Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide.

abstract：:The ability of chemically detoxified E. coli endotoxins and membrane-active agents to modify the toxicity of native E. coli endotoxin in vivo was examined. The time- and dose-dependent increase in plasma acid phosphatase activity following toxin administration to rats provided a convenient quantitative measure of in v...

journal_title：British journal of pharmacology

authors： Godin DV,Tuchek JM

更新日期：1983-06-01 00:00:00

abstract：:1. Alterations of 5-hydroxytryptaminergic mechanisms are thought to play a special role in the pathogenesis of depression and antidepressant treatments are assumed to restore these changes. 2. We have used one of the most reliable models of depression, the olfactory bulbectomized rat to study the long term consequence...

journal_title：British journal of pharmacology

authors： Grecksch G,Zhou D,Franke C,Schröder U,Sabel B,Becker A,Huether G

更新日期：1997-12-01 00:00:00

abstract：:1 The binding of [3H]-5-hydroxytryptamine ([3H]-5-HT), [3H]-haloperidol and [3H]-dopamine to human blood platelets was investigated and the effects of unlabelled haloperidol on [3H]-5-HT binding and (+)- and (-)-butaclamol on [3H]-haloperidol were studied. 2 Scatchard analysis did not show any specific binding of [3H]...

journal_title：British journal of pharmacology

authors： Boullin DJ,Molyneux D,Roach B

更新日期：1978-07-01 00:00:00

abstract：:1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and acetylcholine and enhanced those to nitroprusside in the rat isolated perfused kidney, preconstricted with phenylephrine. 2. Inhibition of cyclo-oxygenase with indomethacin, decreased the v...

journal_title：British journal of pharmacology

authors： Fulton D,McGiff JC,Quilley J

更新日期：1992-11-01 00:00:00

abstract：:1. The effects of purinergic stimulation on action potential, force of contraction, 86Rb efflux and 45Ca uptake were investigated in guinea-pig left atria. 2. Adenosine exerted a negative inotropic effect which was antagonized by adenosine deaminase but enhanced by dipyridamole. 3. The negative inotropic effect of ade...

journal_title：British journal of pharmacology

authors： Jahnel U,Nawrath H

更新日期：1989-08-01 00:00:00

abstract：:Myeloperoxidase (MPO), a member of the haem peroxidase-cyclooxygenase superfamily, is abundantly expressed in neutrophils and to a lesser extent in monocytes and certain type of macrophages. MPO participates in innate immune defence mechanism through formation of microbicidal reactive oxidants and diffusible radical s...

journal_title：British journal of pharmacology

authors： Malle E,Furtmüller PG,Sattler W,Obinger C

更新日期：2007-11-01 00:00:00

abstract：:Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the pharmacology of these subtypes using whole-cell patch clamp recordings. The bee venom peptide apamin blocked hSK1 as well as rSK2 with IC(50) values of 3.3 nM...

journal_title：British journal of pharmacology

authors： Strøbaek D,Jørgensen TD,Christophersen P,Ahring PK,Olesen SP

更新日期：2000-03-01 00:00:00

abstract：:1. In isolated detrusor strips from the guinea-pig urinary bladder, contractile responses to electrical field stimulation were mostly mediated by neurally released acetylcholine (ACh) and adenosine 5'-triphosphate (ATP). 2. 5-Hydroxytryptamine (5-HT) produced a concentration-dependent increase in the amplitude of stim...

journal_title：British journal of pharmacology

authors： Messori E,Rizzi CA,Candura SM,Lucchelli A,Balestra B,Tonini M

更新日期：1995-06-01 00:00:00

abstract：:1. In order to determine whether the renin-angiotensin system is involved in myocardial ischaemia-reperfusion injury, we investigated and compared the effects on infarct size of two different drugs which interfere with this system, i.e., an angiotensin II (AT1) antagonist, EXP3174, and an angiotensin I-converting enzy...

journal_title：British journal of pharmacology

authors： Richard V,Ghaleh B,Berdeaux A,Giudicelli JF

更新日期：1993-11-01 00:00:00

abstract：:Peroxynitrite, a potent oxidant formed by the reaction of nitric oxide and superoxide causes thymocyte necrosis, in part, via activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS). The cytotoxic PARS pathway initiated by DNA strand breaks and excessive PARS activation has been shown to deplete cellular e...

