Abstract:
:1 In the isolated kidney of the rabbit perfused with oxygenated Tyrode solution, we studied the effect of bradykinin on the vasoconstriction evoked by sympathetic nerve stimulation (3Hz, 1 ms) and by injections of noradrenaline (50 to 75 ng) in the presence and in the absence of indomethacin (1 microgram/ml), an inhibitor of prostaglandin biosynthesis. Prostaglandin E(PGE)-like material in the renal effluent was measured by bioassay after extraction with organic solvents and separation by thin layer chromatography. 2 Bradykinin in concentrations of 10 to 100 ng/ml reduced the vasoconstrictor response to sympathetic nerve stimulation and to injected noradrenaline. Also, the peptide (1 to 10 ng/ml) increased the basal release of PGE-like material and the release induced by sympathetic nerve stimulation. 3 Indomethacin, 1 microgram/ml, diminished the inhibitory effect of bradykinin on the vasoconstrictor response to nerve stimulation, minimized the reduction of the noradrenaline-induced vasoconstriction caused by bradykinin (100 ng/ml), and abolished the release of PGE-like material. 4 This study indicates that bradykinin reduces the renal vascular reactivity to adrenergic stimuli and suggests that part of the action of the kinin at the vascular adrenergic neuroeffector junction in the rabbit kidney depends upon the biosynthesis of renal prostaglandins.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Malik KU,Nasjletti Adoi
10.1111/j.1476-5381.1979.tb08676.xsubject
Has Abstractpub_date
1979-10-01 00:00:00pages
269-75issue
2eissn
0007-1188issn
1476-5381journal_volume
67pub_type
杂志文章abstract::1. The effect on membrane currents of infection of mouse neuroblastoma NA cells with rabies virus was studied by using the whole-cell patch clamp technique. 2. Three types of membrane currents, namely voltage-dependent Na+ current (I(Na)), delayed rectifier K+ current (I(K-DR)) and inward rectifier K+ current (I(K-IR)...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0702473
更新日期:1999-04-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0707394
更新日期:2007-10-01 00:00:00
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journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1980.tb07937.x
更新日期:1980-10-01 00:00:00
abstract::The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and h...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1984.tb10069.x
更新日期:1984-02-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Inhibitors of histone deacetylase (HDAC) are emerging as a promising class of anti-cancer drugs, but a generic deregulation of transcription in neoplastic cells cannot fully explain their therapeutic effects. In this study we evaluated alternative molecular mechanisms by which HDAC inhibitors cou...
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更新日期:2008-02-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1990.tb12043.x
更新日期:1990-05-01 00:00:00
abstract::1. The present study addressed the role of neuropeptide (NPY) Y2 receptors in neurogenic contraction of mesenteric resistance arteries from female spontaneously hypertensive rats (SHR). Arteries were suspended in microvascular myographs, electrical field stimulation (EFS) was performed, and protein evaluated by Wester...
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doi:10.1038/sj.bjp.0706774
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1992.tb12771.x
更新日期:1992-10-01 00:00:00
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更新日期:1996-04-01 00:00:00
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更新日期:1999-09-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1972.tb06860.x
更新日期:1972-09-01 00:00:00
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doi:10.1111/j.1476-5381.1995.tb15940.x
更新日期:1995-12-01 00:00:00
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更新日期:1999-07-01 00:00:00
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更新日期:1982-04-01 00:00:00
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更新日期:1986-07-01 00:00:00
abstract::1. The prostate function is regulated by androgens and alpha-adrenergic activity. Clinically, antiandrogens and/or alpha(1)-adrenergic antagonists are commonly used to treat symptomatic prostatic hypertrophy. To elucidate the effects of androgen deprivation on prostate contractility via alpha(1)-adrenoceptor, the char...
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更新日期:2000-12-01 00:00:00
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更新日期:2001-04-01 00:00:00
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更新日期:2007-07-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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更新日期:1991-05-01 00:00:00
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pub_type: 杂志文章
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