Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.

Abstract:

:1. Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol.3. The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus.4. Acetylcholinesterase activity was 60-70% inhibited in all three tissues.

journal_name

Br J Pharmacol

authors

Foley DJ,McPhillips JJ

doi

10.1111/j.1476-5381.1973.tb08350.x

subject

Has Abstract

pub_date

1973-07-01 00:00:00

pages

418-25

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

48

pub_type

杂志文章
  • The potent depolarizing action of palytoxin isolated from Palythoa tubercurosa on the isolated spinal cord of the frog.

    abstract::1. The effects of palytoxin (PTX) isolated from Palythoa tubercurosa were tested on the isolated intra-arterially perfused spinal cord of the frog. The resting and evoked potentials were recorded by means of a sucrose-gap technique. 2. PTX caused a marked depolarization of both ventral and dorsal roots. The minimum ef...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1980.tb10975.x

    authors: Kudo Y,Shibata S

    更新日期:1980-01-01 00:00:00

  • Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer.

    abstract::1. We have investigated the inhibitory effects of RP 73401 (piclamilast) and rolipram against human monocyte cyclic AMP-specific phosphodiesterase (PDE4) in relation to their effects on prostaglandin (PG)E2-induced cyclic AMP accumulation and lipopolysaccharide (LPS)-induced TNF alpha production and TNF alpha mRNA exp...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1996.tb15450.x

    authors: Souness JE,Griffin M,Maslen C,Ebsworth K,Scott LC,Pollock K,Palfreyman MN,Karlsson JA

    更新日期:1996-06-01 00:00:00

  • Mechanism of the vasodilator action of calcitonin gene-related peptide in conscious rats.

    abstract::1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressu...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1992.tb14290.x

    authors: Abdelrahman A,Wang YX,Chang SD,Pang CC

    更新日期:1992-05-01 00:00:00

  • Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.

    abstract::1. Riluzole has been shown to have beneficial effects in motoneurone disease, yet its effect on motoneurones is not known. To address this question, we investigated synaptic modulation by riluzole in hypoglossal motoneurones by recording glycinergic inhibitory postsynaptic currents evoked by stimulation of nearby sing...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1995.tb15128.x

    authors: Umemiya M,Berger AJ

    更新日期:1995-12-01 00:00:00

  • The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo.

    abstract::1. Bradykinin (BK) instilled directly into the airway lumen caused bronchoconstriction in anaesthetized, mechanically ventilated guinea-pigs in the presence of propranolol (1 mg kg-1 i.v.). The geometric mean dose of BK required to produce 100% increase in airway opening pressure (PD100) was 22.9 nmol (95% c.i. 11.7-4...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1990.tb12092.x

    authors: Ichinose M,Barnes PJ

    更新日期:1990-09-01 00:00:00

  • Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig.

    abstract::1. Nine non-steroidal anti-inflammatory drugs were tested for antagonism of bradykinin-induced bronchoconstriction in guinea-pig lungs in vivo. Only one, benzydamine, was inactive.2. The descending order of potency of the active anti-inflammatory drugs was meclofenamate = Scha 306>Scha 87/2>indoxole>Mi85>indomethacin>...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1968.tb07952.x

    authors: Collier HO,James GW,Piper PJ

    更新日期:1968-09-01 00:00:00

  • Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages.

    abstract::The incubation of rat peritoneal macrophages in the presence of staurosporine, a non-specific protein kinase inhibitor, induced interleukin-6 (IL-6) production in a time- and concentration-dependent manner at 6.3-63 nM, but at 210 nM, the stimulant effect on IL-6 production was reduced. The levels of IL-6 mRNA as dete...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0702659

    authors: Yamaki K,Ohuchi K

    更新日期:1999-07-01 00:00:00

  • Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy.

    abstract:BACKGROUND AND PURPOSE:Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.12845

    authors: Lanzerstorfer P,Stadlbauer V,Chtcheglova LA,Haselgrübler R,Borgmann D,Wruss J,Hinterdorfer P,Schröder K,Winkler SM,Höglinger O,Weghuber J

    更新日期:2014-12-01 00:00:00

  • Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat.

    abstract::1. The present study characterizes and classifies alpha 1-adrenoceptor-mediated vasoconstriction in the isolated perfused kidney of rat using quantitative receptor pharmacology and compares the results to radioligand binding studies (made in cloned alpha 1-adrenoceptor subtypes, native alpha 1A-adrenoceptors in submax...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1995.tb15875.x

    authors: Blue DR Jr,Bonhaus DW,Ford AP,Pfister JR,Sharif NA,Shieh IA,Vimont RL,Williams TJ,Clarke DE

    更新日期:1995-05-01 00:00:00

  • The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species.

    abstract::By examination of compound action potentials in the saphenous nerve of the anaesthetized rat it has been shown that capsaicin causes a rapid, dose-dependent, failure of conduction in many C-fibres when applied directly to the nerve. A large reduction in C-fibre conduction occurs with concentrations as low as 110 micro...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1986.tb10256.x

    authors: Baranowski R,Lynn B,Pini A

    更新日期:1986-10-01 00:00:00

  • Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse.

