Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell.

Abstract:

:Although it is clear that thrombopoietin is the primary regulator of thrombopoiesis, several lines of evidence indicate that the hormone affects multiple aspects of hematopoiesis: the in vivo administration of TPO increases marrow levels of erythroid, myeloid, and megakaryocytic progenitor cells and its genetic elimination or that of its receptor (c-mpl) reduces the numbers of these cells; all hematopoietic stem cells (HSCs) are c-mpl+; genetic elimination of c-mpl reduces the numbers of murine HSCs by 7-8-fold; and its null mutation in humans leads to congenital amegakaryocytic thrombocytopenia, a disorder that almost invariably leads to aplastic anemia. Recently, we have begun to explore the role of TPO in the HSC self-renewal and expansion that characterizes the post-stem-cell-transplantation period. Using limiting dilution cell transplantation analyses, we found that HSC self-renewal and expansion is reduced 10-20-fold after transplantation of normal stem cells into tpo null mice compared to their wild-type counterparts. Although the molecular mechanisms responsible for these findings are only now being explored, it is expected that a greater understanding of the roles played by TPO in HSC physiology will lead to novel therapeutic opportunities.

journal_name

Ann N Y Acad Sci

authors

Kaushansky K

doi

10.1111/j.1749-6632.2003.tb03230.x

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

39-43

eissn

0077-8923

issn

1749-6632

journal_volume

996

pub_type

杂志文章
  • Achalasia: what to do in the face of failures of Heller myotomy.

    abstract::Achalasia is a primary motility disorder of the esophagus, and while there are several treatment options, there is no consensus regarding them. When therapeutic intervention for achalasia fails, a careful evaluation of the cause of the persistent or recurrent symptoms using upper endoscopy, esophageal manometry, and c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14440

    authors: Felix VN,Murayama KM,Bonavina L,Park MI

    更新日期:2020-12-01 00:00:00

  • Surgical treatment for fetal disease. The state of the art.

    abstract::Sophisticated imaging and fetal sampling techniques have defined the natural history and pathophysiologic characteristics of many previously mysterious conditions of newborn. Although most prenatally diagnosed malformations are best managed by appropriate medical and surgical therapy after delivery, an increasing numb...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb08928.x

    authors: Albanese CT,Harrison MR

    更新日期:1998-06-18 00:00:00

  • Trends in private insurance, Medicaid/State Children's Health Insurance Program, and the Healthcare Safety Net: implications for vulnerable populations and health disparities.

    abstract::This chapter examines trends in private and public health coverage, as well as implications for vulnerable populations and health disparities. We find that there has been erosion in employment-based health benefits. Both the percentage of employers offering coverage and the percentage of workers with coverage declined...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1425.029

    authors: Shields AE,McGinn-Shapiro M,Fronstin P

    更新日期:2008-01-01 00:00:00

  • Molecular genetics of hypothalamic-pituitary-adrenal axis activity and function.

    abstract::The hypothalamic-pituitary-adrenocortical (HPA) axis is a major neuroendocrine system involved in the regulation of numerous physiological processes and in adaptation to stress. A wide range of variability can be observed in all the components of the system, and the contribution of genetic factors has been shown in th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05902.x

    authors: Mormede P,Foury A,Barat P,Corcuff JB,Terenina E,Marissal-Arvy N,Moisan MP

    更新日期:2011-03-01 00:00:00

  • Uterine leiomyoma: a treatable condition.

    abstract::Many risk factors have been identified as having either a protective or a negative effect on the development of fibroids, but due to methodological issues and a lack of long-term studies, the exact effect of these factors is ambiguous. In similar dispute is the proper treatment of fibroids. Recent technological advanc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Moorehead ME,Conard CJ

    更新日期:2001-12-01 00:00:00

  • Selfobject as dramatis personae: cultivating the improvisational in self-psychological psychoanalysis.

    abstract::This chapter discusses the influence of drama in the author's background in conceptualizing psychoanalytic theory and practice. The history of ideas relevant to a dramaturgical analysis from Freud to Kohut's revolution, with additional modifications by relational psychoanalysis, is explored. The author poses a trimoda...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04355.x

    authors: Ringstrom PA

    更新日期:2009-04-01 00:00:00

  • E-cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring.

    abstract::Approximately 15% of pregnant women vape electronic cigarettes (e-cigarettes), exposing the fetus to a range of toxic compounds, including nicotine and by-products of e-cigarette liquid (e-liquid) pyrolysis. Owing to the recent emergence of these products, research mainly focuses on immediate users, and not on in uter...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14411

    authors: Li G,Chan YL,Wang B,Saad S,George J,Oliver BG,Chen H

    更新日期:2020-09-01 00:00:00

  • The neural basis of moral cognition: sentiments, concepts, and values.

