Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats.

abstract：:In addition to their classical known effects, such as analgesia, impairment of cognition and learning and appetite enhancement, cannabinoids have also been related to the regulation of cardiovascular responses and implicated in cardiovascular pathology. Elevated levels of endocannabinoids have been related to the extr...

journal_title：British journal of pharmacology

authors： Mendizábal VE,Adler-Graschinsky E

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and atherosclerosis. Consequently, antagonists of CXCR3 are of therapeutic interest. In this study, we set out to characterize binding sites of the specific low MW CXCR3 antagoni...

journal_title：British journal of pharmacology

authors： Nedjai B,Viney JM,Li H,Hull C,Anderson CA,Horie T,Horuk R,Vaidehi N,Pease JE

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tobacco smoke represents a relevant risk factor for coronary heart disease (CHD). Although peroxisome proliferator-activated receptor (PPAR)gamma activation reduces inflammation and atherosclerosis, expression of PPARgamma in cells and its modulation by smoking are poorly investigated. We previou...

journal_title：British journal of pharmacology

authors： Amoruso A,Gunella G,Rondano E,Bardelli C,Fresu LG,Ferrero V,Ribichini F,Vassanelli C,Brunelleschi S

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH:A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain librar...

journal_title：British journal of pharmacology

authors： Fonfria E,Clay WC,Levy DS,Goodwin JA,Roman S,Smith GD,Condreay JP,Michel AD

更新日期：2008-02-01 00:00:00

abstract：:1 The cardiovascular effects of the anthelmintic drug diethylcarbamazine citrate (DECC) were examined in cats anaesthetized with pentobarbitone. There were two quite distinct haemodynamic responses, an initial transient hypotension (occurring within 10 s of an intravenous injection) and a pronounced secondary hyperten...

journal_title：British journal of pharmacology

authors： Abaitey AK,Parratt JR

更新日期：1976-02-01 00:00:00

abstract：:1. By use of the whole-cell configuration of the patch-clamp technique, membrane currents induced by cyclopiazonic acid (CPA; an inhibitor of the sarcoplasmic reticulum (SR) calcium-ATPase) were investigated in single smooth muscle cells freshly dispersed from the mouse anococcygeus. Voltage-dependent calcium currents...

journal_title：British journal of pharmacology

authors： Wayman CP,McFadzean I,Gibson A,Tucker JF

更新日期：1996-02-01 00:00:00

abstract：:1. This study examined the impact of allopurinol on the renal functional responses to a 30 min period of ischaemia in anaesthetized rats. 2. Immediately on reperfusion, blood pressure rose transiently, while renal blood flow remained stable throughout at control values. Glomerular filtration rate was decreased by some...

journal_title：British journal of pharmacology

authors： Hestin D,Johns EJ

更新日期：1999-09-01 00:00:00

abstract：:5-Hydroxytryptamine(1B/1D) (5-HT(1B/1D)) receptor coupling to contraction was investigated in endothelium-denuded rabbit isolated renal arteries, by simultaneously measuring tension and intracellular [Ca(2+)], and tension in permeabilized smooth muscle cells. In intact arterial segments, 1 nM - 10 microM 5-HT failed t...

journal_title：British journal of pharmacology

authors： Hill PB,Dora KA,Hughes AD,Garland CJ

更新日期：2000-06-01 00:00:00

abstract：:The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many normal physiological functions and the pathophysiology of several diseases. Since the discovery and introduction of sildenafil, inhibitors of PDE5 have been the first-line therapy for erectile dysfunction (ED). The success of si...

journal_title：British journal of pharmacology

authors： Andersson KE

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ca(2+)-dependent Cl(-) secretion (CaCC) in airways and other tissues is due to activation of the Cl(-) channel TMEM16A (anoctamin 1). Earlier studies suggested that Ca(2+) -activated Cl(-) channels are regulated by membrane lipid inositol phosphates, and that 1-O-octyl-2-O-butyryl-myo-inositol 3,...

journal_title：British journal of pharmacology

authors： Tian Y,Schreiber R,Wanitchakool P,Kongsuphol P,Sousa M,Uliyakina I,Palma M,Faria D,Traynor-Kaplan AE,Fragata JI,Amaral MD,Kunzelmann K

更新日期：2013-01-01 00:00:00

abstract：:1 The relationship of agonist efficacy to the rate of G protein-coupled receptor signaling desensitization is controversial. 2 Expressing inwardly rectifying potassium channels (GIRKs) in Xenopus oocytes, we have devised a signaling assay that clearly identifies CB1 cannabinoid receptor agonists with low intrinsic eff...

journal_title：British journal of pharmacology

authors： Luk T,Jin W,Zvonok A,Lu D,Lin XZ,Chavkin C,Makriyannis A,Mackie K

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:(-)-Englerin A (EA) is a potent cytotoxic agent against renal carcinoma cells. It achieves its effects by activation of transient receptor potential canonical (TRPC)4/TRPC1 heteromeric channels. It is also an agonist at channels formed by the related protein, TRPC5. Here, we sought an EA analogue...

journal_title：British journal of pharmacology

authors： Rubaiy HN,Seitz T,Hahn S,Choidas A,Habenberger P,Klebl B,Dinkel K,Nussbaumer P,Waldmann H,Christmann M,Beech DJ

更新日期：2018-03-01 00:00:00

abstract：:1. Endothelial cell damage in glomeruli and kidney arterioles appears to play a pivotal role in glomerular inflammatory diseases. Glomerular endothelial cells, a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration, die by apoptosis in response to tumour necrosis factor-alpha (T...

journal_title：British journal of pharmacology

authors： Messmer UK,Winkel G,Briner VA,Pfeilschifter J

更新日期：1999-08-01 00:00:00

abstract：:We utilized a rat model of myocardial infarction to investigate whether manganese superoxide dismutase (Mn-SOD), an intrinsic radical scavenger, and tumour necrosis factor- alpha (TNF-alpha) and/or interleukin-1beta (IL-1beta) are involved in the late phase of ischaemic preconditioning (IP). IP was induced in anaesthe...

journal_title：British journal of pharmacology

authors： Yamashita N,Hoshida S,Otsu K,Taniguchi N,Kuzuya T,Hori M

更新日期：2000-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to atrophy and paralysis of voluntary muscles responsible for motion and breathing. Except for a minority of patients harbouring genetic mutatio...

journal_title：British journal of pharmacology

authors： Manzano R,Toivonen JM,Moreno-Martínez L,de la Torre M,Moreno-García L,López-Royo T,Molina N,Zaragoza P,Calvo AC,Osta R

更新日期：2020-09-28 00:00:00

abstract：:1. Leptin, a pleiotropic hormone believed to regulate body weight, has recently been associated with inflammatory states and immune activity. Here we have studied the effect of leptin on expression of IFN-gamma-induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage act...

journal_title：British journal of pharmacology

authors： Raso GM,Pacilio M,Esposito E,Coppola A,Di Carlo R,Meli R

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:GoSlo-SR compounds are efficacious BK (KCa 1.1) channel openers, but little is known about their mechanism of action or effect on bladder contractility. We examined the effects of two closely related compounds on BK currents and bladder contractions. EXPERIMENTAL APPROACH:A combination of electr...

journal_title：British journal of pharmacology

authors： Large RJ,Kshatri A,Webb TI,Roy S,Akande A,Bradley E,Sergeant GP,Thornbury KD,McHale NG,Hollywood MA

更新日期：2015-05-01 00:00:00

abstract：:1. [3H]-ouabain uptake in resting guinea-pig papillary muscles depended directly on incubation time and inversely with muscle radius. The equivalence of both parameters support the relevance of diffusion. A particular mechanism of receptor-controlled diffusion was implicated by the saturation of initial rates of uptak...

journal_title：British journal of pharmacology

authors： Ebner F,Siegl H

更新日期：1988-10-01 00:00:00

abstract：:1. Effects of phorbol esters on the cytosolic Ca2+ level ([Ca2+]i) and muscle tension in the intestinal smooth muscle of guinea-pig taenia caeci were examined. 2. 12-Deoxyphorbol 13-isobutyrate (DPB, 1 microM) did not change the [Ca2+]i and tension in resting muscle. 3. In high K(+)-stimulated muscle, 1 microM DPB tra...

journal_title：British journal of pharmacology

authors： Mitsui M,Karaki H

更新日期：1993-05-01 00:00:00

abstract：:1. We studied the lactotroph cells of the rat by both in vivo and in vitro pharmacological techniques for the presence of D1-receptors. Both approaches revealed the presence of D2-receptor, stimulated by quinpirole (resulting in an inhibition of prolactin secretion) and blocked by domperidone. 2. Administration of fen...

journal_title：British journal of pharmacology

authors： Schoors DF,Vauquelin GP,De Vos H,Smets G,Velkeniers B,Vanhaelst L,Dupont AG

