5-Hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig.

abstract：BACKGROUND AND PURPOSE:Melanocortins reverse circulatory shock and improve survival by counteracting the systemic inflammatory response, and through the activation of the vagus nerve-mediated cholinergic anti-inflammatory pathway. To gain insight into the potential therapeutic value of melanocortins against multiple or...

journal_title：British journal of pharmacology

authors： Bitto A,Polito F,Altavilla D,Irrera N,Giuliani D,Ottani A,Minutoli L,Spaccapelo L,Galantucci M,Lodi R,Guzzo G,Guarini S,Squadrito F

更新日期：2011-02-01 00:00:00

abstract：:Recent genome-wide analyses of rare and common sequence variations have brought greater clarity to the genetic architecture of pulmonary arterial hypertension and implicated novel genes in disease development. Transcriptional signatures have been reported in whole lung tissue, pulmonary vascular cells and peripheral c...

journal_title：British journal of pharmacology

authors： Harbaum L,Rhodes CJ,Otero-Núñez P,Wharton J,Wilkins MR

更新日期：2021-01-01 00:00:00

abstract：:1. In order to clarify the mechanism of Ca-dependent excitatory action of maitotoxin (MTX), the most potent marine toxin known, patch-clamp techniques were used to analyse electrophysiological effects of MTX on guinea-pig isolated cardiac myocytes. 2. The whole-cell recordings showed that MTX (0.3 ng ml-1) produced a ...

journal_title：British journal of pharmacology

authors： Kobayashi M,Ochi R,Ohizumi Y

更新日期：1987-11-01 00:00:00

abstract：:1. Preparations were developed whereby the hypogastric ganglion of the rat or guinea-pig was perfused through its vasculature with saline solutions. Drugs were injected into the perfusion stream, and their effects were indicated by contractions of the vas deferens. The base of this organ could be ligated to prevent th...

journal_title：British journal of pharmacology

authors： Bentley GA

更新日期：1972-03-01 00:00:00

abstract：:1. The effects of various inhibitors of the mitochondrial electron transport chain on the activity of ATP-sensitive K+ channels were examined in the Cambridge rat insulinoma G1 (CRI-G1) cell line using a combination of whole cell and single channel recording techniques. 2. Whole cell current clamp recordings, with 5 m...

journal_title：British journal of pharmacology

authors： Harvey J,Hardy SC,Ashford ML

更新日期：1999-01-01 00:00:00

abstract：:Nicotine and dimethyl-phenylpiperazinium (DMPP) increased intravesicular pressure and then transiently depressed the spontaneous activity of the urinary bladder in chloralose anaesthetized cats. Adrenaline (5-10 micrograms kg-1), noradrenaline (5-20 micrograms kg-1) and isoprenaline (40-50 micrograms kg-1) which depre...

journal_title：British journal of pharmacology

authors： Koley B,Koley J,Saha JK

更新日期：1984-10-01 00:00:00

abstract：:1 In cats anaesthetized with pentobarbitone and vagotomized, observations were made on the phrenic nerve action potential and the diaphragm electromyogram (EMG) at constant end-tidal Pco(2). Arterial blood pressure was stabilized by intravenous infusions of noradrenaline.2 Intravenous administration of saxitoxin (STX)...

journal_title：British journal of pharmacology

authors： Borison HL,Culp WJ,Gonsalves SF,McCarthy LE

更新日期：1980-02-01 00:00:00

abstract：:The opioid receptors are key targets in the treatment of acute and chronic pain, and the development of novel analgesics with reduced side effects is crucial in the search for more effective medications. The crystal structures of opioid receptors have provided a wealth of knowledge on many aspects of opioid receptor p...

journal_title：British journal of pharmacology

authors： Marino KA,Shang Y,Filizola M

更新日期：2018-07-01 00:00:00

abstract：:1. We have investigated the potency and duration of action of isoprenaline and a range of beta-adrenoceptor agonists as relaxants of inherent tone in human superfused, isolated bronchial smooth muscle, a tissue reported to contain a homogeneous population of beta 2-adrenoceptors. 2. All of the beta-adrenoceptor agonis...

journal_title：British journal of pharmacology

authors： Nials AT,Coleman RA,Johnson M,Magnussen H,Rabe KF,Vardey CJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sphingosine-1-phosphate (S1P) has been shown to be involved in the asthmatic disease as well in preclinical mouse experimental models of this disease. The aim of this study was to understand the mechanism(s) underlying S1P effects on the lung. EXPERIMENTAL APPROACH:BALB/c, mast cell-deficient an...

