Abstract：
:Twenty-six young pigs were infected with encephalomyocarditis virus, observed clinically, studied at intervals by noninvasive and invasive methods to assess cardiac function and eventually examined pathologically. All infected animals appeared ill, usually manifesting diminished appetite, lethargy and fever. Spontaneous mortality occurred either 1 to 4 or 20 to 21 days after infection. Electrocardiographic abnormalities, seen in the majority of animals, comprised ST-T wave changes, conduction disturbances or ventricular ectopic rhythm. The majority of animals manifested echocardiographic evidence of left ventricular dilation and decreased systolic function, which improved with time in some animals. Hemodynamic studies revealed elevation of biventricular filling pressures in 3 of 10 animals; as a group, infected animals manifested significantly elevated right ventricular filling pressures. In selected animals, the feasibility of gallium scans as well as left ventriculography and coronary angiography was demonstrated. At autopsy, heart weight/body weight ratio was significantly elevated in infected animals. The heart of all but two animals showed active myocarditis associated with fibrosis and focal calcification in the later stages. In general, the cardiovascular manifestations were parallel with those seen in acute and subacute myocarditis in humans. It is concluded that encephalomyocarditis infection in the pig is a large animal model of viral myocarditis suitable for assessing alterations in the structure and function of the cardiovascular system and the effects of interventions.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Gwathmey JK,Nakao S,Come PC,Goad ME,Serur JR,Als AV,Abelmann WHdoi
10.1016/0735-1097(92)90533-ssubject
Has Abstractpub_date
1992-03-15 00:00:00pages
864-9issue
4eissn
0735-1097issn
1558-3597pii
0735-1097(92)90533-Sjournal_volume
19pub_type
杂志文章abstract：:Cardiovascular disease is the leading cause of mortality in the world, and the increasing burden is largely a consequence of modifiable behavioral risk factors that interact with genomics and the environment. Continuous cardiovascular health promotion and disease prevention throughout the lifespan is critical, and the...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2016.01.036
更新日期：2016-04-12 00:00:00
abstract：OBJECTIVES:The goal of this study was to detect transplant arteriopathy (Tx-CHD) by a reduced myocardial perfusion reserve (MPR) and resting endomyocardial/epimyocardial perfusion ratio (Endo/Epi ratio). BACKGROUND:Transplant arteriopathy often lacks clinical symptoms and is the reason for frequent surveillance angiog...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(03)00924-0
更新日期：2003-09-17 00:00:00
abstract：:Sudden death in healthy athletes is uncommon but, when it occurs, the primary mechanism is cardiovascular. The major cause of sudden death in the young athlete is hypertrophic cardiomyopathy or related conditions characterized by left ventricular hypertrophy, aortic rupture due to cystic medial necrosis and congenital...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/s0735-1097(86)80285-6
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM). BACKGROUND:One hundred thirty-three patients with NICM and minimal symptoms on standard therapy we...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.jacc.2010.11.017
更新日期：2011-02-15 00:00:00
abstract：OBJECTIVES:We sought to characterize the predictors of incident congestive heart failure (CHF), as determined by central adjudication, in a community-based elderly population. BACKGROUND:The elderly constitute a growing proportion of patients admitted to the hospital with CHF, and CHF is a leading source of morbidity ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(00)00582-9
更新日期：2000-05-01 00:00:00
abstract：:The safety of thrombolytic therapy of acute myocardial infarction could be improved if a method were developed to dissolve fresh occlusive coronary thrombus without simultaneously dissolving hemostatic thrombi outside the coronary arteries. This study is based on the assumption that, in a patient with evolving acute m...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(89)90441-5
更新日期：1989-11-01 00:00:00
abstract：:Twenty patients with a chronic total coronary artery occlusion were studied before and 1 to 48 months (mean 9) after successful recanalization by angioplasty and compared with a group of 20 normal subjects. Before angioplasty, 19 of these 20 patients had angina. Collateral vessels to the distal part of the occluded ve...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(87)80230-9
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVES:This study tested the hypothesis that response to antiarrhythmic drugs (AADs) is modulated by 3 common loci associated with atrial fibrillation (AF). BACKGROUND:Recent genome-wide association studies have identified 3 loci, on chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), that associ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2012.01.070
更新日期：2012-08-07 00:00:00
abstract：:The opening of the tricuspid valve and the onset of right ventricular filling precede the opening of the mitral valve and the onset of flow in the normal adult. Sixty-five studies of atrioventricular flow with range-gated pulsed Doppler echocardiography, performed on 32 normal neonates, consistently demonstrated the r...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(88)80062-7
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this research was to evaluate the Thrombolysis In Myocardial Infarction risk index (TRI) to characterize the risk of death among patients with non-ST-segment elevation myocardial infarction (NSTEMI). BACKGROUND:The TRI, calculated from baseline age, systolic pressure, and heart rate, was esta...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2005.11.075
更新日期：2006-04-18 00:00:00
abstract：OBJECTIVES:We assessed the hypothesis that changes in endothelial vasomotor function in response to optimized therapy for atherosclerotic coronary artery disease predict future cardiovascular events. BACKGROUND:Although endothelial vasomotor dysfunction is a predictor of cardiovascular events, it remains unclear wheth...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2008.08.074
更新日期：2009-01-27 00:00:00
abstract：:To determine the rate of induction, specificity and evolution of electrically induced postmyocardial infarction ventricular arrhythmias, 10 dogs that underwent a sham operation and 20 dogs with experimental transmural apical myocardial infarction underwent serial closed chest electrophysiologic studies with programmed...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(85)80010-3
更新日期：1985-05-01 00:00:00
