Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5.

abstract：:The prognostic significance of c-kit receptor expression on leukemic blast cells was determined in 122 children with acute myeloid leukemia (AML) entered onto Childrens Cancer Group protocol 213. Clinical and laboratory characteristics as well as outcome were analyzed according to the percentage of blast cells express...

journal_title：Blood

authors： Smith FO,Broudy VC,Zsebo KM,Lampkin BC,Buckley CV,Buckley JD,Opie T,Woods WG,Hammond GD,Bernstein ID

更新日期：1994-08-01 00:00:00

abstract：:Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)-driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This ma...

journal_title：Blood

authors： Xu W,Roos A,Schlagwein N,Woltman AM,Daha MR,van Kooten C

更新日期：2006-06-15 00:00:00

abstract：:Graft failure was analyzed in 625 patients receiving allogeneic bone marrow transplants from HLA-identical sibling donors as treatment for severe aplastic anemia. Sixty-eight (11%) had no or only transient engraftment. Second bone marrow transplants were successful in achieving extended survival in 16 of 27 patients w...

journal_title：Blood

authors： Champlin RE,Horowitz MM,van Bekkum DW,Camitta BM,Elfenbein GE,Gale RP,Gluckman E,Good RA,Rimm AA,Rozman C

更新日期：1989-02-01 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:A gamma-chain variant with a lower molecular weight than the normal gamma chain was detected in a new congenital abnormal fibrinogen with impaired polymerization of the fibrin monomer and with normal release of fibrinopeptides A and B in a 45-year-old male. Purified fibrinogen analyzed on SDS-polyacrylamide gel electr...

journal_title：Blood

authors： Yoshida N,Okuma M,Moroi M,Matsuda M

更新日期：1986-09-01 00:00:00

abstract：:The mechanisms by which transforming growth factor beta (TGF-beta) exerts a negative effect on cell-cycle entry in primary human hematopoietic stem/progenitor cells were examined at the molecular and cellular levels. After treatment of primary human CD34+ progenitors with TGF-beta there was a decrease in the levels of...

journal_title：Blood

authors： Dao MA,Hwa J,Nolta JA

更新日期：2002-01-15 00:00:00

abstract：:The use of 8-methoxypsoralen (8-MOP) and UV-A irradiation to inactivate contaminating donor leukocytes in platelet concentrates and to prevent primary alloimmunization against donor class I major histocompatibility (MHC) antigens in mice was investigated. CBA/CaH-T6J mice with the H2k haplotype and BALB/cByJ mice with...

journal_title：Blood

authors： Grana NH,Kao KJ

更新日期：1991-06-01 00:00:00

abstract：:Electron microscopic (EM) studies were performed to clarify the interactions of membrane proteins in the red blood cell membrane structure in situ of a homozygous patient with total deficiency of protein 4.1 who carried a point mutation of the downstream translation initiation codon (AUG --> AGG) of the protein 4.1 ge...

journal_title：Blood

authors： Yawata A,Kanzaki A,Gilsanz F,Delaunay J,Yawata Y

更新日期：1997-09-15 00:00:00

abstract：:Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We s...

journal_title：Blood

authors： Poli M,Asperti M,Naggi A,Campostrini N,Girelli D,Corbella M,Benzi M,Besson-Fournier C,Coppin H,Maccarinelli F,Finazzi D,Arosio P

更新日期：2014-03-06 00:00:00

abstract：:The receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are heterodimers comprised of ligand specific alpha chains and a common beta chain. The genes encoding the IL-5 receptor alpha chain and the common beta chain reside on chromosome 3 and 22 respectively, while th...

journal_title：Blood

authors： Kremer E,Baker E,D'Andrea RJ,Slim R,Phillips H,Moretti PA,Lopez AF,Petit C,Vadas MA,Sutherland GR

更新日期：1993-07-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signal...