更新日期：1991-08-01 00:00:00

abstract：:1. This study describes attempts to compare prostacyclin (IP-) receptors in human, pig, horse, rabbit and rat platelets and in circular muscle of human, rabbit and dog mesenteric and pig gastroepiploic arteries. Three stable prostacyclin analogues, iloprost, cicaprost and 6a-carba-prostacyclin (6a-carba-PGI2) and a pr...

journal_title：British journal of pharmacology

authors： Armstrong RA,Lawrence RA,Jones RL,Wilson NH,Collier A

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While remifentanil can be used either during labour or fetal surgery, more should be known about the transplacental transfer of this opioid. The aim of this study was to investigate the placental transfer and haemodynamic effects of remifentanil after i.v. administration to pregnant ewes. EXPERI...

journal_title：British journal of pharmacology

authors： Coonen JB,Marcus MA,Joosten EA,van Kleef M,Neef C,van Aken H,Gogarten W

更新日期：2010-12-01 00:00:00

abstract：:1. The present study was designed to evaluate the nature of intervening agents in L-DOPA- and dopamine-induced neurotoxicity in Neuro-2A cells. 2. In the absence of cells and in conditions of light protection, at 37 degrees C, L-DOPA or dopamine (1 mM) in culture medium degraded spontaneously in a time-dependent manne...

journal_title：British journal of pharmacology

authors： Pedrosa R,Soares-da-Silva P

更新日期：2002-12-01 00:00:00

abstract：:The cardiotoxic effects of fenfluramine hydrochloride on mechanical and electrical activity were studied in papillary muscles, Purkinje fibres, left atria and ventricular myocytes of guinea-pigs. Force of contraction (f(c)) was measured isometrically, action potentials and maximum rate of rise of the action potential ...

journal_title：British journal of pharmacology

authors： Rajamani S,Studenik C,Lemmens-Gruber R,Heistracher P

更新日期：2000-03-01 00:00:00

abstract：:Using an in vitro mouse cerebellar slice preparation and whole-cell electrophysiological recording techniques we have characterized Purkinje and basket cell inhibitory post-synaptic currents (IPSCs), and examined the effects of a number of selective peptidergic K+ channel blockers. Spontaneous IPSC amplitude ranged fr...

journal_title：British journal of pharmacology

authors： Southan AP,Robertson B

更新日期：1998-11-01 00:00:00

abstract：:1. Systemic infusion of neuropeptide Y (NPY) reduces renal blood flow and can concomitantly increase diuresis, natriuresis and calciuresis in anaesthetized rats. The present study was designed to investigate whether the apparently contradictory NPY effects on renal blood flow and urine formation and composition are me...

journal_title：British journal of pharmacology

authors： Bischoff A,Avramidis P,Erdbrügger W,Münter K,Michel MC

更新日期：1997-04-01 00:00:00

abstract：:1. Histamine and carbachol produced concentration-related increases in the accumulation of 3H-inositol phosphates in slices of bovine tracheal smooth muscle. 2. Noradrenaline alone produced a small stimulation of 3H-inositol phosphate accumulation which was inhibited by the alpha-adrenoceptor antagonist phentolamine. ...

journal_title：British journal of pharmacology

authors： Hall IP,Hill SJ

更新日期：1988-12-01 00:00:00

abstract：:Allergic inflammatory responses contribute to the symptoms of a number of diseases including atopic dermatitis, asthma and rhinitis. Cationic proteins are released from inflammatory cells and levels are known to be raised in disease states. Using an in vivo model of acute inflammation, we investigated the characterist...

journal_title：British journal of pharmacology

authors： Jones H,Paul W,Page CP

更新日期：2001-08-01 00:00:00

abstract：:1. The effects of drugs and altering stimulus parameters on neurogenic responses to electrical field stimulation (EFS) have been investigated in distal and proximal portions of the guinea-pig trachea. 2. In the presence of indomethacin (3 microM) and propranolol (1 microM) two contractile phases were evident in both t...

journal_title：British journal of pharmacology

authors： Ellis JL,Undem BJ

更新日期：1990-12-01 00:00:00

abstract：:The arterial endothelium critically contributes to blood pressure control by releasing vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed 'endothelium-derived hyperpolarizing factor' (EDHF). The nature of EDHF and EDHF-signalling pathways is not fully understood yet. However...

journal_title：British journal of pharmacology

authors： Grgic I,Kaistha BP,Hoyer J,Köhler R

更新日期：2009-06-01 00:00:00