Modification by steroids of pulmonary oedema and prostaglandin E2 pharmacokinetics induced by endotoxin in rats.

abstract：:The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent a...

journal_title：British journal of pharmacology

authors： Boullin DJ,Grimes RP,Orr MW

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS). This study evaluated several possible reasons for differing sensiti...

journal_title：British journal of pharmacology

authors： Petrov KA,Yagodina LO,Valeeva GR,Lannik NI,Nikitashina AD,Rizvanov AA,Zobov VV,Bukharaeva EA,Reznik VS,Nikolsky EE,Vyskočil F

更新日期：2011-06-01 00:00:00

abstract：:Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades, most work on cell death has focused on apoptosis, which is generally considered as the only form of regulated cell death, whereas necros...

journal_title：British journal of pharmacology

authors： Zhang J,Liu D,Zhang M,Zhang Y

更新日期：2019-11-01 00:00:00

abstract：:The complement system plays a major role in threat recognition and in orchestrating responses to microbial intruders and accumulating debris. This immune surveillance is largely driven by lectins that sense carbohydrate signatures on foreign, diseased and healthy host cells and act as complement activators, regulators...

journal_title：British journal of pharmacology

authors： Hevey R,Pouw RB,Harris C,Ricklin D

更新日期：2020-11-03 00:00:00

abstract：:1 Magnolol, an active component isolated from the root and stem bark of Magnolia officinalis, has been reported to exhibit antitumour effects, but little is known about its molecular mechanisms of action. 2 Magnolol inhibited proliferation of human lung squamous carcinoma CH27 cells at low concentrations (10-40 microM...

journal_title：British journal of pharmacology

authors： Yang SE,Hsieh MT,Tsai TH,Hsu SL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cholecystokinin (CCK) is secreted by intestinal I cells and regulates important metabolic functions. In pancreatic islets, CCK controls beta cell functions primarily through CCK1 receptors, but the signalling pathways downstream of these receptors in pancreatic beta cells are not well defined. E...

journal_title：British journal of pharmacology

authors： Ning SL,Zheng WS,Su J,Liang N,Li H,Zhang DL,Liu CH,Dong JH,Zhang ZK,Cui M,Hu QX,Chen CC,Liu CH,Wang C,Pang Q,Chen YX,Yu X,Sun JP

更新日期：2015-11-01 00:00:00

abstract：:1. The pharmacology of the slow afterhyperpolarization (sAHP) was studied in cultured rat hippocampal pyramidal neurones. 2. Clotrimazole, its in vivo metabolite, 2-chlorophenyl-bisphenyl-methanol (CBM) and the novel analogues, UCL 1880 and UCL 2027, inhibited the sI(AHP) with similar IC50s (1-2 microM). 3. Clotrimazo...

journal_title：British journal of pharmacology

authors： Shah MM,Miscony Z,Javadzadeh-Tabatabaie M,Ganellin CR,Haylett DG

更新日期：2001-02-01 00:00:00

abstract：:We have recently shown that in polymorphonuclear leukocytes, 11-keto boswellic acids (KBAs) induce Ca2+ mobilisation and activation of mitogen-activated protein kinases (MAPK). Here we addressed the effects of BAs on central signalling pathways in human platelets and on various platelet functions. We found that beta-B...

journal_title：British journal of pharmacology

authors： Poeckel D,Tausch L,Altmann A,Feisst C,Klinkhardt U,Graff J,Harder S,Werz O

更新日期：2005-10-01 00:00:00

abstract：:Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this rev...

journal_title：British journal of pharmacology

authors： Zhang SY,Xu MJ,Wang X

更新日期：2018-04-01 00:00:00

abstract：:1. [Phe1psi(CH2-NH)Gly2]nociceptin-(1 - 13)-NH2 (Phepsi), a tridecapeptide analogue of orphanin FQ/nociceptin (OFQ/N), was introduced as a competitive antagonist of opioid receptor-like orphan receptor (ORL1) in guinea-pig ileum and mouse vas deferens preparations in vitro but was recently found to act as an agonist i...

