Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. Australia-New Zealand Heart Failure Research Collaborative Group.

Abstract:

OBJECTIVES:The aim of this study, a substudy of the Australia-New Zealand trial of carvedilol in patients with heart failure due to ischemic heart disease, was to determine the effects of this treatment on left ventricular size and function with the use of quantitative two-dimensional (2D) echocardiography. BACKGROUND:Beta-adrenergic blocking drugs have been shown to improve left ventricular ejection fraction in patients with heart failure due to either ischemic heart disease or idiopathic dilated cardiomyopathy. However, the effects of such treatment on left ventricular size remain uncertain. METHODS:One hundred twenty-three patients from 10 centers in New Zealand and Australia participated in the 2D echocardiographic substudy. Echocardiography was performed before randomization and was repeated after 6 and 12 months of treatment. Left ventricular end-diastolic and end-systolic volumes were measured from apical four- and two-chamber views with the use of a modified Simpson's rule method. RESULTS:After 12 months, heart rate was 8 beats/min lower in the carvedilol than in the placebo group, whereas left ventricular end-diastolic and end-systolic volumes were increased in the placebo group but reduced in the carvedilol group. At 12 months, left ventricular end-diastolic volume index was 14 ml/m2 less in the carvedilol than in the placebo group (p = 0.0015); left ventricular end-systolic volume index was 15.3 ml/m2 less (p = 0.0001), and left ventricular ejection fraction was 5.8% greater (p = 0.0015). CONCLUSIONS:In patients with heart failure due to ischemic heart disease, carvedilol therapy for 12 months reduced left ventricular volumes, increased left ventricular ejection fraction and prevented progressive left ventricular dilation. These changes demonstrate a beneficial effect of carvedilol on left ventricular remodeling in heart failure. The observed changes may explain in part the improved clinical outcomes produced by treatment with carvedilol.

journal_name

J Am Coll Cardiol

authors

Doughty RN,Whalley GA,Gamble G,MacMahon S,Sharpe N

doi

10.1016/s0735-1097(97)00012-0

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

1060-6

issue

5

eissn

0735-1097

issn

1558-3597

pii

S0735109797000120

journal_volume

29

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Persistent transient myocardial ischemia despite beta-adrenergic blockade predicts a higher risk of adverse cardiac events in patients with coronary artery disease.

    abstract:OBJECTIVES:We evaluated the prevalence and prognostic significance of transient myocardial ischemia despite beta-adrenergic blockade in patients with coronary artery disease. BACKGROUND:Persistence of transient ischemia despite therapy may correspond to a subset of high risk patients with coronary disease. The impact ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(96)00050-2

    authors: Madjlessi-Simon T,Mary-Krause M,Fillette F,Lechat P,Jaillon P

    更新日期:1996-06-01 00:00:00

  • Permanent Percutaneous Carotid Artery Filter to Prevent Stroke in Atrial Fibrillation Patients: The CAPTURE Trial.

    abstract:BACKGROUND:Patients with high stroke risk and atrial fibrillation who are unsuitable to oral anticoagulants (OACs) require other stroke prevention strategies. A novel permanent coil filter directly placed into both common carotid arteries (CCAs) was designed to capture emboli >1.4 mm in diameter. OBJECTIVES:The multic...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.jacc.2019.04.035

    authors: Reddy VY,Neuzil P,de Potter T,van der Heyden J,Tromp SC,Rensing B,Jiresova E,Dujka L,Lekesova V

    更新日期:2019-08-20 00:00:00

  • Cardiac Implantable Electronic Devices in Patients With Left Ventricular Assist Systems.

    abstract::Recent progress and evolution in device engineering, surgical implantation practices, and periprocedural management have advanced the promise of durable support with left ventricular assist systems (LVAS) in patients with stage D heart failure. With greater uptake of LVAS globally, a growing population of LVAS recipie...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2018.01.061

    authors: Berg DD,Vaduganathan M,Upadhyay GA,Singh JP,Mehra MR,Stewart GC

    更新日期:2018-04-03 00:00:00

  • Subclavian artery stenosis: prevalence, risk factors, and association with cardiovascular diseases.

