Abstract:
:An efficient one-pot step by step t-BuOK-mediated procedure for the synthesis of N-arylindoles has been developed in moderate to good yields. The protocol involves the consecutive deprotection of N-arylsulfonylindoles as latent indoles and subsequent S(N)Ar reactions with activated aryl halides. This tandem reaction affords an efficient and convenient preparation of N-arylindoles that benefit from prior indoles protection by arylsulfonyl group, and can shorten a reaction sequence and improve synthetic efficiency.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Xu H,Fan LLdoi
10.1248/cpb.57.321subject
Has Abstractpub_date
2009-03-01 00:00:00pages
321-3issue
3eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.321journal_volume
57pub_type
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