Abstract：
:Glucosamine oligomers--monomer through tetramer--form complexes with Cu2+ that catalyse the hydrolysis of the 'nerve gas' 1,2,2-trimethylpropyl- methylphosphonofluroidate (soman) by cleaving the P-F bond. A 1/1 glucosamine/Cu2+ ratio whether as glucosamine or glucosamine units, gives the highest hydrolytic rate over the 11.5/1 to 1/1 range. This trend also appears to hold for a glucosamine polymer, chitosan, which, when complexed with Cu2+ also hydrolyzes soman. The relatively low rate of hydrolysis by this polymer-Cu2+ complex, while not yet explainable, is consistent with an extrapolation of the monomer-through-tetramer series. The question may be raised as to whether these biopolymer metal complexes provide any clues to the involvement of Mn2+ in the functioning of one class of P-F cleaving enzymes.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Hoskin FC,Rajan KS,Remy D,Walker JEdoi
10.1016/0009-2797(93)90031-ssubject
Has Abstractpub_date
1993-06-01 00:00:00pages
109-16issue
1-3eissn
0009-2797issn
1872-7786pii
0009-2797(93)90031-Sjournal_volume
87pub_type
杂志文章abstract：:Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) and Ritonavir, a protease inhibitor, are antiviral drugs that cause c...
journal_title：Chemico-biological interactions
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abstract：:6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The combined treatment w...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
pub_type： 杂志文章,评审
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更新日期：2007-04-25 00:00:00
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：2020-01-05 00:00:00
abstract：:Excessive osteoclast leads to the imbalance in bone reconstruction and results in osteolytic diseases, such as osteoporosis and rheumatic arthritis. Integrin αvβ3 abundantly expresses on osteoclast and plays a critical role in the formation and function of osteoclast, therefore, blockage of αvβ3 has become an attracti...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
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abstract：:Microsomal epoxide hydrase (EH) and 176 000 g supernatant fraction glutathione-S-transferase (GSH-S-T) activities were determined with styrene oxide as substrate in rat testes during postnatal development. The development of these enzymes was also followed in liver for comparison. Testes of 6-day-old rats had high GSH...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/0009-2797(78)90122-9
更新日期：1978-09-01 00:00:00
abstract：:Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
