Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.

abstract：:1. We have studied the mechanical response of circular strips of the guinea-pig ileum to tachykinins and characterized the receptors involved by means of receptor-selective agonists. 2. The strips responded to both substance P (SP) and neurokinin A (NKA), as well as to [Pro9]-SP sulphone (selective NK1-receptor agonis...

journal_title：British journal of pharmacology

authors： Maggi CA,Patacchini R,Giachetti A,Meli A

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Selective oestrogen receptor (ER) modulators (SERMs) are of great value in the treatment of breast cancer and osteoporosis. The aim of this study was to characterize pharmacologically a new class of SERMs synthesized based on the core structure of raloxifene. EXPERIMENTAL APPROACH:Competitive re...

journal_title：British journal of pharmacology

authors： Ning M,Zhou C,Weng J,Zhang S,Chen D,Yang C,Wang H,Ren J,Zhou L,Jin C,Wang MW

更新日期：2007-01-01 00:00:00

abstract：:1. The effects of fenoverine, an antispasmodic drug, have been studied on the Ca2+ channel currents of isolated cells from rat portal vein and pregnant myometrium by the patch-clamp technique (whole-cell configuration). 2. Fenoverine inhibited both fast and slow Ca2+ channel currents in a concentration-dependent manne...

journal_title：British journal of pharmacology

authors： Mironneau J,Arnaudeau S,Mironneau C

更新日期：1991-09-01 00:00:00

abstract：:Since its discovery over 50 years ago, cAMP has been the archetypal second messenger introducing students to the concept of cell signalling at the simplest level. As explored in this review, however, there are many more facets to cAMP signalling than the path from Gs-coupled receptor to adenylyl cyclase (AC) to cAMP t...

journal_title：British journal of pharmacology

authors： Billington CK,Hall IP

更新日期：2012-05-01 00:00:00

abstract：:Muscularis mucosa of the distal oesophagus of the opossum contains nerves which release acetylcholine and substance P(SP)-like material on field stimulation. The release of SP-like material appeared to be inhibited by the presence of exogenous muscarinic agonists and potentiated by muscarinic antagonists. Analysis of ...

journal_title：British journal of pharmacology

authors： Daniel EE,Jury J,Robotham KH

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoi...

journal_title：British journal of pharmacology

authors： Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR

更新日期：2007-11-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) caused concentration-dependent relaxation in precontracted segments of trachea, hilar bronchus, intrapulmonary bronchus and intrapulmonary artery (IPA) isolated from cat lungs. VIP-induced relaxation responses were abolished by preincubation of tissues with the proteolytic enzyme, a...

journal_title：British journal of pharmacology

authors： Altiere RJ,Diamond L

更新日期：1984-06-01 00:00:00

abstract：:Des-Arg9-bradykinin (des-Arg9-BK) caused endothelium-dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des-Arg9-BK were inhibited by the B1 receptor antagonist, des-Arg9-[Leu3]-BK (pK(B), 6.14 +/- 0.11) but were unaffected by the B2 receptor anta...

journal_title：British journal of pharmacology

authors： Drummond GR,Cocks TM

更新日期：1995-12-01 00:00:00

abstract：:1. Fluoxetine (Prozac) is widely used as an antidepressant drug and is assumed to be a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI). Claims that its beneficial psychotropic effects extend beyond those in treatment of depression have drawn clinical and popular attention to this compound, raising the q...

journal_title：British journal of pharmacology

authors： Tytgat J,Maertens C,Daenens P

更新日期：1997-12-01 00:00:00

abstract：:1. We have studied the transcellular biosynthesis of bioactive leukotrienes (LTs), generated upon blood cell-vascular wall interactions and their functional consequences, in the spontaneously beating, cell-perfused, heart of the rabbit. Rabbit isolated hearts were perfused under recirculating conditions (50 ml) with 5...

