Some central effects in mice of compounds related to nicotine.

abstract：:1 The actions of ethylenediamine (EDA) and structurally related compounds were investigated by microiontophoresis in Wistar rats. 2 EDA inhibited, via a bicuculline-sensitive mechanism, the spontaneous firing rate of all cortical and pallidal cells tested. 3 The results with the analogues suggest that two amine groups...

journal_title：British journal of pharmacology

authors： Perkins MN,Stone TW

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agmatine, a putative neurotransmitter, plays a vital role in learning and memory. Although it is considered an endogenous ligand of imidazoline receptors, agmatine exhibits high affinity for α-adrenoceptors, NOS and NMDA receptors. These substrates within the locus coeruleus (LC) are critically i...

journal_title：British journal of pharmacology

authors： Shelkar GP,Gakare SG,Chakraborty S,Dravid SM,Ugale RR

更新日期：2016-09-01 00:00:00

abstract：:The oestrogenic and antioestrogenic activities of a series of substituted derivatives of 1,1,2 triphenylbut-1-ene have been determined using primary cultures of rat pituitary gland cells to monitor prolactin synthesis in vitro. The relative binding affinity of the agonists for the oestrogen receptor was consistent wit...

journal_title：British journal of pharmacology

authors： Jordan VC,Koch R,Mittal S,Schneider MR

更新日期：1986-01-01 00:00:00

abstract：:1. The ability of the putative, selective post-junctional alpha 2-adrenoceptor antagonist, SK&F 104078 to antagonize the effects of structurally-diverse agonists at pre-junctional alpha 2-adrenoceptors in the guinea-pig ileum and rat vas deferens in vitro and in the rat heart in vivo, and at post-junctional alpha 2-ad...

journal_title：British journal of pharmacology

authors： Akers I,Coates J,Drew GM,Sullivan AT

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:During angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre-existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2 S), the newest member of the gasotransmitter family, act...

journal_title：British journal of pharmacology

authors： Abdollahi Govar A,Törő G,Szaniszlo P,Pavlidou A,Bibli SI,Thanki K,Resto VA,Chao C,Hellmich MR,Szabo C,Papapetropoulos A,Módis K

更新日期：2020-02-01 00:00:00

abstract：:Although cyclosporin (CsA) is considered to be the best immunosuppressive molecule in transplantation, it has been suspected to alter mitochondrial respiration of various tissues. We evaluated the acute effect of CsA and its vehicle on maximal oxidative capacity (V(max)) of cardiac, soleus and gastrocnemius muscles of...

journal_title：British journal of pharmacology

authors： Sanchez H,Zoll J,Bigard X,Veksler V,Mettauer B,Lampert E,Lonsdorfer J,Ventura-Clapier R

更新日期：2001-07-01 00:00:00

abstract：:1. The goal of this study was to determine if an increase in cytoplasmic calcium concentration ([Ca2+]i), in the absence of additional second messengers derived from membrane phospholipid turnover, is a sufficient signal to induce chloride secretion across monolayers of the human colonic epithelial line, T84. 2. Thaps...

journal_title：British journal of pharmacology

authors： Kachintorn U,Vajanaphanich M,Traynor-Kaplan AE,Dharmsathaphorn K,Barrett KE

更新日期：1993-06-01 00:00:00

abstract：:1. The effects of forskolin, prostaglandin E1 (PGE1), dibutyryl cyclic AMP (db cyclic AMP), dibutyryl cyclic GMP (db cyclic GMP) and 3-isobutyl-l-methyl-xanthine (IBMX) were investigated on the expression of tissue factor and thrombomodulin activities on the surface of human saphenous vein endothelial cells (HSVEC) in...

journal_title：British journal of pharmacology

authors： Archipoff G,Beretz A,Bartha K,Brisson C,de la Salle C,Froget-Léon C,Klein-Soyer C,Cazenave JP

更新日期：1993-05-01 00:00:00

abstract：:1. This study investigated whether a single administration of a range of doses (1, 4 and 8 mg kg-1, i.p.) of paroxetine, citalopram or venlafaxine may simultaneously increase extracellular levels of 5-HT ([5-HT]ext) and noradrenaline ([NA]ext) by using in vivo microdialysis in the frontal cortex (FCx) of awake, freely...