journal_title：British journal of pharmacology

authors： Virág L,Szabó C

更新日期：1999-02-01 00:00:00

abstract：:1. [35S]t-butylbicyclophosphorothionate (TBPS) is a high affinity ligand for the picrotoxin site of GABA(A) receptors. Here we examined TBPS binding to the cloned receptors made of alpha 1, alpha 3 or alpha 6 in combination with beta 2 or beta 2 and gamma 2 subunits, in the presence of GABA and several allosteric liga...

journal_title：British journal of pharmacology

authors： Im WB,Pregenzer JF,Thomsen DR

更新日期：1994-08-01 00:00:00

abstract：:1. We have investigated the effects of the selective phosphodiesterase (PDE) type 4 inhibitor, rolipram (0.01-1 microM) on cytosolic Ca2+ fluxes in FMLP-activated human neutrophils, as well as on superoxide production by, and release of elastase from, these cells. 2. Cytosolic Ca2+ fluxes were measured by use of fura-...

journal_title：British journal of pharmacology

authors： Anderson R,Goolam Mahomed A,Theron AJ,Ramafi G,Feldman C

更新日期：1998-06-01 00:00:00

abstract：:RSD 921 is a novel, structurally unique, class I Na+ channel blocking drug under development as a local anaesthetic agent and possibly for the treatment of cardiac arrhythmias. The effects of RSD 921 on wild-type heart, skeletal muscle, neuronal and non-inactivating IFMQ3 mutant neuronal Na+ channels expressed in Xeno...

journal_title：British journal of pharmacology

authors： Pugsley MK,Goldin AL

更新日期：1999-05-01 00:00:00

abstract：:Carbon monoxide (CO) is firmly established as an important, physiological signalling molecule as well as a potent toxin. Through its ability to bind metal-containing proteins, it is known to interfere with a number of intracellular signalling pathways, and such actions can account for its physiological and pathologica...

journal_title：British journal of pharmacology

authors： Peers C,Boyle JP,Scragg JL,Dallas ML,Al-Owais MM,Hettiarachichi NT,Elies J,Johnson E,Gamper N,Steele DS

更新日期：2015-03-01 00:00:00

abstract：:1 Vasoactive intestinal polypeptide (VIP, 0.01- MicroM) produced dose-related relaxations of the mouse anococcygeus muscle. 2 Following incubation with indomethacin (2.8 microM 1 h) adenosine 5'-triphosphate (ATP, 0.5-10 mM) produced dose-related relaxations of the mouse anococcygeus. 3 Haemolysed blood reduced inhibi...

journal_title：British journal of pharmacology

authors： Gibson A,Tucker JF

更新日期：1982-09-01 00:00:00

abstract：:1. The aim of the present study was to investigate the role of nitric oxide (NO), histamine and leukotrienes in bronchial obstruction. For this, guinea-pigs immunised against ovalbumin were studied under anaesthesia during challenge with antigen or agonists. 2. Challenge with nebulised antigen (0.1-1 mg) elicited dose...

journal_title：British journal of pharmacology

authors： Persson MG,Friberg SG,Gustafsson LE,Hedqvist P

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regul...

journal_title：British journal of pharmacology

authors： Pathania D,Kuang Y,Sechi M,Neamati N

更新日期：2015-01-01 00:00:00

abstract：:1. Neurotensin was infused intravenously, in the presence or absence of intravenous atropine or intraarterial tetrodotoxin, into dogs anaesthetized with sodium pentobarbitone. Net and unidirectional fluxes of sodium and blood flows in the ileum were measured. Arterial and mesenteric venous blood pressures, haematocrit...

journal_title：British journal of pharmacology

authors： Mailman D

更新日期：1988-05-01 00:00:00

abstract：:Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure following the pathological remodelling of small pulmonary arteries. An increase in right ventricular (RV) afterload results in RV hypertrophy and RV failure. The pathophysiology of PH, and RV remodelling in particular, is not well unders...

journal_title：British journal of pharmacology

authors： Maarman GJ,Schulz R,Sliwa K,Schermuly RT,Lecour S

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Biased GPCR ligands are able to engage with their target receptor in a manner that preferentially activates distinct downstream signalling and offers potential for next generation therapeutics. However, accurate quantification of ligand bias in vitro is complex, and current best practice is not a...

journal_title：British journal of pharmacology

authors： Winpenny D,Clark M,Cawkill D

更新日期：2016-04-01 00:00:00

abstract：:1. The effect of the myorelaxant drugs baclofen, diazepam and tizanidine have been compared on in vitro preparations of baby rat spinal cord and adult rat superior cervical ganglion. 2. Dorsal root-elicited long duration (time to half decay 9.71 +/- 0.29 s.e. mean, n = 31) ipsilateral ventral root reflexes (DR-VRP), m...

