Abstract：
BACKGROUND:Asthma guidelines recommend combining inhaled corticosteroids and long-acting inhaled B2-agonists when inhaled corticosteroids alone are insufficient to achieve good control of the disease. OBJECTIVES:To determine in routine practice whether the fixed-dose fluticasone-salmeterol combination (FP/s) is as least as effective as inhaled corticosteroids combined with long-acting B2-agonists administered separately and to study patient perception. METHODOLOGY:An open multicentric randomized study was conducted in two matched populations stratified by the prior treatment. Patients insufficiently controlled by moderate-dose inhaled corticosteroids +/- long-acting B2-agonists or high-dose inhaled corticosteroids alone were treated for 3 months using one inhalation of FP/S twice daily or inhaled corticosteroids and long-acting B2-agonists given separately (TC). RESULTS:Mean improvement in morning PEFR at 3 months was 39.2 +/- 4.1 l/min with FP/S and 30.7 +/- 4.0 l/min with TC. The difference (FP/S-TC: 8.5 l/min, CI95: -0.7 - 17.7 l/min) did not reach significance. There was no difference between the two groups for criteria other than TC. Tolerance was good in both groups. CONCLUSION:The fixed-dose fluticasone-salmeterol combination is as least as effective as open combinations of inhaled corticosteroids and long-acting B2-agonists and is appreciated by patients (easier dosing, easier administration).
journal_name
Rev Pneumol Clinjournal_title
Revue de pneumologie cliniqueauthors
Martinat Y,Desfougères JLsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
139-48issue
3eissn
0761-8417issn
1776-2561pii
MDOI-RPC-06-2003-59-3-0761-8417-101019-ART3journal_volume
59pub_type
临床试验,杂志文章,随机对照试验abstract：:The increasing precision of exercise testing modalities has contributing to making it an excellent means of evaluating functional impairment in dyspnea patients. It has become an indispensable diagnostic tool. Interpretation of data acquired during an exercise test depends on the reliability of data collection and the...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Lung cancer is the leading cause of death by cancer and cirrhosis is the fourteenth, all causes included. Surgery increases postoperative risks in cirrhotic patients. Our purpose was to analyze this point in lung cancer surgery. METHODS:We collected, among 7162 patients, the data concerning those operated...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2014.09.006
更新日期：2015-02-01 00:00:00
abstract：:The various physiopathological components of asthmatic disease are interwoven. Experimental models used to study the sites of impact of an anti-asthmatic substance seek to separate the different mechanisms. The in vitro bronchial tissue model is rarely available in man. Progress is being made towards the development o...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1985-01-01 00:00:00
abstract：:Nicardipine is a commonly used anti-hypertensive drug for acute situations. We report the case of a 55-year-old man with hypoxemic pneumonia, who presented a worsening of his hypoxia secondary to the injection of this calcium channel inhibitor (CCI). This side effect was probably caused by inhibition of hypoxic pulmon...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.08.003
更新日期：2012-06-01 00:00:00
abstract：:Forty-five bronchoalveolar lavages (BAL) were performed in Brazzaville in AIDS patients who did not expectorate acid- and alcohol-resistant bacilli (AARB). All patients presented with respiratory symptoms (cough, dyspnoea or chest pain), and all but 6 of them had abnormal radiography of the chest. Four cases of pneumo...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Nutritional status assessment during the comprehensive management of patients treated for cancer is becoming increasingly necessary. Various data are currently available which show a relationship between the nutritional status and certain morbidity-mortality parameters. In contrast, there is a paucity of data concerni...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2008.03.002
更新日期：2008-04-01 00:00:00
abstract：:The observation of 3 cases has prompted the authors to review the characteristics of vascular abnormalities that may be found in Behçet's disease. These lesions, the frequency of which has diversely been estimated, involve the veins more often than the arteries. Arterial lesions occur, after a varying length of time, ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:Obstructive sleep apnea, obesity-related hypoventilation - a hypoventilation which is independent of apneas and increased by sleep -, and hypoxemia related to local ventilation-perfusion disorders are the main mechanisms of respiratory failure occurring during acute respiratory decompensation following an often minima...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-01 00:00:00
abstract：:Melioidosis is most frequently encountered in pulmonary localization. Melioidosis is an infectious disease caused by Burkholderia pseudomallei first described by Whitmore in 1912 in Burma. B. pseudomallei is a Gram negative rod belonging to the Pseudomonadaceae family. Soil and water are the natural reservoirs for the...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:A case of Carrington's chronic eosinophilic pneumonia associated with bronchocentric granulomatosis in a young asthmatic woman is reported. Among the numerous forms of "eosinophilic lung", the characteristic features of these two diseases in asthmatic patients are briefly described. Concerning the association, the aut...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Few studies have described pulmonary non-infectious diseases (PNID) in patients with common variable immunodeficiency (CVID). Indeed the most frequent complications in these patients are infectious. The aim of our study is to analyze the characteristics of PNID in a retrospective study of patients with CVID of two pne...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.06.005
更新日期：2011-09-01 00:00:00
abstract：:Complications observed after lung transplantation are well described for the different indications. Certain complications are specifically observed in patients with cystic fibrosis who have reached the stage of major respiratory failure. The most specific complications result from digestive tract manifestations of the...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:We report 3 cases of recurrent idiopathic pneumothorax treated first by video-surgery then by classical surgery. These cases illustrate the difference in hospital stay and patient satisfaction, which is not always in favor of video-surgery. We also examine our personal experience with a series of 480 cases of pneumoth...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Despite the dramatic decline in the incidence of tuberculosis during the last decades, the disease remains a significant public health problem especially in developing countries. Chest wall tuberculosis is a very rare location. Clinically, it can present as a pyogenic abscess or soft tumor, making diagnosis difficult,...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2014.12.006
