Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates by heteroduplex analysis and determination of rifamycin cross-resistance in rifampin-resistant isolates.

Abstract:

:Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.

journal_name

J Clin Microbiol

authors

Saribaş Z,Kocagöz T,Alp A,Günalp A

doi

10.1128/jcm.41.2.816-818.2003

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

816-8

issue

2

eissn

0095-1137

issn

1098-660X

journal_volume

41

pub_type

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