Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma.

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...

journal_title：Oncogene

authors： To MD,Rosario RD,Westcott PM,Banta KL,Balmain A

更新日期：2013-08-22 00:00:00

abstract：:Mammalian Mip/LIN-9 is a cell cycle regulatory protein that is negatively regulated by CDK4/cyclin D. It has been demonstrated that Mip/LIN-9 collaborates with B-Myb during S and G(2)/M in the induction of cyclins A and B, and CDK1. The ortholog of Mip/LIN-9 in Drosophila, Mip130, is part of a large multisubunit prote...

journal_title：Oncogene

authors： Pilkinton M,Sandoval R,Colamonici OR

更新日期：2007-11-29 00:00:00

abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...

journal_title：Oncogene

authors： Kato Y,Sasagawa I,Kaneko M,Osawa M,Fujita N,Tsuruo T

更新日期：2004-11-04 00:00:00

abstract：:It has been suggested that the embryonic microenvironment can control the survival and the transformed phenotype of tumour cells. Here, we addressed the hypothesis that the murine embryonic microenvironment can induce the differentiation of human tumour cells. To examine such interactions, we injected human leukaemic ...

journal_title：Oncogene

authors： Dürr M,Harder F,Merkel A,Bug G,Henschler R,Müller AM

更新日期：2003-12-11 00:00:00

abstract：:Telomerase-negative cancer cells can maintain their telomeres by a recombination-mediated alternative lengthening of telomeres (ALT) process. We reported previously that sequestration of MRE11/RAD50/NBS1 complexes represses ALT-mediated telomere length maintenance, and suppresses formation of ALT-associated promyelocy...

journal_title：Oncogene

authors： Jiang WQ,Zhong ZH,Henson JD,Reddel RR

更新日期：2007-07-12 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...

journal_title：Oncogene

authors： Chen H,Cai W,Chu ESH,Tang J,Wong CC,Wong SH,Sun W,Liang Q,Fang J,Sun Z,Yu J

更新日期：2017-08-01 00:00:00

abstract：:Inhibitor of growth (ING)4, member of a gene family encoding potential tumor suppressors, is implicated as a repressor of angiogenesis and tumor growth and suppresses loss of contact inhibition in vitro. Here, we report that ING4 undergoes alternative splicing. Expression analysis identified novel ING4 spliced variant...

journal_title：Oncogene

authors： Raho G,Miranda C,Tamborini E,Pierotti MA,Greco A

更新日期：2007-08-09 00:00:00

abstract：:Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...

journal_title：Oncogene

authors： Dong Y,Richards JA,Gupta R,Aung PP,Emley A,Kluger Y,Dogra SK,Mahalingam M,Wajapeyee N

更新日期：2014-09-18 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and RNA sequencing in a patient with glioblastoma multiforme to identify a rearr...

journal_title：Oncogene

authors： Weinberg F,Griffin R,Fröhlich M,Heining C,Braun S,Spohr C,Iconomou M,Hollek V,Röring M,Horak P,Kreutzfeldt S,Warsow G,Hutter B,Uhrig S,Neumann O,Reuss D,Heiland DH,von Kalle C,Weichert W,Stenzinger A,Brors B,Gli

更新日期：2020-01-01 00:00:00

abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...

journal_title：Oncogene

authors： Keegan K,Cooper JA

更新日期：1996-04-04 00:00:00

abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

journal_title：Oncogene

authors： Kim H,You S,Farris J,Foster LK,Foster DN

更新日期：2001-05-31 00:00:00

abstract：:Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton's tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma ce...

journal_title：Oncogene

authors： Li T,Deng Y,Shi Y,Tian R,Chen Y,Zou L,Kazi JU,Rönnstrand L,Feng B,Chan SO,Chan WY,Sun J,Zhao H