journal_title：British journal of pharmacology

authors： Chiou LC

更新日期：1999-09-01 00:00:00

abstract：:1. A pentobarbitone-anaesthetized canine model of myocardial conduction was developed to evaluate drug effects on intra-atrial (I-A), intra-ventricular (I-V) and atrioventricular (A-V) conduction parameters, both at rest and during electrical pacing of the right atrium or ventricle. Drug effects on the ability of the ...

journal_title：British journal of pharmacology

authors： Allely MC,Alps BJ

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats. EXPERIMENTAL APPROAC...

journal_title：British journal of pharmacology

authors： Martel JC,Assié MB,Bardin L,Depoortère R,Cussac D,Newman-Tancredi A

更新日期：2009-09-01 00:00:00

abstract：:Class A1 scavenger receptors (SR-A1) are membrane glycoproteins that can form homotrimers. This receptor was originally defined by its ability to mediate the accumulation of lipids in macrophages. Subsequent studies reveal that SR-A1 plays critical roles in innate immunity, cell apoptosis and proliferation. This revie...

journal_title：British journal of pharmacology

authors： Ben J,Zhu X,Zhang H,Chen Q

更新日期：2015-12-01 00:00:00

abstract：:1. Prostanoids induce a wide range of biological actions which are mediated by specific membrane-bound receptors. We have recently shown that the E-type prostaglandins, PGE1 and PGE2, effectively inhibit eosinophil aggregation induced by platelet-activating factor (PAF). In an attempt to determine which prostanoid rec...

journal_title：British journal of pharmacology

authors： Teixeira MM,al-Rashed S,Rossi AG,Hellewell PG

更新日期：1997-05-01 00:00:00

abstract：:1. The aim of this study was to investigate the mechanism(s) of the vasoconstrictor effect of cantharidin in bovine preparations. 2. Catalytic subunits of protein phosphatase type 1 (PP 1) and type 2A (PP 2A) were immunologically identified in coronary arteries, isolated smooth muscle cells and ventricular myocardium....

journal_title：British journal of pharmacology

authors： Knapp J,Bokník P,Huke S,Lüss H,Müller FU,Müller T,Nacke P,Schmitz W,Vahlensieck U,Neumann J

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that not only the monoaminergic but also the glutamatergic system is involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). Hyperactivity of glutamate metabolism might be causally related to a hypoactive state in the dopaminergic system. A...

journal_title：British journal of pharmacology

authors： Ludolph AG,Udvardi PT,Schaz U,Henes C,Adolph O,Weigt HU,Fegert JM,Boeckers TM,Föhr KJ

更新日期：2010-05-01 00:00:00

abstract：:1. RS-15385-197 ((8aR, 12aS, 13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulphonyl)-6H-isoquino [2,1-g][1,6]-naphthyridine) was evaluated in a series of in vitro and in vivo tests as an antagonist at alpha 2-adrenoceptors. 2. RS-15385-197 had a pKi of 9.45 for alpha 2-adrenoceptors in the rat cor...

journal_title：British journal of pharmacology

authors： Brown CM,MacKinnon AC,Redfern WS,Hicks PE,Kilpatrick AT,Small C,Ramcharan M,Clague RU,Clark RD,MacFarlane CB

更新日期：1993-02-01 00:00:00

abstract：:1 The effect of intrarenal histamine, dimaprit (H2-agonist) and 2-(2-pyridyl) ethylamine (H1-agonist) on renin release was examined in anaesthetized dogs. 2 In dogs with intact kidneys, histamine and dimaprit administration resulted in renal vasodilatation, a two fold increase in urinary sodium excretion, and no chang...

journal_title：British journal of pharmacology

authors： Gerber JG,Nies AS

更新日期：1983-05-01 00:00:00

abstract：:1. The role of both exogenously administered and endogenously generated bradykinin (BK) on LPS-induced eosinophil accumulation in the mice pleural cavity was investigated by means of treatment with BK selective receptor agonists/antagonists and captopril. 2. Intrathoracic (i.t.) injection of LPS (250 ng cavity(-1)) in...

journal_title：British journal of pharmacology

authors： Silva AR,Larangeira AP,Pacheco P,Calixto JB,Henriques MG,Bozza PT,Castro-Faria-Neto HC

