Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature.

abstract：:The neuroprotective drug riluzole has multiple effects on cellular signaling. We found that riluzole rapidly and reversibly inhibited spontaneous Ca2+ oscillations in both immortalized GnRH-secreting hypothalamic neurons (GT1 cells) and in the prolactin and growth-hormone-secreting GH3 cell line. At lower concentratio...

journal_title：British journal of pharmacology

authors： Beltran-Parrazal L,Charles A

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves c...

journal_title：British journal of pharmacology

authors： Roberson DP,Binshtok AM,Blasl F,Bean BP,Woolf CJ

更新日期：2011-09-01 00:00:00

abstract：:1. Partial agonists of the beta2-adrenoceptor which activate adenylyl cyclase are widely used as bronchodilators for the relief of bronchoconstriction accompanying many disease conditions, including bronchial asthma. The bronchodilator salmeterol has both a prolonged duration of action in bronchial tissue and the abil...

journal_title：British journal of pharmacology

authors： January B,Seibold A,Allal C,Whaley BS,Knoll BJ,Moore RH,Dickey BF,Barber R,Clark RB

更新日期：1998-02-01 00:00:00

abstract：:It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvement in symptoms. The present study describes the alpha1-adrenoceptor (a...

journal_title：British journal of pharmacology

authors： Williams TJ,Blue DR,Daniels DV,Davis B,Elworthy T,Gever JR,Kava MS,Morgans D,Padilla F,Tassa S,Vimont RL,Chapple CR,Chess-Williams R,Eglen RM,Clarke DE,Ford AP

更新日期：1999-05-01 00:00:00

abstract：:For almost three decades intrathecal baclofen therapy has been the standard treatment for spinal cord injury spasticity when oral medication is ineffective or produces serious side effects. Although intrathecal baclofen therapy has a good clinical benefit-risk ratio for spinal spasticity, tolerance and the life-threat...

journal_title：British journal of pharmacology

authors： Gómez-Soriano J,Goiriena E,Taylor J

更新日期：2010-11-01 00:00:00

abstract：:In circular smooth muscle cells of the guinea-pig stomach (antrum), diltiazem (10(-6)-10(-5)M) blocked the overshooting spike potential generated either spontaneously or by electrical stimulation in the presence of 2 mM tetraethylammonium chloride, but did not block the slow wave and the abortive spike potential. The ...

journal_title：British journal of pharmacology

authors： Ishikawa S,Komori K,Nagao T,Suzuki H

更新日期：1985-12-01 00:00:00

abstract：:The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This complex, acellular entity is composed of hundreds of individual molecules whose assembly, architecture and biomechanical properties are critical to controlling the behaviour and phenotype of the different cell types residing...

journal_title：British journal of pharmacology

authors： Hastings JF,Skhinas JN,Fey D,Croucher DR,Cox TR

更新日期：2019-01-01 00:00:00

abstract：:1. Rat cultured aortic vascular smooth muscle cells (VSMC) express both cyclic GMP-inhibited cyclic AMP phosphodiesterase (PDE3) and Ro 20-1724-inhibited cyclic AMP phosphodiesterase (PDE4) activities. By utilizing either cilostamide, a PDE3-selective inhibitor, or Ro 20-1724, a PDE4-selective inhibitor, PDE3 and PDE4...

journal_title：British journal of pharmacology

authors： Rose RJ,Liu H,Palmer D,Maurice DH

更新日期：1997-09-01 00:00:00

abstract：:1. The effects of melanotrophin release inhibiting factor (MIF) and its cyclic analogue cyclo (Leu-Gly) on tolerance to the analgesic effect of morphine were studied in male Sprague-Dawley rats. 2. Tolerance to morphine was induced by implantation of four morphine pellets (each containing 75 mg of morphine free base) ...

journal_title：British journal of pharmacology

authors： Bhargava HN

更新日期：1981-04-01 00:00:00

abstract：:1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches th...

journal_title：British journal of pharmacology

authors： Barth H,Lorenz W,Troidl H

更新日期：1975-11-01 00:00:00

abstract：:1. To elucidate whether K+ channels play a role in the action of epithelium-dependent bronchodilatation, we studied responses in human bronchial strips in the presence of indomethacin and NG-nitro-L-arginine methylester under isometric conditions, in vitro. 2. Mechanical removal of the epithelium increased the contrac...

