Riluzole inhibits spontaneous Ca2+ signaling in neuroendocrine cells by activation of K+ channels and inhibition of Na+ channels.

abstract：BACKGROUND AND PURPOSE:Lung cancer is one of the leading causes of cancer death worldwide. Despite advances in therapy, conventional therapy is still the main treatment and has a high risk of chemotherapy resistance. Caspase-8 is involved in cell death and is a recognized marker for poor patient prognosis. EXPERIMENTA...

journal_title：British journal of pharmacology

authors： Terlizzi M,Di Crescenzo VG,Perillo G,Galderisi A,Pinto A,Sorrentino R

更新日期：2015-08-01 00:00:00

abstract：:1. The effect of adenosine A1-receptor and P2-purinoceptor agonists on [3H]-inositol phosphate accumulation has been investigated in CHO-K1 cells transfected with the human adenosine A1-receptor. 2. Adenosine receptor agonists stimulated [3H]-inositol phosphate accumulation in CHO-K1 cells with a rank potency order of...

journal_title：British journal of pharmacology

authors： Megson AC,Dickenson JM,Townsend-Nicholson A,Hill SJ

更新日期：1995-08-01 00:00:00

abstract：:1. Behavioural activity (delayed differentiation and spatial delayed alternation) and pharmacokinetics of diazepam and its metabolites, N-desmethyldiazepam (nordiazepam), 3-hydroxydiazepam (temazepam) and 3-hydroxy-N-desmethyldiazepam (oxazepam), and of dipotassium clorazepate (clorazepate), were studied in the monkey...

journal_title：British journal of pharmacology

authors： Curry SH,Whelpton R,Nicholson AN,Wright CM

更新日期：1977-11-01 00:00:00

abstract：:1. Recombinant human ETA receptors were expressed in a mouse fibroblast cell line (Ltk- cell) and functional coupling of the receptors with Ca2+ permeable channels at low concentrations of endothelin-1 (ET-1) was investigated using whole-cell recordings and monitoring the changes in intracellular free Ca2+ concentrati...

journal_title：British journal of pharmacology

authors： Enoki T,Miwa S,Sakamoto A,Minowa T,Komuro T,Kobayashi S,Ninomiya H,Masaki T

更新日期：1995-06-01 00:00:00

abstract：:NO is a neurotransmitter released from enteric inhibitory neurons and responsible for modulating gastrointestinal (GI) motor behaviour. Enteric neurons express nNOS (NOS1) that associates with membranes of nerve varicosities. NO released from neurons binds to soluble guanylate cyclase in post-junctional cells to gener...

journal_title：British journal of pharmacology

authors： Sanders KM,Ward SM

更新日期：2019-01-01 00:00:00

abstract：:1. Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2. Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through...

journal_title：British journal of pharmacology

authors： Crocker IP,Kenny LC,Thornton WA,Szabo C,Baker PN

更新日期：2005-03-01 00:00:00

abstract：:1. In mouse pancreatic beta-cells the regulation of the diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel (K-ATP-channel) was examined by use of the patch-clamp technique. 2. In intact beta-cells incubated at 37 degrees C in the presence of 3 mM D-glucose, diazoxide did not affect the single ...

journal_title：British journal of pharmacology

authors： Schwanstecher C,Dickel C,Ebers I,Lins S,Zünkler BJ,Panten U

更新日期：1992-09-01 00:00:00

abstract：:1. The class III antiarrhythmic azimilide has previously been shown to inhibit I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance I(Kr), in human heart, the effects of azimilide on HERG channels expressed in Xenopus oocyt...

journal_title：British journal of pharmacology

authors： Busch AE,Eigenberger B,Jurkiewicz NK,Salata JJ,Pica A,Suessbrich H,Lang F

更新日期：1998-01-01 00:00:00

abstract：:1. The modulation by alpha 2-adrenoceptors of the jaw-opening reflex (digastric electromyographic responses) elicited by orofacial electrical stimulation (OF-JOR) in pentobarbitone anaesthetized rats was investigated. 2. Increasing doses of clonidine (0.1-1000 micrograms kg-1, i.v.) reduced, in a dose-dependent manner...

journal_title：British journal of pharmacology

authors： García-Vallejo P,Barturen F,García-Sevilla JA

更新日期：1994-04-01 00:00:00

abstract：:1. The agonist action of the opioid peptide dynorphin A(1-8) on the myenteric plexus-longitudinal muscle of the guinea-pig ileum has been characterized. 2. The endogenous opioid peptide dynorphin A(1-8) was rapidly degraded by slices of myenteric plexus-longitudinal muscle of the guinea-pig ileum. 3. A product of the ...