journal_title：British journal of pharmacology

authors： Sala A,Rossoni G,Buccellati C,Berti F,Folco G,Maclouf J

更新日期：1993-11-01 00:00:00

abstract：:1. A new method for the estimation of 4-hydroxy-3-methoxyphenylethylamine (3-methoxytyramine) in brain tissue is described. This is based on the formation of a fluorescent derivative by oxidation with potassium ferricyanide in ammonium hydroxide solution.2. The effects of some drugs on the concentration of 3-methoxyty...

journal_title：British journal of pharmacology

authors： Guldberg HC,Sharman DF,Tegerdine PR

更新日期：1971-08-01 00:00:00

abstract：:1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 ...

journal_title：British journal of pharmacology

authors： Liang Y,Li C,Guzman VM,Chang WW,Evinger AJ,Pablo JV,Woodward DF

更新日期：2004-06-01 00:00:00

abstract：:In rat aortic rings, hydroxocobalamin (10-30 microM) produced concentration-dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium-dependent, NO-mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10-30 microM) reduced but also prolonged, NO-induced rela...

journal_title：British journal of pharmacology

authors： Rajanayagam MA,Li CG,Rand MJ

更新日期：1993-01-01 00:00:00

abstract：:1. Cold storage (2 degrees C) treatment progressively reduced noradrenaline uptake by the taenia caecum of the guinea-pig. After 15 days of cold treatment, [(3)H]-noradrenaline uptake by tissue was reduced to about 10% of control. On the other hand, prolonged cold storage failed to decrease [(3)H]-adenosine uptake by ...

journal_title：British journal of pharmacology

authors： Kuchii M,Miyahara JT,Shibata S

更新日期：1973-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The age-related decline in vasorelaxation is largely due to ceramide-induced induction of phosphatase 2A (PP2A), which limits nitric oxide synthase (eNOS) phosphorylation at stimulatory sites. We hypothesized that ceramide accumulation was from an age-related loss of endothelial glutathione (GSH)...

journal_title：British journal of pharmacology

authors： Smith AR,Visioli F,Frei B,Hagen TM

更新日期：2008-04-01 00:00:00

abstract：:1. FPL 67156 (6-N,N-diethyl-beta, gamma-dibromomethylene-D-ATP), is a newly synthesized analogue of ATP. 2. In a rabbit isolated tracheal epithelium preparation, measuring P2U-purinoceptor-dependent chloride secretion, FPL 67156 was discovered to potentiate the responses to UTP but not those to ATP-gamma-S. UTP agonis...

journal_title：British journal of pharmacology

authors： Crack BE,Pollard CE,Beukers MW,Roberts SM,Hunt SF,Ingall AH,McKechnie KC,IJzerman AP,Leff P

更新日期：1995-01-01 00:00:00

abstract：:1. The ability of the nitric oxide (NO)-releasing aspirin, NCX 4016, to control vasoconstrictor responses induced by electrical field stimulation (TNS) or by exogenous norepinephrine (NE) was investigated in perfused rat tail artery with intact endothelium. 2. NCX 4016 (25, 50 and 100 microM) dose-dependently antagoni...

journal_title：British journal of pharmacology

authors： Rossoni G,Manfredi B,Del Soldato P,Berti F

更新日期：2002-09-01 00:00:00

abstract：:1. The interactions between two K+ channel openers, cromakalim and SR 44866 (infused i.v. at equihypotensive doses), and the sympathetic nervous system at the systemic and regional (mesentery, kidney, hindlimb) vascular levels were investigated in the pithed spontaneously hypertensive rat (SHR) by use of the pulsed Do...

journal_title：British journal of pharmacology

authors： Richer C,Mulder P,Doussau MP,Gautier P,Giudicelli JF

更新日期：1990-07-01 00:00:00

abstract：:Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and inhibits stimulated adenylate cyclase. Adenosine 5'-O-(1-thiodiphosphate) (ADP-alpha-S) and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) act at the ADP receptor and achieve the same maximal rate of human platelet aggregation as each other. Adenos...

journal_title：British journal of pharmacology

authors： Cusack NJ,Hourani SM

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Selective cannabinoid CB2 receptor agonists have demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and broad spectrum analgesic activity in rodent models, but is not an antag...

