The involvement of cytokines in the second window of ischaemic preconditioning.

abstract：:Lignocaine suppresses insulin-stimulated glucose transport into the cells and insulin-stimulated glycogenesis at doses equivalent to that used in the treatment of muscle pain disorder. We evaluated the direct effect of lignocaine on insulin receptor (IR) kinase activity. After lignocaine (40 mM, approximately equivale...

journal_title：British journal of pharmacology

authors： Hirose M,Martyn JA,Kuroda Y,Marunaka Y,Tanaka Y

更新日期：2002-05-01 00:00:00

abstract：:The tachykinin, neurokinin A (NKA), contracts guinea-pig airways both in vitro and in vivo, preferentially activating smooth muscle NK(2) receptors, although smooth muscle NK(1) receptors may also contribute. In vitro evidence suggests that NKA activates epithelial NK(1) receptors, inducing the release of nitric oxide...

journal_title：British journal of pharmacology

authors： Ricciardolo FL,Trevisani M,Geppetti P,Nadel JA,Amadesi S,Bertrand C

更新日期：2000-03-01 00:00:00

abstract：:1. Human formyl peptide-receptor-like-1 (FPRL-1) is a promiscuous G protein-coupled receptor (GPCR), and belongs to a chemoattractant receptor family protein. This receptor has been reported to interact with various host-derived peptides and lipids involved in inflammatory responses. We described here, a novel role fo...

journal_title：British journal of pharmacology

authors： Elagoz A,Henderson D,Babu PS,Salter S,Grahames C,Bowers L,Roy MO,Laplante P,Grazzini E,Ahmad S,Lembo PM

更新日期：2004-01-01 00:00:00

abstract：:1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 ...

journal_title：British journal of pharmacology

authors： Liang Y,Li C,Guzman VM,Chang WW,Evinger AJ,Pablo JV,Woodward DF

更新日期：2004-06-01 00:00:00

abstract：:1 Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by strand breaks in DNA, which are caused by reactive oxygen species (ROS). Here we investigate the effects of the PARS inhibitors 3-aminobenzamide (3-AB), nicotinamide and 1,5-dihydroxyisoquinoline (ISO) on the circulatory failure and the organ injur...

journal_title：British journal of pharmacology

authors： McDonald MC,Filipe HM,Thiemermann C

更新日期：1999-11-01 00:00:00

abstract：:Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. [(3)H]-SB-269970 (1 nM) showed full association with h5-HT(7(a...

journal_title：British journal of pharmacology

authors： Thomas DR,Atkinson PJ,Ho M,Bromidge SM,Lovell PJ,Villani AJ,Hagan JJ,Middlemiss DN,Price GW

更新日期：2000-05-01 00:00:00

abstract：:1. Salmeterol, a novel, long-acting beta-adrenoceptor agonist, has been compared with isoprenaline and salbutamol for activity in vitro on a range of beta-adrenoceptor containing preparations from laboratory animals and man, and in vivo for bronchodilator activity in the conscious guinea-pig. 2. Salmeterol, like isopr...

journal_title：British journal of pharmacology

authors： Ball DI,Brittain RT,Coleman RA,Denyer LH,Jack D,Johnson M,Lunts LH,Nials AT,Sheldrick KE,Skidmore IF

更新日期：1991-11-01 00:00:00

abstract：:ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, were evaluated with a fibroblastic cell line from bovine embryonic trachea (EBTr) which specifically responds to prostaglandin D2 (PGD2). ZK110841, equipotent to PGD2, elevated the adenosine 3':5'-cyclic monophosphate (...

journal_title：British journal of pharmacology

authors： Ito S,Okuda E,Sugama K,Negishi M,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Peptides from venomous animals have long been important for understanding pain mechanisms and for the discovery of pain treatments. Here, we hypothesized that Phα1β, a peptide from the venom of the armed spider Phoneutria nigriventer, produces analgesia by blocking the TRPA1 channel. EXPERIMENTA...

journal_title：British journal of pharmacology

authors： Tonello R,Fusi C,Materazzi S,Marone IM,De Logu F,Benemei S,Gonçalves MC,Coppi E,Castro-Junior CJ,Gomez MV,Geppetti P,Ferreira J,Nassini R

更新日期：2017-01-01 00:00:00

abstract：:Bovine culture endothelial cells (BAECs) generate platelet-activating factor (Paf) following activation by bradykinin (Bk 0.1 nM), the ionophore, A23187 (3 microM), and ATP (10 microM), but Paf is not released from the cells. These stimuli also elicit generation of prostacyclin (PGI2). The specific and competitive Paf...

journal_title：British journal of pharmacology

authors： Stewart AG,Dubbin PN,Harris T,Dusting GJ

更新日期：1989-03-01 00:00:00

abstract：:1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was no...

