Abstract:
:A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalcemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected for further investigation, proving 10-fold as potent as pamidronate in the PIH model and an immobilization bone atrophy model in rats (DA model). The structure-activity relationships of this series of bisphosphonates are discussed.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Takeuchi M,Sakamoto S,Yoshida M,Abe T,Isomura Ydoi
10.1248/cpb.41.688subject
Has Abstractpub_date
1993-04-01 00:00:00pages
688-93issue
4eissn
0009-2363issn
1347-5223journal_volume
41pub_type
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