Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways.

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective death of upper and lower motor neurons which ultimately leads to paralysis and ultimately death. Pathological changes in ALS are closely associated with pronounced and progressive changes in mitochondrial mor...

journal_title：British journal of pharmacology

authors： Muyderman H,Chen T

更新日期：2014-04-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory disease affecting 1-3% of the general population. Among psoriatic patients, 5-40% are affected by psoriatic arthritis. Due to the chronic nature of the disease, patients suffer from substantial psychological and financial burdens, thus adding to a significantly impaired quality of l...

journal_title：British journal of pharmacology

authors： Weger W

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calcitonin gene-related peptide (CGRP) is a potent vasodilator, implicated in the pathogenesis of migraine. CGRP activates a receptor complex comprising, calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). In vitro studies indicate recycling of CLR●RAMP1 is ...

journal_title：British journal of pharmacology

authors： McNeish AJ,Roux BT,Aylett SB,Van Den Brink AM,Cottrell GS

更新日期：2012-12-01 00:00:00

abstract：:The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand propert...

journal_title：British journal of pharmacology

authors： Alexander SP,Peters JA,Kelly E,Marrion N,Benson HE,Faccenda E,Pawson AJ,Sharman JL,Southan C,Davies JA,CGTP Collaborators.

更新日期：2015-12-01 00:00:00

abstract：:1. Phenylephrine-induced contractions of rabbit isolated trigone and urethra were antagonized in a competitive manner by alfuzosin (pA2 7.44 and 7.30, respectively) and prazosin. 2. The characteristics of [3H]-prazosin binding to human prostatic adenoma tissue were evaluated. [3H]-prazosin was potently displaced by al...

journal_title：British journal of pharmacology

authors： Lefèvre-Borg F,O'Connor SE,Schoemaker H,Hicks PE,Lechaire J,Gautier E,Pierre F,Pimoule C,Manoury P,Langer SZ

更新日期：1993-08-01 00:00:00

abstract：:1. The aim of the present study was to examine whether ramipril induces delayed myocardial protection against free radical injuries ex vivo and to determine the possible role of the bradykinin B2-nitric oxide (NO) pathway, prostaglandins(PGs) and protein synthesis in this delayed adaptive response. 2. Rats were pretre...

journal_title：British journal of pharmacology

authors： Jin ZQ,Chen X

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Airway hyperresponsiveness (AHR) is a central abnormality in asthma. IL-5 may modulate AHR in animal models of asthma, but the available data is inconsistent on the impact of targeting IL-5 pathway against AHR. The difference between targeting IL-5 or the IL-5 receptor, α subunit (IL-5Rα) in modu...

journal_title：British journal of pharmacology

authors： Calzetta L,Ritondo BL,Matera MG,Facciolo F,Rogliani P

更新日期：2020-10-01 00:00:00

abstract：:A hallmark of heart failure is mitochondrial dysfunction leading to a bioenergetics imbalance in the myocardium. Consequently, there is much interest in targeting mitochondrial abnormalities to attenuate the pathogenesis of heart failure. This review discusses (i) how electron microscopy (EM) techniques have been fund...

journal_title：British journal of pharmacology

authors： Daghistani HM,Rajab BS,Kitmitto A

更新日期：2019-11-01 00:00:00

abstract：:1 Sheep were injected with either methotrexate or melphalan in an attempt to lower the numbers of neutrophil granulocytes in peripheral blood. 2 Methotrexate, 5.0 mg/kg intravenously, on three consecutive days, produced no noticeable clinical or haematological changes. 3 A single dose of melphalan, 1.0 mg/kg intraveno...

journal_title：British journal of pharmacology

authors： Greenwood B,Kerry PJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro. EXPERIMENTAL APPROACH:We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4-APB, 7-APB, 5-EAPB and ...

journal_title：British journal of pharmacology

authors： Rickli A,Kopf S,Hoener MC,Liechti ME

更新日期：2015-07-01 00:00:00

abstract：:BACKGROUND AND PURPOSE Selective hyperpolarization activated, cyclic nucleotide-gated channel (HCN) blockers represent an important therapeutic goal due to the wide distribution and multiple functions of these proteins, representing the molecular correlate of f- and h-current (I(f) or I(h) ). Recently, new compounds ...

journal_title：British journal of pharmacology

authors： Del Lungo M,Melchiorre M,Guandalini L,Sartiani L,Mugelli A,Koncz I,Szel T,Varro A,Romanelli MN,Cerbai E