journal_title：Blood

authors： Liu G,Place AT,Chen Z,Brovkovych VM,Vogel SM,Muller WA,Skidgel RA,Malik AB,Minshall RD

更新日期：2012-08-30 00:00:00

abstract：:The coagulation factors V (FV) and VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Natural variants of these factors frequently lead to severe bleeding disorders. To understand the mechanisms of activation of FVIII by thrombin, we used a bank of mutant thrombins to...

journal_title：Blood

authors： Myles T,Yun TH,Leung LL

更新日期：2002-10-15 00:00:00

abstract：:Murine IgM monoclonal antibody STRO-1 identifies a cell surface antigen expressed by stromal elements in human bone marrow (BM). STRO-1 binds to approximately 10% of BM mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming un...

journal_title：Blood

authors： Simmons PJ,Torok-Storb B

更新日期：1991-07-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNLs) exposed to influenza A virus (IAV) undergo activation of the respiratory burst followed by depression of cell function when subsequently exposed to particulate or soluble stimuli. The effect of IAV on PMNLs is likely to be mediated through the attachment of IAV to one or more speci...

journal_title：Blood

authors： Abramson JS,Hudnor HR

更新日期：1995-03-15 00:00:00

abstract：:The belief is widely held, on the basis of indirect evidence, that a substantial, even brief elevation of red cell Ca content must result in a marked shortening of circulatory survival. To test this notion directly, we exposed rabbit red cells in vitro to the ionophore A23187 and Ca so as to produce sustained uniform ...

journal_title：Blood

authors： Bookchin RM,Roth EF Jr,Lew VL

更新日期：1985-07-01 00:00:00

abstract：:Emerging successful clinical data on gene therapy using adeno-associated viral (AAV) vector for hemophilia B (HB) showed that the risk of cellular immune response to vector capsid is clearly dose dependent. To decrease the vector dose, we explored AAV-8 (1-3 × 10(12) vg/kg) encoding a hyperfunctional factor IX (FIX-Pa...

journal_title：Blood

authors： Crudele JM,Finn JD,Siner JI,Martin NB,Niemeyer GP,Zhou S,Mingozzi F,Lothrop CD Jr,Arruda VR

更新日期：2015-03-05 00:00:00

abstract：:Pharmacologic and immunologic methods of ex-vivo bone marrow (BM) purging for acute nonlymphocytic leukemia (ANLL) were combined to augment the effect of either method alone. Etoposide (VP16; 20 to 30 micrograms/mL) with or without cytosine arabinoside (Ara C; 10 mg/mL) was used in tandem with the anti-CD33 monoclonal...

journal_title：Blood

authors： Stiff PJ,Schulz WC,Bishop M,Marks L

更新日期：1991-01-15 00:00:00

abstract：:The presence of multiple VHDJH joinings in upwards of 30% of acute lymphoblastic leukemias (ALL) suggests a relative instability of the rearranged immunoglobulin heavy chain (IgH) gene, but the mechanisms involved are not completely understood. An investigation of the structure of the VHDJH joinings using complementar...

journal_title：Blood

authors： Wasserman R,Yamada M,Ito Y,Finger LR,Reichard BA,Shane S,Lange B,Rovera G

更新日期：1992-01-01 00:00:00

abstract：:Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells....

journal_title：Blood

authors： Keren Z,Naor S,Nussbaum S,Golan K,Itkin T,Sasaki Y,Schmidt-Supprian M,Lapidot T,Melamed D

更新日期：2011-03-17 00:00:00

abstract：:Direct sequencing of VWF genomic DNA in 21 patients with type 3 von Willebrand disease (VWD) failed to reveal a causative homozygous or compound heterozygous VWF genotype in 5 cases. Subsequent analysis of VWF mRNA led to the discovery of a deletion (c.221-977_532 + 7059del [p.Asp75_Gly178del]) of VWF in 7 of 12 white...