更新日期：1999-05-01 00:00:00

abstract：:1. The electrophysiological effects of prazosin, a highly specific alpha 1-adrenoceptor antagonist, on transmembrane action potential characteristics were studied in guinea-pig papillary muscles. 2. At concentrations between 10(-6) M and 10(-5) M, prazosin produced a concentration-dependent decrease in the maximum ups...

journal_title：British journal of pharmacology

authors： Pérez O,Valenzuela C,Delpón E,Tamargo J

更新日期：1994-03-01 00:00:00

abstract：:5-Hydroxytryptamine(1B/1D) (5-HT(1B/1D)) receptor coupling to contraction was investigated in endothelium-denuded rabbit isolated renal arteries, by simultaneously measuring tension and intracellular [Ca(2+)], and tension in permeabilized smooth muscle cells. In intact arterial segments, 1 nM - 10 microM 5-HT failed t...

journal_title：British journal of pharmacology

authors： Hill PB,Dora KA,Hughes AD,Garland CJ

更新日期：2000-06-01 00:00:00

abstract：:Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of ac...

journal_title：British journal of pharmacology

authors： Roche D,Gil D,Giraldo J

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The dietary trace amines tyramine and beta-phenylethylamine (beta-PEA) can increase blood pressure. However, the mechanisms involved in the vascular effect of trace amines have not been fully established. The purpose of this study was to evaluate whether trace amine-dependent vasoconstriction was...

journal_title：British journal of pharmacology

authors： Herbert AA,Kidd EJ,Broadley KJ

更新日期：2008-10-01 00:00:00

abstract：:The effects of repeated electroconvulsive shock (ECS) administration, repeated desmethylimipramine injection (5 mg kg-1, twice daily for 14 days) and acute administration of the beta-adrenoceptor, clenbuterol, on 5-hydroxytryptamine (5-HT)- and dopamine-mediated behaviours in mice have been examined. All three treatme...

journal_title：British journal of pharmacology

authors： Green AR,Heal DJ,Johnson P,Laurence BE,Nimgaonkar VL

更新日期：1983-10-01 00:00:00

abstract：UNLABELLED:Midkine (MK) is a heparin-binding growth factor or cytokine and forms a small protein family, the other member of which is pleiotrophin. MK enhances survival, migration, cytokine expression, differentiation and other activities of target cells. MK is involved in various physiological processes, such as devel...

journal_title：British journal of pharmacology

authors： Muramatsu T

更新日期：2014-02-01 00:00:00

abstract：:Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB(1) and CB(2) receptors and of endogeno...

journal_title：British journal of pharmacology

authors： Pertwee RG

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Abdominal aortic aneurysm (AAA) is a degenerative disease with irreversible and progressive dilation of the artery. But there are few options for efficacious treatment except for traditional surgery. Probucol has been widely applied to treat hyperlipidaemia and atherosclerosis in clinic, but whet...

journal_title：British journal of pharmacology

authors： Chen C,Wang Y,Cao Y,Wang Q,Anwaier G,Zhang Q,Qi R

更新日期：2020-01-01 00:00:00

abstract：:1. A study has been made of the effects of cocaine and sympathetic denervation on responses of the cat spleen to (-)-noradrenaline and (-)-isoprenaline.2. Responses of isolated strips of spleen capsule to (-)-noradrenaline or to (-)-isoprenaline were not affected by reserpine-pretreatment.3. In adult cats, cocaine (1 ...

journal_title：British journal of pharmacology

authors： Granata AR,Langer SZ

更新日期：1973-08-01 00:00:00

abstract：:1. Calcium entry via neuronal calcium channels is essential for the process of neurotransmission. We investigated the calcium channel subtypes involved in the operation of cardiac autonomic neurotransmission by examining the effects of selective calcium channel blockers on the inotropic responses to electrical field s...

journal_title：British journal of pharmacology

authors： Serone AP,Angus JA

更新日期：1999-06-01 00:00:00

abstract：:1. Electrically-evoked contractions in different regions of the rabbit isolated pulmonary artery have been investigated using stimulation parameters generally assumed to stimulate nerves selectively. 2. In extrapulmonary artery, trains of stimuli (10 Hz; pulse width 0.1 ms) evoked monophasic contractions. In contrast,...

journal_title：British journal of pharmacology

authors： Jackson VM,Trout SJ,Cunnane TC

更新日期：2002-10-01 00:00:00