Ramiprilat increases bradykinin outflow from isolated hearts of rat.

abstract：:1. The 5-hydroxytryptamine (5-HT)-receptor subtype and affinity for 5-HT was determined in large and small coronary arteries isolated as ring segments from the proximal and distal part of the left coronary artery of 3 month (young) and 2-year old (old) rats. 2. Ketanserin induced a rightward shift of the 5-HT concentr...

journal_title：British journal of pharmacology

authors： Nyborg NC

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This paper is intended to assist pharmacologists to make the most of statistical analysis and in avoid common errors. APPROACH:A scenario is presented where an experimenter performed an experiment to test the effects of two drugs on cultured cells. Analysis of the results, expressed as percentag...

journal_title：British journal of pharmacology

authors： Lew M

更新日期：2007-10-01 00:00:00

abstract：:1. We have taken advantage of our recent development of highly potent and specific phosphinic inhibitors of endopeptidase 3.4.24.15 to examine the putative contribution of the enzyme in the secretion of A beta by HK293 transfected cells overexpressing the wild type and the Swedish (Sw) double mutated form of beta APP7...

journal_title：British journal of pharmacology

authors： Chevallier N,Jiracek J,Vincent B,Baur CP,Spillantini MG,Goedert M,Dive V,Checler F

更新日期：1997-06-01 00:00:00

abstract：:Δ9 -tetrahydrocannabinol, the principal active component in Cannabis sativa extracts such as marijuana, participates in cell signalling by binding to cannabinoid CB1 and CB2 receptors on the cell surface. The CB1 receptors are present in both inhibitory and excitatory presynaptic terminals and the CB2 receptors are fo...

journal_title：British journal of pharmacology

authors： Basavarajappa BS,Joshi V,Shivakumar M,Subbanna S

更新日期：2019-09-01 00:00:00

abstract：:The effects of intravenous sufentanil and pre-administration of N-methyl-D-aspartate (NMDA) receptor antagonists were tested on a reflex triggered by C-fibre activation. The reflex was elicited by electrical stimulation of the sural nerve and recorded from the ipsilateral biceps femoris muscle in halothane anaesthetiz...

journal_title：British journal of pharmacology

authors： Adam F,Gairard AC,Chauvin M,Le Bars D,Guirimand F

更新日期：2001-08-01 00:00:00

abstract：:1 A range of opioid receptor agonists were tested for activity in five antinociceptive models: the acetylcholine-induced abdominal constriction, tail-flick and hot plate tests in the mouse and the paw pressure test in the rat and guinea-pig. 2 Agonists acting preferentially at the kappa-opioid receptor were significan...

journal_title：British journal of pharmacology

authors： Hayes AG,Sheehan MJ,Tyers MB

更新日期：1987-08-01 00:00:00

abstract：:The concentration in rat striatum of the meta and para isomers of tyramine and alpha-methyltyramine, after the administration of (+)-amphetamine, alpha-methyl-p-tyrosine (AMPT) and alpha-methylphenylalanine (AMPA) has been determined using chemical ionization gas chromatography mass spectrometry (c.i.g.c.m.s.). Twenty...

journal_title：British journal of pharmacology

authors： Dougan DF,Duffield AM,Duffield PH,Wade DN

更新日期：1983-10-01 00:00:00

abstract：:1 Nine antibiotic compounds in common use were studied to determine their ability to affect intestinal motility in vitro, in the guinea-pig ileum and rabbit colon. 2 Ampicillin, doxycycline, mecillinam and metronidazole were without effect over a concentration range which included typical serum levels found when these...

journal_title：British journal of pharmacology

authors： Lees GM,Percy WH

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Dimebolin (latrepirdine), a compound with multiple potential drug targets, is being evaluated in clinical trials for the treatment of Alzheimer's disease (AD) and preliminary results suggest it can slow the disease process. There is also evidence that dimebolin directly improves aspects of cognition. Here we...

journal_title：British journal of pharmacology

authors： Webster SJ,Wilson CA,Lee CH,Mohler EG,Terry AV Jr,Buccafusco JJ

更新日期：2011-10-01 00:00:00

abstract：:1 The effects of presynaptic alpha-adrenoceptor blockade on both the efflux of 3H-transmitter and on the magnitude of the effector response were measured simultaneously in a smooth muscle preparation which responds to field stimulation with noradrenergic beta-receptor-mediated relaxation. 2 In the presence of atropine...

