当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE).

Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE).

Abstract：

OBJECTIVES:Our aim was to examine the relationships between serum hematocrit (Hct) and risk of all-cause mortality among patients with severe heart failure (HF). BACKGROUND:Anemia occurs with increased frequency in severe HF. However, few studies have examined the impact of anemia on mortality in this population. METHODS:Using a prospective cohort design, we evaluated the relationships between baseline serum Hct and mortality among 1,130 patients with left ventricular EF <30% and New York Heart Association functional class IIIB or IV HF treated with angiotensin-converting enzyme inhibitors, diuretics, and digitalis. Mortality was ascertained by centralized adjudication. RESULTS:The mean Hct was 41.8% (range 25.4% to 58.8%). Over 15 months of mean follow-up, there were 407 deaths (29 per 100 person-years). After adjustment for potential confounders, those in the lowest quintile of Hct (range 25.4% to 37.5%) had a 52% higher risk of death (hazard ratio 1.52, 95% confidence interval 1.11 to 2.10), compared with the highest quintile (range 46.1% to 58.8%). Within the lowest quintile of Hct, each 1% decrease in Hct was associated with an 11% higher risk of death (p < 0.01), whereas within the four higher quintiles of Hct, Hct was not associated with total mortality. Evaluation of different causes of death indicated that a lower Hct was strongly associated with death from progressive HF, rather than sudden death or other deaths. CONCLUSIONS:Among patients with severe HF, anemia is a significant independent risk factor for death, with a progressively higher risk with increasing severity of anemia. Further investigation of the etiologies, prevention, and treatment of anemia in severe HF is warranted.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Mozaffarian D,Nye R,Levy WC

doi

10.1016/s0735-1097(03)00425-x

subject

Has Abstract

pub_date

2003-06-04 00:00:00

pages

1933-9

issue

eissn

0735-1097

issn

1558-3597

pii

S073510970300425X

journal_volume

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

在线工具

Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE).