The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.

abstract：BACKGROUND AND PURPOSE:Melanocortins reverse circulatory shock and improve survival by counteracting the systemic inflammatory response, and through the activation of the vagus nerve-mediated cholinergic anti-inflammatory pathway. To gain insight into the potential therapeutic value of melanocortins against multiple or...

journal_title：British journal of pharmacology

authors： Bitto A,Polito F,Altavilla D,Irrera N,Giuliani D,Ottani A,Minutoli L,Spaccapelo L,Galantucci M,Lodi R,Guzzo G,Guarini S,Squadrito F

更新日期：2011-02-01 00:00:00

abstract：:1. Aqueous extracts of stratum corneum were found to cause histamine-like contractions of the guinea-pig ileum which were not antagonized by mepyramine, atropine or bromolysergic acid diethylamide.2. The compounds responsible for this contraction were isolated by chromatography and shown to be common amino acids, part...

journal_title：British journal of pharmacology

authors： Lewis GP,McMartin C,Rosenthal SR,Yates C

更新日期：1972-05-01 00:00:00

abstract：:1. Neurogenic responses to transmural electrical stimulation were examined in endothelium-denuded extrameningeal (vertebral and carotid) and intrameningeal (spinal, basilar and middle cerebral) arteries isolated from dogs. 2. In the extrameningeal arteries, transmural electrical stimulation produced a phasic contracti...

journal_title：British journal of pharmacology

authors： Kohno Y,Saito T,Saito H,Aoyama H,Nojyo Y,Kigoshi S,Muramatsu I

更新日期：1995-11-01 00:00:00

abstract：:1. The polymorphonuclear neutrophils (PMN) activation and mobilization observed in acute cerebral infarction contribute to the brain tissue damage, but PMN could also be involved in postischemic functional injury of ischemied blood vessel. 2. This study was undertaken to investigate whether pharmacological neutropenia...

journal_title：British journal of pharmacology

authors： Pétrault O,Ouk T,Gautier S,Laprais M,Gelé P,Bastide M,Bordet R

更新日期：2005-04-01 00:00:00

abstract：:Three neurotoxin homologues (CM10 and CM12 from Naja haje annulifera and S5C10 from Dendroaspis jamesoni kaimosae) and two short neurotoxins (CM14 from Naja haje annulifera and erabutoxin b from Laticauda semifasciata) were examined by circular dichroism (c.d.) and tested for neuromuscular activity on chick biventer c...

journal_title：British journal of pharmacology

authors： Harvey AL,Hider RC,Hodges SJ,Joubert FJ

更新日期：1984-07-01 00:00:00

abstract：:1 Post-tetanic potentiation (p.t.p.) of the compound action potential in the presence of hexamethonium was observed in the isolated stellate ganglion of the hamster using extracellular postganglionic recordings. 2 The magnitude of the p.t.p. was small (less than a 20% increase) in the control solution, but increased a...

journal_title：British journal of pharmacology

authors： Christ D

更新日期：1980-06-01 00:00:00

abstract：:1. The dihydropyridine calcium channel activator, Bay K 8644, is believed to increase mean arterial blood pressure in several animal models, as a result of direct activation of vascular smooth muscle cells by increasing calcium influx through the voltage-dependent calcium channels. The purpose of the current study was...

journal_title：British journal of pharmacology

authors： Moreland S,Ushay MP,Kimball SD,Powell JR,Moreland RS

更新日期：1988-04-01 00:00:00

abstract：:We synthesized a small-molecule opioid receptor-like 1 (ORL1) receptor agonist, 2-{3-[1-((1R)-acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide (W-212393), and investigated its effect on the circadian body temperature rhythm of rats. W-212393 has high affinity for ORL1 receptors i...

journal_title：British journal of pharmacology

authors： Teshima K,Minoguchi M,Tounai S,Ashimori A,Eguchi J,Allen CN,Shibata S

更新日期：2005-09-01 00:00:00

abstract：:The past two decades have seen an immense increase in our appreciation of the vast range of signalling processes and supporting machinery that occur in cells. Pivotal to this is the notion of signal compartmentalization (compartmentation). Targeting by protein domains is critical in allowing signalling complexes to be...

