Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract.

abstract：:1. CS-747 is a novel antiplatelet agent that generates an active metabolite, R-99224, in vivo. CS-747 itself was totally inactive in vitro. This study examined in vivo pharmacological profiles of CS-747 after single oral administration to rats. 2. Orally administered CS-747 (0.3 - 10 mg kg(-1)) partially but significa...

journal_title：British journal of pharmacology

authors： Sugidachi A,Asai F,Ogawa T,Inoue T,Koike H

更新日期：2000-04-01 00:00:00

abstract：:The processes underpinning post-developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both in...

journal_title：British journal of pharmacology

authors： Prenderville JA,Kelly ÁM,Downer EJ

更新日期：2015-08-01 00:00:00

abstract：:1. An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents.2. Radioisotope studies showed that cadmium and zinc ...

journal_title：British journal of pharmacology

authors： Schnieden H,Small RC

更新日期：1971-03-01 00:00:00

abstract：:1. Catecholamine release from cat adrenal glands perfused at a high rate (4 ml min-1) at 37 degrees C with modified Krebs solutions lacking Ca and containing 1.2 mM K (hyperpolarizing solution) or 118 mM K (depolarizing solution) was triggered by 10-s pulses of Ca (0.5 mM) in the presence of 118 mM K. Hyperpolarized g...

journal_title：British journal of pharmacology

authors： López MG,Moro MA,Castillo CF,Artalejo CR,García AG

更新日期：1989-03-01 00:00:00

abstract：:1. We have investigated the in vitro interaction between chloride ions and endothelium as revealed by alterations in vascular contractility and smooth muscle cell membrane potential in isolated pulmonary arteries from Dahl salt-resistant normotensive and salt-sensitive hypertensive rats. 2. Exposure to nitro-l-arginin...

journal_title：British journal of pharmacology

authors： Bieger D,Duggan JA,Tabrizchi R

更新日期：2004-03-01 00:00:00

abstract：:This paper is intended to assist pharmacologists to make the most of statistical analysis and avoid common errors. A scenario, in which an experimenter performed an experiment in two separate stages, combined the control groups for analysis and found some surprising results, is presented. The consequences of combined ...

journal_title：British journal of pharmacology

authors： Lew MJ

更新日期：2008-11-01 00:00:00

abstract：:1. Porcine neuromedin U-8 produced a concentration (0.3 nM-1 microM)-dependent contraction of the longitudinal muscle of the human isolated ileum, which was unaffected by either atropine (1 microM) or tetrodotoxin (1 microM). 2. By contrast, neuromedin U-8 had only a weak effect on the circular muscle of the human iso...

journal_title：British journal of pharmacology

authors： Maggi CA,Patacchini R,Giuliani S,Turini D,Barbanti G,Rovero P,Meli A

更新日期：1990-01-01 00:00:00

abstract：:1. The alpha 2-adrenoceptor binding sites of rabbit spleen and rat kidney, labelled with [3H]-rauwolscine, were characterized using a range of subtype selective ligands. 2. In rabbit spleen, the alpha-2-adrenoceptor binding sites displayed high affinity for oxymetazoline and WB 4101 and low affinity for prazosin and c...

journal_title：British journal of pharmacology

authors： Michel AD,Loury DN,Whiting RL

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to block PAR2 signalling associated with disease without inhibiting PAR2 activation in normal physiology could be provided by studies of biased signalling. EXPERIMENT...

journal_title：British journal of pharmacology

authors： Suen JY,Cotterell A,Lohman RJ,Lim J,Han A,Yau MK,Liu L,Cooper MA,Vesey DA,Fairlie DP

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The age-related decline in vasorelaxation is largely due to ceramide-induced induction of phosphatase 2A (PP2A), which limits nitric oxide synthase (eNOS) phosphorylation at stimulatory sites. We hypothesized that ceramide accumulation was from an age-related loss of endothelial glutathione (GSH)...