    abstract:OBJECTIVES:The objective was to assess the prevalence of subclavian artery stenosis (SS) in four cohorts (two free-living and two clinical populations) and determine both risk factors for this condition and the association with other cardiovascular conditions. BACKGROUND:The prevalence of SS in the general population ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jacc.2004.04.044

    authors: Shadman R,Criqui MH,Bundens WP,Fronek A,Denenberg JO,Gamst AC,McDermott MM

    更新日期:2004-08-04 00:00:00

  • Prognostic implications of atrial fibrillation in patients undergoing myocardial perfusion single-photon emission computed tomography.

    abstract:OBJECTIVES:The aim of this research was to determine whether presence of atrial fibrillation (AF) provides incremental prognostic information relative to myocardial perfusion single-photon emission computed tomography (MPS) with respect to risk of cardiac death (CD). BACKGROUND:The prognostic significance of AF in pat...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.05.076

    authors: Abidov A,Hachamovitch R,Rozanski A,Hayes SW,Santos MM,Sciammarella MG,Cohen I,Gerlach J,Friedman JD,Germano G,Berman DS

    更新日期:2004-09-01 00:00:00

  • Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality.

    abstract:OBJECTIVES:The purpose of this study was to test whether mitochondrial dysfunction is causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation and perforation. Inhibition of mitochondrial permeability transition was achieved by means of pharmacological drugs and overexpression of the ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2006.02.069

    authors: Larche J,Lancel S,Hassoun SM,Favory R,Decoster B,Marchetti P,Chopin C,Neviere R

    更新日期:2006-07-18 00:00:00

  • Ability of troponin I to predict cardiac events in patients admitted from the emergency department.

    abstract:OBJECTIVES:We sought to determine the predictive ability of troponin I (TnI) in a heterogeneous group of patients with chest pain admitted from the emergency department (ED) for exclusion of myocardial infarction (MI). BACKGROUND:Previous studies in high-risk patients demonstrated that troponin elevations are associat...

    journal_title:Journal of the American College of Cardiology

    pub_type: 评论,杂志文章

    doi:10.1016/s0735-1097(00)00943-8

    authors: Kontos MC,Anderson FP,Alimard R,Ornato JP,Tatum JL,Jesse RL

    更新日期:2000-11-15 00:00:00

  • Predicting Persistent Left Ventricular Dysfunction Following Myocardial Infarction: The PREDICTS Study.

    abstract:BACKGROUND:Persistent severe left ventricular (LV) systolic dysfunction after myocardial infarction (MI) is associated with increased mortality and is a class I indication for implantation of a cardioverter-defibrillator. OBJECTIVES:This study developed models and assessed independent predictors of LV recovery to >35%...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jacc.2015.12.042

    authors: Brooks GC,Lee BK,Rao R,Lin F,Morin DP,Zweibel SL,Buxton AE,Pletcher MJ,Vittinghoff E,Olgin JE,PREDICTS Investigators.

    更新日期:2016-03-15 00:00:00

  • Heart rate adjustment of ST segment depression and performance of the exercise electrocardiogram: a critical evaluation.

    abstract::Analysis of the rate-related change in exercise-induced ST segment depression using the exercise ST segment/heart rate slope and ST segment/heart rate index can improve the accuracy of the exercise electrocardiogram (ECG) for the identification of patients with coronary artery disease, recognition of patients with ana...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0735-1097(95)00085-i

    authors: Okin PM,Kligfield P

    更新日期:1995-06-01 00:00:00

  • Dobutamine stress echocardiography for noninvasive assessment and risk stratification of patients with rheumatic mitral stenosis.