journal_title：British journal of pharmacology

authors： Houslay MD

更新日期：2009-09-01 00:00:00

abstract：:1. The release of prostaglandin D2 (PGD2) during immediate allergic reactions in human skin was investigated in vivo and in vitro. 2. Skin exudates were collected from abraded sites on the thigh of atopic subjects sensitive to D. pteronyssinus antigen and from non-atopic control subjects. Challenge with antigen caused...

journal_title：British journal of pharmacology

authors： Barr RM,Koro O,Francis DM,Black AK,Numata T,Greaves MW

更新日期：1988-07-01 00:00:00

abstract：:1 The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid (ETYA) on the contractile response of the transmurally stimulated rabbit portal vein were studied in vitro.2 When the veins were stimulated for 240 pulses at 1 and 2 Hz, the responses were potentiated by indomethacin and ETYA. However, responses to 4 a...

journal_title：British journal of pharmacology

authors： Greenberg R

更新日期：1974-09-01 00:00:00

abstract：:AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targ...

journal_title：British journal of pharmacology

authors： Esteban JA

更新日期：2008-03-01 00:00:00

abstract：:1 In spontaneously active Purkinje fibres of young cows the dose-response curves of the action of isoprenaline upon different electrophysiological parameters were measured.2 The increase in slope of diastolic depolarization could roughly be described by a one-for-one binding curve with a half maximum effect near 10(-8...

journal_title：British journal of pharmacology

authors： Grabowski W,Lüttgau HC,Schulze JJ

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sarcoplasmic reticulum Ca²⁺-ATPase (SERCA) plays a role in thermogenesis. The exogenous compound capsaicin increased SERCA-mediated ATP hydrolysis not coupled to Ca²⁺ transport. Here, we have sought to identify endogenous compounds that may function as SERCA uncoupling agents. EXPERIMENTAL A...

journal_title：British journal of pharmacology

authors： Mahmmoud YA,Gaster M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

journal_title：British journal of pharmacology

authors： Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

更新日期：2009-08-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is described as a mediator of diverse biological effects, and is known to produce irritation and injury in the lung following inhalation. Recently, H(2)S has been found to cause contraction in the rat urinary bladder via a neurogenic mechanism. Here, we studied whether sodium hydrogen sulfide ...

journal_title：British journal of pharmacology

authors： Trevisani M,Patacchini R,Nicoletti P,Gatti R,Gazzieri D,Lissi N,Zagli G,Creminon C,Geppetti P,Harrison S

更新日期：2005-08-01 00:00:00

abstract：:1. Histamine (2-4 micrograms kg-1 i.v.) increased airways resistance (Raw) and decreased dynamic lung compliance (Cdyn) in urethane-anaesthetized guinea-pigs. The effects on Raw were almost abolished by atropine (0.1 mg kg-1 i.v.) and reduced by vagal cooling (11-16 degrees C). 2. Histamine-induced changes in Raw and ...

journal_title：British journal of pharmacology

authors： Mitchell HW

更新日期：1988-06-01 00:00:00

abstract：:1. In the present study we have characterized the parathyroid hormone (PTH)-induced calcium signalling in 293 cells stably transfected with the human PTH receptor cDNA. In these cells, human PTH-1(1-38) strongly stimulates adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation (EC50 = 0.39 nM) but fails to activa...

journal_title：British journal of pharmacology

authors： Seuwen K,Boddeke HG

更新日期：1995-04-01 00:00:00

abstract：:BACKGROUND AND PURPOSE The transepithelial absorption of Na(+) in the lungs is crucial for the maintenance of the volume and composition of epithelial lining fluid. The regulation of Na(+) transport is essential, because hypo- or hyperabsorption of Na(+) is associated with lung diseases such as pulmonary oedema or cys...

journal_title：British journal of pharmacology

authors： Althaus M,Urness KD,Clauss WG,Baines DL,Fronius M

更新日期：2012-07-01 00:00:00

abstract：:1. We aimed to determine whether there are any changes in responsiveness of the mesenteric arterial beds to phenylephrine (Phe) and KCl in exercise-trained rats, and whether vascular endothelium and/or vascular smooth muscle play a role in these changes. 2. Adult male rats were subjected to a swimming schedule every d...