abstract：OBJECTIVES:we tested the hypothesis that bi-directional, gene-targeted regulation of cardiomyocyte cyclic guanosine monophosphate-selective phosphodiesterase type 5 (PDE5) influences maladaptive remodeling in hearts subjected to sustained pressure overload. BACKGROUND:PDE5 expression is up-regulated in human hypertrop...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2010.08.612
更新日期：2010-12-07 00:00:00
abstract：OBJECTIVES:This study was designed to assess the risk of significant bleeding complications in patients receiving antiplatelet or anticoagulation medications at the time of implantable cardioverter-defibrillator (ICD) device implantation. BACKGROUND:Periprocedural management of antiplatelet or anticoagulation therapy ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2009.12.056
更新日期：2010-05-25 00:00:00
abstract：:The short-term effects of oral diltiazem on hemodynamics and distribution of cardiac output at rest and during semiupright bicycle exercise were evaluated in eight patients with stable effort angina on long-term beta 1-adrenergic blockade. Cardiac output and iliofemoral blood flow were measured using thermodilution. T...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90198-x
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:We sought to test the hypothesis that activation of the serotonergic system in patients with vasovagal syndrome during the head-up tilt test provokes syncope. BACKGROUND:Central serotonergic activation participates in the pathogenesis of neurocardiogenic syncope. Drugs increasing serotonin (5-HT) in the cen...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(00)00719-1
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Routine apolipoprotein (apo) measurements for cardiovascular disease (CVD) are restricted to apoA-I and apoB. Here, the authors measured an unprecedented range of apolipoproteins in a prospective, population-based study and relate their plasma levels to risk of CVD. OBJECTIVES:This study sought to measure a...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2016.11.065
更新日期：2017-02-21 00:00:00
abstract：:The development of aortic valve-sparing operations (reimplantation of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for treating patients with aortic root dilation caused by a variety of disorders. Young adults with aortic root aneurysms associated with genetic syndromes are i...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2016.04.062
更新日期：2016-08-09 00:00:00
abstract：OBJECTIVE:We studied the effect of the angiotensin II type 1 (AT1)-receptor antagonist candesartan on infarct size resulting from regional myocardial ischemia in pigs. BACKGROUND:The effects of AT1-receptor blockade on infarct size in different species remain controversial and its potential cardioprotective mechanisms...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(98)00441-0
更新日期：1998-11-15 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine the spatial distribution of myocardial function (myofiber shortening and work) within the left ventricular (LV) wall during ventricular pacing. BACKGROUND:Asynchronous electrical activation, as induced by ventricular pacing, causes various abnormalities in LV funct...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(99)00068-6
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to assess the value of implantable cardioverter-defibrillator (ICD) electrograms (EGMs) in identifying clinically documented ventricular tachycardias (VTs). BACKGROUND:Twelve-lead electrocardiograms (ECG) of spontaneous VT often are not available in patients referred for cathet...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2010.04.043
更新日期：2010-09-14 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine whether restrictive right ventricular (RV) physiology (the presence of antegrade pulmonary arterial flow in late diastole) occurred in patients with moderate to severe isolated pulmonary valvular stenosis (PVS) and to estimate its prevalence and relationship to RV functio...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.06.042
更新日期：2007-10-09 00:00:00
abstract：:Left ventricular noncompaction (LVNC) describes a ventricular wall anatomy characterized by prominent left ventricular (LV) trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme, and trabeculae represent a sort of individual "cardioprinting." By itself, the diagnosis ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2016.05.096
更新日期：2016-08-30 00:00:00
abstract：OBJECTIVES:The purpose of this study was to assess the effects of ramipril on left ventricular mass (LVM) and function in vascular disease patients with controlled blood pressure (BP) and with preserved left ventricular ejection fraction (LVEF). BACKGROUND:Increased LVM and left ventricular (LV) volume and decreased L...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2003.10.073
更新日期：2004-06-16 00:00:00
abstract：OBJECTIVES:The study aimed to evaluate inclacumab for the reduction of myocardial damage during a percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation myocardial infarction. BACKGROUND:P-selectin is an adhesion molecule involved in interactions between endothelial cells, platelets, and le...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2013.03.003
更新日期：2013-05-21 00:00:00
abstract：:It has been suggested that intracardiac lymphatics may play a role in the pathophysiologic processes involving the conduction system. To test the possibility of linkage between the ventricular septum and the atrioventricular (AV) node, india ink was injected into the ventricular septum of freshly removed human hearts....
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(83)80114-4
更新日期：1983-04-01 00:00:00
abstract：OBJECTIVES:This study sought to analyze the outcomes of revascularization procedures in the treatment of allograft coronary disease. BACKGROUND:Allograft vasculopathy is the main factor limiting survival of heart transplant recipients. Because no medical therapy prevents allograft atherosclerosis, and retransplantatio...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/0735-1097(95)00124-i
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVES:The purpose of the study was to assess the cardiovascular risk of impaired fasting glucose (IFG). BACKGROUND:The associations between IFG, incident type 2 diabetes mellitus (T2DM), and cardiovascular (CV) events remains unclear. METHODS:The MESA (Multi-Ethnic Study of Atherosclerosis) study included partic...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2011.03.025
更新日期：2011-07-05 00:00:00
abstract：:Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remod...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2017.09.002
更新日期：2017-10-17 00:00:00
abstract：:Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or re...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2018.05.038
更新日期：2018-07-31 00:00:00
