Endometrial destruction by hyperthermia--a possible treatment of menorrhagia. An experimental study.

Abstract:

BACKGROUND:Treatment of menorrhagia by heat-destruction of the endometrium, intended to be an alternative to hysterectomy, was investigated in an experimental study. METHOD:A specially designed catheter (CavatermTM) with a silicone balloon containing a self-regulating containing heating element is inserted into the uterus, filled with glycine to a pressure of around 180 mmHg and heated to about 75 degrees C. We investigated the treatment effect in vitro in five extirpated uteri (series A) and in vivo in three patients treated peroperatively just before hysterectomy, temperatures being monitored in the surrounding tissues (series B). In both series we monitored the following variables: heating-power, balloon-pressure, temperature of the heating element (around 85 degrees C) and the temperatures at five locations from top to bottom of the balloon surface. RESULTS:After 30 min in vitro treatment at 75 degrees C, the endometrium was partly destructed, and condensed. Histological examination showed smooth muscle cells to be destroyed to a depth of 2-5 mm close to the endometrium. With in vivo treatment for 30 min at a heating power of about 20 W (resulting in balloon surface temperatures of 58-65 degrees C), the increases in temperature of the surrounding tissue were too small to measure accurately (+/-1 degree C). Histological examination showed destruction of cells in the corpus uteri to a maximum depth of 8 mm. CONCLUSION:Findings in in vitro and in vivo experiments suggest that 30 min heating of the endometrium to 58-65 degrees C with an intrauterine silicone balloon filled with a liquid to a pressure of 180 mmHg exerts therapeutic effects on both endometrium and uterine cavity smooth muscle cells without damage to surrounding tissues.

authors

Friberg B,Persson BR,Willén R,Ahlgren M

doi

10.3109/00016349609033325

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

330-5

issue

4

eissn

0001-6349

issn

1600-0412

journal_volume

75

pub_type

临床试验,杂志文章
  • Treatment of vaginal recurrence in endometrial cancer. A review.

    abstract:BACKGROUND:We have reviewed the literature concerning vaginal recurrence in endometrial cancer with emphasis on prognostics and therapeutic results. Compared to the overall outcome of recurrences (11-17 per cent survive more than 3-19 years) the survival rate of strictly vaginal recurrence appears significantly higher ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.3109/00016349609033275

    authors: Møller LA,Engelholm SA

    更新日期:1996-01-01 00:00:00

  • Evaluation of fetal and neonatal mortality at the University Hospital of Tromsø, Norway, from 1976 to 1989.

    abstract::To investigate developments in perinatal care, all fetal and neonatal deaths among those born after at least 24 weeks of gestation at the University Hospital of Tromsø, Norway from 1976 to 1989, were subjected to medical audit. A decrease in total mortality rate was found when based on maturity (greater than or equal ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349109007872

    authors: Berge LN,Rasmussen S,Dahl LB

    更新日期:1991-01-01 00:00:00

  • Increased frequency of carcinoma of the uterine cervix in women married to men with a previous gonorrheal infection. An epidemiological study.

    abstract::An earlier investigation showed an increased frequency of squamous epithelial carcinoma of the cervix in women who had experienced gonorrhea, but that there was a long lag between the infection and diagnosis of the cervical malignancy. The present work is a retrospective study of cervical malignancy in women married t...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348509155122

    authors: Furgyik S

    更新日期:1985-01-01 00:00:00

  • Impact of night shifts on laparoscopic skills and cognitive function among gynecologists.

    abstract:OBJECTIVE:To assess whether gynecologists have impaired laparoscopic skills and/or reduced cognitive function after long on-call hours. DESIGN:Prospective cohort study. SETTING:Department of Gynecology and Obstetrics, Norway. POPULATION:28 gynecologists working long shifts in a single department. METHODS:Pre-traini...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12496

    authors: Veddeng A,Husby T,Engelsen IB,Kent A,Flaatten H

    更新日期:2014-12-01 00:00:00

  • Duration of human singleton pregnancy. A population-based study.

    abstract::We have analysed the duration of pregnancy for singleton births in Sweden during 1976-80 by means of data from the Swedish Birth Registry. Information, which was obtained from special forms with standard questions, include date of first day of last menstrual period (LMP) and whether that date was considered reliable o...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349009028681

    authors: Bergsjø P,Denman DW 3rd,Hoffman HJ,Meirik O

    更新日期:1990-01-01 00:00:00

  • Factors associated with cone margin involvement in CIN patients undergoing conization-equivalent electrosurgical procedure.