    abstract:OBJECTIVES:We sought to evaluate the impact of dobutamine stress echocardiography (DSE) in patients with known rheumatic mitral stenosis (MS) in order to assess its safety, feasibility, and prognostic correlation to well-known clinical outcomes. BACKGROUND:Noninvasive prognostic assessment of MS still represents an un...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2003.09.037

    authors: Reis G,Motta MS,Barbosa MM,Esteves WA,Souza SF,Bocchi EA

    更新日期:2004-02-04 00:00:00

  • A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies.

    abstract:OBJECTIVES:The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND:Published findings demonstrate that youth with MetS are at increased risk of cardio-metaboli...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2012.05.056

    authors: Magnussen CG,Koskinen J,Juonala M,Chen W,Srinivasan SR,Sabin MA,Thomson R,Schmidt MD,Nguyen QM,Xu JH,Skilton MR,Kähönen M,Laitinen T,Taittonen L,Lehtimäki T,Rönnemaa T,Viikari JS,Berenson GS,Raitakari OT

    更新日期:2012-10-23 00:00:00

  • Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene.

    abstract:OBJECTIVES:The purpose of this study was to determine the spectrum of left ventricular hypertrophy and ventricular morphology in adults with hypertrophic cardiomyopathy due to mutations of the beta-myosin heavy-chain gene. BACKGROUND:Although echocardiography is an important test in diagnosing hypertrophic cardiomyopa...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(93)90055-6

    authors: Solomon SD,Wolff S,Watkins H,Ridker PM,Come P,McKenna WJ,Seidman CE,Lee RT

    更新日期:1993-08-01 00:00:00

  • Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study)

    abstract:OBJECTIVES:To determine the effect of angiotensin-converting enzyme (ACE) inhibition on brachial flow-mediated vasodilation. BACKGROUND:Quinapril, an ACE inhibitor with high affinity, has been shown to improve coronary endothelial dysfunction in patients with coronary artery disease. The effectiveness of different vas...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0735-1097(99)00537-9

    authors: Anderson TJ,Elstein E,Haber H,Charbonneau F

    更新日期:2000-01-01 00:00:00

  • Carotid artery stenting in acute stroke.

    abstract:OBJECTIVES:The purpose of this study is to demonstrate the technical success of carotid artery stenting in acute extracranial internal carotid artery (ICA) occlusion as well as the benefit in clinical outcome. BACKGROUND:Stroke caused by acute occlusion of the ICA is associated with a significant level of morbidity an...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2011.08.044

    authors: Papanagiotou P,Roth C,Walter S,Behnke S,Grunwald IQ,Viera J,Politi M,Körner H,Kostopoulos P,Haass A,Fassbender K,Reith W

    更新日期:2011-11-29 00:00:00

  • The histology of viable and hibernating myocardium in relation to imaging characteristics.

    abstract:OBJECTIVES:This study characterizes the histology of myocardium predicted to be hibernating using three different imaging techniques to explain the discordance among them. BACKGROUND:Both radionuclide and functional imaging techniques were used to assess myocardial hibernation. The former have high sensitivity and the...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01766-1

    authors: Gunning MG,Kaprielian RR,Pepper J,Pennell DJ,Sheppard MN,Severs NJ,Fox KM,Underwood SR

    更新日期:2002-02-06 00:00:00

  • Reprint of: Cardiovascular Disease Prevention by Diet Modification: JACC Health Promotion Series.

    abstract::Reduction in excess calories and improvement in dietary composition may prevent many primary and secondary cardiovascular events. Current guidelines recommend diets high in fruits, vegetables, whole grains, nuts, and legumes; moderate in low-fat dairy and seafood; and low in processed meats, sugar-sweetened beverages,...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2018.10.019

    authors: Yu E,Malik VS,Hu FB

    更新日期:2018-12-11 00:00:00

  • Duration of Pre-Operative Antibiotic Treatment and Culture Results in Patients With Infective Endocarditis.

