Abstract:
BACKGROUND:The aim of this study was to validate a new diagnostic tool, nitrate echocardiography (NE), for the identification of viable noncontracting myocardium in patients with a history of prior myocardial infarction (MI). Nitroglycerin (NTG) may be useful for this purpose for its peculiar pharmacodynamic action and may represent an option other than dobutamine echocardiography for the detection of hibernating segments in the presence of severely reduced coronary reserve. METHODS:Twenty selected patients (pts) with an old MI were studied with NE and planar thallium scintigraphy with reinjection. NE was performed by administering i.v. NTG starting at 0.4 mcg/kg/minute with equal increments every five minutes up to 2 mcg/kg/minute or to early interruption of the test (decrease of systolic blood pressure > or = 20% or improvement of previously akinetic segments). Left ventricular wall motion was analyzed by dividing the left ventricle (LV) into 16 segments, and a wall motion score index (WMSI) was calculated. Thallium images were obtained at peak exercise, at four hours, and after reinjection. Myocardial viability was defined as an improvement in thallium uptake after reinjection in fixed defects. RESULTS:Basal echo demonstrated 74 akinetic segments; of these 21 (28%, 11 pts) showed improved contractility during NTG infusion at a mean dose of 0.87 +/-0.33 mcg/kg/minute. WMSI decreased from 1.69 +/- 0.29 to 1.46 +/- 0.31 (P = .001). The only hemodynamic response was a drop in systolic blood pressure (136 mmHg to 124; P = .02). Thallium studies showed 29 segments with a four-hour reversible defect and 79 segments with a four-hour fixed defect; of the latter, 14 regions demonstrated improvement in tracer uptake after reinjection (17.7%; 10 pts). Nine pts had a positive echo and thallium study, while 8 showed no improvement either during NE or after thallium reinjection. Two pts had a false-positive nitrate echocardiogram. Therefore, according to an echo/thallium study match, sensitivity, specificity, and accuracy are 90%, 80%, 85%, respectively. CONCLUSION:NE is a reliable and low-cost method for the detection of viable noncontracting myocardium in selected patients with CAD but needs further validation for widespread application.
journal_name
Angiologyjournal_title
Angiologyauthors
Pontillo D,Carboni GP,Capezzuto A,Alessi C,Achilli A,Piccini F,Guerra Rdoi
10.1177/000331979604700502subject
Has Abstractpub_date
1996-05-01 00:00:00pages
437-46issue
5eissn
0003-3197issn
1940-1574journal_volume
47pub_type
杂志文章相关文献
ANGIOLOGY文献大全abstract::The authors previously reported a new syndrome, angiotensin-converting enzyme dysfunction syndrome (ACEDS), which is clinically characterized by mild systemic hypertension, a hypokalemic alkalosis, and hyperreninism with a high concentration of angiotensin-I (ANG-I), a normal angiotensin-II (ANG-II) value, and a norma...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978803900110
更新日期:1988-01-01 00:00:00
abstract:UNLABELLED:Endurance training has been shown to increase arterial compliance; however, the effect of resistance training is unclear. PURPOSE:The purpose of this study was to examine the effect lower body resistance training on arterial compliance in healthy premenopausal women. METHODS:Thirty-two women were assigned ...