更新日期：2018-11-01 00:00:00

abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

journal_title：Oncogene

authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

更新日期：2001-10-11 00:00:00

abstract：:A 56 kDa protein kinase was molecularly cloned from human fetal brain. This protein kinase (p56 KKIAMRE) shares homology with p42 KKIALRE (Meyerson et al., 1992) and is related to the proline-directed protein kinase group of signal transducing enzymes. The p56 KKIAMRE and p42 KKIALRE protein kinases exhibit mutually e...

journal_title：Oncogene

authors： Taglienti CA,Wysk M,Davis RJ

更新日期：1996-12-19 00:00:00

abstract：:Terminal differentiation of skeletal myoblasts is accompanied by down-regulation of vimentin and beta-, gamma-actins and up-regulation of desmin and sarcomeric alpha-actin(s). To investigate whether the normal decline in expression of vimentin and beta-, gamma-actins was coupled to withdrawal of proliferating myoblast...

journal_title：Oncogene

authors： Olson EN,Capetanaki YG

更新日期：1989-07-01 00:00:00

abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

journal_title：Oncogene

authors： Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

更新日期：2015-07-01 00:00:00

abstract：:Class I HLA expression is low in neuroblastoma tumours and cell lines. We have recently mapped a modifier of methylation for HLA-C (MEMO-1) to chromosomal bands 1p35-36.1, a region deleted in many neuroblastomas. Hypomethylation of HLA-C is strongly correlated with allelic loss of the MEMO-1 locus. Here, we show that ...

journal_title：Oncogene

authors： Cheng NC,Beitsma M,Chan A,Op den Camp I,Westerveld A,Pronk J,Versteeg R

更新日期：1996-10-17 00:00:00

abstract：:Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...

journal_title：Oncogene

authors： Imatani A,Callahan R

更新日期：2000-01-13 00:00:00

abstract：:The stress-activated pathways leading to activation of p38 MAP kinase (p38 MAPK) and c-jun N-terminal kinases (JNK) have been shown to be activated by pro-inflammatory cytokines, physical and chemical stresses as well as a variety of hematopoietic growth factors. One exception is interleukin (IL)-4, which does not act...

journal_title：Oncogene

authors： Wery-Zennaro S,Zugaza JL,Letourneur M,Bertoglio J,Pierre J

更新日期：2000-03-16 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00

abstract：:Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)...

journal_title：Oncogene

authors： Zheng R,Bailey E,Nguyen B,Yang X,Piloto O,Levis M,Small D

更新日期：2011-09-22 00:00:00

abstract：:We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently, and that tyrosine kinase activity of the NGF receptor is essential for the activation of Ras (Muroya et a...

journal_title：Oncogene

authors： Hashimoto Y,Matuoka K,Takenawa T,Muroya K,Hattori S,Nakamura S

更新日期：1994-03-01 00:00:00

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00

abstract：:The serine threonine checkpoint kinase 2 (CHK2) is a critical protein involved in the DNA damage-response pathway, which is activated by phosphorylation inducing cellular response such as DNA repair, cell-cycle regulation or apoptosis. Although CHK2 activation mechanisms have been amply described, very little is known...

journal_title：Oncogene

authors： García-Limones C,Lara-Chica M,Jiménez-Jiménez C,Pérez M,Moreno P,Muñoz E,Calzado MA

更新日期：2016-08-18 00:00:00

abstract：:The chromatin organizer SATB1 has been implicated in the development and progression of multiple cancers including breast and colorectal cancers. However, the regulation and role of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression of SATB1 is induced upon hyperactivation of Wnt/β-...

journal_title：Oncogene

authors： Mir R,Pradhan SJ,Patil P,Mulherkar R,Galande S

更新日期：2016-03-31 00:00:00

abstract：:Activation of the p53 tumor suppressor protein can lead to either cell cycle arrest or apoptosis. Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain. The proline-rich domain is located within residues 60-90, which comprise five PXXP...

journal_title：Oncogene

authors： Zhu J,Jiang J,Zhou W,Zhu K,Chen X

更新日期：1999-03-25 00:00:00