Physical fitness and C-reactive protein level in children and young adults: the Columbia University BioMarkers Study.

Abstract:

OBJECTIVE:To examine the association of physical fitness with C-reactive protein (CRP) level in children and young adults. METHODS:Subjects (N = 205) aged 6 to 24 years were enrolled in the Columbia University BioMarkers Study (1994-1998). Physical fitness was assessed using a non-effort-dependent treadmill testing protocol (physical work capacity at heart rate of 170 beats per minute). CRP level was measured using a high-sensitivity assay. RESULTS:Subjects were 54% female and 65% of Hispanic origin. Mean fitness level was higher in boys than in girls, but CRP levels did not differ by gender. Fitness level was inversely correlated with CRP (r = -0.22). This relationship was significant in boys (r = -0.32) but not in girls (r = -0.15). After multivariate regression adjustment for age, race/ethnicity, body mass index, and family history of early-onset ischemic heart disease, physical fitness remained inversely associated with CRP level in boys (beta = -0.02; standard error = 0.01). CONCLUSIONS:These findings indicate that physical fitness is inversely related to CRP level in children and that this relationship is more pronounced in boys than in girls.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Isasi CR,Deckelbaum RJ,Tracy RP,Starc TJ,Berglund L,Shea S

doi

10.1542/peds.111.2.332

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

332-8

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

111

pub_type

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