journal_title:Angiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/0003319709331393
更新日期:2009-12-01 00:00:00
abstract::Low albumin and the albumin-globulin ratio (AGR) were associated with vascular adverse events. Our study explores the AGR as a predictor of mortality after non-ST-segment elevation myocardial infarction (NSTEMI). In an observational study of 570 NSTEMI patients admitted to a tertiary center between 2004 and 2006, pati...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319712436577
更新日期:2013-02-01 00:00:00
abstract::Interventricular septal and left ventricular posterior wall excursions and velocities were determined by M-mode echocardiography in the early hours of acute myocardial infarction in 43 patients. In the group with anterior infarction, including 24 patients, the systolic septal excursion (SSE), systolic septal velocity ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978003100902
更新日期:1980-09-01 00:00:00
abstract::Thirty adult patients with distal, monolateral deep vein thrombosis of the lower limbs were randomly treated for sixty days either with subcutaneous Ca-Heparin or with Sulodexide, administered IM for ten days and orally for fifty days. The thrombus accretion above the knee, the venous pressures of the affected leg, th...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331979704800907
更新日期:1997-09-01 00:00:00
abstract::The aim of this study was to assess the value of the early exercise test (ET) in patients with acute myocardial infarction (AMI) treated with IV streptokinase (SK). The authors studied 70 patients with first AMI; 31 were treated with SK and 39 were not. Before discharge everyone was given early exercise up to 5-6 METs...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979104200903
更新日期:1991-09-01 00:00:00
abstract::Study on 295 consecutive medical patients to evaluate the potential of routine blood tests to identify the risk of deep vein thrombosis (DVT). The tests included in a DVT risk stratification model system were erythrocyte sedimentation rate, antithrombin III, C-reactive protein, D-dimer, and N-terminal pro-brain natriu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319716673011
更新日期:2017-08-01 00:00:00
abstract::The authors evaluated a screening program for lower extremity arterial disease (LEAD) in diabetic patients and focused on the value of toe blood pressure assessment. They recruited 437 subjects, ages 30-70 years (134 healthy controls, 166 type 1 and 137 type 2 diabetic patients; control [Ctr], DM1, and DM2) with no pr...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/00033197040550i605
更新日期:2004-11-01 00:00:00
abstract::A forty-eight-year-old man presented with cavitary pulmonary tuberculosis and widening of the mediastinum. Mediastinal widening was due to multiple saccular aneurysms of the ascending aorta and the arch of the aorta. The various presentations of tubercular aortitis and the reasons for considering alternative etiology ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100411
更新日期:1990-04-01 00:00:00
abstract::Transcutaneous oxygen tension measurement (TcPO2) is widely applied for the evaluation of chronic limb-threatening ischemia (CLTI). Nevertheless, studies that focused on the clinical value of TcPO2 have shown varying results. We identified factors that potentially play a role in TcPO2 measurement variation such as pro...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319719866958
更新日期:2020-03-01 00:00:00
abstract::The thoracic outlet syndromes of the upper extremities consist of many disorders. The most important two are the costoclavicular syndrome (compression of neurovascular structures between the clavicle and the first rib) and the scalenus anticus syndrome (compression of these structures within the scalene triangle). Con...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978904000901
更新日期:1989-09-01 00:00:00
abstract::Clinical observations and animal experiments indicate that T wave alternans (TWA) is associated with an increased propensity for ventricular fibrillation, and thus it may be considered as a noninvasive marker of life-threatening ventricular arrhythmias. There is substantial evidence indicating that TWA is an intrinsic...
journal_title:Angiology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::Every day, thousands of people in the United States receive polycyclic antidepressants (PCAs) prescribed by their primary care physicians. We have examined the cardiovascular manifestations of polycyclic antidepressants in 14 patients with primary depression receiving various antidepressant drugs for a period of six m...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978603701003
更新日期:1986-10-01 00:00:00
abstract::A case of aorticopulmonary window associated with tetralogy of Fallot is reported with its clinical, hemodynamic, angiocardiographic, surgical, and necropsy findings. The difficulty in diagnosing a tetralogy of Fallot in the presence of a large aorticopulmonary shunt is emphasized. It is also noted that the only means...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977602700906
更新日期:1976-09-01 00:00:00
abstract::Lymphangiomyomatosis was first reported more than forty years ago. Although its incidence is rare, its occurrence is being increasingly recognized and has been the subject of a growing number of cases reports in recent years. This study adds 2 more cases to the file. Both cases involved young women with the characteri...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004101110
更新日期:1990-11-01 00:00:00
abstract::To find out whether there is an underestimated severity of narrowing in obstructive lesions of the pulmonary outflow tract in the first day of life, Doppler measurement of the pulmonary outflow tract gradient and estimation of the pulmonary artery systolic pressure in 15 neonates with pulmonary outflow tract obstructi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979604700308
