Effects of noradrenaline and carbachol on temperature regulation of rats.

abstract：:1. We set out to elucidate the pharmacological mechanisms by which alpha 2-adrenoceptor and 5-HT-receptor ligands affect the haemodynamic response to acute central hypovolaemia in conscious rabbits. 2. Acute central hypovolaemia was produced by inflating an inferior vena caval cuff so that cardiac output fell at a con...

journal_title：British journal of pharmacology

authors： Evans RG,Haynes JM,Ludbrook J

更新日期：1993-05-01 00:00:00

abstract：:Recent clinical studies have demonstrated that angiotensin II type 1 (AT(1) ) receptor blockers (ARBs) reduce the onset of stroke, stroke severity and the incidence and progression of Alzheimer's disease and dementia. We can expect that ARBs exert these effects by both AT(1) receptor blockade and angiotensin II type 2...

journal_title：British journal of pharmacology

authors： Horiuchi M,Mogi M

更新日期：2011-07-01 00:00:00

abstract：:1. The subtype of alpha1-adrenoceptor mediating contractions to phenylephrine of the rat thoracic aorta, mesenteric artery and pulmonary artery were investigated by use of antagonists which show selectivity between the cloned alpha1-adrenoceptor subtypes in binding studies. 2. Cumulative concentration-contraction curv...

journal_title：British journal of pharmacology

authors： Hussain MB,Marshall I

更新日期：1997-11-01 00:00:00

abstract：:1. The effects of fenoverine, an antispasmodic drug, have been studied on the Ca2+ channel currents of isolated cells from rat portal vein and pregnant myometrium by the patch-clamp technique (whole-cell configuration). 2. Fenoverine inhibited both fast and slow Ca2+ channel currents in a concentration-dependent manne...

journal_title：British journal of pharmacology

authors： Mironneau J,Arnaudeau S,Mironneau C

更新日期：1991-09-01 00:00:00

abstract：:There is a long-known hyper-responsiveness of vascular adrenergic transmission in the spontaneously hypertensive rat (SHR) that is uncovered specifically in the presence of cocaine and attributed to blockade of the neuronal monoamine transporter. We have now used the rat anococcygeus muscle to investigate whether this...

journal_title：British journal of pharmacology

authors： Jimenez-Altayo F,Giraldo J,McGrath JC,Vila E

更新日期：2003-10-01 00:00:00

abstract：:The cardiotoxic effects of fenfluramine hydrochloride on mechanical and electrical activity were studied in papillary muscles, Purkinje fibres, left atria and ventricular myocytes of guinea-pigs. Force of contraction (f(c)) was measured isometrically, action potentials and maximum rate of rise of the action potential ...

journal_title：British journal of pharmacology

authors： Rajamani S,Studenik C,Lemmens-Gruber R,Heistracher P

更新日期：2000-03-01 00:00:00

abstract：:Growing evidence suggests that interleukin (IL)-13, a Th2-type cytokine, plays a critical role in the development of bronchial hyper-responsiveness (BHR), an essential feature of asthma, although the underlying mechanisms remain unknown. In the present study, we investigated whether IL-13 directly affects airway smoot...

journal_title：British journal of pharmacology

authors： Tliba O,Deshpande D,Chen H,Van Besien C,Kannan M,Panettieri RA Jr,Amrani Y

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Resurgence in the use of chloroquine as a potential treatment for COVID-19 has seen recent cases of fatal toxicity due to unintentional overdoses. Protocols for the management of poisoning recommend diazepam, although there are uncertainties in its pharmacology and efficacy in this context. The a...

journal_title：British journal of pharmacology

authors： Hughes DA

更新日期：2020-11-01 00:00:00

abstract：:1. In this study 3 protocols were utilized to determine the role of endogenous kinins in the resistance of the inbred Dahl (Rapp) salt-resistant (SR/Jr) rats to high salt diet-induced blood pressure elevation. 2. The bradykinin B2 receptor antagonist, Hoe 140 (D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin) at doses of ei...

journal_title：British journal of pharmacology

authors： Mukai H,Fitzgibbon WR,Ploth DW,Margolius HS

更新日期：1998-05-01 00:00:00

abstract：:Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas ch...