journal_title：British journal of pharmacology

authors： Smith AR,Visioli F,Frei B,Hagen TM

更新日期：2008-04-01 00:00:00

abstract：:1. The effect of a single injection of the monoamine oxidase inhibitor, tranylcypromine, administered intravenously (20 mg/kg) or into the lateral cerebral ventricle (5-10 mg), on hypothalamic and rectal temperature, has been investigated.2. Intravenous tranylcypromine causes a significant rise in body temperature, wh...

journal_title：British journal of pharmacology

authors： Cranston WI,Rosendorff C

更新日期：1970-05-01 00:00:00

abstract：:1. To determine the role of G protein-coupled receptor kinases (GRKs) in the regulation of endogenous secretin receptor responsiveness, we have transiently overexpressed both wild-type (WT) and dominant negative mutant (DNM) GRKs in NG108-15 mouse neuroblastoma x rat glioma hybrid cells and investigated the effects of...

journal_title：British journal of pharmacology

authors： Ghadessy RS,Willets JM,Kelly E

更新日期：2003-02-01 00:00:00

abstract：:1. Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did no...

journal_title：British journal of pharmacology

authors： Foley DJ,McPhillips JJ

更新日期：1973-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide reduces uterine contractility and is of potential interest as a treatment for uterine disorders. The aim of this study was to explore the mechanism of sodium sulphide (Na2 S)-induced relaxation of rat uterus, investigate the importance of redox effects and ion channel-mediated m...

journal_title：British journal of pharmacology

authors： Mijušković A,Kokić AN,Dušić ZO,Slavić M,Spasić MB,Blagojević D

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study investigated whether the pathophysiological changes induced by burn and smoke inhalation are modulated by parenteral administration of Na(2)S, a H(2)S donor. EXPERIMENTAL APPROACH:The study used a total of 16 chronically instrumented, adult female sheep. Na(2)S was administered...

journal_title：British journal of pharmacology

authors： Esechie A,Enkhbaatar P,Traber DL,Jonkam C,Lange M,Hamahata A,Djukom C,Whorton EB,Hawkins HK,Traber LD,Szabo C

更新日期：2009-11-01 00:00:00

abstract：:1. Pharmacological studies of alpha7 nicotinic acetylcholine receptors are confounded by the fact that rapid desensitization to high agonist concentration causes alpha7 peak responses to occur well in advance of complete solution exchange. For this reason, peak currents are an invalid measure of response to applied ag...

journal_title：British journal of pharmacology

authors： Papke RL,Porter Papke JK

更新日期：2002-09-01 00:00:00

abstract：:1 A newly synthesized substance P (SP) analogue, (D-Pro2, D-Trp7,9)-SP, specifically antagonizes the contractile effects of SP on the guinea-pig isolated taenia coli. In addition, previous studies had indicated that the SP analogue per se is capable of contracting this preparation. The results of the present study on ...

journal_title：British journal of pharmacology

authors： Håkanson R,Hörig J,Leander S

更新日期：1982-12-01 00:00:00

abstract：:1. The effect of 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex that exhibits neuroprotective, anxiolytic and antidepressant-like actions, was investigated in a functional assay for presynaptic NMDA receptors. 2. NMDA (100 microM) pr...

journal_title：British journal of pharmacology

authors： Clos MV,Garcia Sanz A,Trullas R,Badia A

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although CB(1) receptor activation evokes neuroprotection in response to cannabinoids, some cannabinoids have been reported to be peroxisome proliferator activated receptor (PPAR) ligands, offering an alternative protective mechanism. We have, therefore, investigated the ability of a range of can...

journal_title：British journal of pharmacology

authors： Sun Y,Alexander SP,Garle MJ,Gibson CL,Hewitt K,Murphy SP,Kendall DA,Bennett AJ

更新日期：2007-11-01 00:00:00

abstract：:1. The role of vasoconstrictor 5-HT1-like receptors in the control of vascular reactivity in vivo has been relatively little studied, particularly with regards to venous function. Using an anaesthetized dog model, we have investigated the haemodynamic profile of the selective 5-HT1-like agonist, sumatriptan, focussing...