    abstract:BACKGROUND:Most studies of cervical conization have considered the frequency of complications and the outcome of follow-up. The determinants of cone margin positivity have been inadequately described. In a series of CIN patients undergoing conization-equivalent electrosurgical procedure, we evaluated the factors associ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Costa S,De Nuzzo M,Terzano P,Santini D,De Simone P,Bovicelli A,Bovicelli L,Bucchi L

    更新日期:2000-07-01 00:00:00

  • The importance of maternal BMI on infant's birth weight in four BMI groups for the period 1978-2001.

    abstract:OBJECTIVE:To study whether increased maternal weight and other factors of importance is associated with higher birth weights of the children over a period of almost 25 years. DESIGN:Retrospective cohort study. SETTING:Delivery wards in southeast Sweden. SAMPLE:A total of 4,330 delivered women and their children from...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340902807199

    authors: Brynhildsen J,Sydsjö A,Ekholm-Selling K,Josefsson A

    更新日期:2009-01-01 00:00:00

  • Side and site of deep vein thrombosis in women using oral contraceptives.

    abstract::The anatomy of the thrombus in acute deep vein thrombosis (DVT) in women using oral contraceptives was studied in 277 reports on DVT received by the Swedish Adverse Drug Reaction Advisory Committee (SADRAC). The study revealed a similarity between the anatomy of DVT in women on oral contraceptives and that of DVT in p...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348509155155

    authors: Kierkegaard A

    更新日期:1985-01-01 00:00:00

  • Diagnostic value of ultrasound scanning and curettage in ectopic pregnancy. A prospective controlled trial.

    abstract::The object of this study was to assess the diagnostic value of ultrasonic scanning alone and of ultrasonic scanning combined with histological examination of endometrial tissue on suspicion of subacute ectopic pregnancy. For the 93 patients comprising the study, ectopic pregnancy was diagnosed in 21 cases. The diagnos...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016348209156539

    authors: Legarth J,Eriksen PS

    更新日期:1982-01-01 00:00:00

  • No effect of vitamin B-6 against premenstrual tension. A controlled clinical study.

    abstract::Vitamin B-6 100 mg given daily throughout the menstrual cycle was compared with placebo in a randomized, double-blind crossover trial in 34 women who suffered from premenstrual tension. Vitamin B-6 was no better than placebo. There was a substantial period effect, as the women evidenced a considerable preference for t...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016348509158211

    authors: Hagen I,Nesheim BI,Tuntland T

    更新日期:1985-01-01 00:00:00

  • Cause of and factors associated with stillbirth: a systematic review of classification systems.

    abstract:INTRODUCTION:An estimated 2.6 million stillbirths occur worldwide each year. A standardized classification system setting out possible cause of death and contributing factors is useful to help obtain comparative data across different settings. We undertook a systematic review of stillbirth classification systems to hig...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aogs.13126

    authors: Aminu M,Bar-Zeev S,van den Broek N

    更新日期:2017-05-01 00:00:00

  • Antenatal diagnosis of placenta accreta leads to reduced blood loss.

    abstract:OBJECTIVE:Placenta accreta is one of the most devastating pregnancy complications. We sought to compare outcomes between women with placenta accreta when diagnosed antenatally or intrapartum, and to define predictors of the antenatal diagnosis. DESIGN:Retrospective case-control study. SETTING:University teaching hosp...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2011.01147.x

    authors: Tikkanen M,Paavonen J,Loukovaara M,Stefanovic V

    更新日期:2011-10-01 00:00:00

  • Diagnosis of pelvic masses with transabdominal color Doppler, CA 125 and ultrasonography.

    abstract:BACKGROUND:The objective of this study was to test the accuracy of transabdominal color Doppler imaging in the prediction of malignancy of adnexal tumors when integrated in combination with CA 125 levels and two-dimensional ultrasound. METHODS:We considered 129 consecutive patients with a suspected adnexal mass at cli...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349509021184

    authors: Franchi M,Beretta P,Ghezzi F,Zanaboni F,Goddi A,Salvatore S

    更新日期:1995-10-01 00:00:00

  • Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells.