journal_title：British journal of pharmacology

authors： David DJ,Bourin M,Jego G,Przybylski C,Jolliet P,Gardier AM

更新日期：2003-11-01 00:00:00

abstract：:1. Bicyclic compounds with potential thymoleptic properties (Lu-compounds) have recently become available, and their effects on the membrane pumps of the central and peripheral monoamine neurones have now been tested and compared with those of the tricyclic antidepressant drugs.2. Biochemical and histochemical in vivo...

journal_title：British journal of pharmacology

authors： Carlsson A,Fuxe K,Hamberger B,Malmfors T

更新日期：1969-05-01 00:00:00

abstract：:1. Pithed rats were respired at a fixed rate of 54 cycles min-1 and with a ventilation volume of either 20 (control) or 10 ml kg-1. In these two preparations, the dose-response relationships for the systemic blood pressure responses to endothelin-1, administered i.v., were examined. Also, cardiac output, its distribut...

journal_title：British journal of pharmacology

authors： MacLean MR,Randall MD,Hiley CR

更新日期：1989-11-01 00:00:00

abstract：:Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age-matched men. However, women are more likely than me...

journal_title：British journal of pharmacology

authors： Taylor LE,Ramirez LA,Musall JB,Sullivan JC

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lithocholic acid (LCA), the most toxic bile acid, induces cholestatic liver injury in rodents. We previously showed that LCA activates the oxidative stress-responsive nuclear factor (erythroid-2 like), factor 2 (Nrf2) in cultured liver cells, triggering adaptive responses that reduce cell injury....

journal_title：British journal of pharmacology

authors： Tan KP,Wood GA,Yang M,Ito S

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Na+/Ca2+ exchanger (NCX) may contribute to triggered activity and transmural dispersion of repolarization, which are substrates of torsades de pointes (TdP) type arrhythmias. This study examined the effects of selective inhibition of the NCX by SEA0400 on the occurrence of dofetilide-induced ...

journal_title：British journal of pharmacology

authors： Farkas AS,Makra P,Csík N,Orosz S,Shattock MJ,Fülöp F,Forster T,Csanády M,Papp JG,Varró A,Farkas A

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:MLN4924 prevents the formation of active cullin-RING ubiquitin ligase complexes and thus inhibits NF-κB signalling. Here, we evaluated the effects of this compound on monocytes and dendritic cells (DCs). EXPERIMENTAL APPROACH:Monocytes and DCs were challenged with TNF or LPS in the presence and ...

journal_title：British journal of pharmacology

authors： El-Mesery M,Seher A,Stühmer T,Siegmund D,Wajant H

更新日期：2015-03-01 00:00:00

abstract：:1. The relaxant effects of Zeneca ZD7114, BRL37344 (putative beta 3-adrenoceptor agonists) and various phenylethylamine-based agonists were studied in isolated ileum of the rat where tone was increased with carbachol (0.5 microM). Agonist-induced relaxation.was measured under equilibrium conditions with alpha-, beta 1...

journal_title：British journal of pharmacology

authors： Growcott JW,Holloway B,Green M,Wilson C

更新日期：1993-12-01 00:00:00

abstract：:781094 (2-(2(1, 4-benzodioxanyl))-2-imidazoline hydrochloride) is a potent competitive inhibitor of the aggregatory responses of human platelets induced by adrenaline (pA2 = 7.3) and UK-14304. 781094 is a more potent inhibitor of the pro-aggregatory response to clonidine than of that to methoxamine. The alpha 2/alpha ...

journal_title：British journal of pharmacology

authors： Kerry R,Scrutton MC

更新日期：1983-06-01 00:00:00

abstract：:1. A quantitative in vitro study has been made of the actions of glyceryl trinitrate and sodium nitrite on vascular smooth muscle (dog femoral artery and saphenous vein; rat portal vein); these have been compared with the actions of papaverine, isoprenaline, salbutamol, pentaerythritol tetranitrate and trimetazidine. ...

journal_title：British journal of pharmacology

authors： Mackenzie JE,Parratt JR

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Impaired function of spinal strychnine-sensitive glycine receptors gives rise to chronic pain states and movement disorders. Therefore, increased activity of glycine receptors should help to treat such disorders. Although compounds targeting glycine receptors with a high selectivity are lacking, ...

journal_title：British journal of pharmacology

authors： Eckle VS,Grasshoff C,Mirakaj V,O'Neill PM,Berry NG,Leuwer M,Antkowiak B

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. The aim of this study was to characteri...