journal_title：British journal of pharmacology

authors： Angerio AD,Fitzpatrick TM,Kot PA,Ramwell PW,Rose JC

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Methylene blue (MB) is commonly employed as a treatment for methaemoglobinaemia, malaria and vasoplegic shock. An increasing number of studies indicate that MB can cause 5-HT toxicity when administered with a 5-HT reuptake inhibitor. MB is a potent inhibitor of monoamine oxidases, but other targe...

journal_title：British journal of pharmacology

authors： Oz M,Isaev D,Lorke DE,Hasan M,Petroianu G,Shippenberg TS

更新日期：2012-05-01 00:00:00

abstract：:1. Some hydroxy-, amino-, and methoxy- phenylalkyltrimethylammonium compounds, beta-pyridylmethyl- dimethylamine and pyrrolidine, and beta-pyridylethyltrimethylammonium, were tested on avoidance learning in mice and their effects were compared with those of (-)-nicotine.2. The o- and m- hydroxybenzyl-, o-hydroxyphenet...

journal_title：British journal of pharmacology

authors： Barlow RB,Oliverio A,Satta M,Thompson GM

更新日期：1970-07-01 00:00:00

abstract：:1. Receptor phosphorylation and down-regulation by protein kinases may be a key event initiating desensitization. The present studies were designed to investigate the effect of a potent protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), on antinociception induced by intrathecal (i.t.) administration of...

journal_title：British journal of pharmacology

authors： Narita M,Mizoguchi H,Kampine JP,Tseng LF

更新日期：1996-08-01 00:00:00

abstract：:The novel urotensin-II (U-II) receptor (UT) ligand, [Pen(5),DTrp(7),Dab(8)]U-II(4-11) (UFP-803), was pharmacologically evaluated and compared with urantide in in vitro and in vivo assays. In the rat isolated aorta, UFP-803 was inactive alone but, concentration dependently, displaced the contractile response to U-II to...

journal_title：British journal of pharmacology

authors： Camarda V,Spagnol M,Song W,Vergura R,Roth AL,Thompson JP,Rowbotham DJ,Guerrini R,Marzola E,Salvadori S,Cavanni P,Regoli D,Douglas SA,Lambert DG,Calò G

更新日期：2006-01-01 00:00:00

abstract：:1. This study describes attempts to compare prostacyclin (IP-) receptors in human, pig, horse, rabbit and rat platelets and in circular muscle of human, rabbit and dog mesenteric and pig gastroepiploic arteries. Three stable prostacyclin analogues, iloprost, cicaprost and 6a-carba-prostacyclin (6a-carba-PGI2) and a pr...

journal_title：British journal of pharmacology

authors： Armstrong RA,Lawrence RA,Jones RL,Wilson NH,Collier A

更新日期：1989-07-01 00:00:00

abstract：:1. We have characterized the 5-hydroxytryptamine (5-HT)-induced calcium signalling in endothelial cells from the human pulmonary artery. Using RT-PCR we show, that of all cloned G-protein coupled 5-HT receptors, these cells express only 5-HT1D beta, 5-HT2B and little 5-HT4 receptor mRNA. 2. In endothelial cells 5-HT i...

journal_title：British journal of pharmacology

authors： Ullmer C,Boddeke HG,Schmuck K,Lübbert H

更新日期：1996-03-01 00:00:00

abstract：:1. In the present paper, we describe the in vitro pharmacological properties of LF 16.0335 (1-[[3-[(2,4-dimethylquinolin-8-yl)oxymethyl]-2,4-dichloro-p henyl]sulphonyl] -2(S) - [[4 -[4-(aminoiminomethyl)phenylcarbonyl]piperazin-1-yl]ca rbonyl]pyrrolidine), a novel and potent nonpeptide antagonist of the human bradykin...

journal_title：British journal of pharmacology

authors： Pruneau D,Luccarini JM,Fouchet C,Defrêne E,Franck RM,Loillier B,Duclos H,Robert C,Cremers B,Bélichard P,Paquet JL

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates. We therefore sought to support the hypothesis that bioactivation by ALDH-2 cri...

journal_title：British journal of pharmacology

authors： Wenzel P,Hink U,Oelze M,Seeling A,Isse T,Bruns K,Steinhoff L,Brandt M,Kleschyov AL,Schulz E,Lange K,Weiner H,Lehmann J,Lackner KJ,Kawamoto T,Münzel T,Daiber A

更新日期：2007-02-01 00:00:00

abstract：:1. Using a guinea-pig model of allergic asthma, we investigated the role of L-arginine limitation in the allergen-induced deficiency of nitric oxide (NO) and airway hyperreactivity (AHR) after the early asthmatic reaction, by examining the effects of various concentrations of the NO synthase (NOS) substrate on the res...