journal_title：British journal of pharmacology

authors： Yao BB,Hsieh GC,Frost JM,Fan Y,Garrison TR,Daza AV,Grayson GK,Zhu CZ,Pai M,Chandran P,Salyers AK,Wensink EJ,Honore P,Sullivan JP,Dart MJ,Meyer MD

更新日期：2008-01-01 00:00:00

abstract：:1. The role played by endogenous lipocortin 1 in the anti-migratory action exerted by dexamethasone (Dex) on monocyte recruitment in an in vivo model of acute inflammation was investigated by use of several neutralizing polyclonal antibodies raised against lipocortin 1 or a lipocortin 1-derived N-terminus peptide (pep...

journal_title：British journal of pharmacology

authors： Getting SJ,Flower RJ,Perretti M

更新日期：1997-03-01 00:00:00

abstract：:1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was no...

journal_title：British journal of pharmacology

authors： Angerio AD,Fitzpatrick TM,Kot PA,Ramwell PW,Rose JC

更新日期：1981-05-01 00:00:00

abstract：:In this issue of the BJP, Green et al. suggest that animal data could not be used to predict the adverse effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans and that MDMA did not produce 5-HT neurotoxicity in the human brain. This proposal was, however, not accompanied by a review of the empirical evidence i...

journal_title：British journal of pharmacology

authors： Parrott AC

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is growing evidence that inflammation plays a major role in the pathogenesis of neural damage caused by deposition of amyloid β (Aβ) in the brain. Nimodipine has received attention as a drug that might improve learning and reduce cognitive deficits in Alzheimer's disease, but the mechanism ...

journal_title：British journal of pharmacology

authors： Sanz JM,Chiozzi P,Colaianna M,Zotti M,Ferrari D,Trabace L,Zuliani G,Di Virgilio F

更新日期：2012-12-01 00:00:00

abstract：:Intraperitoneal and intracerebral injections of methyl beta-carboline-3-carboxylate (beta CCM) and intracerebral injections of RO 15-1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by beta CCM were mediated in part b...

journal_title：British journal of pharmacology

authors： Hindley SW,Hobbs A,Paterson IA,Roberts MH

更新日期：1985-11-01 00:00:00

abstract：:1. The prostate function is regulated by androgens and alpha-adrenergic activity. Clinically, antiandrogens and/or alpha(1)-adrenergic antagonists are commonly used to treat symptomatic prostatic hypertrophy. To elucidate the effects of androgen deprivation on prostate contractility via alpha(1)-adrenoceptor, the char...

journal_title：British journal of pharmacology

authors： Homma Y,Hamada K,Nakayama Y,Tsujimoto G,Kawabe K

更新日期：2000-12-01 00:00:00

abstract：:The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density o...

journal_title：British journal of pharmacology

authors： Nayler WG,Liu JJ,Panagiotopoulos S,Casley DJ

更新日期：1989-08-01 00:00:00

abstract：:1. The effect of in vivo desensitization to leukotriene B4 (LTB4) on eosinophil infiltration in response to recombinant C5a was examined in guinea-pig skin. 2. LTB4 (10-300 ng) and C5a (1-10 micrograms) caused a dose-dependent increase in the levels of eosinophil peroxidase activity (a measure of eosinophil infiltrati...

journal_title：British journal of pharmacology

authors： Pettipher ER,Salter ED,Showell HJ

更新日期：1994-09-01 00:00:00

abstract：:1. The effects of some rapidly metabolized sympathomimetic amines, such as beta-phenylethylamine and p-tyramine, in eliciting hypertensive responses to reserpine in the anaesthetized rat, have been studied.2. Retardation of metabolism, by pretreatment with the monoamineoxidase inhibitors iproniazid or phenelzine, caus...

journal_title：British journal of pharmacology

authors： Cashin CH

更新日期：1972-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aucubin, the predominant component of Eucommia ulmoides Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart ...

journal_title：British journal of pharmacology

authors： Wu QQ,Xiao Y,Duan MX,Yuan Y,Jiang XH,Yang Z,Liao HH,Deng W,Tang QZ

更新日期：2018-05-01 00:00:00