Spasticity therapy reacts to astrocyte GluA1 receptor upregulation following spinal cord injury.

abstract：:The concentrations of catecholamines and the activities of dopamine-beta-hydroxylase were measured in blood obtained from decapitated diabetic and aged-matched control rats. The activity of dopamine-beta-hydroxylase in blood from diabetic rats was much greater (5 fold) than that seen for control rats. For both diabeti...

journal_title：British journal of pharmacology

authors： Berkowitz BA,Head RJ

更新日期：1978-09-01 00:00:00

abstract：:1. In the present study we tested the hypothesis that insulin-like growth factor-1 (IGF-1) modulates resting chloride conductance (G(Cl)) of rat skeletal muscle by activating a phosphatase and that the chloride channel, based on the activity of phosphorylating-dephosphorylating pathways, has different sensitivity to s...

journal_title：British journal of pharmacology

authors： De Luca A,Pierno S,Liantonio A,Camerino C,Conte Camerino D

更新日期：1998-10-01 00:00:00

abstract：:Using a rat model which allows serial blood sampling and concurrent brain microdialysis sampling, we have investigated the temporal kinetic inter-relationship of levetiracetam in serum and brain extracellular fluid (frontal cortex and hippocampus) following systemic administration of levetiracetam, a new antiepileptic...

journal_title：British journal of pharmacology

authors： Tong X,Patsalos PN

更新日期：2001-07-01 00:00:00

abstract：:1 The influence of the external calcium concentration on the effect of harmine 2 x 10(-5) M upon the guinea-pig atrial muscle was analysed. Transmembrane potentials of contractile fibres were measured during exposure to the drug at 30 degrees C. 2 In preparations superfused with 1.35 mM Ca2+-Tyrode solution and driven...

journal_title：British journal of pharmacology

authors： Carpentier RG

更新日期：1981-10-01 00:00:00

abstract：:1. Unique among the phospholipids, phosphatidylserine depresses brain energy metabolism when injected intravenously into mice in the form of sonicated liposomes. The possibility that this effect results from a metabolic transformation of phosphatidylserine is examined in this paper. 2. A strong enhancement of the phos...

journal_title：British journal of pharmacology

authors： Bigon E,Boarato E,Bruni A,Leon A,Toffano G

更新日期：1979-12-01 00:00:00

abstract：:1. Ethanol has been reported to inhibit the induction of long-term potentiation (LTP) in the hippocampus. However, the correlation between the effects of ethanol in vivo and in vitro remained unclear. In addition, previous works have little considered the possibility that the effect of ethanol is mediated by its metab...

journal_title：British journal of pharmacology

authors： Abe K,Yamaguchi S,Sugiura M,Saito H

更新日期：1999-08-01 00:00:00

abstract：:Since protease-activated receptors (PARs) are distributed throughout the gastrointestinal tract, we investigated the role of PARs in modulation of the motility of the rat oesophageal muscularis mucosae. Thrombin produced contraction of segments of the upper and lower part of the smooth muscle. Trypsin contracted both ...

journal_title：British journal of pharmacology

authors： Kawabata A,Kuroda R,Kuroki N,Nishikawa H,Kawai K

更新日期：2000-10-01 00:00:00

abstract：:1. Morphine, oxotremorine and physostigmine showed antinociceptive activity in mice using the hot plate reaction time test.2. The action of morphine, but not that of oxotremorine, was antagonized by naloxone and by nalorphine, whereas the effect of physostigmine was unaffected by naloxone and increased by nalorphine.3...

journal_title：British journal of pharmacology

authors： Pleuvry BJ,Tobias MA

更新日期：1971-12-01 00:00:00

abstract：:The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaemia. Sustained cerebral ischaemia was induced by the injection of 900 ...

journal_title：British journal of pharmacology

authors： Nagakura A,Niimura M,Takeo S

更新日期：2002-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to atrophy and paralysis of voluntary muscles responsible for motion and breathing. Except for a minority of patients harbouring genetic mutatio...

journal_title：British journal of pharmacology

authors： Manzano R,Toivonen JM,Moreno-Martínez L,de la Torre M,Moreno-García L,López-Royo T,Molina N,Zaragoza P,Calvo AC,Osta R