更新日期：2012-05-01 00:00:00

abstract：:In the present study we used a bioassay to study the effects of peroxynitrite (ONOO-) on angiotensin II (A-II)-triggered tension in isolated bovine coronary arteries in order to show the consequences of the previously reported PGI2-synthase inhibition by ONOO- in this model. The following results were obtained: 1. 1 m...

journal_title：British journal of pharmacology

authors： Zou M,Jendral M,Ullrich V

更新日期：1999-03-01 00:00:00

abstract：:1,1-Azobis[3-methyl-2-phenylbenzimidazolinium]dimethanesulphonate (AH 10407) has an ultrashort, competitive neuromuscular blocking action in the mouse, cat, dog, Cynamolgus monkey and cotton-eared marmoset. 2 AH 10407 is chemically unstable in bicarbonate-containing solutions and is degraded to inactive products. The ...

journal_title：British journal of pharmacology

authors： Brittain RT,Jack D,Tyers MB

更新日期：1977-09-01 00:00:00

abstract：:1. The pharmacological characteristics of alpha 1-adrenoceptor binding sites in rat pineal gland membranes, detected by use of a selective alpha 1-adrenoceptor antagonist ([125I]-iodo-2-[beta-(4-hydroxyphenyl) ethylaminomethyl]tetralone, [125I]-HEAT), were investigated with the alkylating agent, chloroethylclonidine (...

journal_title：British journal of pharmacology

authors： Sugden D,Anwar N,Klein DC

更新日期：1996-07-01 00:00:00

abstract：:1. The regulatory mechanism for the hypertrophy of skeletal muscles induced by clenbuterol is unclear. The purpose of the present study was to determine the extent to which transforming growth factor betas (TGFbetas), fibroblast growth factors (FGFs), hepatocyte growth factor (HGF), and platelet-derived growth factors...

journal_title：British journal of pharmacology

authors： Akutsu S,Shimada A,Yamane A

更新日期：2006-02-01 00:00:00

abstract：:Translational sciences increasingly emphasize the measurement of functions in native human tissues. However, such studies must confront variations in patient age, gender, genetic background and disease. Here, these are discussed with reference to neuromuscular and neurosecretory functions of the human gastrointestinal...

journal_title：British journal of pharmacology

authors： Sanger GJ,Broad J,Kung V,Knowles CH

更新日期：2013-01-01 00:00:00

abstract：:1. The effect of mastoparan on phosphatidylcholine hydrolysis was examined in 1321N1 human astrocytoma cells. Mastoparan (3-30 microM) caused an accumulation of diacylglycerol (DG) and phosphatidic acd (PA) accompanied by choline release in a concentration- and time-dependent manner. 2. In the presence of 2% n-butanol...

journal_title：British journal of pharmacology

authors： Mizuno K,Nakahata N,Ohizumi Y

更新日期：1995-10-01 00:00:00

abstract：:1. Intra-arterial blood pressures and heart rates were recorded in conscious, unrestrained, Long Evans and Brattleboro rats receiving sequential, continuous administrations of selective alpha 1- (prazosin) and alpha 2- (idazoxan) adrenoceptor antagonists. The same protocols were also run in the presence of ICI 118551 ...

journal_title：British journal of pharmacology

authors： Gardiner SM,Bennett T

更新日期：1988-01-01 00:00:00

abstract：:The complement system plays a major role in threat recognition and in orchestrating responses to microbial intruders and accumulating debris. This immune surveillance is largely driven by lectins that sense carbohydrate signatures on foreign, diseased and healthy host cells and act as complement activators, regulators...

journal_title：British journal of pharmacology

authors： Hevey R,Pouw RB,Harris C,Ricklin D

更新日期：2020-11-03 00:00:00

abstract：:1. We have investigated the role of endogenous nitric oxide on renal vascular reactivity in late pregnancy in in situ blood perfused kidneys of alpha-chloralose anaesthetized Wistar-Kyoto rats. Nitric oxide synthesis inhibition was achieved by intravenous administration of NG-nitro-L-arginine or NG-nitro-L-arginine me...

journal_title：British journal of pharmacology

authors： Chu ZM,Beilin LJ

更新日期：1997-09-01 00:00:00

abstract：:Injection of carrageenan 1% (50 microl) in the mouse paw causes a biphasic response: an early inflammatory response that lasts 6 h and a second late response that peaks at 72 h, declining at 96 h. Only mice 7- or 8-week old, weighing 32-34 g, displayed a consistent response in both phases. In 8-week-old mice, myeloper...