journal_title：British journal of pharmacology

authors： Kalsner S

更新日期：1983-01-01 00:00:00

abstract：:1. The effect of synthetic tachykinin selective receptor agonists was studied on the growth of cultured human skin fibroblasts (HF). 2. Human fibroblasts were grown in serum-free conditions in the presence of natural tachykinins (substance P and neurokinin A) and of three synthetic agonists, [beta-Ala4, Sar9, Met(O2)1...

journal_title：British journal of pharmacology

authors： Ziche M,Morbidelli L,Pacini M,Dolara P,Maggi CA

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some neurosteroids, notably 3alpha-hydroxysteroids, positively modulate GABA(A) receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulate GABA receptors. We examined whether there was similarity among t...

journal_title：British journal of pharmacology

authors： Chisari M,Shu HJ,Taylor A,Steinbach JH,Zorumski CF,Mennerick S

更新日期：2010-05-01 00:00:00

abstract：:1 Acetylcholine-induced contractions of the isolated chronically denervated soleus muscle of the mouse consist of two phases, but both phases are equivalent to the contracture phase seen in vivo.2 Low [Ca(2+)](0) (0.5-1.5 mM) augmented peak tension, as well as the rate of relaxation, of the first phase, but inhibited ...

journal_title：British journal of pharmacology

authors： Hall MT,Maleque MA,Wadsworth RM

更新日期：1977-12-01 00:00:00

abstract：:1. The aim of this study was to investigate the relationship between airway reactivity, leukocyte influx and nitric oxide (NO), in conscious guinea-pigs after aerosolized lipopolysaccharide (LPS) exposure. 2. Inhaled histamine (1 mM, 20 s), causing no bronchoconstriction before LPS exposure (30 microg ml(-1), 1 h), ca...

journal_title：British journal of pharmacology

authors： Toward TJ,Broadley KJ

更新日期：2000-09-01 00:00:00

abstract：:Nebivolol, a selective beta-adrenoceptor (beta1-AR) antagonist, induces vasodilatation by an endothelium- and NO-cGMP-dependent pathway. However, the mechanisms involved in the vascular effect of nebivolol have not been established. Thus, we evaluated the role of alpha1 and beta3-ARs in nebivolol-induced vasodilatatio...

journal_title：British journal of pharmacology

authors： Rozec B,Quang TT,Noireaud J,Gauthier C

更新日期：2006-04-01 00:00:00

abstract：:1. We have determined which cytokines induce and modulate the production of the chemokine interleukin-8 (IL-8) by the human colonic epithelial cell line HT-29. 2. Growth arrested cell cultures were stimulated with the human recombinant cytokines interleukin-1 alpha (IL-1 alpha), tumour necrosis factor-alpha (TNF-alpha...

journal_title：British journal of pharmacology

authors： Kolios G,Robertson DA,Jordan NJ,Minty A,Caput D,Ferrara P,Westwick J

更新日期：1996-09-01 00:00:00

abstract：:Myoclonus induced by catechol in the guinea-pig is not altered by manipulation of cerebral 5-hydroxytryptamine (5-HT). The administration of catechol does not alter brain levels of 5-HT or its metabolite 5-hydroxyindole acetic acid. This form of myoclonus therefore is not of relevance to the 5-HT-sensitive post-anoxic...

journal_title：British journal of pharmacology

authors： Chadwick D,Jenner P,Marsden CD

更新日期：1979-07-01 00:00:00

abstract：:For almost three decades intrathecal baclofen therapy has been the standard treatment for spinal cord injury spasticity when oral medication is ineffective or produces serious side effects. Although intrathecal baclofen therapy has a good clinical benefit-risk ratio for spinal spasticity, tolerance and the life-threat...

journal_title：British journal of pharmacology

authors： Gómez-Soriano J,Goiriena E,Taylor J

更新日期：2010-11-01 00:00:00

abstract：:1. This study investigated whether (a) cannabinoid CB(1) receptor knockout (CB(1)(-/-)) mice displayed altered gastrointestinal transit and (b) cannabinoid CB(1) and opioid receptors functionally interact in the regulation of gastrointestinal transit. 2. Gastrointestinal transit was assessed by the Whole Gastrointesti...

journal_title：British journal of pharmacology

authors： Carai MA,Colombo G,Gessa GL,Yalamanchili R,Basavarajappa BS,Hungund BL

更新日期：2006-08-01 00:00:00

abstract：:Opioid drugs such as morphine and meperidine are widely used in clinical pain management, although they can cause some adverse effects. A number of studies indicate that N-methyl-D-aspartate (NMDA) receptors may play a role in the mechanism of morphine analgesia, tolerance and dependence. Being an antitussive with NMD...