    abstract::The human moral nature has perplexed laymen and academics for millennia. Recent developments in cognitive neuroscience are opening new venues for unveiling the complex psychological and neurobiological mechanisms underling human morality and its impairments. Here we review these lines of evidence and key topics of deb...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1440.005

    authors: Moll J,De Oliveira-Souza R,Zahn R

    更新日期:2008-03-01 00:00:00

  • Recovery of tobacco BY-2 cells after high hydrostatic pressure treatment.

    abstract::The recovery of Nicotiana tabacum L. cv. Bright Yellow 2 (BY-2) cells in Linsmaire and Skoog medium after treatment at high hydrostatic pressure was investigated using an Evans Blue staining method to discriminate live from dead cells. The survival of BY-2 cells just after the high-pressure treatment at 5 degrees C an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05185.x

    authors: Kusube M,Nishino T,Nishikawa Y,Goto M,Matsuki H,Iwahashi H

    更新日期:2010-02-01 00:00:00

  • Effects of low-molecular-weight heparin on adhesion and vesiculation of phospholipid membranes: a possible mechanism for the treatment of hypercoagulability in antiphospholipid syndrome.

    abstract::Heparins represent an efficient treatment of acute thrombosis and obstetric complications in antiphospholipid syndrome (APS). Enhanced microvesiculation of cell membranes, as detected by reduced membrane adhesion, can contribute to hypercoagulability in APS. Healthy donor IgG antibodies significantly increased beta2-g...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04745.x

    authors: Frank M,Sodin-Semrl S,Rozman B,Potocnik M,Kralj-Iglic V

    更新日期:2009-09-01 00:00:00

  • Assessment of carotenoid intakes in humans.

    abstract::The availability of new food composition carotenoid values for fruits and vegetables increases our ability to test hypotheses concerning the role of antioxidant nutrients and cancer risk. To estimate the usual carotenoid intakes, a quantitative diet history covering a one-year period is recommended for epidemiologic s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb26158.x

    authors: Hankin JH,Le Marchand L,Kolonel LN,Wilkens LR

    更新日期:1993-12-31 00:00:00

  • Binocular coordination in fore/aft motion.

    abstract::Stabilization of images on the fovea during either fore/aft translation of a subject or fore/aft movement of a visual target in front of a stationary observer imposes complex geometrical requirements that depend upon the eccentricity of the object of interest with respect to the eyes. Each eye needs to be rotated inde...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.005

    authors: Ramat S,Zee DS

    更新日期:2005-04-01 00:00:00

  • Individualistic and social motives for justice judgments.

    abstract::Justice judgments are subjective by nature, and are influenced substantially by motivational processes. In the present contribution, two motives underlying justice judgments are examined: individualistic motives to evaluate solutions to social problems that benefit the self in material or immaterial ways as fair versu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12143

    authors: van Prooijen JW

    更新日期:2013-09-01 00:00:00

  • Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.

    abstract::The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1380.012

    authors: Zhou L,Yu X,Cabrera ME,Stanley WC

    更新日期:2006-10-01 00:00:00

  • Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid.

    abstract::Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (tetanus toxoid), that absolute levels of proliferation, minimally detecta...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02963.x

    authors: Narendran P,Elsegood K,Leech NJ,Dayan CM

    更新日期:2002-04-01 00:00:00

  • Combined neurostimulation and neuroimaging in cognitive neuroscience: past, present, and future.

    abstract::Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12110

    authors: Bestmann S,Feredoes E

    更新日期:2013-08-01 00:00:00

  • Cl-dependent Na-H exchange. A novel colonic crypt transport mechanism.

    abstract::This communication summaries a series of observations of the transport function of the crypt of the rat distal colon. Development of methods to study both 22Na uptake by apical membrane vesicles prepared from crypt cells and intracellular pHi (pHi), fluid movement (Jv), and bicarbonate secretion during microperfusion ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05222.x

    authors: Binder HJ,Rajendran VM,Geibel JP

    更新日期:2000-01-01 00:00:00

  • Amyloid-beta protein angiopathies masquerading as Alzheimer's disease?

    abstract::Current evidence from genetic and epidemiological studies supports the view that Alzheimer's disease (AD) is a heterogeneous disorder. While the disease is pathologically defined by the presence of specified lesions in form of amyloid plaques and neurofibrillary tangles within the parenchyma, other features of patholo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb48490.x

    authors: Cohen DL,Hedera P,Premkumar DR,Friedland RP,Kalaria RN

    更新日期:1997-09-26 00:00:00

  • Lice infestation and lice control remedies in the Ukraine.

