Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium.

abstract：:The effect of adenosine on transepithelial ion transport was investigated in isolated preparations of murine trachea mounted in Ussing chambers. The possible regulation of adenosine receptors in an established model of allergic airway inflammation was also investigated. Mucosally applied adenosine caused increases in ...

journal_title：British journal of pharmacology

authors： Kornerup KN,Page CP,Moffatt JD

更新日期：2005-04-01 00:00:00

abstract：:1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocripti...

journal_title：British journal of pharmacology

authors： Maeda-Hagiwara M,Watanabe K

更新日期：1983-05-01 00:00:00

abstract：:Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure following the pathological remodelling of small pulmonary arteries. An increase in right ventricular (RV) afterload results in RV hypertrophy and RV failure. The pathophysiology of PH, and RV remodelling in particular, is not well unders...

journal_title：British journal of pharmacology

authors： Maarman GJ,Schulz R,Sliwa K,Schermuly RT,Lecour S

更新日期：2017-04-01 00:00:00

abstract：:1. TRPM8 (CMR1) is a Ca(2+)-permeable channel, which can be activated by low temperatures, menthol, eucalyptol and icilin. It belongs to the transient receptor potential (TRP) family, and therefore is related to vanilloid receptor type-1 (VR1, TRPV1). We tested whether substances which are structurally related to ment...

journal_title：British journal of pharmacology

authors： Behrendt HJ,Germann T,Gillen C,Hatt H,Jostock R

更新日期：2004-02-01 00:00:00

abstract：:1 In order to address mechanistic differences between arterial vessel types, we have compared the vasorelaxant actions of anandamide in resistance (G3) and conduit (G0) mesenteric arteries. 2 Anandamide produced concentration-dependent relaxations of pre-constricted G3 arteries with a maximal response that was signifi...

journal_title：British journal of pharmacology

authors： O'Sullivan SE,Kendall DA,Randall MD

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Voltage-operated sodium channels constitute major target sites for local anaesthetic-like action. The clinical use of local anaesthetics is still limited by severe side effects, in particular, arrhythmias and convulsions. These side effects render the search for new local anaesthetics a matter of...

journal_title：British journal of pharmacology

authors： Haeseler G,Karst M,Foadi N,Gudehus S,Roeder A,Hecker H,Dengler R,Leuwer M

更新日期：2008-09-01 00:00:00

abstract：:The intravenous administration of naloxone 2 min before coronary artery occlusion in anaesthetized dogs reduced the incidence and severity of cardiac arrhythmias during coronary occlusion (20 min) and reperfusion (120 min) in a dose-related manner. It also reduced the mortality. At a dose of 1 mg kg-1 (the maximum dos...

journal_title：British journal of pharmacology

authors： Huang XD,Lee AY,Wong TM,Zhan CY,Zhao YY

更新日期：1986-03-01 00:00:00

abstract：:1. The aim of the study was to investigate the mechanism of a novel effect of hypoxia on intracellular Ca(2+) signalling in rabbit cerebral arteriolar smooth muscle cells, an effect that was resistant to the L-type Ca(2+) channel antagonist methoxyverapamil (D600). 2.[Ca(2+)](i) of smooth muscle cells in intact arteri...

journal_title：British journal of pharmacology

authors： Guibert C,Flemming R,Beech DJ

更新日期：2002-02-01 00:00:00

abstract：:1 Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by strand breaks in DNA, which are caused by reactive oxygen species (ROS). Here we investigate the effects of the PARS inhibitors 3-aminobenzamide (3-AB), nicotinamide and 1,5-dihydroxyisoquinoline (ISO) on the circulatory failure and the organ injur...

journal_title：British journal of pharmacology

authors： McDonald MC,Filipe HM,Thiemermann C

更新日期：1999-11-01 00:00:00

abstract：:1. The series of cycloalcohols C6, C7, C8 and C10 have been used to probe the molecular dimensions of a variety of general anaesthetic target sites. 2. The general anaesthetic EC50 concentrations of the cycloalcohols were determined for tadpoles (Xenopus laevis). All of the cycloalcohols tested were found to be potent...

journal_title：British journal of pharmacology

authors： Curry S,Moss GW,Dickinson R,Lieb WR,Franks NP

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions due to altered drug metabolism and disposition. The closely related liver X receptors (LXRα/β), oestrogen receptors (ERα/β) and glucocorticoid receptor (GR) reg...

