai...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：:The accuracy of oculoplethysmography (OPG) and carotid phonoangiography (CPA) singly and in combination, the Doppler velocity detector, and photoplethysmography (PPG) was checked by measurement of the degree of stenosis as shown on arteriograms in 308 internal carotid arteries. In a second study using arteriographic m...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：INTRODUCTION:Tertiary hyperparathyroidism (3HPTH) patients who undergo parathyroidectomy (PTX) are often managed with calcium lowering medications such as cinacalcet (Sensipar) before surgery. Here, we assess how cinacalcet treatment influences intraoperative parathyroid hormone (IOPTH) kinetics and surgical findings i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.08.003
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Most of the available data on multiglandular disease (MGD) originate from long-term series. The spectrum of the disease has changed now because of earlier diagnosis. We decided to assess the current frequency of MGD in seemingly sporadic primary hyperparathyroidism. METHODS:MGD was defined as the finding th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：INTRODUCTION:Propranolol has been shown previously to decrease the mobilization of hematopoietic progenitor cells (HPCs) after acute injury in rodent models; however, this acute injury model does not reflect the prolonged period of critical illness after severe trauma. Using our novel lung contusion/hemorrhagic shock/c...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.06.031
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Preconditioning is injury-induced protection against subsequent injury and may be induced by a variety of stimuli. Both males and females may be preconditioned; however, if females are relatively protected against the initial insult, is their preconditioning threshold higher? We hypothesized that preconditio...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.03.016
更新日期：2005-08-01 00:00:00
abstract：:We studied parathyroid hormone (PTH) release from cell suspensions of fresh and cryopreserved human parathyroid tissue. A sensitive PTH assay with midregion specificity and adaptation of "micro" methods of cell plating permitted conservation of tissue (200 microliters aliquots) and high reproducibility (5 to 10 aliquo...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：BACKGROUND:Because the adhesive glycoprotein von Willebrand Factor (vWF) mediates initial platelet attachment at sites of vascular injury and may also contribute to shear-dependent platelet thrombus formation, we have determined in vivo the relative antithrombotic efficacy and hemostatic safety of infusing murine monoc...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:A new concept of surgical stress has been proposed that consists of both aggressiveness of operation and systemic reactions to an operation. METHODS AND RESULTS:We have investigated a possible modulation of such systemic reactions to operation and have demonstrated the following 3 points: (1) coagulation an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.120116
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The present study evaluates 111In-pentetreotide scanning as a method for detection of gastrinomas. Operative findings serve as the benchmark for comparison of the efficacy of 111In-pentetreotide versus conventional imaging studies. METHODS:Twelve patients (seven female and five male; age, 37 to 80 years) wi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80121-7
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1067/msy.2001.115898
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Small intestinal submucosa (SIS) represents a novel bio-scaffolding material that may be used to repair hollow-organ defects. However, it is unclear whether neurophysiologic responses return to SIS-grafted areas in the gut. We evaluated the functional recovery of a stomach defect grafted with the porcine-der...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.04.019
更新日期：2007-09-01 00:00:00
abstract：:From 1960 to 1988, 266 patients underwent resection of colorectal secondaries to the liver with curative intent. All patients were followed until April 1, 1990, or death, with a median follow-up time of 52 months. Nine patients with minimal macroscopic residual disease and 38 patients with all gross tumor removed but ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Prophylactic central neck dissection (PCND) for papillary thyroid carcinoma (PTC) is controversial. We compared 3 different approaches to the management of central compartment nodes in patients with clinically unifocal and N0 PTC. METHODS:A total of 186 patients were prospectively assigned to one of the fol...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.08.053
更新日期：2012-12-01 00:00:00
abstract：:We report a case in which a large, postoperative, biliary cutaneous fistula was successfully treated by means of endoscopic insertion of two endoprostheses into the common bile duct. Twenty-four hours after the procedure, bile flow from the cutaneous fistula ceased completely. The endoprostheses were removed after 6 w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：BACKGROUND:The deliberate induction of carbon dioxide pneumoperitoneum during laparoscopic surgery could be a possible source of cardiovascular collapse. The effects of elevated intraabdominal pressure (IAP) on systemic hemodynamics and splanchnic blood flow created by insufflation of carbon dioxide were examined in an...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Detailed knowledge of the dimensions and shape of the main arteries of the body and how they change with age and disease is important for understanding arterial pathophysiology and improving minimally invasive devices to treat arterial diseases. Our goal was to describe and compare geometric remodeling of th...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.05.013
更新日期：2015-12-01 00:00:00
abstract：:The release of oxygen radicals, in particular the hydroxyl radical, from sequestered neutrophils produces acute lung injury after a number of insults. Our purpose was to determine whether hydroxyl radical, OH., is responsible for the lung injury from endotoxin characterized by (1) pulmonary leukostasis, (2) increased ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:Solid tumors constantly require a vascular supply for their progression and metastasis. Hepatocellular carcinoma (HCC) is known to gain its hypervascularity during the process of dedifferentiation and progression. Various angiogenic growth factors and inhibitors regulate this angiogenic switch of HCC. The known endoth...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：10.1067/msy.2002.119365
更新日期：2002-01-01 00:00:00
abstract：:We studied the effect of the topical application of the nonsteroidal anti-inflammatory agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation. Twelve sheep with a 15% total body surface third-degree burn were monitored over a 4-day postburn period. In six sheep, a single application of a 5% f...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
