Noradrenaline-induced relaxation of rat oesophageal muscularis mucosae: mediation solely by innervated beta 3-adrenoceptors.

abstract：:We investigated the action of the phenylalkylamines verapamil and N-methyl-verapamil on the Kv1.3 potassium channel using the whole-cell configuration of the patch-clamp technique. Our goal was to identify their binding as a prerequisite for using the phenylalkylamines as small, well-defined molecular probes, not only...

journal_title：British journal of pharmacology

authors： Rauer H,Grissmer S

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells. The prototype compound 1-EBIO or the more potent compound NS309, do not distinguish between the SK subtypes a...

journal_title：British journal of pharmacology

authors： Hougaard C,Eriksen BL,Jørgensen S,Johansen TH,Dyhring T,Madsen LS,Strøbaek D,Christophersen P

更新日期：2007-07-01 00:00:00

abstract：:To characterize the volume-sensitive, osmolyte permeable anion channels responsible for the osmodependent release of taurine from supraoptic nucleus (SON) astrocytes, we investigated the pharmacological properties of the [(3)H]-taurine efflux from acutely isolated SON. Taurine release induced by hypotonic stimulus (25...

journal_title：British journal of pharmacology

authors： Brès V,Hurbin A,Duvoid A,Orcel H,Moos FC,Rabié A,Hussy N

更新日期：2000-08-01 00:00:00

abstract：:Photorelaxation of vascular smooth muscle (VSM) is caused by the release of nitric oxide (NO) from a finite molecular store that can be depleted by irradiating pre-contracted arteries with visible light. The ability of an 'exhausted' vessel to respond to a further period of illumination is lost temporarily but then re...

journal_title：British journal of pharmacology

authors： Megson IL,Holmes SA,Magid KS,Pritchard RJ,Flitney FW

更新日期：2000-08-01 00:00:00

abstract：:1 The venom of the green mamba, Dendroaspis angusticeps, was tested for effects on neuromuscular transmission and skeletal muscle contractility in isolated phrenic nerve-hemidiaphragm preparations of the rat and mouse, chick biventer cervicis muscle preparations and in aneural cultures of embryonic chick skeletal musc...

journal_title：British journal of pharmacology

authors： Barrett JC,Harvey AL

更新日期：1979-10-01 00:00:00

abstract：:The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of signal transduction pathways with a physiological role under acute stress and a pathological role after excessive activation under chronic stress. The seven isoforms differ in their regulation,...

journal_title：British journal of pharmacology

authors： Teixeira G,Szyndralewiez C,Molango S,Carnesecchi S,Heitz F,Wiesel P,Wood JM

更新日期：2017-06-01 00:00:00

abstract：:Bovine culture endothelial cells (BAECs) generate platelet-activating factor (Paf) following activation by bradykinin (Bk 0.1 nM), the ionophore, A23187 (3 microM), and ATP (10 microM), but Paf is not released from the cells. These stimuli also elicit generation of prostacyclin (PGI2). The specific and competitive Paf...

journal_title：British journal of pharmacology

authors： Stewart AG,Dubbin PN,Harris T,Dusting GJ

更新日期：1989-03-01 00:00:00

abstract：:1. A single i.p. injection of bacterial endotoxin in rats (3.5 mg kg-1) caused lung injury assessed as changes in lung dry:wet weight ratio and leukopaenia over the subsequent 28 h. 2. This treatment also slowed the efflux of 14C from [14C]-prostaglandin E2 (PGE2), i.e., increased t1/2 and increased the survival of PG...

journal_title：British journal of pharmacology

authors： Izumi T,Bakhle YS

更新日期：1988-04-01 00:00:00

abstract：:1. The effect of 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex that exhibits neuroprotective, anxiolytic and antidepressant-like actions, was investigated in a functional assay for presynaptic NMDA receptors. 2. NMDA (100 microM) pr...

journal_title：British journal of pharmacology

authors： Clos MV,Garcia Sanz A,Trullas R,Badia A

更新日期：1996-06-01 00:00:00

abstract：:1. 5-Hydroxytryptamine (5-HT) transport has been investigated in rat blood platelets poisoned with dinitrophenol-sodium fluoride or ouabain.2. The inhibition of transport produced by different concentrations of the metabolic inhibitors has been correlated with changes in the internal Na(+) and K(+) concentrations of t...

journal_title：British journal of pharmacology

authors： Sneddon JM

更新日期：1971-12-01 00:00:00

abstract：:Strips of human pulmonary arteries from patients undergoing surgery for lung tumour were incubated with [3H]-noradrenaline. Subsequently, they were superfused with physiological salt solution containing cocaine and corticosterone. Tritium overflow from the strips was stimulated by transmural electrical impulses (2 Hz)...