journal_title：British journal of pharmacology

authors： Roviezzo F,Sorrentino R,Bertolino A,De Gruttola L,Terlizzi M,Pinto A,Napolitano M,Castello G,D'Agostino B,Ianaro A,Sorrentino R,Cirino G

更新日期：2015-04-01 00:00:00

abstract：:The interaction of a new nonribose ligand (LUF5831) with the human adenosine A1 receptor was investigated in the present study. Radioligand binding experiments were performed in the absence and presence of diverse allosteric modulators on both wild-type (wt) and mutant (T277A) adenosine A1 receptors. Thermodynamic dat...

journal_title：British journal of pharmacology

authors： Heitman LH,Mulder-Krieger T,Spanjersberg RF,von Frijtag Drabbe Künzel JK,Dalpiaz A,IJzerman AP

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The endocannabinoid, anandamide, has anti-arrhythmic effects. The aim of the present study was to explore the electrophysiological effects of anandamide on rat myocardium. EXPERIMENTAL APPROACH:Evoked action potentials (APs) were recorded using intracellular recording technique in rat cardiac pa...

journal_title：British journal of pharmacology

authors： Li Q,Ma HJ,Zhang H,Qi Z,Guan Y,Zhang Y

更新日期：2009-12-01 00:00:00

abstract：:1 We have examined the effect of the histone deacetylase inhibitors apicidin, trichostatin A (TSA) and n-butyrate on the histone acetylation and the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into eosinophils. 2 Viability of the cells incubated with apicidin (100 nm), TSA (30 nm) or n-butyrate...

journal_title：British journal of pharmacology

authors： Ishihara K,Hong J,Zee O,Ohuchi K

更新日期：2004-07-01 00:00:00

abstract：:Preclinical and clinical data suggest that a modification in GABA(B) receptor expression and function may contribute to the symptoms of major depression and the response to antidepressants. This includes laboratory animal experiments demonstrating that antidepressants modify brain GABA(B) receptor expression and funct...

journal_title：British journal of pharmacology

authors： Ghose S,Winter MK,McCarson KE,Tamminga CA,Enna SJ

更新日期：2011-01-01 00:00:00

abstract：:The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentrati...

journal_title：British journal of pharmacology

authors： Zhang JJ,Jacob TJ,Hardy SP,Higgins CF,Valverde MA

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Using an innovative chemical approach, peptide welding technology (PWT), a tetrabranched derivative of nociceptin/orphanin FQ (N/OFQ) has been generated and pharmacologically characterized. Both in vitro and in vivo PWT2-N/OFQ displayed the same pharmacological profile to the natural ligand. It w...

journal_title：British journal of pharmacology

authors： Rizzi A,Sukhtankar DD,Ding H,Hayashida K,Ruzza C,Guerrini R,Calò G,Ko MC

更新日期：2015-07-01 00:00:00

abstract：:1. The effects of prejunctional beta-adrenoceptor activation on electrically evoked noradrenaline (NA) and adenosine 5'-triphosphate (ATP) were studied by use of continuous amperometry and conventional intracellular recording techniques. Excitatory junction potentials (e.j.ps) were used as a measure of ATP release, an...

journal_title：British journal of pharmacology

authors： Brock JA,Bridgewater M,Cunnane TC

更新日期：1997-03-01 00:00:00

abstract：:1. The distribution of sympathetic adrenergic nerves on the rat middle cerebral artery and on the arterioles which originated from it was determined by use of gloxylic histochemistry. 2. Whereas the middle cerebral artery and proximal arterioles arising from this artery received a sympathetic innervation, the distal r...

journal_title：British journal of pharmacology

authors： Edwards FR,Hards D,Hirst GD,Silverberg GD

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Memantine and ketamine are clinically used, open-channel blockers of NMDA receptors exhibiting remarkable pharmacodynamic similarities despite strikingly different clinical profiles. Although NMDA channel gating constitutes an important difference between memantine and ketamine, it is unclear how...

journal_title：British journal of pharmacology

authors： Emnett CM,Eisenman LN,Mohan J,Taylor AA,Doherty JJ,Paul SM,Zorumski CF,Mennerick S

更新日期：2015-03-01 00:00:00

abstract：:1. Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2. Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through...

journal_title：British journal of pharmacology

authors： Crocker IP,Kenny LC,Thornton WA,Szabo C,Baker PN

更新日期：2005-03-01 00:00:00

abstract：:In this issue of the British Journal of Pharmacology, Ryberg et al. present convincing in vitro evidence that the orphan GPCR, GPR55, is a cannabinoid receptor. GPR55 was activated by a range of plant, synthetic and endogenous cannabinoids and blocked by the non-psychoactive phytocannabinoid, cannabidiol. Their experi...