更新日期：2020-09-28 00:00:00

abstract：:1. In the present work, we have studied the expression of Fos during acute and chronic administration of the kappa-opioid receptor agonist U-50488H and after U-5088H withdrawal in the rat hypothalamic paraventricular nucleus (PVN). Fos production was also studied in brainstem regions that innervate the PVN: the A(2) c...

journal_title：British journal of pharmacology

authors： Laorden ML,Castells MT,Milanés MV

更新日期：2003-04-01 00:00:00

abstract：:In recent years, late-stage clinical drug development that primarily focuses on urogenital targets has centered around four areas of medical need (both unmet need and aiming to improve on existing therapies). These include male sexual dysfunction (MSD), female sexual dysfunction (FSD), prostatic pathology (neoplastic,...

journal_title：British journal of pharmacology

authors： Azam U

更新日期：2006-02-01 00:00:00

abstract：:1 The effects of general anaesthetics on the responses of neurones to iontophoretically applied L-glutamate have been examined in slices of the guinea-pig olfactory cortex in vitro. 2 Concentrations of pentobarbitone, ether, methoxyflurance, trichloroethylene and alphaxalone that are known to depress synaptic transmis...

journal_title：British journal of pharmacology

authors： Richards CD,Smaje JC

更新日期：1976-11-01 00:00:00

abstract：:In this issue, BJP is proud to publish an Endothelium Themed Section to celebrate the life of Robert F. Furchgott, who died on May 19th 2009. It is 30 years since he discovered endothelium-derived relaxant factor and a decade since he was awarded the Nobel Prize for this work. His discovery has led to an array of new ...

journal_title：British journal of pharmacology

authors： McGrath JC

更新日期：2009-06-01 00:00:00

abstract：:1. The effect of adenosine A1-receptor and P2-purinoceptor agonists on [3H]-inositol phosphate accumulation has been investigated in CHO-K1 cells transfected with the human adenosine A1-receptor. 2. Adenosine receptor agonists stimulated [3H]-inositol phosphate accumulation in CHO-K1 cells with a rank potency order of...

journal_title：British journal of pharmacology

authors： Megson AC,Dickenson JM,Townsend-Nicholson A,Hill SJ

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aucubin, the predominant component of Eucommia ulmoides Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart ...

journal_title：British journal of pharmacology

authors： Wu QQ,Xiao Y,Duan MX,Yuan Y,Jiang XH,Yang Z,Liao HH,Deng W,Tang QZ

更新日期：2018-05-01 00:00:00

abstract：:1. alpha 1-Adrenoceptor densities were studied in cardiac membrane preparations from several mammalian species including human failing hearts under identical experiment conditions; the alpha 1-adrenoceptor antagonist, [3H]-prazosin, was used as radioligand. End-stage heart failure (NYHA IV) in human hearts was due to ...

journal_title：British journal of pharmacology

authors： Steinfath M,Chen YY,Lavický J,Magnussen O,Nose M,Rosswag S,Schmitz W,Scholz H

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Imiquimod is an immunomodulator approved for the treatment of basal cell carcinoma and has adverse side effects, including taste disturbances. Paracrine transmission, representing cell-cell communication within taste buds, has the potential to shape the final signals that taste buds transmit to t...

journal_title：British journal of pharmacology

authors： Huang AY,Wu SY

更新日期：2016-11-01 00:00:00

abstract：:Asthma is an inflammatory disease of the lungs and the transcription factor NF-kappa B regulates the production of numerous inflammatory mediators that may have a role in the pathogenesis of asthma. Hence, the signalling pathways leading to NF-kappa B activation are considered prime targets for novel anti-inflammatory...

journal_title：British journal of pharmacology

authors： Catley MC,Chivers JE,Holden NS,Barnes PJ,Newton R

更新日期：2005-05-01 00:00:00

abstract：:1. Porcine neuromedin U-8 produced a concentration (0.3 nM-1 microM)-dependent contraction of the longitudinal muscle of the human isolated ileum, which was unaffected by either atropine (1 microM) or tetrodotoxin (1 microM). 2. By contrast, neuromedin U-8 had only a weak effect on the circular muscle of the human iso...