journal_title：British journal of pharmacology

authors： Chen SL,Huang EY,Chow LH,Tao PL

更新日期：2005-02-01 00:00:00

abstract：:It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvement in symptoms. The present study describes the alpha1-adrenoceptor (a...

journal_title：British journal of pharmacology

authors： Williams TJ,Blue DR,Daniels DV,Davis B,Elworthy T,Gever JR,Kava MS,Morgans D,Padilla F,Tassa S,Vimont RL,Chapple CR,Chess-Williams R,Eglen RM,Clarke DE,Ford AP

更新日期：1999-05-01 00:00:00

abstract：:Chemotherapy-induced immune-suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer and strategies with capacity to boost the immune cell populations are needed. Physical exercise training is a potent regulator of immune cell viability and function and may serve...

journal_title：British journal of pharmacology

authors： Schauer T,Hojman P,Gehl J,Christensen JF

更新日期：2020-05-25 00:00:00

abstract：:1. The beta-adrenoceptor blocking and calcitonin gene-related peptide (CGRP)-releasing properties of capsinolol (N-[4-(2-hydroxy-3 (isopropylamino) propoxy)-3-methoxybenzyl]-nonanamide), derived from nonivamide, were investigated under in vivo and in vitro conditions. 2. Capsinolol (0.1, 0.5, 1.0 mg kg-1, i.v.), as we...

journal_title：British journal of pharmacology

authors： Chen IJ,Yeh JL,Lo YC,Sheu SH,Lin YT

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A non-psychoactive phytocannabinoid, cannabidiol (CBD), shows promising results as an effective potential antiepileptic drug in some forms of refractory epilepsy. To elucidate the mechanisms by which CBD exerts its anti-seizure effects, we investigated its effects at synaptic connections and on t...

journal_title：British journal of pharmacology

authors： Khan AA,Shekh-Ahmad T,Khalil A,Walker MC,Ali AB

更新日期：2018-06-01 00:00:00

abstract：:1. We have investigated the effect of the potassium channel opener, NIP-121, on contraction elicited by melittin (a phospholipase A2 activator) in epithelium-intact and epithelium-denuded trachea isolated from guinea-pigs. The effects of NIP-121 were compared with those of isoprenaline, aminophylline and hydrocortison...

journal_title：British journal of pharmacology

authors： Shikada K,Tanaka S

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arachidonyl trifluoromethyl ketone (ATK) is widely used as an inhibitor of cytosolic group IV phospholipase A(2) (cPLA(2)) and calcium-independent group VI phospholipase A(2) (iPLA(2)). ATK thus reduces arachidonic acid (AA) substrate for cyclooxygenase (COX; also known as prostaglandin H synthas...

journal_title：British journal of pharmacology

authors： Leis HJ,Windischhofer W

更新日期：2008-11-01 00:00:00

abstract：:The pharmaceutical industry is testing new potential drugs for their propensity to prolong human cardiac repolarization, and regards this as a sign of proarrhythmic risk. Many studies have dethroned the common perception that prolonged repolarization is a reliable surrogate marker for torsades de pointes (TdP) arrhyth...

journal_title：British journal of pharmacology

authors： Thomsen MB

更新日期：2007-08-01 00:00:00

abstract：:1. beta-Bungarotoxin and other snake toxins with phospholipase activity augment acetylcholine release evoked from mouse motor nerve terminals before they produce blockade. This action of the toxins is independent of their phospholipase A2 activity, but the underlying mechanism for the facilitation of release is unclea...

journal_title：British journal of pharmacology

authors： Rowan EG,Harvey AL

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of Na(+)-K(+)-ATPase is known to attenuate endothelium-dependent relaxation in many arteries. The purpose of this study was to evaluate the role of Na(+)-K(+)-ATPase in the regulation of endothelial membrane potential at rest and during stimulation by ACh. EXPERIMENTAL APPROACH:Membra...

journal_title：British journal of pharmacology

authors： Bondarenko A,Sagach V

更新日期：2006-12-01 00:00:00

abstract：:This paper is intended to assist pharmacologists to make the most of statistical analysis and avoid common errors. A scenario, in which an experimenter performed an experiment in two separate stages, combined the control groups for analysis and found some surprising results, is presented. The consequences of combined ...

journal_title：British journal of pharmacology

authors： Lew MJ

更新日期：2008-11-01 00:00:00