journal_title：British journal of pharmacology

authors： Barrow SE,Dollery CT,Heavey DJ,Hickling NE,Ritter JM,Vial J

更新日期：1986-01-01 00:00:00

abstract：:1 Nine antibiotic compounds in common use were studied to determine their ability to affect intestinal motility in vitro, in the guinea-pig ileum and rabbit colon. 2 Ampicillin, doxycycline, mecillinam and metronidazole were without effect over a concentration range which included typical serum levels found when these...

journal_title：British journal of pharmacology

authors： Lees GM,Percy WH

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Glucocorticoids appear to control Na⁺ absorption in pulmonary epithelial cells via a mechanism dependent upon serum and glucocorticoid-inducible kinase 1 (SGK1), a kinase that allows control over the surface abundance of epithelial Na⁺ channel subunits (α-, β- and γ-ENaC). However, not all data s...

journal_title：British journal of pharmacology

authors： Watt GB,Ismail NA,Caballero AG,Land SC,Wilson SM

更新日期：2012-06-01 00:00:00

abstract：:1 The cardiovascular effects of intravenous desipramine (0.03 and 0.1 mg/kg), maprotiline (0.5 mg/kg), mianserin (1.0 and 3.0 mg/kg) and phentolamine (0.25 mg/kg) were examined and compared in pithed rats. Several experimental procedures were used in order to distinguish between the effects of the compounds on cardiac...

journal_title：British journal of pharmacology

authors： Cavero I,Gomeni R,Lefèvre-Borg F,Roach AG

更新日期：1980-02-01 00:00:00

abstract：:1. The irritant fungal terpenoid isovelleral caused protective eye-wiping movements in the rat upon intraocular instillation and showed cross-tachyphylaxis with capsaicin, the pungent principle in hot pepper. 2. Isovelleral induced a dose-dependent calcium uptake by rat dorsal root ganglion neurones cultured in vitro ...

journal_title：British journal of pharmacology

authors： Szallasi A,Jonassohn M,Acs G,Bíró T,Acs P,Blumberg PM,Sterner O

更新日期：1996-09-01 00:00:00

abstract：:1. The role of nitric oxide in the coronary circulation under basal conditions and when exposed to various vasodilator stimuli was studied in instrumented, anaesthetized goats, by examining the action of inhibiting endogenous nitric oxide production with NG-nitro-L-arginine methyl ester (L-NAME). 2. In 12 goats, left ...

journal_title：British journal of pharmacology

authors： García JL,Fernández N,García-Villalón AL,Monge L,Gómez B,Diéguez G

更新日期：1992-07-01 00:00:00

abstract：:1. The pharmacology of the slow afterhyperpolarization (sAHP) was studied in cultured rat hippocampal pyramidal neurones. 2. Clotrimazole, its in vivo metabolite, 2-chlorophenyl-bisphenyl-methanol (CBM) and the novel analogues, UCL 1880 and UCL 2027, inhibited the sI(AHP) with similar IC50s (1-2 microM). 3. Clotrimazo...

journal_title：British journal of pharmacology

authors： Shah MM,Miscony Z,Javadzadeh-Tabatabaie M,Ganellin CR,Haylett DG

更新日期：2001-02-01 00:00:00

abstract：:1. The effects of the spasmogenic agents, carbachol (CCh), histamine, 5-hydroxytryptamine (5-HT) and 9,11-epithio-11,12-methano-thromboxane A2 (STA2) were investigated on smooth muscle tissues of the dog trachea. 2. CCh (10 microM) produced a larger contraction than high K (128 mM), 10 microM histamine, 5-HT or STA2. ...

journal_title：British journal of pharmacology

authors： Katsuyama H,Suzuki S,Nishiye E

更新日期：1990-05-01 00:00:00

abstract：:1 We investigated the peripheral haemodynamic effects of human alpha-calcitonin gene-related peptide (CGRP) following administration of endothelin-1 or NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide production, in conscious, chronically-instrumented, Long Evans rats. 2 Infusion of endothelin-1...

journal_title：British journal of pharmacology

authors： Gardiner SM,Compton AM,Kemp PA,Bennett T,Foulkes R,Hughes B

更新日期：1991-05-01 00:00:00

abstract：:1. The effects of adenosine A1 receptor stimulation on basal and histamine-stimulated levels of intracellular free calcium ion concentration ([Ca2+]i) have been investigated in primary astrocyte cultures derived from neonatal rat forebrains. 2. Histamine (0.1 microM-1 mM) caused rapid, concentration-dependent increase...