journal_title：British journal of pharmacology

authors： Drieu la Rochelle C,O'Connor SE

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pyrazole derivatives have recently been suggested as selective blockers of transient receptor potential cation (TRPC) channels but their ability to distinguish between the TRPC and Orai pore complexes is ill-defined. This study was designed to characterize a series of pyrazole derivatives in term...

journal_title：British journal of pharmacology

authors： Schleifer H,Doleschal B,Lichtenegger M,Oppenrieder R,Derler I,Frischauf I,Glasnov TN,Kappe CO,Romanin C,Groschner K

更新日期：2012-12-01 00:00:00

abstract：:1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization wa...

journal_title：British journal of pharmacology

authors： Allard B,Jacquemond V,Lemtiri-Chlieh F,Pourrias B,Rougier O

更新日期：1991-11-01 00:00:00

abstract：:1. Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function is associated with reduced endoneural blood flow (EBF) which may contribute to nerve dys...

journal_title：British journal of pharmacology

authors： Terata K,Coppey LJ,Davidson EP,Dunlap JA,Gutterman DD,Yorek MA

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In mammalian cells, the anti-parasitic drug ivermectin is known as a positive allosteric modulator of the ATP-activated ion channel P2X4 and is used to discriminate between P2X4- and P2X7-mediated cellular responses. In this paper we provide evidence that the reported isoform selectivity of iverm...

journal_title：British journal of pharmacology

authors： Nörenberg W,Sobottka H,Hempel C,Plötz T,Fischer W,Schmalzing G,Schaefer M

更新日期：2012-09-01 00:00:00

abstract：:[3H]-guanfacine (N-amidino-2-(2,6-dichloro 3[3H] phenyl) acetamide hydrochloride; 24.2 Ci/mmol) has been used as a radioligand in homogenates of rat cerebral cortex. Specific binding of [3H]-guanfacine was linear with respect to tissue concentration (2.5-15 mg/ml), saturable and not markedly affected in the pH range 6...

journal_title：British journal of pharmacology

authors： Jarrott B,Louis WJ,Summers RJ

更新日期：1982-02-01 00:00:00

abstract：:1. Receptor phosphorylation and down-regulation by protein kinases may be a key event initiating desensitization. The present studies were designed to investigate the effect of a potent protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), on antinociception induced by intrathecal (i.t.) administration of...

journal_title：British journal of pharmacology

authors： Narita M,Mizoguchi H,Kampine JP,Tseng LF

更新日期：1996-08-01 00:00:00

abstract：:1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated phospholipase C activity was determined by mas...

journal_title：British journal of pharmacology

authors： Pyne S,Pyne NJ

更新日期：1993-09-01 00:00:00

abstract：:Asthma is an inflammatory disease of the lungs and the transcription factor NF-kappa B regulates the production of numerous inflammatory mediators that may have a role in the pathogenesis of asthma. Hence, the signalling pathways leading to NF-kappa B activation are considered prime targets for novel anti-inflammatory...

journal_title：British journal of pharmacology

authors： Catley MC,Chivers JE,Holden NS,Barnes PJ,Newton R

更新日期：2005-05-01 00:00:00

abstract：:Obesity has reached epidemic proportions in the Western society and is increasing in the developing world. It is considered as one of the major contributors to the global burden of disability and chronic diseases, including autoimmune, inflammatory and degenerative diseases. Research conducted on obesity and its compl...

journal_title：British journal of pharmacology

authors： Francisco V,Pino J,Gonzalez-Gay MA,Mera A,Lago F,Gómez R,Mobasheri A,Gualillo O

更新日期：2018-05-01 00:00:00

abstract：:1. Elevated plasminogen activator inhibitor 1 (PAI-1) is a risk factor for thrombosis, and inhibitors of the interaction between PAI-1 and tissue plasminogen activator (t-PA) have antithrombotic and prothrombolytic activity in animals. We describe the antithrombotic effects in the rat of a monoclonal antibody (MA33H1)...

journal_title：British journal of pharmacology

authors： Berry CN,Lunven C,Lechaire I,Girardot C,O'Connor SE

更新日期：1998-09-01 00:00:00