    abstract::A permanent decrease was seen in the prevalence of lice infestation among population of the Ukraine from 1990-2004. The prevalence of lice infestation among children under 14 years of age was 6-27 times more than that in adults. The highest figures were among children 7-14 years old. During all of the observation peri...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1374.070

    authors: Kurhanova I

    更新日期:2006-10-01 00:00:00

  • Measurement of the cell migration index with a HeNe laser.

    abstract::Human diploid fibroblasts (WI38) were inoculated into Rose multipurpose culture chambers, using a high population density to develop confluency. After 24 hours, cells from a 1 mm swath were scraped from the center of the chamber. This cleared path was positioned to permit an unobstructed transmission of a 0.9 X 20 mm ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb41605.x

    authors: Rounds DE,Olson RS,Booher J

    更新日期:1976-01-30 00:00:00

  • Ketoconazole treatment of coccidioidal meningitis.

    abstract::Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb40446.x

    authors: Graybill JR,Stevens DA,Galgiani JN,Sugar AM,Craven PC,Gregg C,Huppert M,Cloud G,Dismukes WE

    更新日期:1988-01-01 00:00:00

  • The phenomenon of resveratrol: redefining the virtues of promiscuity.

    abstract::Cancer chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of carcinogenesis. With support provided by the National Cancer Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05849.x

    authors: Pezzuto JM

    更新日期:2011-01-01 00:00:00

  • Presence of PACAP and VIP in embryonic chicken brain.

    abstract::The aim of the present article was to investigate the occurrence and temporary changes of pituitary adenylate cyclase-activating polypeptide (PACAP)-38 and vasoactive intestinal peptide (VIP) in various brain areas of chicken embryos by means of radioimmunoassay. The highest concentrations of PACAP-38 were measured in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1317.039

    authors: Jozsa R,Hollosy T,Nemeth J,Tamás A,Lubics A,Jakab B,Olah A,Arimura A,Reglödi D

    更新日期:2006-07-01 00:00:00

  • How to design a therapeutic study in patients with the post-polio syndrome. Methodological concerns and status of present therapies.

    abstract::The innervation of muscles in patients with the post-polio syndrome (PPS) may differ from limb to limb or even within the same limb because of the segmental nature of the initial involvement and the varying degree of subsequent recovery. Consequently, the compensatory effort of the neighboring muscles varies even in t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb27557.x

    authors: Dalakas MC

    更新日期:1995-05-25 00:00:00

  • The neurotoxicity of polybrominated biphenyls: results of a medical field survey.

    abstract::Neurologic symptoms were the earliest and most prominent symptoms recorded in Michigan farm residents exposed to PBB as compared to a non-PBB exposed control farm population in Wisconsin. In Michigan (particularly among males) those who exhibited the most marked symptoms tended to show diminished performance as assess...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1979.tb56617.x

    authors: Valciukas JA,Lilis R,Anderson HA,Wolff MS,Petrocci M

    更新日期:1979-05-31 00:00:00

  • Death and consciousness--an overview of the mental and cognitive experience of death.

    abstract::Advances in resuscitation science have indicated that, contrary to perception, death by cardiorespiratory criteria can no longer be considered a specific moment but rather a potentially reversible process that occurs after any severe illness or accident causes the heart, lungs, and brain to stop functioning. The resul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12582

    authors: Parnia S

    更新日期:2014-11-01 00:00:00

  • New technologies to prevent and treat contact hypersensitivity responses.

    abstract::Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06880.x

    authors: Takashima A,Mummert M,Kitajima T,Matsue H

    更新日期:2000-01-01 00:00:00

  • The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain.

    abstract::Transcription regulatory factors are rapidly induced in brain by a wide variety of stimuli and may be important in coordinating changes in gene expression under-lying neuronal plasticity. Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust indu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Humblot N,Thiriet N,Gobaille S,Aunis D,Zwiller J

    更新日期:1998-05-30 00:00:00

  • Possible link between NO concentrations and COX-2 expression in systems treated with soy-isoflavones.

    abstract::The production of nitric oxide (NO) emerges as an essential determinant in auto- and paracrine signaling. NO is known to be generated under inflammatory conditions, carcinogenesis, and circulatory shock. The large amount of NO produced in response to cytokines plays an important role in inflammatory conditions. Cycloo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.061

    authors: Shin JI,Lee YK,Kim YM,Hwang JT,Park OJ

    更新日期:2007-01-01 00:00:00

  • Effect of anionic amphophiles on erythrocyte properties.

    abstract::This preliminary study describes effects of two pharmacologic agents on erythrocyte behavior. Increased erythrocyte aggregation has been proposed as important in the pathogenesis of a number of disorders, but the exact mechanism by which it plays a role in disease production remains unclear. Several anionic amphophile...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb35216.x

    authors: McMillan DE,Utterback NG,Wujek JJ

    更新日期:1983-01-01 00:00:00