journal_title：British journal of pharmacology

authors： Boer J,Duyvendak M,Schuurman FE,Pouw FM,Zaagsma J,Meurs H

更新日期：1999-11-01 00:00:00

abstract：:The ability of gamma-aminobutyric acid (GABA) to affect the release of [3H]-dopamine in rat brain synaptosomes prepared from corpus striatum, frontal cortex and hypothalamus and prelabelled with the radioactive catecholamine in the presence of desipramine was examined. GABA (10-300 microM) increased in a concentration...

journal_title：British journal of pharmacology

authors： Bonanno G,Raiteri M

更新日期：1987-05-01 00:00:00

abstract：:1. The effect of synthetic tachykinin selective receptor agonists was studied on the growth of cultured human skin fibroblasts (HF). 2. Human fibroblasts were grown in serum-free conditions in the presence of natural tachykinins (substance P and neurokinin A) and of three synthetic agonists, [beta-Ala4, Sar9, Met(O2)1...

journal_title：British journal of pharmacology

authors： Ziche M,Morbidelli L,Pacini M,Dolara P,Maggi CA

更新日期：1990-05-01 00:00:00

abstract：:1. The possibility that a purine nucleotide is involved in excitatory transmission to the urinary bladder has been tested. All the purine compounds tested which contained a pyrophosphate bond produced contraction, adenosine triphosphate (ATP) being the most potent. Adenosine and adenosine monophosphate caused relaxati...

journal_title：British journal of pharmacology

authors： Burnstock G,Dumsday B,Smythe A

更新日期：1972-03-01 00:00:00

abstract：:1. Experiments were performed with peptidase inhibitors on rabbit aortic strip preparations, to determine whether endogenous peptidase activity can influence the potency estimates for angiotensin receptor agonists and antagonists in this tissue. 2. Angiotensin II (A II) and angiotensin III (A III) both induced concent...

journal_title：British journal of pharmacology

authors： Robertson MJ,Cunoosamy MP,Clark KL

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tumour cell migration and adhesion constitute essential features of metastasis. G-protein coupled receptor 55 (GPR55), a lysophospholipid receptor, has been shown to play an important role in carcinogenesis. Here, we investigated the involvement of GPR55 in migration and metastasis of colon cance...

journal_title：British journal of pharmacology

authors： Kargl J,Andersen L,Hasenöhrl C,Feuersinger D,Stančić A,Fauland A,Magnes C,El-Heliebi A,Lax S,Uranitsch S,Haybaeck J,Heinemann A,Schicho R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiotensin AT1 receptor antagonists induce weight loss; however, the mechanism underlying this phenomenon is unknown. The Mas receptor agonist angiotensin-(1-7) is a metabolite of angiotensin I and of angiotensin II . As an agonist of Mas receptors, angiotensin-(1-7) has beneficial cardiovascula...

journal_title：British journal of pharmacology

authors： Schuchard J,Winkler M,Stölting I,Schuster F,Vogt FM,Barkhausen J,Thorns C,Santos RA,Bader M,Raasch W

更新日期：2015-08-01 00:00:00

abstract：:1. The effects of 8-bromoguanosine 3':5'-cyclic monophosphate (8-bromo-cyclic GMP) on phenylephrine-induced contractions and phosphatidylinositol (PI) hydrolysis were investigated in rat isolated caudal artery. The effects of the nucleotide were compared to those of felodipine, a dihydropyridine Ca2+ channel antagonis...

journal_title：British journal of pharmacology

authors： Lum Min SA,Tabrizchi R

更新日期：1995-09-01 00:00:00

abstract：:1. Microfluorimetry techniques with fura-2 were used to characterize the effects of efaroxan (200 microM), phenotolamine (200-500 microM) and idazoxan (200-500 microM) on the intracellular free Ca2+ concentration ([Ca2+]i) in mouse isolated islets of Langerhans. 2. The imidazoline receptor agonists efaroxan and phento...

journal_title：British journal of pharmacology

authors： Shepherd RM,Hashmi MN,Kane C,Squires PE,Dunne MJ

更新日期：1996-11-01 00:00:00

abstract：:Along with many other mammalian ATP-binding cassette (ABC) transporters, members of the ABCG group are involved in the regulated transport of hydrophobic compounds across cellular membranes. In humans, five ABCG family members have been identified, encoding proteins ranging from 638 to 678 amino acids in length. All f...

journal_title：British journal of pharmacology

authors： Kerr ID,Haider AJ,Gelissen IC

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In endothelial dysfunction, signalling by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem. The sGC activator 4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid (BAY 58-2667) is a haem-mimetic abl...

journal_title：British journal of pharmacology

authors： Hoffmann LS,Schmidt PM,Keim Y,Schaefer S,Schmidt HH,Stasch JP

更新日期：2009-07-01 00:00:00