Abstract:
:1 In unanaesthetized cats, the administration of 6-hydroxydopamine (6-OHDA), 750 mug, via the lateral cerebral ventricle produced a pronounced fall in rectal temperature but only a slight fall when repeated 7 days later. At this time hypothalamic noradrenaline concentration had diminished to 4% of control.2 In these animals, the hypothermic response to exogenous noradrenaline, 100 mug, given via the same route was uninfluenced by pretreatment with 6-OHDA.3 In unanaesthetized rabbits, intraventricular noradrenaline, 100 mug, produced a rise in rectal temperature and a biphasic effect on arterial pressure, a rise lasting 30 min followed by a fall.4 Intraventricular 6-OHDA, 750 mug, in unanaesthetized rabbits produced a rise in body temperature and a rise in arterial pressure. The same dose given to rabbits depleted of central noradrenaline with central 6-OHDA produced rises in body temperature and arterial pressure of similar magnitude, but of slower onset.5 These results suggest that intraventricular 6-OHDA releases noradrenaline from central neurones and that these neurones subserve thermoregulatory functions in both species. In the rabbit, central noradrenergic neurones can raise arterial pressure.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Lewis PJ,Rawlins MD,Reid JLdoi
10.1111/j.1476-5381.1974.tb09648.xsubject
Has Abstractpub_date
1974-06-01 00:00:00pages
207-12issue
2eissn
0007-1188issn
1476-5381journal_volume
51pub_type
杂志文章abstract::Growing evidence suggests that interleukin (IL)-13, a Th2-type cytokine, plays a critical role in the development of bronchial hyper-responsiveness (BHR), an essential feature of asthma, although the underlying mechanisms remain unknown. In the present study, we investigated whether IL-13 directly affects airway smoot...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0705558
更新日期:2003-12-01 00:00:00
abstract::The concentration of intracellular free Ca2+ ( [Ca2+]i) in human blood platelets was measured by use of the fluorescent probe quin-2. 5-Hydroxytryptamine (5-HT) caused a rapid increase of [Ca2+]i in the presence or absence of Ca2+ in the medium. The [Ca2+]i-rise was less marked in the absence of Ca2+ and could be anta...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1985.tb12939.x
更新日期:1985-02-01 00:00:00
abstract::1. Tachycardia and bronchodilatation were produced by intravenous dimethylphenylpiperazinium iodide (DMPP) in the spinal or pithed cat. Responses other than those involving beta-adrenoceptors were minimized by appropriate blocking agents.2. With intact adrenals, both the tachycardia and bronchodilatation with 10 mug/k...
journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1973.tb08256.x
更新日期:1973-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is growing interest in the physiological functions of flavonoids, especially in their effects on cognitive function and on neurodegenerative diseases. The aim of the current investigation was to evaluate the role of the flavonoid baicalein in long-term potentiation (LTP) in the hippocampal ...
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1994.tb17004.x
更新日期:1994-10-01 00:00:00
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更新日期:1980-01-01 00:00:00
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更新日期:1993-04-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1992.tb12771.x
更新日期:1992-10-01 00:00:00
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更新日期:1969-05-01 00:00:00
abstract::1. The role of smooth muscle-derived lipoprotein lipase (LPL) that translocates to the endothelium surface on vascular dysfunction during atherogenesis is unclear. Thus, the role of vascular LPL on blood vessel reactivity was assessed in transgenic mice that specifically express human LPL in the circulatory system. 2....
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更新日期:2002-01-01 00:00:00
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journal_title:British journal of pharmacology
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjp.0702434
更新日期:1999-03-01 00:00:00
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更新日期:2012-02-01 00:00:00