更新日期：2015-10-01 00:00:00
abstract：:Infectious complications are rarely observed in the course of sarcoidosis. Only small series or cases reports of infection are described in sarcoidosis. Corticosteroids-induced immune suppression, pulmonary fibrosis and T-CD4 lymphopenia, are often present. Pulmonary nocardiosis is an important cause of opportunistic ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2012.12.001
更新日期：2013-06-01 00:00:00
abstract：:Osteosarcoma is a tumour that is encountered in children and young adults but is exceptional in elderly people. Moreover, it is very rarely located in the chest. A case of costal osteosarcoma revealed by a pleural blood effusion is reported in a 66-year old male patient. Full surgical excision completed by parietal re...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:We report the case of a 46-year-old-woman who presented with anosmia and nasal obstruction. Primary nasal tuberculosis was discovered. Primary nasal tuberculosis is very rare. Women are more touched than men. Symptomatology is often unilateral with nasal obstruction, anterior rhinorrhea or epistaxis. Diagnosis relies ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2014.02.001
更新日期：2014-10-01 00:00:00
abstract：:In adults, mediastinal neurogenic tumours constitute the third group of mediastinal tumours, after thymomas and lymphomas. If the group of neurogenic tumour is frequent, each type of tumour is relatively unusual in everyday's clinic. Among them, nerve sheath tumours are the more frequent, followed by tumour of the aut...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2009.12.010
更新日期：2010-02-01 00:00:00
abstract：:Lambert-Eaton syndrome is a myasthenia-like syndrome of paraneoplastic origin which is often associated with anaplastic small-cell lung cancer. It seems to be an autoimmune disease responsible for a deficit of acetylcholine ejection in the motor end plate. On the occasion of two recent cases, we review the clinical, p...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:We describe a mediastinal myxoid liposarcoma in a 47-year-old man who developed recurrent lung infection, treated by surgery associated with radiotherapy. The report of this case and a review of literature bring the authors to outline the epidemiological, clinical and therapeutic profile of this rare tumor. ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:Dermatofibrosarcoma protuberans (Darrier-Ferrand sarcoma, DFSP) is an uncommon tumor. This sarcoma has a tendency to local recurrence, requiring a wide surgical resection. OBSERVATION:We report herein two cases of patients presenting with recurrent dermatofibrosarcoma protuberans after several surgical re...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2016.09.005
更新日期：2017-04-01 00:00:00
abstract：:We report the case of a 57-year-old patient with primary malignant melanoma of the mediastinum who survived nine months despite immunotherapy, radiotherapy and chemotherapy. The primary nature of the intrathoracic melanoma was difficult to prove. Definitive diagnosis was based on the uniform morphology of the melanoma...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Acute chest syndrome is a frequent complication of sickle cell disease. This syndrome is characterized by recent infiltrate on chest X-ray with chest pain or fever or dyspnea. We report the case of a 26-year-old man in whom an acute chest syndrome with fat embolism was the inaugural sign of sickle cell disease. This r...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/s0761-8417(06)75439-6
更新日期：2006-06-01 00:00:00
abstract：:Four patients in status asthmaticus and with alveolar hypoventilation were given a helium-oxygen (He-O2) mixture to breathe during 4 hours. Clinical improvement and return to normal of arterial blood gas levels were rapid and dramatic in all patients. The He-O2 mixture, which is a low density gas, causes a reduction i...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Surgery is the most effective treatment of lung cancer provided that there is complete resection. Even though the results in the early stages of small cell lung cancers (SCLC) are encouraging, many oncologists still consider SCLC a contra-indication. The authors report their experience. They retrospectively reviewed t...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.02.001
更新日期：2009-06-01 00:00:00
abstract：:The medical and social prognosis of occupational asthma has only been assessed with retrospective studies. The main findings are analyzed here. The wide range of methods used to obtain a positive diagnosis of occupational asthma and more or less complete eviction of the causal agent hinder interpretation of the result...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Inflammatory pseudo-tumors of the lung are generally unifocal lesions with a benign prognosis. The pathogenesis is unknown. We report the case of a 71-year-old man who underwent exploration for dyspnea and chest pain associated with weight loss and a heterogeneous opacity in the lingula. This radiological and clinical...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/s0761-8417(04)72085-4
更新日期：2004-02-01 00:00:00
abstract：INTRODUCTION:In some Tunisian cities, especially semi-urbanized, the exposure to the smoke produced during combustion of the biomass, main source of pollution of indoor air, remains prevalent among non-smoking women. AIM:To assess the relationship between exposure to biomass smoke and the presence of obstructive venti...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2016.10.004
更新日期：2017-04-01 00:00:00
abstract：:A case of tracheo-bronchial lipomatosis is reported. Bronchial lipomas are benign fatty tumours which frequently result in bronchial superinfection or dyspnoea. The radiological image is often one of atelectasis, and the diagnosis is made at endoscopy. Treatment, rendered necessary by destruction of the underlying lun...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Lung transplantation is now considered a valid option in the management of end-stage respiratory failure. The postoperative period remains a key stage that will influence the average long-term prognosis of the patients. Primary graft failure, postoperative bleeding, infection, acute rejection and complications linked ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2010.12.005
更新日期：2010-02-01 00:00:00