journal_title：British journal of pharmacology

authors： Tamaoki J,Tagaya E,Isono K,Kondo M,Konno K

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of inflammatory disorders, including atherosclerosis and rheumatoid arthritis. Here, we describe the molecul...

journal_title：British journal of pharmacology

authors： Nedjai B,Li H,Stroke IL,Wise EL,Webb ML,Merritt JR,Henderson I,Klon AE,Cole AG,Horuk R,Vaidehi N,Pease JE

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dilatation of cerebral and dural arteries causes a throbbing, migraine-like pain, indicating that these structures are involved in migraine. Clinical trials suggest that adenosine 5'-triphosphate-sensitive K(+) (K(ATP)) channel opening may cause migraine by dilatating intracranial arteries, inclu...

journal_title：British journal of pharmacology

authors： Ploug KB,Boni LJ,Baun M,Hay-Schmidt A,Olesen J,Jansen-Olesen I

更新日期：2008-05-01 00:00:00

abstract：:1. An obligatory step in the biosynthesis of endothelin-1 (ET-1) is the conversion of its inactive precursor, big ET-1, into the mature form by the action of specific, phosphoramidon-sensitive, endothelin converting enzyme(s) (ECE). Disparate effects of big ET-1 and ET-1 on renal tubule function suggest that big ET-1 ...

journal_title：British journal of pharmacology

authors： Beara-Lasić L,Knotek M,Cejvan K,Jaksić O,Lasić Z,Skorić B,Brkljacić V,Banfić H

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. From our previous work N-(4-Hydroxyphenethyl)-3-mercapto-2-methylpropanamide (HMPA) is a potential T2DM drug. We evaluated the effect of HMPA on gut microbiota and studied the molecular mechanism underlying HMP...

journal_title：British journal of pharmacology

authors： Liu H,Qin Y,Li K,Li M,Yang J,Tao H,Tang Y,Yang L,Chen S,Liu Y,Yang C,Gao W,Sun T

更新日期：2020-12-07 00:00:00

abstract：:1. Measurements were made of the in vivo formation of inositol phosphates in the brains of C57/B1/601a mice treated acutely or chronically with lithium chloride (LiCl). 2. A single injection of LiCl (10 mEquiv kg-1, s.c.) 18 h before death increased the accumulation of [3H]-inositol phosphates ([3H]-Ins P's) in the br...

journal_title：British journal of pharmacology

authors： Whitworth P,Heal DJ,Kendall DA

更新日期：1990-09-01 00:00:00

abstract：:1. We have investigated the potency and duration of action of isoprenaline and a range of beta-adrenoceptor agonists as relaxants of inherent tone in human superfused, isolated bronchial smooth muscle, a tissue reported to contain a homogeneous population of beta 2-adrenoceptors. 2. All of the beta-adrenoceptor agonis...

journal_title：British journal of pharmacology

authors： Nials AT,Coleman RA,Johnson M,Magnussen H,Rabe KF,Vardey CJ

更新日期：1993-11-01 00:00:00

abstract：:1. The effects of methylflavonolamine hydrochloride (4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA) were investigated and compared with verapamil and papaverine on rabbit isolated aortic strips, which were contracted by noradrenaline, calcium and potassium. 2. Pre-incubation for 25 min wi...

journal_title：British journal of pharmacology

authors： Zhang MS,Zhou EF

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While the slow delayed rectifier K(+) current (I(Ks)) is known to be enhanced by the stimulation of β-adrenoceptors in several mammalian species, phosphorylation-dependent regulation of the rapid delayed rectifier K(+) current (I(Kr)) is controversial. EXPERIMENTAL APPROACH:In the present study,...

journal_title：British journal of pharmacology

authors： Harmati G,Bányász T,Bárándi L,Szentandrássy N,Horváth B,Szabó G,Szentmiklósi JA,Szénási G,Nánási PP,Magyar J

更新日期：2011-02-01 00:00:00

abstract：:1. Losigamone is a novel anticonvulsant the mechanism of action of which is not known. This study investigated the effect of losigamone on spontaneous, NMDA- and AMPA-induced depolarizations in the cortical wedge preparation of the DBA/2 mouse (which are susceptible to sound-induced seizures) and on endogenous amino a...

journal_title：British journal of pharmacology

authors： Srinivasan J,Richens A,Davies JA

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early soluble epoxide hydrolase inhibitors (sEHIs) such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) are effective anti-hypertensive and anti-inflammatory agents in various animal models. However, their poor metabolic stability and limited water solubility make them difficult to use pha...