    abstract::1. The sigma(1) (sigma(1)) receptor cDNA was cloned in several animal species. Molecular tools are now available to identify its endogenous effectors, such as neuroactive steroids, and to establish its precise physiological role. In particular, the sigma(1) receptor is involved in memory processes, as observed in phar...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704355

    authors: Maurice T,Phan VL,Urani A,Guillemain I

    更新日期:2001-12-01 00:00:00

  • Classification of tachykinin receptors in muscularis mucosae of opossum oesophagus.

    abstract::1. Muscularis mucosae of the distal oesophagus of the opossum contracts in response to substance P and to a variety of tachykinins. To delineate the nature of the receptors present in this tissue, we evaluated contractile responses to substance P, neurokinin A, neurokinin B, eledoisin and analogues believed to be high...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1989.tb12556.x

    authors: Daniel EE,Cipris S,Manaka Y,Bowker P,Regoli D

    更新日期:1989-08-01 00:00:00

  • Short-term desensitization of guinea-pig taenia caecum induced by carbachol occurs at intracellular Ca stores and that by histamine at H1-receptors.

    abstract::1. In Ca-free solution, the contractile response of guinea-pig taenia caecum to 10(-4) M carbachol was mediated through muscarinic receptors and was reduced time-dependently by desensitization with 10(-4) M carbachol, but not 10(-4) M histamine. On the other hand, the response to 10(-4) M histamine was shown to be med...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1988.tb11600.x

    authors: Hishinuma S,Uchida MK

    更新日期:1988-07-01 00:00:00

  • Prevention of cultured rat stellate cell transformation and endothelin-B receptor upregulation by retinoic acid.

    abstract::1 Physiologically, perisinusoidal hepatic stellate cells (HSC) are quiescent and store retinoids. During liver injury and in cell culture, HSC transform into proliferating myofibroblast-like cells that express alpha-smooth muscle actin (alpha-sma) and produce excessive amounts of extracellular matrix. During transform...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0705303

    authors: Chi X,Anselmi K,Watkins S,Gandhi CR

    更新日期:2003-06-01 00:00:00

  • Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.

    abstract::1. In order to investigate the vasodilator mechanisms of the K+ channel openers, cromakalim, pinacidil and nicorandil, we measured changes in cytoplasmic Ca2+ concentration [( Ca2+]i) simultaneously with force by a microfluorimetric method using fura-2, a calcium indicator, in canine coronary arterial smooth muscle ce...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1990.tb12106.x

    authors: Yanagisawa T,Teshigawara T,Taira N

    更新日期:1990-09-01 00:00:00

  • Tachykinin receptors in the circular muscle of the guinea-pig ileum.

    abstract::1. We have studied the mechanical response of circular strips of the guinea-pig ileum to tachykinins and characterized the receptors involved by means of receptor-selective agonists. 2. The strips responded to both substance P (SP) and neurokinin A (NKA), as well as to [Pro9]-SP sulphone (selective NK1-receptor agonis...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1990.tb14195.x

    authors: Maggi CA,Patacchini R,Giachetti A,Meli A

    更新日期:1990-12-01 00:00:00

  • Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production.

    abstract::The molecular mechanisms involved in veratridine-induced chromaffin cell death have been explored. We have found that exposure to veratridine (30 microM, 1 h) produces a delayed cellular death that reaches 55% of the cells 24 h after veratridine exposure. This death has the features of apoptosis as DNA fragmentation c...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0703451

    authors: Jordán J,Galindo MF,Calvo S,González-García C,Ceña V

    更新日期:2000-08-01 00:00:00

  • Uncoupling activity of the anthelmintic oxyclozanide in rodents.

    abstract::The uncoupling activity of oxyclozanide in warm blooded animals has been studied in whole animals, isolated tissue in vitro and on mitochondrial preparations. The onset of post mortem rigidity in mice and rats is accelerated and a contracture of striated muscle is produced. Oxyclozanide (1 muM) stimulated rat liver mi...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1974.tb09622.x

    authors: Veenendaal GH,de Waal MJ

    更新日期:1974-03-01 00:00:00

  • Phenthonium, a quaternary derivative of (-)-hyoscyamine, enhances the spontaneous release of acetylcholine at rat motor nerve terminals.

    abstract::1. A quaternary derivative of (-)-hyoscyamine, phenthonium (Phen) induced a concentration-dependent increase in the rate of spontaneous quantal release of acetylcholine (ACh) at the mammalian neuromuscular junction, as shown by intracellular recordings of the miniature endplate potentials (m.e.p.ps) in rat diaphragm m...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1990.tb15825.x

    authors: Fann ML,Souccar C,Lapa AJ

    更新日期:1990-07-01 00:00:00

  • Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helix.