journal_title：British journal of pharmacology

authors： Göthert M,Hentrich F

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Alcohol exposure in utero may lead to a wide range of long-lasting morphological and behavioural deficiencies known as fetal alcohol spectrum disorders (FASD), associated with a higher risk of later developing neuropsychiatric disorders. However, little is known about the long-term consequences o...

journal_title：British journal of pharmacology

authors： Cantacorps L,Montagud-Romero S,Luján MÁ,Valverde O

更新日期：2020-03-01 00:00:00

abstract：:1. The class III antiarrhythmic azimilide has previously been shown to inhibit I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance I(Kr), in human heart, the effects of azimilide on HERG channels expressed in Xenopus oocyt...

journal_title：British journal of pharmacology

authors： Busch AE,Eigenberger B,Jurkiewicz NK,Salata JJ,Pica A,Suessbrich H,Lang F

更新日期：1998-01-01 00:00:00

abstract：:1. Vasorelaxant properties of three nitric oxide (NO) donor drugs (glyceryl trinitrate, sodium nitroprusside and spermine NONOate) in mouse aorta (phenylephrine pre-contracted) were compared with those of endothelium-derived NO (generated with acetylcholine), NO free radical (NO*; NO gas solution) and nitroxyl ion (NO...

journal_title：British journal of pharmacology

authors： Wanstall JC,Jeffery TK,Gambino A,Lovren F,Triggle CR

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Montelukast and S-carbocysteine have been used in asthmatic patients as an anti-inflammatory or mucolytic agent respectively. S-carbocysteine also exhibits anti-inflammatory properties. EXPERIMENTAL APPROACH:Ovalbumin (OVA) sensitized BALB/c mice were challenged with OVA for 3 days followed by s...

journal_title：British journal of pharmacology

authors： Takeda K,Shiraishi Y,Matsubara S,Miyahara N,Matsuda H,Okamoto M,Joetham A,Gelfand EW

更新日期：2010-07-01 00:00:00

abstract：:Previous studies have provided evidence for the presence on B cell membrane of adenosine receptors (P1-purinoceptors) of the A1-subtype which inhibit insulin secretion. In this work we have investigated the implication of a guanosine triphosphate (GTP) binding protein (G protein) in the A1 purinoceptor-induced inhibit...

journal_title：British journal of pharmacology

authors： Hillaire-Buys D,Gross R,Loubatières-Mariani MM,Ribes G

更新日期：1989-01-01 00:00:00

abstract：:1. N(G)-monomethyl-L-arginine (L-NMMA) constricts human forearm resistance vasculature and selectively attenuates vasodilator responses to endothelium-dependent vasodilators. Incomplete inhibition of such responses could be due to an inadequate dose of L-NMMA or to NO-independent vasodilator mechanisms. 2. This study ...

journal_title：British journal of pharmacology

authors： Dawes M,Chowienczyk PJ,Ritter JM

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In mammalian cells, the anti-parasitic drug ivermectin is known as a positive allosteric modulator of the ATP-activated ion channel P2X4 and is used to discriminate between P2X4- and P2X7-mediated cellular responses. In this paper we provide evidence that the reported isoform selectivity of iverm...

journal_title：British journal of pharmacology

authors： Nörenberg W,Sobottka H,Hempel C,Plötz T,Fischer W,Schmalzing G,Schaefer M

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chemokines and their receptors form an intricate interaction and signalling network that plays critical roles in various physiological and pathological cellular processes. The high promiscuity and apparent redundancy of this network makes probing individual chemokine/receptor interactions and fun...

journal_title：British journal of pharmacology

authors： Szpakowska M,Nevins AM,Meyrath M,Rhainds D,D'huys T,Guité-Vinet F,Dupuis N,Gauthier PA,Counson M,Kleist A,St-Onge G,Hanson J,Schols D,Volkman BF,Heveker N,Chevigné A

更新日期：2018-05-01 00:00:00

abstract：:1. Murine left atrium lacks inotropic beta(2)-adrenoceptor function. We investigated whether beta(2)-adrenoceptors are involved in the cardiostimulant effects of (-)-adrenaline on spontaneously beating right atria and paced right ventricular myocardium of C57BL6 mice. We also studied a negative inotropic effect of (-)...