journal_title：British journal of pharmacology

authors： Svärd J,Blanco F,Nevin D,Fayne D,Mulcahy F,Hennessy M,Spiers JP

更新日期：2014-01-01 00:00:00

abstract：:1. The modulation of L-type calcium channel current (ICa) by fendiline, a diphenylalkylamine type of calcium channel blocker was investigated on guinea-pig ventricular myocytes by use of the whole-cell patch-clamp technique. 2. Fendiline-induced block of ICa is accompanied by modulation of the channel kinetics in a co...

journal_title：British journal of pharmacology

authors： Schreibmayer W,Tripathi O,Tritthart HA

更新日期：1992-05-01 00:00:00

abstract：:Biological nitrogen oxide signalling and stress is an area of extreme clinical, pharmacological, toxicological, biochemical and chemical research interest. The utility of nitric oxide and derived species as signalling agents is due to their novel and vast chemical interactions with a variety of biological targets. Her...

journal_title：British journal of pharmacology

authors： Heinrich TA,da Silva RS,Miranda KM,Switzer CH,Wink DA,Fukuto JM

更新日期：2013-08-01 00:00:00

abstract：:1. Fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; I.C.I. 54,450; "Myalex") is one representative of a new class of compounds with antiinflammatory, analgesic and antipyretic properties as evidenced by its activity in a variety of tests in rats, mice and guinea-pigs.2. In tests of short duration the potency...

journal_title：British journal of pharmacology

authors： Newbould BB

更新日期：1969-03-01 00:00:00

abstract：:1. The study was designed to test the hypothesis that nitric oxide (NO)-releasing compounds increase guanosine 3':5'-cyclic monophosphate (cyclic GMP) production in human polymorphonuclear leucocytes (PMNs) and concomitantly inhibit PMN functions, i.e. leukotriene B4 (LTB4) synthesis, degranulation, chemotaxis and sup...

journal_title：British journal of pharmacology

authors： Moilanen E,Vuorinen P,Kankaanranta H,Metsä-Ketelä T,Vapaatalo H

更新日期：1993-07-01 00:00:00

abstract：:1. In isolated detrusor strips from the guinea-pig urinary bladder, contractile responses to electrical field stimulation were mostly mediated by neurally released acetylcholine (ACh) and adenosine 5'-triphosphate (ATP). 2. 5-Hydroxytryptamine (5-HT) produced a concentration-dependent increase in the amplitude of stim...

journal_title：British journal of pharmacology

authors： Messori E,Rizzi CA,Candura SM,Lucchelli A,Balestra B,Tonini M

更新日期：1995-06-01 00:00:00

abstract：:Cholesterol and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally. Despite the importance, very few studies have analysed and linked th...

journal_title：British journal of pharmacology

authors： Sanchez LD,Pontini L,Marinozzi M,Sanchez-Aranguren LC,Reis A,Dias IHK

更新日期：2020-08-06 00:00:00

abstract：:Oestrogens are important sex hormones central to health and disease in both genders that have protective effects on the cardiovascular and metabolic systems. These hormones act in complex ways via both genomic and non-genomic mechanisms. The genomic mechanisms are relatively well characterized, whereas the non-genomic...

journal_title：British journal of pharmacology

authors： Nilsson BO,Olde B,Leeb-Lundberg LM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An ever-growing wealth of information on current drugs and their pharmacological effects is available from online databases. As our understanding of systems biology increases, we have the opportunity to predict, model and quantify how drug combinations can be introduced that outperform convention...

journal_title：British journal of pharmacology

authors： Benson HE,Watterson S,Sharman JL,Mpamhanga CP,Parton A,Southan C,Harmar AJ,Ghazal P

更新日期：2017-12-01 00:00:00

abstract：:1 Cellulose sulphate, like heparin, prolonged the clotting time in partial thromboplastin time (PTT) assays, inhibited the amidolytic activity of thrombin, was without effect on amidolysis catalysed by activated coagulation factor X(Xa), and potentiated the inhibition of both thrombin and Xa by antithrombin III (AT). ...