journal_title：British journal of pharmacology

authors： Dixon DM,Traynor JR

更新日期：1990-11-01 00:00:00

abstract：:1 delta'-trans-Tetrahydrocannabinol (THC) is more active orally in mice than previously thought, as cataleptic responses occur at doses from 0.06 mg/kg upwards, with peak activity at 2 to 4 h after dosing. These doses and peaks correspond well with the effects in man. 2 Comparison with chlorpromazine in mice shows tha...

journal_title：British journal of pharmacology

authors： Fairbairn JW,Pickens JT

更新日期：1979-11-01 00:00:00

abstract：:1 Histamine produced dose-dependent contractile responses on both isolated perfused ear arteries and aortic strips of the rabbit. These responses were blocked by mepyramine and potentiated by both metiamide and dithiothreitol. 2 In the presence of maximum potentiation by metiamide, dithiothreitol still potentiated the...

journal_title：British journal of pharmacology

authors： Carroll PR,Glover WE

更新日期：1977-02-01 00:00:00

abstract：:The hypothesis of negative feedback regulation of noradrenaline release was studied in guinea-pig left atrial halves mounted in vitro. Tissues were transmurally stimulated with 30, 100 or 300 pulses at 2 Hz with pulse durations ranging from 50 mus to 2,000 mus, and the efflux of 3H-transmitter determined. The efflux o...

journal_title：British journal of pharmacology

authors： Kalsner S

更新日期：1983-08-01 00:00:00

abstract：:1. Inhibition of human polymorphonuclear leucocyte (PMN) function by adenosine was studied with respect to effects of adenosine on intracellular cyclic AMP and calcium during the PMN respiratory burst. 2. The adenosine analogue 5'-N-ethylcarboxamide-adenosine (NECA) and L-N6-phenyl-isopropyl-adenosine (L-PIA) inhibite...

journal_title：British journal of pharmacology

authors： Nielson CP,Vestal RE

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rosiglitazone is an anti-diabetic drug improving insulin sensitivity and glucose uptake in skeletal muscle and adipose tissues. However, several recent clinical trials suggest that rosiglitazone can increase the risk of cardiovascular ischaemia, although other studies failed to show such risks. T...

journal_title：British journal of pharmacology

authors： Yu L,Jin X,Yang Y,Cui N,Jiang C

更新日期：2011-12-01 00:00:00

abstract：:1 Noradrenaline (0.2 to 20 micrograms) and carbachol (0.1 to 1 microgram) injected into the preoptic/anterior hypothalamic area, evoked dose-dependent falls in core temperature at all sites tested, followed in most experiments by delayed increases that were not dose-related. Muscarine (0.1 to 10 microgram) produced ef...

journal_title：British journal of pharmacology

authors： Poole S,Stephenson JD

更新日期：1979-01-01 00:00:00

abstract：:1. The psychoactive cannabinoids (-)-delta 9-tetrahydrocannabinol ((-)-delta 9-THC) and the 1,1-dimethyl-heptyl homologue of (-)-11-hydroxy-delta 8-tetrahydrocannabinol ((-)-DMH) both inhibited electrically-evoked contractions of the mouse isolated vas deferens and the myenteric plexus-longitudinal muscle preparation ...

journal_title：British journal of pharmacology

authors： Pertwee RG,Stevenson LA,Elrick DB,Mechoulam R,Corbett AD

更新日期：1992-04-01 00:00:00

abstract：:Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging-related arterial stiffness and the associated CVD risk, which increases disproportionately in postmenopausal women. Th...

journal_title：British journal of pharmacology

authors： DuPont JJ,Kenney RM,Patel AR,Jaffe IZ

更新日期：2019-11-01 00:00:00

abstract：:1. We investigated the role of two conserved basic residues in the second transmembrane helix arginine 172 (R172) and lysine 179 (K179) of the VPAC(2) receptor. 2. Vasoactive intestinal polypeptide (VIP) activated VPAC(2) receptors with an EC(50) value of 7 nM, as compared to 150, 190 and 4000 nM at R172L, R172Q and K...

journal_title：British journal of pharmacology

authors： Vertongen P,Solano RM,Perret J,Langer I,Robberecht P,Waelbroeck M

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH:A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain librar...