    abstract:BACKGROUND:Bacterial growth in cultures of resected heart valves of patients with infective endocarditis (IE) is influenced by pre-operative antibiotic treatment (preop-AT). OBJECTIVES:This study sought to evaluate the time dependency of valve culture results (positive valve culture [PVC] vs. negative valve culture) o...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2020.04.075

    authors: Gisler V,Dürr S,Irincheeva I,Limacher A,Droz S,Carrel T,Englberger L,Sendi P

    更新日期:2020-07-07 00:00:00

  • Effect of cardiac resynchronization therapy on the risk of first and recurrent ventricular tachyarrhythmic events in MADIT-CRT.

    abstract:OBJECTIVES:This study aimed to evaluate the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risks of first and recurrent ventricular tachyarrhythmic events (VTEs) in the MADIT-CRT. BACKGROUND:Reverse remodeling associated with CRT-D therapy was suggested to reduce arrhythmic risk. Howev...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jacc.2012.05.057

    authors: Ouellet G,Huang DT,Moss AJ,Hall WJ,Barsheshet A,McNitt S,Klein H,Zareba W,Goldenberg I

    更新日期:2012-10-30 00:00:00

  • Cardiac tamponade and pericardial effusion: respiratory variation in transvalvular flow velocities studied by Doppler echocardiography.

    abstract::Cardiac tamponade has been associated with an abnormally increased respiratory variation in transvalvular blood flow velocities. To determine whether this finding is consistently present in cardiac tamponade, seven patients were studied prospectively with Doppler echocardiography before and after pericardiocentesis an...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0735-1097(98)90060-2

    authors: Appleton CP,Hatle LK,Popp RL

    更新日期:1988-05-01 00:00:00

  • Complexity of atherosclerotic coronary artery disease and long-term outcomes in patients with unprotected left main disease treated with drug-eluting stents or coronary artery bypass grafting.

    abstract:OBJECTIVES:The aim of this study was to compare treatment effects of drug-eluting stents (DES) or coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease according to the complexity of atherosclerotic disease burden. BACKGROUND:Limited information is available on the relationships between t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2011.01.033

    authors: Park DW,Kim YH,Yun SC,Song HG,Ahn JM,Oh JH,Kim WJ,Lee JY,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

    更新日期:2011-05-24 00:00:00

  • Intraaortic balloon counterpulsation as a temporary support measure in decompensated critical aortic stenosis.

    abstract::Intraaortic balloon counterpulsation was instituted in two adult patients whose condition was rapidly deteriorating because of critical decompensated valvular aortic stenosis. The acute hemodynamic effect of counterpulsation in these patients was compared with the effect of counterpulsation in three control patients w...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80399-5

    authors: Folland ED,Kemper AJ,Khuri SF,Josa M,Parisi AF

    更新日期:1985-03-01 00:00:00

  • Therapeutic Fibrinolysis: How Efficacy and Safety Can Be Improved.

    abstract::Therapeutic fibrinolysis has been dominated by the experience with tissue-type plasminogen activator (t-PA), which proved little better than streptokinase in acute myocardial infarction. In contrast, endogenous fibrinolysis, using one-thousandth of the t-PA concentration, is regularly lysing fibrin and induced Thrombo...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2016.07.780

    authors: Gurewich V

    更新日期:2016-11-08 00:00:00

  • Endurance testing for evaluation of antianginal therapy with amlodipine, a calcium channel blocking agent.

    abstract::The utility of using an endurance test as well as a maximal exercise test to assess the effect of amlodipine, a dihydropyridine calcium antagonist, was evaluated in 16 patients with angina pectoris. Amlodipine, 10 mg/day, was compared with placebo in a double blind crossover study. After a 2 week single blind placebo ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(88)90323-3

    authors: Kinnard DR,Harris M,Hossack KF

    更新日期:1988-09-01 00:00:00

  • Blood flow to infarct and surviving myocardium: implications regarding the action of verapamil on the acutely ischemic dog heart.