    abstract:BACKGROUND:Both the estrogen receptor (ER) alpha and beta isoforms are expressed in the endothelium. The ER beta has been assigned a crucial role in normal vascular wall function. Prostacyclin has been ascribed a beneficial effect on vessel wall physiology. Isoflavones bind with higher affinity to ER beta. We investiga...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1080/j.1600-0412.2003.00178.x

    authors: García-Martínez MC,Hermenegildo C,Tarín JJ,Cano A

    更新日期:2003-08-01 00:00:00

  • Expression of selected genes in preterm premature rupture of fetal membranes.

    abstract:OBJECTIVE:To analyse the expression of 15 genes encoding receptors and enzymes associated with the molecular mechanism of the tocolytic drugs atosiban (oxytocin receptor antagonist), nifedipine (calcium channel blocker) and celecoxib (selective cyclo-oxygenase-2 inhibitor) in preterm labor patients with premature ruptu...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2012.01445.x

    authors: Kuć P,Laudański P,Kowalczuk O,Chyczewski L,Laudański T

    更新日期:2012-08-01 00:00:00

  • The Danish anal sphincter rupture questionnaire: validity and reliability.

    abstract:OBJECTIVE:To revise, validate and test for reliability an anal sphincter rupture questionnaire in relation to construct, content and face validity. SETTING AND BACKGROUND: Since 1996 women with anal sphincter rupture (ASR) at one of the public university hospitals in Copenhagen, Denmark have been offered pelvic floor m...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340802443814

    authors: Due U,Ottesen M

    更新日期:2009-01-01 00:00:00

  • Who uses Norplant. A study from Finland.

    abstract:OBJECTIVE:Although Norplant implantable contraceptives were introduced first in Finland, their use has been infrequent. The objective of this study was to investigate what kind of women use Norplant in Finland, who suggested its use, and from what source women get their information on Norplant. METHODS:A questionnaire...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349409013435

    authors: Sihvo S,Ollila E,Hemminki E

    更新日期:1994-07-01 00:00:00

  • Maternal and fetal serum levels of organochlorine compounds in cases of premature rupture of membranes.

    abstract::Blood residue levels of some organochlorine pesticides (DDT and its analogues, lindane, dieldrin, heptachlor epoxide) and polychlorinated biphenyls were measured in maternal and cord blood in 20 cases of premature rupture of fetal membranes at term and in 15 matched controls. No evidence of a possible organochlorine c...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349809004291

    authors: Ron M,Cucos B,Rosenn B,Hochner-Celnikier D,Ever-Hadani P,Pines A

    更新日期:1988-01-01 00:00:00

  • Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study.

    abstract:INTRODUCTION:Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subseque...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/aogs.12915

    authors: Yamada T,Obata-Yasuoka M,Hamada H,Baba Y,Ohkuchi A,Yasuda S,Kawabata K,Minakawa S,Hirai C,Kusaka H,Murabayashi N,Inde Y,Nagura M,Umazume T,Itakura A,Maeda M,Sagawa N,Ohno Y,Kataoka S,Fujimori K,Kudo Y,Ikeda T,

    更新日期:2016-09-01 00:00:00

  • Rupture of rudimentary horn pregnancy.

    abstract::A rare case of rupture of an noncommunicating rudimentary horn pregnancy is reported. The pregnancy proceeded to 25 gestational weeks, when the rudimentary horn ruptured. The patient had signs and symptoms of massive hemoperitoneum. An emergency exploratory laparotomy revealed rupture of the gravid rudimentary horn an...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349209009926

    authors: Chang JC,Lin YC

    更新日期:1992-04-01 00:00:00

  • Fetal cardiovascular hemodynamics in type 1 diabetic pregnancies at near-term gestation.

    abstract:INTRODUCTION:Poor glycemic control in maternal type 1 diabetes mellitus during pregnancy can affect fetal cardiac and placental function. However, studies concerning fetal central hemodynamics have revealed conflicting results. We hypothesized that in pregnancies complicated by maternal type 1 diabetes, fetal cardiovas...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13987

    authors: Lehtoranta L,Haapsamo M,Vuolteenaho O,Palo P,Ekholm E,Räsänen J

    更新日期:2021-02-01 00:00:00

  • Distension of painful structures in the treatment for chronic pelvic pain in women.

    abstract:BACKGROUND:There is a lack of established treatment for Chronic pelvic pain (CPP), defined as acyclic pain of at least six months duration. We decided to study the pain-alleviating effects of stretching on defined structures in women with CPP, and the treatment's impact on quality of life variables. DESIGN OF STUDY:An...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00016340500495017

    authors: Heyman J,Ohrvik J,Leppert J

    更新日期:2006-01-01 00:00:00

  • Placental abruption. Maternal risk factors and associated fetal conditions.