journal_title：British journal of pharmacology

authors： Heubach JF,Rau T,Eschenhagen T,Ravens U,Kaumann AJ

更新日期：2002-05-01 00:00:00

abstract：:1. The effect of in vivo desensitization to leukotriene B4 (LTB4) on eosinophil infiltration in response to recombinant C5a was examined in guinea-pig skin. 2. LTB4 (10-300 ng) and C5a (1-10 micrograms) caused a dose-dependent increase in the levels of eosinophil peroxidase activity (a measure of eosinophil infiltrati...

journal_title：British journal of pharmacology

authors： Pettipher ER,Salter ED,Showell HJ

更新日期：1994-09-01 00:00:00

abstract：:1. The effects of formoterol, a beta 2-adrenoceptor agonist, on plasma protein exudation and microvascular permeability induced by topical, i.e. applied onto the tracheal mucosal surface, bradykinin (10 nmol; 20 microM, 5 min, 0.1 ml min-1) were studied in a perfused segment of trachea prepared in situ in anaesthetize...

journal_title：British journal of pharmacology

authors： O'Donnell SR,Anderson GP

更新日期：1995-09-01 00:00:00

abstract：:1. ZENECA ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride, formerly ICI D7288) is a novel sino-atrial node function modulator which selectively slows sinus node rate. Its effects on haemodynamic function have been studied in pentobarbitone anaesthetized dogs, in comparison with zat...

journal_title：British journal of pharmacology

authors： Rouse W,Johnson IR

更新日期：1994-11-01 00:00:00

abstract：:Substance P and substance K (neurokinin A) (dose range: 0.08-80 nmol kg-1) were tested for their effects on gastrointestinal propulsion in the rat. The peptides were given by intraperitoneal injection concurrently with the intragastric administration of a test meal containing charcoal and 51Cr. Examination 3 min after...

journal_title：British journal of pharmacology

authors： Holzer P

更新日期：1985-09-01 00:00:00

abstract：:1. We studied the effects of various K+ channel blockers on the vasodilator responses of guinea-pig isolated basilar arteries to nitrergic nerve stimulation, the nitric oxide (NO) donor sodium nitroprusside (SNP), and the membrane permeable guanosine-3',5'-cyclic monophosphate (cyclic GMP) analogue 8-bromo-cyclic GMP ...

journal_title：British journal of pharmacology

authors： Jiang F,Li CG,Rand MJ

更新日期：1998-01-01 00:00:00

abstract：:1. Female mice of the Hough/Porton and Tuck/TO strains were found to be more sensitive than male mice to the diuretic effects of oral and intravenous doses of ethacrynic acid. 2. The sensitivity of Hough/Porton male mice to ethacrynic acid was increased after pretreatment with stilboestrol and the sensitivity of femal...

journal_title：British journal of pharmacology

authors： Cooling MJ,Sim MF

更新日期：1977-08-01 00:00:00

abstract：:1. Magnesium sulphate was studied for its effects on diarrhoea, fluid secretion, gastrointestinal transit and nitric oxide (NO) synthase activity in rats. 2. At a dose of 2 g kg-1 orally magnesium sulphate produced diarrhoea that was delayed in onset and intensity in a dose-related manner by the NO synthase inhibitor ...

journal_title：British journal of pharmacology

authors： Izzo AA,Gaginella TS,Mascolo N,Capasso F

更新日期：1994-09-01 00:00:00

abstract：:1. The alpha 2-adrenoceptor agonists TL99 (2-(N N-dimethyl)amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene) and UK14304 (5-bromo-6-[2-imidazoline-2-yl-aminol]-quinoxaline), in concentrations that are less than 1% of those producing vasoconstriction, enhance vasoconstrictor responses to noradrenaline and phenylephrin...

journal_title：British journal of pharmacology

authors： Xiao XH,Rand MJ

更新日期：1989-11-01 00:00:00

abstract：:1. Ca currents in rat and mouse sensory dorsal root ganglion (DRG) neurones were inhibited by concentrations of (-)-baclofen as low as 1 micron. The proportion of neurones responding to baclofen was low (less than 20%), except in young cultures of neonate rat DRG neurones (3 days in culture), where 86% of the neurones...

journal_title：British journal of pharmacology

authors： Green KA,Cottrell GA

更新日期：1988-05-01 00:00:00

abstract：:1. Histamine contracted the tracheal and major bronchial muscles of sheep and relaxed the muscles of the lesser bronchi and bronchioles.2. The stimulant action of histamine on the trachea was antagonized by mepyramine, whereas the relaxant effect on the bronchial tree was not.3. 5-Hydroxytryptamine contracted the musc...

journal_title：British journal of pharmacology

authors： Yre P

更新日期：1969-07-01 00:00:00