journal_title：British journal of pharmacology

authors： Posadas I,Bucci M,Roviezzo F,Rossi A,Parente L,Sautebin L,Cirino G

更新日期：2004-05-01 00:00:00

abstract：:The effects of 5-hydroxytryptamine (5-HT) on the release of gamma-aminobutyric acid (GABA) were examined in the longitudinal muscle-myenteric plexus (LM-MP) preparation of guinea-pig ileum. 5-HT increased the spontaneous release and inhibited the electrically-evoked release of [3H]-GABA. The 5-HT-evoked release was Ca...

journal_title：British journal of pharmacology

authors： Shirakawa J,Takeda K,Taniyama K,Tanaka C

更新日期：1989-10-01 00:00:00

abstract：:The development of myocardial and large vessel stiffness with aging underlies the development of diastolic heart failure and isolated systolic hypertension. Nonenzymatic reaction between glucose and proteins (Maillard reaction) leading to collagen crosslinking in the myocardium and arterial wall has been implicated in...

journal_title：British journal of pharmacology

authors： Aronson D

更新日期：2004-08-01 00:00:00

abstract：:1. The cardiovascular and behavioural effects elicted by the intracerebroventricular (i.c.v.) injection of substance P (SP), neurokinin A (NKA), [MePhe7]neurokinin B ([MePhe7]NKB) or angiotensin II (AII) in the conscious rat were assessed before and 5 min after i.c.v. pretreatment with antagonists selective for angiot...

journal_title：British journal of pharmacology

authors： Picard P,Chrétien L,Couture R

更新日期：1995-04-01 00:00:00

abstract：:1. The effect of a standardized mixture of beta-hydroxyethyl rutosides against oxidative damage in singlet oxygen-challenged isolated cardiac myocytes from adult rats was investigated. The morphology of the myocytes was evaluated as an indicator for cell viability (elongated, rod shaped cells vs. hypercontracted, roun...

journal_title：British journal of pharmacology

authors： Olbrich HG,Grabisch P,Grossmann A,Rinne T,Klepzig H,Mutschler E

更新日期：1996-10-01 00:00:00

abstract：:1. S 16257 is a new bradycardic agent. Its electropharmacological profile has been compared to that of the known bradycardic compound UL-FS 49 (Zatebradine). Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2. In the rabbit isolated sino-atrial node (SAN) tiss...

journal_title：British journal of pharmacology

authors： Thollon C,Cambarrat C,Vian J,Prost JF,Peglion JL,Vilaine JP

更新日期：1994-05-01 00:00:00

abstract：:1. We examined the effect of the sulphonylurea glimepiride on three types of recombinant ATP-sensitive potassium (K(ATP)) channels. 2. K(ATP) channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-cells, SUR2A in heart and SUR2B in smooth mus...

journal_title：British journal of pharmacology

authors： Song DK,Ashcroft FM

更新日期：2001-05-01 00:00:00

abstract：:1. Adenosine has been shown to be responsible for the hyperaemic response of the hepatic artery to portal vein occlusion (the hepatic arterial 'buffer response'). 2. The effect of adenosine receptor blockade and of adenosine uptake inhibition on the hepatic arterial response to portal vein occlusion was investigated i...

journal_title：British journal of pharmacology

authors： Mathie RT,Alexander B

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While arachidonyl ethanolamine (anandamide) produces pharmacological effects mediated by cannabinoid CB1 receptors, it is also an agonist at the transient receptor potential vanilloid type 1 (TRPV1) ion channel. This study examined the cellular actions of anandamide in the midbrain periaqueductal...

journal_title：British journal of pharmacology

authors： Kawahara H,Drew GM,Christie MJ,Vaughan CW

更新日期：2011-07-01 00:00:00

abstract：:1. To determine the role of G protein-coupled receptor kinases (GRKs) in the regulation of endogenous secretin receptor responsiveness, we have transiently overexpressed both wild-type (WT) and dominant negative mutant (DNM) GRKs in NG108-15 mouse neuroblastoma x rat glioma hybrid cells and investigated the effects of...

journal_title：British journal of pharmacology

authors： Ghadessy RS,Willets JM,Kelly E

更新日期：2003-02-01 00:00:00