    abstract:OBJECTIVE:To investigate maternal risk factors and fetal conditions associated with abruption. METHODS:Prospective cohort study of 30,681 singleton pregnancies at least 28 weeks' gestation. Data collected by patient questionnaire at the first prenatal visit and by medical record review. RESULTS:307 women had abruptio...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349309021156

    authors: Raymond EG,Mills JL

    更新日期:1993-11-01 00:00:00

  • A case of hepatocellular carcinoma in pregnancy detected by routine screening of maternal alpha-feto-protein.

    abstract::A rare case of hepatocellular carcinoma in a 31-year-old woman is reported. The diagnosis was made at 16 weeks of pregnancy when very high levels of alpha-feto-protein were found upon routine examination. The pregnancy was terminated and cytostatic therapy was given. The patient died one year later. ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349109006217

    authors: Goldberg I,Hod M,Katz I,Friedman S,Ovadia J

    更新日期:1991-01-01 00:00:00

  • Does group training during pregnancy prevent lumbopelvic pain? A randomized clinical trial.

    abstract:BACKGROUND:Prevention of lumbopelvic pain in pregnancy has been sparsely studied. One aim of this study was to assess if a 12-week training program during pregnancy can prevent and/or treat lumbopelvic pain. A randomized controlled trial was conducted at Trondheim University Hospital and three outpatient physiotherapy ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00016340601089651

    authors: Mørkved S,Salvesen KA,Schei B,Lydersen S,Bø K

    更新日期:2007-01-01 00:00:00

  • Neuroendocrine response to violence during pregnancy--impact on duration of pregnancy and fetal growth.

    abstract:OBJECTIVE:To study the neuroendocrine release of cortisol in response to perceived stress among pregnant women exposed to partner violence and how this affects the duration of pregnancy and the intrauterine growth of the infant. DESIGN:Cross-sectional community-based study. SETTING:Health and Demographic Surveillance...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340903015321

    authors: Valladares E,Peña R,Ellsberg M,Persson LA,Högberg U

    更新日期:2009-01-01 00:00:00

  • Oxytocin, somatostatin, insulin and gastrin concentrations vis-à-vis late pregnancy, breastfeeding and oral contraceptives.

    abstract::Oxytocin concentrations increased during pregnancy and during medication with low-dose oral contraceptives (o.c.). Postprandial somatostatin concentrations were lower during medication with o.c. Insulin concentrations were elevated during pregnancy with the same tendency during medication with o.c. Gastrin levels were...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349109007873

    authors: Silber M,Larsson B,Uvnäs-Moberg K

    更新日期:1991-01-01 00:00:00

  • Validation of a computerized algorithm to quantify fetal heart rate deceleration area.

    abstract:INTRODUCTION:Reliability in visual cardiotocography interpretation is unsatisfying, which has led to the development of computerized cardiotocography. Computerized analysis is well established for antenatal fetal surveillance but has yet not performed sufficiently during labor. We aimed to investigate the capacity of a...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13370

    authors: Gyllencreutz E,Lu K,Lindecrantz K,Lindqvist PG,Nordstrom L,Holzmann M,Abtahi F

    更新日期:2018-09-01 00:00:00

  • Ectopic pregnancy revisited in Benin City, Nigeria: analysis of 152 cases.

    abstract:BACKGROUND:Ectopic pregnancy is still a major health problem among women of childbearing age in our community. The majority of the patients with ectopic pregnancy are nulliparous in their mid twenties, with previous induced abortion(s) and or pelvic inflammatory disease. It remains a major challenge to the reproductive...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2002.811207.x

    authors: Gharoro EP,Igbafe AA

    更新日期:2002-12-01 00:00:00

  • Torsion of the previously normal uterine adnexa. Evaluation of the correlation between the pathological changes and the clinical characteristics.

    abstract:BACKGROUND:Treatment of adnexal torsion remains a clinical dilemma when future fertility is wanted. The purpose of this study was to evaluate the correlation between the pathological changes and the clinical characteristics on patients having torsion of the previously normal uterine adnexa which may help us decide whet...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2001.800111.x

    authors: Chen M,Chen CD,Yang YS

    更新日期:2001-01-01 00:00:00