journal_title：British journal of pharmacology

authors： Fonfria E,Clay WC,Levy DS,Goodwin JA,Roman S,Smith GD,Condreay JP,Michel AD

更新日期：2008-02-01 00:00:00

abstract：:1. Des-Arg9 bradykinin (DAB), a classical B1-kinin receptor agonist was without effect when applied to the basolateral surface of rat isolated colon epithelium. Three hours after tissues were isolated DAB caused, after a delay of up to 2 min, a maintained increase of short circuit current (SCC). 2. The SCC increase in...

journal_title：British journal of pharmacology

authors： Teather S,Cuthbert AW

更新日期：1997-07-01 00:00:00

abstract：:1. Murine left atrium lacks inotropic beta(2)-adrenoceptor function. We investigated whether beta(2)-adrenoceptors are involved in the cardiostimulant effects of (-)-adrenaline on spontaneously beating right atria and paced right ventricular myocardium of C57BL6 mice. We also studied a negative inotropic effect of (-)...

journal_title：British journal of pharmacology

authors： Heubach JF,Rau T,Eschenhagen T,Ravens U,Kaumann AJ

更新日期：2002-05-01 00:00:00

abstract：:The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentrati...

journal_title：British journal of pharmacology

authors： Zhang JJ,Jacob TJ,Hardy SP,Higgins CF,Valverde MA

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The glucagon-like peptides GLP-1 and GLP-2 are secreted from enteroendocrine L-cells following nutrient ingestion. Drugs that increase activity of the GLP-1 axis are highly successful therapies for type 2 diabetes, and boosting L-cell secretion is a potential strategy for future diabetes treatmen...

journal_title：British journal of pharmacology

authors： Parker HE,Wallis K,le Roux CW,Wong KY,Reimann F,Gribble FM

更新日期：2012-01-01 00:00:00

abstract：:Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the pharmacology of these subtypes using whole-cell patch clamp recordings. The bee venom peptide apamin blocked hSK1 as well as rSK2 with IC(50) values of 3.3 nM...

journal_title：British journal of pharmacology

authors： Strøbaek D,Jørgensen TD,Christophersen P,Ahring PK,Olesen SP

更新日期：2000-03-01 00:00:00

abstract：:1. In the present study we have characterized the parathyroid hormone (PTH)-induced calcium signalling in 293 cells stably transfected with the human PTH receptor cDNA. In these cells, human PTH-1(1-38) strongly stimulates adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation (EC50 = 0.39 nM) but fails to activa...

journal_title：British journal of pharmacology

authors： Seuwen K,Boddeke HG

更新日期：1995-04-01 00:00:00

abstract：:1. The effects of 2-amino-5-phosphonovalerate and kynurenate, either alone or in combination, were tested on responses evoked by the excitatory amino acid agonists quinolinate, ibotenate, N-methyl-D-aspartate and N-methyl-DL-aspartate by use of an in vitro preparation of mouse neocortex and artificial cerebrospinal fl...

journal_title：British journal of pharmacology

authors： Burton NR,Smith DA,Stone TW

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Small conductance calcium-activated potassium (KCa 2.x) channels have a widely accepted canonical function in regulating cellular excitability. In this study, we address a potential non-canonical function of KCa 2.x channels in breast cancer cell survival, using in vitro models. EXPERIMENTAL APP...

journal_title：British journal of pharmacology

authors： Abdulkareem ZA,Gee JM,Cox CD,Wann KT

更新日期：2016-01-01 00:00:00

abstract：:1. Bepridil (BPD) is a pharmacological compound able to bind to the Ca2+ sensor protein troponin C (TnC), which triggers skeletal muscle contraction upon Ca2+-binding. BPD can thereby modulate the Ca2+-affinity of this protein. 2. The Ca2+-sensitizing action of bepridil was investigated on slow and fast isoforms of Tn...

journal_title：British journal of pharmacology

authors： Kischel P,Stevens L,Mounier Y

更新日期：1999-10-01 00:00:00

abstract：:1. The inflammatory response induced by poly-L-arginine in the rat hind-paw was studied both by measuring paw oedema and histologically. 2. The paw volume was measured with a hydroplethysmometer at 0.5, 1, 2, 4, 6 and 18 h after the subplantar injection of the polycation. Protein extravasation was evaluated with Evans...

journal_title：British journal of pharmacology

authors： Antunes E,Mariano M,Cirino G,Levi S,de Nucci G

更新日期：1990-12-01 00:00:00