    abstract::1. We investigated the role of two conserved basic residues in the second transmembrane helix arginine 172 (R172) and lysine 179 (K179) of the VPAC(2) receptor. 2. Vasoactive intestinal polypeptide (VIP) activated VPAC(2) receptors with an EC(50) value of 7 nM, as compared to 150, 190 and 4000 nM at R172L, R172Q and K...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704195

    authors: Vertongen P,Solano RM,Perret J,Langer I,Robberecht P,Waelbroeck M

    更新日期:2001-08-01 00:00:00

  • Stimulation of presynaptic beta-adrenoceptors enhances [3H]-noradrenaline release druing nerve stimulation in the perfused cat spleen.

    abstract::1 The effects of isoprenaline, propranolol and phosphodiesterase inhibitors on (3)H-transmitter overflow elicited by low frequency nerve stimulation were determined in the isolated perfused spleen of the cat.2 (-)-Isoprenaline (0.14, 1.4, and 14 nM) produced a concentration-dependent increase in [(3)H]-transmitter ove...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1978.tb07779.x

    authors: Celuch SM,Dubocovich ML,Lander SZ

    更新日期:1978-05-01 00:00:00

  • Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.

    abstract:BACKGROUND AND PURPOSE:Memantine and ketamine are clinically used, open-channel blockers of NMDA receptors exhibiting remarkable pharmacodynamic similarities despite strikingly different clinical profiles. Although NMDA channel gating constitutes an important difference between memantine and ketamine, it is unclear how...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13007

    authors: Emnett CM,Eisenman LN,Mohan J,Taylor AA,Doherty JJ,Paul SM,Zorumski CF,Mennerick S

    更新日期:2015-03-01 00:00:00

  • Single pulse stimulation of guinea-pig vas deferens and the presynaptic receptor hypothesis.

    abstract::1 The effect of phenoxybenzamine on the efflux of [3H]-noradrenaline and the mechanical response to single pulse excitation of superfused guinea-pig vas deferens was determined to examine the validity of the currently accepted hypothesis of a presynaptic negative feedback system on adrenergic nerve terminals. 2 The ad...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1979.tb13686.x

    authors: Kalsner S

    更新日期:1979-06-01 00:00:00

  • The effects of prostaglandins on the intraocular pressure of the rabbit.

    abstract::1. The effects of intracameral injections of prostaglandins E(1), E(2), F(1a), F(2a), and A(1) were studied on the intraocular pressure (IOP) of rabbits anaesthetized with urethane.2. With the exception of prostaglandin F(1a), all the prostaglandins studied were found to be capable of producing a large, sustained rise...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1969.tb09533.x

    authors: Beitch BR,Eakins KE

    更新日期:1969-09-01 00:00:00

  • Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse.

    abstract::1. Receptor phosphorylation and down-regulation by protein kinases may be a key event initiating desensitization. The present studies were designed to investigate the effect of a potent protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), on antinociception induced by intrathecal (i.t.) administration of...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1996.tb15610.x

    authors: Narita M,Mizoguchi H,Kampine JP,Tseng LF

    更新日期:1996-08-01 00:00:00

  • Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein.

    abstract::1. Contraction of the rabbit isolated saphenous vein is mediated by a heterogeneous endothelin (ET) receptor population. This study has characterized these receptor subtypes by use of several pharmacologically distinct ET receptor agonists and antagonists. 2. ET-1, ET-3, sarafotoxin S6c (STXc) and [Ala3,11]ET-1 produc...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1995.tb14936.x

    authors: Douglas SA,Beck GR Jr,Elliott JD,Ohlstein EH

    更新日期:1995-04-01 00:00:00

  • Sotalol for the protection of turkeys from the development of -aminopropionitrile-induced aortic ruptures.

    abstract::1. The influence of feeding 2 levels of sotalol on the incidence of beta-aminopropionitrile (BAPN)-induced aortic ruptures of immature turkeys was determined.2. Four of 22 turkeys fed 0.12% sotalol and 0.07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.3. Blood pressure, heart r...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1972.tb08095.x

    authors: Simpson CF

    更新日期:1972-07-01 00:00:00

  • Osteoblasts play key roles in the mechanisms of action of strontium ranelate.

    abstract:BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2009.00305.x

    authors: Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

    更新日期:2009-08-01 00:00:00

  • Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

    abstract:BACKGROUND AND PURPOSE:Histone deacetylase 6 (HDAC6) and silent information regulator 2 (SIRT2) control the dynamics of the microtubule network via their deacetylase activities. Tubulin polymerization promoting protein (TPPP/p25) enhances microtubule acetylation by its direct binding to HDAC6. Our objective was to char...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.12946

    authors: Mangas-Sanjuan V,Oláh J,Gonzalez-Alvarez I,Lehotzky A,Tőkési N,Bermejo M,Ovádi J

    更新日期:2015-02-01 00:00:00

  • Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids.

    abstract:BACKGROUND AND PURPOSE:Red blood cells (RBCs) are reservoirs of vasodilatory, antiaggregatory, and antiinflammatory lipid mediators-epoxyeicosatrienoic acids (EETs). This study addresses the formation and release of erythrocyte-derived EETs in response to ATP receptor stimulation that may represent an important mechani...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0707311

    authors: Jiang H,Zhu AG,Mamczur M,Falck JR,Lerea KM,McGiff JC

    更新日期:2007-08-01 00:00:00