journal_title：British journal of pharmacology

authors： Liu JY,Tsai HJ,Hwang SH,Jones PD,Morisseau C,Hammock BD

更新日期：2009-01-01 00:00:00

abstract：:1. This study was designed to assess the molecular and cellular events involved in the up-regulation (and receptor supersensitivity) of brain alpha(2)-adrenoceptors as a result of chronic depletion of noradrenaline (and other monoamines) by reserpine. 2. Chronic reserpine (0.25 mg kg(-1) s.c., every 48 h for 6 - 14 da...

journal_title：British journal of pharmacology

authors： Ribas C,Miralles A,Busquets X,García-Sevilla JA

更新日期：2001-04-01 00:00:00

abstract：:1. The similarity in molecular structure between the histamine H2-agonist dimaprit (3-dimethylamino-propyl-isothiourea) and the endogenous nitric oxide synthase (NOS) substrate L-arginine prompted us to study the effect of dimaprit and some dimaprit analogues on NOS activity. Dimaprit and some of its analogues were te...

journal_title：British journal of pharmacology

authors： Paquay JB,Hoen PA,Voss HP,Bast A,Timmerman H,Haenen GR

更新日期：1999-05-01 00:00:00

abstract：:The sensitivity of the uterus to the inhibition of contractions by salbutamol, diltiazem or nifedipine was assessed in the ovariectomized, post-partum rat by dose-response curves following bolus intravenous (i.v.) administration. These tests were performed before (day 1), immediately after a 20 h i.v. infusion of salb...

journal_title：British journal of pharmacology

authors： Abel MH,Hollingsworth M

更新日期：1986-07-01 00:00:00

abstract：:Inhalation of cyclopropane in dogs, by the closed circuit method, for a fixed period, produced an emetic response during recovery from anaesthesia. Bilateral surgical ablation of the emetic chemoreceptor trigger zone of the area postrema rendered the dogs refractory to several times (3-6) the threshold emetic dose of ...

journal_title：British journal of pharmacology

authors： Badola RP,Bhargava KP,Dixit KS,Ratra CK

更新日期：1971-09-01 00:00:00

abstract：:1. Systemic infusion of neuropeptide Y (NPY) reduces renal blood flow and can concomitantly increase diuresis, natriuresis and calciuresis in anaesthetized rats. The present study was designed to investigate whether the apparently contradictory NPY effects on renal blood flow and urine formation and composition are me...

journal_title：British journal of pharmacology

authors： Bischoff A,Avramidis P,Erdbrügger W,Münter K,Michel MC

更新日期：1997-04-01 00:00:00

abstract：:Opioid drugs such as morphine and meperidine are widely used in clinical pain management, although they can cause some adverse effects. A number of studies indicate that N-methyl-D-aspartate (NMDA) receptors may play a role in the mechanism of morphine analgesia, tolerance and dependence. Being an antitussive with NMD...

journal_title：British journal of pharmacology

authors： Chen SL,Huang EY,Chow LH,Tao PL

更新日期：2005-02-01 00:00:00

abstract：:1. We investigated the nitric oxide (NO) dependence of vasorelaxation in response to different calcium channel blockers (CCB), in rabbit femoral artery in vivo. 2. Anaesthetized rabbits underwent femoral artery ligation, and blood from the proximal artery was returned distal to the ligature through a constant infusion...

journal_title：British journal of pharmacology

authors： Xu B,Xiao-hong L,Lin G,Queen L,Ferro A

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is...

journal_title：British journal of pharmacology

authors： Lanzerstorfer P,Stadlbauer V,Chtcheglova LA,Haselgrübler R,Borgmann D,Wruss J,Hinterdorfer P,Schröder K,Winkler SM,Höglinger O,Weghuber J

更新日期：2014-12-01 00:00:00

abstract：:1. We have characterized the human smooth muscle endothelin converting enzyme (ECE) present in the media of the endothelium-denuded human umbilical vein preparation. 2. Endothelin-1 (ET-1) and ET-2 were potent constrictors of umbilical vein with EC50 values of 9.2 nM and 29.6 nM, respectively. ET-1 was at least 30 tim...

journal_title：British journal of pharmacology

authors： Maguire JJ,Johnson CM,Mockridge JW,Davenport AP

更新日期：1997-12-01 00:00:00