journal_title：British journal of pharmacology

authors： Kindness G,Long WF,Williamson FB

更新日期：1980-04-01 00:00:00

abstract：:Recent evidence has indicated that the mitogen platelet-derived growth factor (PDGF) can act acutely to regulate arterial tone. In this study we demonstrate that the BB isoform of PDGF (PDGF-BB) can cause endothelium-independent relaxation of rabbit isolated mesenteric arteries. In endothelium-denuded arteries, PDGF-B...

journal_title：British journal of pharmacology

authors： Yamawaki H,Sato K,Hori M,Ozaki H,Karaki H

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuropeptides are involved in the regulation of food intake in the central nervous system, but they might also act on peripheral fat tissue via neuropeptide receptors. EXPERIMENTAL APPROACH:We investigated the receptor expression and activity of pituitary adenylate cyclase-activating polypeptide...

journal_title：British journal of pharmacology

authors： Gericke MT,Kosacka J,Koch D,Nowicki M,Schröder T,Ricken AM,Nieber K,Spanel-Borowski K

更新日期：2009-06-01 00:00:00

abstract：:1. In the present work, we have studied the expression of Fos during acute and chronic administration of the kappa-opioid receptor agonist U-50488H and after U-5088H withdrawal in the rat hypothalamic paraventricular nucleus (PVN). Fos production was also studied in brainstem regions that innervate the PVN: the A(2) c...

journal_title：British journal of pharmacology

authors： Laorden ML,Castells MT,Milanés MV

更新日期：2003-04-01 00:00:00

abstract：:To establish that bradykinin is formed in the heart we measured bradykinin in the venous effluent from rat isolated hearts perfused with Krebs-Henseleit buffer. In addition, we examined the effect on bradykinin outflow of the angiotensin converting enzyme (ACE) inhibitor, ramiprilat. From rat isolated normoxic hearts ...

journal_title：British journal of pharmacology

authors： Baumgarten CR,Linz W,Kunkel G,Schölkens BA,Wiemer G

更新日期：1993-02-01 00:00:00

abstract：:1 The actions of 5-methoxytryptamine (5-MeOT), N,N-dimethyltryptamine (DMT), 5-hydroxy-N,N-dimethyltryptamine (bufotenine, 5-HODMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), and their interactions with 5-hydroxytryptamine (5-HT), acetylcholine, (-)-noradrenaline, and glutamate were studied by microiontophoresis...

journal_title：British journal of pharmacology

authors： Bradley PB,Briggs I

更新日期：1974-03-01 00:00:00

abstract：:1. Although extensively investigated, the extent of differences between receptors mediating negative inotropic and chronotropic responses is still unclear. In the present study atrial and intestinal muscarinic receptors were identified by [3H]-N-methyl-scopolamine ([3H]-NMS) binding and the affinities of some presumab...

journal_title：British journal of pharmacology

authors： Brunner F

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We previously reported that NCX 2057, a compound comprising a nitric oxide (NO)-releasing moiety and the natural antioxidant, ferulic acid (FA), inhibits pro-inflammatory mediators through NO-mediated gene regulation. Here, we have assessed the activities of NCX 2057 in models of inflammatory and...

journal_title：British journal of pharmacology

authors： Ronchetti D,Borghi V,Gaitan G,Herrero JF,Impagnatiello F

更新日期：2009-09-01 00:00:00

abstract：:1. We have shown earlier that pilocarpine strongly inhibits mouse and human liver coumarin 7-hydroxylase activity of CYP 2A and pentoxyresorufin O-deethylase activity of CYP 2B in vitro. Since pilocarpine, like coumarin, contains a lactone structure we have studied in more detail its inhibitory potency on mouse and hu...

journal_title：British journal of pharmacology

authors： Kinonen T,Pasanen M,Gynther J,Poso A,Järvinen T,Alhava E,Juvonen RO

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mitochondria possess their own source of cAMP, that is, soluble adenylyl cyclase (sAC). Activation or expression of mitochondrial sAC promotes mitochondrial function. Oestrogen receptor signalling plays an essential role in the regulation of mitochondrial function. Here we aimed to determine whet...

journal_title：British journal of pharmacology

authors： Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

更新日期：2018-10-01 00:00:00

abstract：:1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole ...

journal_title：British journal of pharmacology

authors： Sayer TJ,Hannon SD,Redfern PH,Martin KF

更新日期：1999-04-01 00:00:00