journal_title：British journal of pharmacology

authors： Maggi CA,Patacchini R,Giuliani S,Turini D,Barbanti G,Rovero P,Meli A

更新日期：1990-01-01 00:00:00

abstract：:1. Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did no...

journal_title：British journal of pharmacology

authors： Foley DJ,McPhillips JJ

更新日期：1973-07-01 00:00:00

abstract：:1. The mechanisms underlying the vasodilator response to urocortin are incompletely understood. The present study was designed to examine the role of endothelial nitric oxide and Ba(2+)-sensitive K(+) channels in the endothelium-dependent component of urocortin-induced relaxation in the rat left anterior descending co...

journal_title：British journal of pharmacology

authors： Huang Y,Chan FL,Lau CW,Tsang SY,He GW,Chen ZY,Yao X

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is...

journal_title：British journal of pharmacology

authors： Lanzerstorfer P,Stadlbauer V,Chtcheglova LA,Haselgrübler R,Borgmann D,Wruss J,Hinterdorfer P,Schröder K,Winkler SM,Höglinger O,Weghuber J

更新日期：2014-12-01 00:00:00

abstract：:Hind paw oedema in rats, measured by plethysmography or extravasation of Evans Blue dye into the skin, after subplantar injection of submaximal doses of carrageenin (1-100 micrograms) was significantly increased for 4 h during kininase II inhibition with captopril (1 mg kg-1, s.c.). Submaximal oedema, as assessed by p...

journal_title：British journal of pharmacology

authors： Boura AL,Svolmanis AP

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves c...

journal_title：British journal of pharmacology

authors： Roberson DP,Binshtok AM,Blasl F,Bean BP,Woolf CJ

更新日期：2011-09-01 00:00:00

abstract：:1. The effects of sulphone have been studied on kinin production in dog plasma and on capillary permeability in the skin of rabbits.2. Dog plasma was used as a substrate for pancreatic kallikrein in vitro and the addition of sulphone caused an inhibition of kinin production, which was dependent on the concentration of...

journal_title：British journal of pharmacology

authors： Abitbol H,Piulats E,Roselló S

更新日期：1969-09-01 00:00:00

abstract：:Bovine culture endothelial cells (BAECs) generate platelet-activating factor (Paf) following activation by bradykinin (Bk 0.1 nM), the ionophore, A23187 (3 microM), and ATP (10 microM), but Paf is not released from the cells. These stimuli also elicit generation of prostacyclin (PGI2). The specific and competitive Paf...

journal_title：British journal of pharmacology

authors： Stewart AG,Dubbin PN,Harris T,Dusting GJ

更新日期：1989-03-01 00:00:00

abstract：:1. Prolongation of action potentials by cooling or pharmacological treatment can restore conduction in demyelinated axons. We have assessed the ability of pyrethroids (in vitro) to modify action potential kinetics and to reverse conduction block in lesioned peripheral nerve. 2. Fast Na+ currents were isolated in mamma...

journal_title：British journal of pharmacology

authors： Lees G

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of bergamot essential oil (BEO; Citrus bergamia, Risso) on excitotoxic neuronal damage was investigated in vitro. EXPERIMENTAL APPROACH:The study was performed in human SH-SY5Y neuroblastoma cells exposed to N-methyl-D-aspartate (NMDA). Cell viability was measured by dye exclusion. R...

journal_title：British journal of pharmacology

authors： Corasaniti MT,Maiuolo J,Maida S,Fratto V,Navarra M,Russo R,Amantea D,Morrone LA,Bagetta G

更新日期：2007-06-01 00:00:00

abstract：:1. To investigate the quantitative relationship between elevation in the intracellular Ca(2+) concentration ([Ca(2+)](i)) and nitric oxide (NO) production, the changes in [Ca(2+)](i) and NO production were determined in parallel, using fluorimetry of fura-2 and 2, 3-diaminonaphthalene, respectively, in endothelial cel...

journal_title：British journal of pharmacology

authors： Mizuno O,Kobayashi S,Hirano K,Nishimura J,Kubo C,Kanaide H

更新日期：2000-07-01 00:00:00