journal_title：British journal of pharmacology

authors： Peakman MC,Hill SJ

更新日期：1995-07-01 00:00:00

abstract：:1. This study exploited established immunoneutralization protocols and an N-terminal annexin 1 peptide (annexin 1(Ac2 - 26)) to advance our knowledge of the role of annexin 1 as a mediator of acute glucocorticoid action in the rat neuroendocrine system in vivo. 2. Rats were treated with corticosterone (500 microg kg(-...

journal_title：British journal of pharmacology

authors： Philip JG,John CD,Cover PO,Morris JF,Christian HC,Flower RJ,Buckingham JC

更新日期：2001-10-01 00:00:00

abstract：:Electrical field stimulation (EFS)-induced non-adrenergic non-cholinergic (NANC) relaxation responses in the rabbit vaginal wall were investigated. These NANC responses were partially inhibited with the nitric oxide synthase (NOS) inhibitors N(G)-nitro-L-arginine methyl ester (L-NAME; 500 microM), N(G)-nitro-L-arginin...

journal_title：British journal of pharmacology

authors： Ziessen T,Moncada S,Cellek S

更新日期：2002-01-01 00:00:00

abstract：:1. In cultured endothelial cells of the pig the endothelium-derived relaxing factor (EDRF) releasing agent thrombin (2 u ml-1) caused a significant increase in basal levels of both guanosine 3':5'-cyclic monophosphate (cyclic GMP) and inositol 1,4,5-trisphosphate (IP3). This increase was time dependent, with peak leve...

journal_title：British journal of pharmacology

authors： Lang D,Lewis MJ

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the pathological features of Alzheimer's disease and on memory-relat...

journal_title：British journal of pharmacology

authors： Cuadrado-Tejedor M,Hervias I,Ricobaraza A,Puerta E,Pérez-Roldán JM,García-Barroso C,Franco R,Aguirre N,García-Osta A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N-arachidonoyl glycine (NAGly) as well the behaviourally inactive atypical cannabinoid, abnormal cannabidiol (Abn-CBD). The presence and/or function of any GPR18-based ocular signalling system remain essential...

journal_title：British journal of pharmacology

authors： Caldwell MD,Hu SS,Viswanathan S,Bradshaw H,Kelly ME,Straiker A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed to investigate whether endothelial mesenchymal transition (EndoMT) contributes to the therapeutic effects of BLM. EXPERIMENTAL APPROACH:Endothelial and mesenchym...

journal_title：British journal of pharmacology

authors： Zhang W,Chen G,Ren JG,Zhao YF

更新日期：2013-11-01 00:00:00

abstract：:1 In unanaesthetized cats, the administration of 6-hydroxydopamine (6-OHDA), 750 mug, via the lateral cerebral ventricle produced a pronounced fall in rectal temperature but only a slight fall when repeated 7 days later. At this time hypothalamic noradrenaline concentration had diminished to 4% of control.2 In these a...

journal_title：British journal of pharmacology

authors： Lewis PJ,Rawlins MD,Reid JL

更新日期：1974-06-01 00:00:00

abstract：:1. The use of pharmacological inhibitors of nitric oxide (NO) synthesis to treat patients with septic shock is limited by the observation that they cause a fall in cardiac output in some subjects. The aim of this work was to investigate this fall and to test whether it was reversible by subsequent administration of ni...

journal_title：British journal of pharmacology

authors： Herity NA,Allen JD,Silke B,Adgey AA

更新日期：1994-06-01 00:00:00

abstract：:1. Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat impaired vasodilator function is associated with reduced endoneural blood flow (EBF) which may contribute to nerve dys...

journal_title：British journal of pharmacology

authors： Terata K,Coppey LJ,Davidson EP,Dunlap JA,Gutterman DD,Yorek MA

更新日期：1999-10-01 00:00:00

abstract：:AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targ...

journal_title：British journal of pharmacology

authors： Esteban JA

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early soluble epoxide hydrolase inhibitors (sEHIs) such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) are effective anti-hypertensive and anti-inflammatory agents in various animal models. However, their poor metabolic stability and limited water solubility make them difficult to use pha...

journal_title：British journal of pharmacology

authors： Liu JY,Tsai HJ,Hwang SH,Jones PD,Morisseau C,Hammock BD

更新日期：2009-01-01 00:00:00