journal_title：British journal of pharmacology

authors： Duggett NA,Flatters SJL

更新日期：2017-12-01 00:00:00

abstract：:1. The effects of the muscarinic agonist carbachol on phosphoinositide metabolism and its relationship to alteration of intracellular calcium were examined in SK-N-SH human neuroblastoma cells. Muscarinic receptors on these cells are coupled to phospholipase C and the myo [2-3H]-inositol phosphates resulting from rece...

journal_title：British journal of pharmacology

authors： Baird JG,Lambert DG,McBain J,Nahorski SR

更新日期：1989-12-01 00:00:00

abstract：:The aim of this study was to evaluate the potency of YM-53601 ((E)-2-[2-fluoro-2-(quinuclidin-3-ylidene) ethoxy]-9H-carbazole monohydrochloride), a new inhibitor of squalene synthase, in reducing both plasma cholesterol and triglyceride levels, compared with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in...

journal_title：British journal of pharmacology

authors： Ugawa T,Kakuta H,Moritani H,Matsuda K,Ishihara T,Yamaguchi M,Naganuma S,Iizumi Y,Shikama H

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear. We investigated, in a mouse model, the effect of exercise intensity during chronic nicotine exposure on nicotine withdrawal severity, binding of α4β2*, α7 n...

journal_title：British journal of pharmacology

authors： Keyworth H,Georgiou P,Zanos P,Rueda AV,Chen Y,Kitchen I,Camarini R,Cropley M,Bailey A

更新日期：2018-06-01 00:00:00

abstract：:Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB(1) and CB(2) receptors and of endogeno...

journal_title：British journal of pharmacology

authors： Pertwee RG

更新日期：2006-01-01 00:00:00

abstract：:1. Series of analogues of acetylcholine have been prepared in which the acetyl group was replaced by phenylacetyl, cyclohexylacetyl, diphenylacetyl, dicyclohexylacetyl, (+/-)-phenylcyclohexylacetyl, benziloyl and (+/-)-phenylcyclohexylhydroxyacetyl groups and the trimethylammonium group was replaced by Me(2)EtN(+), Me...

journal_title：British journal of pharmacology

authors： Abramson FB,Barlow RB,Mustafa MG,Stephenson RP

更新日期：1969-09-01 00:00:00

abstract：:1 The responses of the smooth muscle of the capsule and blood vessels of the isolated, blood-perfused spleen of the dog to angiotensin, oxytocin and vasopressin have been investigated and compared to the actions of the catecholamines, adrenaline and noradrenaline.2 Increasing doses of each of the three polypeptides ca...

journal_title：British journal of pharmacology

authors： Davies BN,Withrington PG

更新日期：1975-06-01 00:00:00

abstract：:1. It was postulated that swelling dependent chloride channels are involved in the proton secretion of parietal cells. Since omeprazole, lansoprazole and its acid activated sulphenamide form AG2000 are structurally related to phenol derivatives known to block swelling dependent chloride channels, we set out to test, w...

journal_title：British journal of pharmacology

authors： Schmarda A,Dinkhauser P,Gschwentner M,Ritter M,Fürst J,Scandella E,Wöll E,Laich A,Rossmann H,Seidler U,Lang F,Paulmichl M

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory response and cytokine activation are markedly stimulated after myocardial infarction, and contribute to cardiac remodelling. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has pleiotropic effects on cardiac remodelling. Adenosine, released by all cell types, binds to a class of G...

journal_title：British journal of pharmacology

authors： Feng W,Song Y,Chen C,Lu ZZ,Zhang Y

更新日期：2010-04-01 00:00:00

abstract：:1. Bradykinin (BK) and Lys-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients. We hypothesized that these peptides may activate specific receptors on the ocular surface, especially the corneal epithelium (CE) and thus the CE cells may represent a potentia...

journal_title：British journal of pharmacology

authors： Wiernas TK,Griffin BW,Sharif NA

更新日期：1997-06-01 00:00:00

abstract：:The human distal gut is home to a rich and dense microbial community with representatives of all three domains of life which are intricately connected with our physiology and health. The combined genomes of these microbes, collectively called the human microbiome, vastly expand the metabolic capacities of our own geno...

journal_title：British journal of pharmacology

authors： Bik EM,Ugalde JA,Cousins J,Goddard AD,Richman J,Apte ZS

更新日期：2018-12-01 00:00:00