journal_title：Blood

authors： Sutherland MS,Cumming AM,Bowman M,Bolton-Maggs PH,Bowen DJ,Collins PW,Hay CR,Will AM,Keeney S

更新日期：2009-07-30 00:00:00

abstract：:We recently demonstrated that immunoglobulin E (IgE), in the absence of cross-linking agents, activates signaling pathways in healthy murine bone marrow-derived mast cells (BMMCs) and that this activation enhances BMMC survival, at least in part, via secretion of autocrine-acting cytokines. We report herein that IgE a...

journal_title：Blood

authors： Lam V,Kalesnikoff J,Lee CW,Hernandez-Hansen V,Wilson BS,Oliver JM,Krystal G

更新日期：2003-08-15 00:00:00

abstract：:Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

journal_title：Blood

authors： Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

更新日期：2004-01-15 00:00:00

abstract：:A hairy cell leukemia population was used as a clonal model for studying the direct immunomodulatory effects of recombinant interferon-alpha A (rIFN-alpha A) and rIFN-gamma on human B-cell proliferation. The leukemic cell population KON was notably quiescent when incubated in medium alone but was induced to significan...

journal_title：Blood

authors： Mongini P,Seremetis S,Blessinger C,Rudich S,Winchester R,Brunda M

更新日期：1988-11-01 00:00:00

abstract：:Growing evidence supports a pathophysiological role for platelets during the manifestation of postischemic reperfusion injury; in the current study, we investigated the nature and the molecular determinants of platelet-endothelial cell interactions induced by ischemia/reperfusion (I/R). Platelet-endothelium and leukoc...

journal_title：Blood

authors： Massberg S,Enders G,Leiderer R,Eisenmenger S,Vestweber D,Krombach F,Messmer K

更新日期：1998-07-15 00:00:00

abstract：:A semiquantitative polymerase chain reaction assay was used to monitor the blood levels of Epstein-Barr virus (EBV)-DNA in 9 patients receiving allogeneic bone marrow transplants (BMT). Four of 5 recipients of HLA-mismatched T-cell-depleted grafts showed a 4- to 5-log increase of EBV-DNA within 1 to 3 months after BMT...

journal_title：Blood

authors： Gustafsson A,Levitsky V,Zou JZ,Frisan T,Dalianis T,Ljungman P,Ringden O,Winiarski J,Ernberg I,Masucci MG

更新日期：2000-02-01 00:00:00

abstract：:Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In ...

journal_title：Blood

authors： Erkers T,Xie BJ,Kenyon LJ,Smith B,Rieck M,Jensen KP,Ji X,Basina M,Strober S,Negrin RS,Maecker HT,Meyer EH

更新日期：2020-03-12 00:00:00

abstract：:In this issue of Blood, Buchlis and colleagues describe the long-term persistence (up to 10 years) of factor IX (FIX) expression in adeno-associated virus serotype 2 (AAV-2)–injected muscles of a patient with hemophilia B. ...

journal_title：Blood

authors： Benveniste O

更新日期：2012-03-29 00:00:00

abstract：:In this issue of Blood, Palomo et al provide new insight into the mechanism of action of defibrotide as an endothelial protective agent, while Richardson et al present the encouraging final results of the phase 3 clinical study of defibrotide for the treatment of severe hepatic veno-occlusive disease (VOD), showing a ...

journal_title：Blood

authors： Arai S

更新日期：2016-03-31 00:00:00

abstract：:Bcr-abl fusion peptide-specific CD4+ T-lymphocyte clones have recently been shown to augment colony formation by chronic myelogenous leukemia (CML) cells in a bcr-abl type-specific and HLA class II-restricted manner without addition of exogenous antigen. These findings suggest that CML cells can naturally process and ...

journal_title：Blood

authors： Yasukawa M,Ohminami H,Kojima K,Hato T,Hasegawa A,Takahashi T,Hirai H,Fujita S

更新日期：2001-09-01 00:00:00