journal_title：British journal of pharmacology

authors： Siarey RJ,Long SK,Evans RH

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sildenafil is a selective inhibitor of cGMP-specific phosphodiesterase. Sildenafil, acting via NO-dependent mechanisms, prevents indomethacin-induced gastropathy. Activation of ATP-sensitive potassium channels (K(ATP)) is involved in gastric defence. Our objective was to evaluate the role of the ...

journal_title：British journal of pharmacology

authors： Medeiros JV,Gadelha GG,Lima SJ,Garcia JA,Soares PM,Santos AA,Brito GA,Ribeiro RA,Souza MH

更新日期：2008-02-01 00:00:00

abstract：:Data presentation and statistical analysis in scientific writing are agreed to be in need of improvement, despite the profusion of advice and instruction. Recent evidence supports the need for better planning and analysis of animal experiments. This series of short articles aims to provide advice in small easily diges...

journal_title：British journal of pharmacology

authors： Drummond GB,Vowler SL

更新日期：2011-05-01 00:00:00

abstract：:1. The present study shows the effects of imipramine in a single dose (10 mg kg(-1), p.o.) or following repeated (14 days, twice a day) treatment on the level of mRNA coding for D2 dopamine receptors in the rat caudate putamen (CP). Repeated administration of imipramine resulted in the increase of the level of mRNA co...

journal_title：British journal of pharmacology

authors： Dziedzicka-Wasylewska M,Rogoz R

更新日期：1998-03-01 00:00:00

abstract：:1. This study compares a cyclo-oxygenase inhibitor (aspirin), a 5-HT2 antagonist (ZM170809) and a combined thromboxane synthase inhibitor/receptor antagonist (ZD1542) as adjuncts to tissue plasminogen activator (rt-PA). 2. Application of an anodal current (332 +/- 4.1 microA) to the stenosed left circumflex coronary a...

journal_title：British journal of pharmacology

authors： McAuliffe SJ,Moors JA,Jones HB

更新日期：1994-05-01 00:00:00

abstract：:1. The radioligand binding characteristics of the 3H-derivative of the novel 5-HT3 receptor antagonist BRL46470 were investigated and directly compared to the well characterized 5-HT3 receptor radioligand [3H]-granisetron, in tissue homogenates prepared from rat cerebral cortex/hippocampus, rat ileum, NG108-15 cells, ...

journal_title：British journal of pharmacology

authors： Steward LJ,Ge J,Bentley KR,Barber PC,Hope AG,Lambert JJ,Peters JA,Blackburn TP,Barnes NM

更新日期：1995-09-01 00:00:00

abstract：:The aims of this study were to develop a technique to measure blood flow in the mouse ear and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK(1) rec...

journal_title：British journal of pharmacology

authors： Grant AD,Gerard NP,Brain SD

更新日期：2002-01-01 00:00:00

abstract：:1 Uniaxial cyclic stretch leads to an upregulation of cyclooxygenase (COX)-2 through increases in the intracellular Ca(2+) concentration via the stretch-activated (SA) channel and following nuclear factor kappa B (NF-kappaB) activation in human fibroblasts. However, the signaling mechanism as to how the elevated Ca(2+...

journal_title：British journal of pharmacology

authors： Amma H,Naruse K,Ishiguro N,Sokabe M

更新日期：2005-06-01 00:00:00

abstract：:1. Phenylephrine-induced contractions of rabbit isolated trigone and urethra were antagonized in a competitive manner by alfuzosin (pA2 7.44 and 7.30, respectively) and prazosin. 2. The characteristics of [3H]-prazosin binding to human prostatic adenoma tissue were evaluated. [3H]-prazosin was potently displaced by al...

journal_title：British journal of pharmacology

authors： Lefèvre-Borg F,O'Connor SE,Schoemaker H,Hicks PE,Lechaire J,Gautier E,Pierre F,Pimoule C,Manoury P,Langer SZ

更新日期：1993-08-01 00:00:00

abstract：:1. The interaction between the cholinergic and nitrergic innervation was investigated in circular muscle strips of the pig gastric fundus. 2. In physiological salt solution containing 4 x 10(-6) M guanethidine, electrical field stimulation (EFS; 40 V, 0.5 ms, 0.5-32 Hz, 10 s at 4 min intervals) induced small transient...

journal_title：British journal of pharmacology

authors： Leclere PG,Lefebvre RA

更新日期：1998-12-01 00:00:00