journal_title：British journal of pharmacology

authors： Jansakul C,Hirunpan P

更新日期：1999-08-01 00:00:00

abstract：:1,2,3,4-Tetrahydro-9-aminoacridine (THA) has an inhibitory effect on the activity of acetylcholinesterase which has led to its use in the treatment of Alzheimer's disease. Other actions of THA include the inhibition of voltage-dependent ion channels. In this paper we describe the effect of THA on the depolarization-in...

journal_title：British journal of pharmacology

authors： de Belleroche J,Gardiner IM

更新日期：1988-08-01 00:00:00

abstract：:Adenosine alone at 0.1 and 1.0 mg per tracheal segment stimulated mucus secretion by 52% and 88%, respectively, compared to baseline (P less than 0.0001). The site of the potent secretagogue effect of adenosine in canine trachea was consistent with A2 activation. A2 site activation and enhanced secretion were also ind...

journal_title：British journal of pharmacology

authors： Johnson HG,McNee ML

更新日期：1985-09-01 00:00:00

abstract：:1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When gluca...

journal_title：British journal of pharmacology

authors： Garcia Leme J,Morato M,Souza MZ

更新日期：1975-09-01 00:00:00

abstract：:1 The actions of parathyroid hormone (PTH) are antagonized in vitro by the peptide [Nle-8, Nle-18, Tyr-34]-bPTH-(3-34)amide, an analogue of PTH. In this paper, the actions of the inhibitory peptide were investigated in vivo. 2 Native parathyroid hormone (bPTH-(1-84)), administered i.v. (0.17-1.51 nmol in volume of 0.3...

journal_title：British journal of pharmacology

authors： Gray DA,Parsons JA,Potts JT Jr,Rosenblatt M,Stevenson RW

更新日期：1982-06-01 00:00:00

abstract：:1. The affinity of the alpha 1-adrenoceptor antagonist SB 216469 (also known as REC 15/2739) has been determined at native and cloned alpha 1-adrenoceptor subtypes by radioligand binding and at functional alpha 1-adrenoceptor subtypes in isolated tissues. 2. In radioligand binding studies with [3H]-prazosin, SB 216469...

journal_title：British journal of pharmacology

authors： Chess-Williams R,Chapple CR,Verfurth F,Noble AJ,Couldwell CJ,Michel MC

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The locus coeruleus (LC) is a major source of noradrenergic projections to the dorsal spinal cord, and thereby plays an important role in the modulation of nociceptive information. The LC receives inputs from substance P (SP)-containing fibres from other regions, and expresses the NK(1) tachykin...

journal_title：British journal of pharmacology

authors： Muto Y,Sakai A,Sakamoto A,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:Knock-out (KO) mouse technology has given pharmacologists a powerful tool to study function in the absence of selective antagonists or inhibitors. Such KO technology can confirm predicted function, serendipitously reveal unrecognized function, or help define the mode of action of a drug. In this issue, Liles et al. de...

journal_title：British journal of pharmacology

authors： Docherty JR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibitory junction potentials (IJP) are responsible for smooth muscle relaxation in the gastrointestinal tract. The aim of this study was to pharmacologically characterize the neurotransmitters [nitric oxide (NO) and adenosine triphosphate (ATP)] and receptors involved at the inhibitory neuromus...

journal_title：British journal of pharmacology

authors： Grasa L,Gil V,Gallego D,Martín MT,Jiménez M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Azithromycin has been reported to modify activation of macrophages towards the M2 phenotype. Here, we have sought to identify the mechanisms underlying this modulatory effect of azithromycin on human monocytes, classically activated in vitro. EXPERIMENTAL APPROACH:Human blood monocytes were prim...

journal_title：British journal of pharmacology

authors： Vrančić M,Banjanac M,Nujić K,Bosnar M,Murati T,Munić V,Stupin Polančec D,Belamarić D,Parnham MJ,Eraković Haber V

更新日期：2012-03-01 00:00:00

abstract：:1 Noradrenaline and clonidine were applied by microiontophoresis to single neurones in the cerebral cortex and medullary reticular formation of anaesthetized rats.2 Of a total of 247 neurones studied, 79% of medullary units and 60% of cortical units responded in the same manner to both noradrenaline and clonidine. The...

journal_title：British journal of pharmacology

authors： Anderson C,Stone TW

更新日期：1974-07-01 00:00:00