更新日期:1996-03-01 00:00:00
abstract::Intravenous clonidine was used to treat systolic hypertension (systolic blood pressure greater than 160 mm Hg) in 15 patients with acute myocardial infarction and documented sympathetic overactivity (high plasma norepinephrine). Its effects on haemodynamics and blood gases were studied. After one hour, clonidine signi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978603700903
更新日期:1986-09-01 00:00:00
abstract::The transradial approach (TRA) has been used as access site for percutaneous coronary intervention (PCI) for years. However, no large sample study has evaluated the effect of TRA in elderly patients. A total of 1098 elderly patients (age ≥ 75 years) who underwent PCI by TRA or transfemoral approach were recruited. A 1...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714535971
更新日期:2015-05-01 00:00:00
abstract::The aim of this study was to evaluate safety and clinically defined efficacy of the implantation of a new stent coated with diamond-like carbon (DLC stent), in a group of patients who underwent percutaneous transluminal coronary revascularization procedures in two hemodynamic centers. This study was an observational p...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319707300360
更新日期:2007-04-01 00:00:00
abstract::Even though the underlying mechanisms of myocardial ischemia may be different, it is difficult to differentiate syndrome X from coronary artery disease (CAD) by means of the treadmill exercise test in elderly patients with chest pain and exercise-induced myocardial ischemia. One hundred sex- and age-matched patients-4...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804900102
更新日期:1998-01-01 00:00:00
abstract::Six cases of suspected multiple cholesterol emboli syndrome were identified by a review of reports contained in the company's records of adverse event reports. Antecedent risk factors in these reports included cardiac catheterization, thrombolytic therapy, translumbar aortography, renal arteriography, subclavian arter...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331979504600903
更新日期:1995-09-01 00:00:00
abstract::The acute effect of glyceryl trinitrate (GTN) is mainly the reduction of systolic blood pressure (SBP) rather than diastolic blood pressure (DBP). To examine the mechanisms for decrease in SBP by GTN, the authors measured arterial compliance (AC), cardiac output (CO), stroke volume (SV), pulmonary capillary wedge pres...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979504600209
更新日期:1995-02-01 00:00:00
abstract::The authors describe a thirty-eight-year-old woman with familial hypercholesterolemia treated by dextran sulfate cellulose adsorption apheresis. This technique and the selective extracorporeal LDL cholesterol elimination by immunoabsorption or heparin-induced precipitation not only dramatically decrease blood lipids b...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979204300710
更新日期:1992-07-01 00:00:00
abstract::To clarify relationships between the (endothelial vasodilatory and vasoconstrictive function) and leukocyte inflammatory mediators in subjects with asymptomatic atherosclerosis, we measured (intraplatelet cyclic 3',5'-guanosine monophosphate [cGMP] and cyclic 3',5'-adenosine monophosphate [cAMP]), plasma endothelin (E...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804901201
更新日期:1998-12-01 00:00:00
abstract::We verified whether vascular reactivity is impaired and whether there is any association between vascular reactivity, walking ability, and peripheral artery disease (PAD) severity in patients with intermittent claudication (IC). We studied 63 patients and 17 age- and sex-matched volunteers without PAD. Vascular reacti...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714545486
更新日期:2015-08-01 00:00:00
abstract::The possible associations between coronary heart disease (CHD) and peripheral arterial disease (PAD), detected by echo-Doppler analysis, with restriction fragment length polymorphism (RFLP) of apo AI/CIII cluster and apo B gene were investigated in a group of men with premature CHD (n = 39) and in a control group of m...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979304401004
更新日期:1993-10-01 00:00:00
abstract::The functional capability of the deep femoral artery (DFA) as a collateral channel is an important feature in patients suffering peripheral arterial occlusive disease (PAOD). A noninvasive method of indirect quantification of the DFA blood flow volume is presented. In normal lower limbs, it was found that the common f...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978403500502
更新日期:1984-05-01 00:00:00
abstract::Venous leg ulcers are common, chronic, debilitating, and expensive. Evidence supports use of compression bandaging, with superficial venous surgery in selected cases, but these interventions frequently fail to achieve healing. We describe a series of 152 consecutive referrals from a nurse-led specialist dermatology cl...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709332901
更新日期:2009-08-01 00:00:00
abstract::The electrocardiographic abnormalities found in 100 patients with acute cerebrovascular disease and previously normal hearts are described. The abnormalities were more often seen in patients with intracerebral and subarachnoid hemorrhages. The most common changes were Q-Tc Prolongation and ST segment and T wave abnorm...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100902
更新日期:1990-09-01 00:00:00
abstract::The syndrome of intermittent claudication can be induced not only by vascular insufficiency of the lower limbs but also by diseases of the spinal cord and cauda equina. The authors describe a sixty-year-old man with intermittent claudication due to spinal canal stenosis who was successfully treated with beraprost sodi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979704800510
更新日期:1997-05-01 00:00:00