    abstract::After coronary occlusion, myocardium originally supplied by the occluded vessel ultimately separates into infarct and surviving muscle. To clarify this process, evolution of collateral blood flow to infarct and to surviving myocardium was retrospectively analyzed after permanent left anterior descending occlusion in 2...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80354-x

    authors: Davenport N,Goldstein RE,Bolli R,Epstein SE

    更新日期:1984-04-01 00:00:00

  • Balloon embolization to occlude a Blalock-Taussig shunt.

    abstract::Balloon embolization was used to successfully occlude a large residual Blalock-Taussig shunt. The use of an "upstream" nondetachable balloon catheter to reduce flow and turbulence during final positioning of the detachable balloon may have made the technique safer and more precise. ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80448-9

    authors: Florentine M,Wolfe RR,White RI Jr

    更新日期:1984-01-01 00:00:00

  • Recommendations for training in vascular medicine. American College of Cardiology Peripheral Vascular Disease Committee.

    abstract::Each trainee in vascular medicine must be eligible for the board certification examination of the American Board of Internal Medicine or its equivalent. Training faculty, preferably at least two members, should meet the qualifications and training requirements described in this report. They must be dedicated, effectiv...

    journal_title:Journal of the American College of Cardiology

    pub_type: 指南,杂志文章

    doi:10.1016/0735-1097(93)90077-e

    authors: Spittell JA Jr,Nanda NC,Creager MA,Ochsner JL,Dorros G,Wexler L,Isner JM,Young JR

    更新日期:1993-08-01 00:00:00

  • Effects of amiodarone and its active metabolite desethylamiodarone on the ventricular defibrillation threshold.

    abstract:OBJECTIVES:We evaluated whether the reported difference in the ventricular defibrillation threshold (DFT) between short-term intravenous and oral amiodarone is due to the effect of amiodarone's active metabolite desethylamiodarone (DEA). BACKGROUND:Amiodarone is frequently used in patients with implantable cardioverte...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00160-0

    authors: Zhou L,Chen BP,Kluger J,Fan C,Chow MS

    更新日期:1998-06-01 00:00:00

  • N-2-mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia.

    abstract::Myocardial reperfusion after reversible regional ischemia is known to result in delayed recovery of contractile function, but the mechanism responsible for this phenomenon remains unclear. We examined the ability of N-2-mercaptopropionylglycine, a synthetic thiol compound with oxygen free radical scavenging properties...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(86)80396-5

    authors: Myers ML,Bolli R,Lekich RF,Hartley CJ,Roberts R

    更新日期:1986-11-01 00:00:00

  • Independent and incremental value of coronary artery calcium for predicting the extent of angiographic coronary artery disease: comparison with cardiac risk factors and radionuclide perfusion imaging.

    abstract:OBJECTIVES:The study was done to test the ability to predict the extent of angiographically determined coronary artery disease (CAD) by quantification of coronary calcium using electron-beam computed tomography (EBCT) and to compare it with more conventional parameters for delineating the angiographic extent of CAD, th...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00265-x

    authors: Schmermund A,Denktas AE,Rumberger JA,Christian TF,Sheedy PF 2nd,Bailey KR,Schwartz RS

    更新日期:1999-09-01 00:00:00

  • Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy.

    abstract:BACKGROUND:Familial restrictive cardiomyopathy (FRCM) has a poor prognosis due to diastolic dysfunction and restrictive physiology (RP). Myocardial stiffness, with or without fibrosis, underlie RP, but the mechanism(s) of restrictive remodeling is unclear. Myopalladin (MYPN) is a messenger molecule that links structura...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2014.09.071

    authors: Huby AC,Mendsaikhan U,Takagi K,Martherus R,Wansapura J,Gong N,Osinska H,James JF,Kramer K,Saito K,Robbins J,Khuchua Z,Towbin JA,Purevjav E

    更新日期:2014-12-30 00:00:00