journal_title：British journal of pharmacology

authors： Pertwee RG

更新日期：2007-12-01 00:00:00

abstract：:1. Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of nitric oxide with superoxide anion, and hydroxyl radical, formed in the iron-catalysed Fenton reaction, are important mediators of reperfusion injury. In in vitro studies, DNA single strand breakage, triggered by peroxynitrite or by hydroxyl radica...

journal_title：British journal of pharmacology

authors： Cuzzocrea S,Zingarelli B,Costantino G,Szabó A,Salzman AL,Caputi AP,Szabó C

更新日期：1997-07-01 00:00:00

abstract：:Antidromic stimulation of sensory peripheral branches of the trigeminal system (mental nerve) leads to cutaneous vasodilatation and increases vascular permeability in the rat. Antidromic vasodilatation is observed only at high intensity stimulation (10 V, 15 Hz, 0.2 or 5 ms) supporting the participation of afferent C-...

journal_title：British journal of pharmacology

authors： Couture R,Cuello AC,Henry JL

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Orexins have been demonstrated to play important roles in many physiological processes. However, it is not known how orexin A affects the activity of the hypoglossal motoneuron (HMN) and genioglossus (GG) muscle. EXPERIMENTAL APPROACH:GG muscle electromyograms (GG-EMG) were recorded in anaesthet...

journal_title：British journal of pharmacology

authors： Zhang GH,Liu ZL,Zhang BJ,Geng WY,Song NN,Zhou W,Cao YX,Li SQ,Huang ZL,Shen LL

更新日期：2014-09-01 00:00:00

abstract：:1. In the presence of indomethacin (IM, 10 microM) and N omega-nitro-L- arginine (L-NOARG, 0.3 mM), acetylcholine (ACh) induces an endothelium-dependent smooth muscle hyperpolarization and relaxation in the rat isolated hepatic artery. The potassium (K) channel inhibitors, tetrabutylammonium (TBA, 1 mM) and to a lesse...

journal_title：British journal of pharmacology

authors： Zygmunt PM,Högestätt ED

更新日期：1996-04-01 00:00:00

abstract：:1 In the isolated kidney of the rabbit perfused with oxygenated Tyrode solution, we studied the effect of bradykinin on the vasoconstriction evoked by sympathetic nerve stimulation (3Hz, 1 ms) and by injections of noradrenaline (50 to 75 ng) in the presence and in the absence of indomethacin (1 microgram/ml), an inhib...

journal_title：British journal of pharmacology

authors： Malik KU,Nasjletti A

更新日期：1979-10-01 00:00:00

abstract：:1. The aim of the present study was to test the effects of DAU 6215 (endo-N-(8-methyl-8-azabicyclo-[3.2.1]-octo-3-yl)-2,3-dihydro-2-ox o-1H- benzimidazole-1-carboxamide carboxamide hydrochloride), a newly synthesized, selective 5-hydroxytryptamine3 (5-HT3) antagonist, on the cell membrane properties and on characteriz...

journal_title：British journal of pharmacology

authors： Passani MB,Pugliese AM,Azzurrini M,Corradetti R

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of inflammatory disorders, including atherosclerosis and rheumatoid arthritis. Here, we describe the molecul...

journal_title：British journal of pharmacology

authors： Nedjai B,Li H,Stroke IL,Wise EL,Webb ML,Merritt JR,Henderson I,Klon AE,Cole AG,Horuk R,Vaidehi N,Pease JE

更新日期：2012-06-01 00:00:00

abstract：:1 The action of iontophoretically administered lithium was studied on spinal Renshaw cells an interneurones and on supraspinal neurones in cerebral cortex, thalamus, hypothalamus and brain stem in anaesthetized cats and rats. 2 There was a correlation between the effects of Li+ and those of acetylcholine (ACh), althou...

journal_title：British journal of pharmacology

authors： Haas HL,Ryall RW

更新日期：1977-06-01 00:00:00

abstract：:Intracellular potentials were recorded from rabbit atria, cardiac Purkinje cells and papillary muscles before and after exposure to various concentrations of indecainide. The effects of aprindine also were studied in the atrial preparations. Both drugs depressed the maximum rate of depolarization (MRD) in a dose-relat...

journal_title：British journal of pharmacology

authors： Dennis PD,Vaughan Williams EM

更新日期：1985-05-01 00:00:00