Abstract：
BACKGROUND:To determine whether the gene expression of both acute-phase reactants (APR) and the major heat-shock protein (hsp-72) can occur simultaneously, transcriptional rates were measured during shock and resuscitation. METHODS:A nuclear runoff technique was applied to hepatic biopsy specimens obtained from pigs before shock, during 40% blood volume hemorrhagic shock (1 and 2 hours), and after resuscitation (4 and 6 hours). RESULTS:Shock-induced transcription of hsp-72 was elevated elevenfold over sham operation at 2 hours (p less than 0.02, Mann-Whitney rank test). Individually shocked animals did not transcribe both classes of stress genes but segregated into two groups: (1) strong APR transcriptional responders and (2) hsp-72 transcriptional responders. In group 2, APR transcription was significantly suppressed. Antichymotrypsin transcription was an average of eighteenfold lower in group 2 versus group 1 (p less than 0.05 at 1,2, and 6 hours). CONCLUSIONS:Different classes of stress protein genes are not transcribed simultaneously. We infer that their increased accumulation at the mRNA level is the result of sequential transcription. Hsp-72 transcription excludes that of the APR genes that may be critical to survival after stress.
journal_name
Surgeryjournal_title
Surgeryauthors
Schoeniger LO,Reilly PM,Bulkley GB,Buchman TGsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
355-62; discussion 362-3issue
2eissn
0039-6060issn
1532-7361pii
0039-6060(92)90231-Njournal_volume
112pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:In primary hyperparathyroidism, successful parathyroidectomy leads to improved bone mineral density in the majority of cases. Our aim was to further explore the relationship between hypercalciuria, kidney function, and bone recovery after parathyroidectomy. METHODS:Bone mineral density, estimated glomerular...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2017.02.017
更新日期：2017-08-01 00:00:00
abstract：CONTEXT:The rate and the extent of bone remineralization at cancellous versus cortical sites after treatment of hyperthyroidism is unclear. Few studies have examined the effect of operative management of hyperthyroidism on recovery of bone mass. OBJECTIVE:To evaluate prospectively the bone mineral density (BMD), bone ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.10.002
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The electronic medical record (EMR) of a large, tertiary referral center was examined to study the prevalence of undiagnosed and unrecognized primary hyperparathyroidism (PHPT). METHODS:The EMR was queried for outpatient serum calcium >10.5 mg/dL over a 2-year period. RESULTS:Of 2.7 million patients, 54,19...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.06.051
更新日期：2013-12-01 00:00:00
abstract：:This study compares the National Board of Medical Examiners Part II (NBME II) subtest scores of medical students attaining honors in a clinical clerkship to those of students receiving a passing score to determine if the NBME II examinations could be considered independently as valid indicators of clinical achievement...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Parathyroid autotransplantation (PTHAT) during thyroidectomy has been shown to reduce the incidence of permanent hypoparathyroidism. Although selective PTHAT is most commonly adopted, the value of routine PTHAT has not been well documented. METHODS:From January, 1998 to March, 1999, an operative strategy in...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.111125
更新日期：2001-03-01 00:00:00
abstract：:Endothelial cell (EC) seeding has been proposed as a method to improve the performance of small-caliber synthetic vascular prostheses. Seeding experiments to date have all been carried out in the dog. This study investigates EC seeding of small-caliber Dacron carotid interposition grafts compared with contralateral co...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Laser ablation of veins after injection of wavelength-specific dyes to enhance and localize energy absorption could provide a useful adjunct to current treatment options. To enhance the absorption of diode laser energy at 808 nm, ear veins of 41 rabbits were infused with 2 to 3 ml of indocyanine green dye (maximum abs...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：BACKGROUND:Benign thyroid cysts have been successfully treated with nonoperative sclerotherapy. Although OK-432 is a safe and effective sclerosing agent used to treat benign cystic lesions, little is known about its effectiveness in thyroid cysts. This study tested the efficacy of OK-432 sclerotherapy for thyroid cysts...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2008.06.014
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Traumatic injury and the presence of a central venous catheter are 2 of the strongest risk factors for venous thromboembolism in children. The purpose of this study was to determine the incidence of symptomatic, catheter-associated thrombosis in critically injured children. We hypothesized that femoral venou...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.05.018
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The number of dendritic cells (DC) in the local tumor environment correlates with patient survival in numerous tumors. The relationship of DC infiltration in the tumor microenvironment and prognosis was examined in patients with pancreatic adenocarcinoma. METHODS:Forty-seven pancreatectomy specimens with a ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.119937
更新日期：2002-02-01 00:00:00
abstract：:Aneurysms of the gastroduodenal artery are rare. Only nine cases have been reported previously. These aneurysms are extremely difficult to diagnose preoperatively. A case of ruptured gastroduodenal artery aneurysm, which was diagnosed by aortography prior to operation, is reported, and the literature is reviewed. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：:The relationship between the cyclosporine A (CSA) dose and rejection of varying lengths of small-bowel grafts was studied in a rat heterotopic microsurgical small-bowel transplantation model involving a haploidentical strain combination. When Lewis X Brown Norway F1 hybrid (LBN) small-bowel grafts were transplanted in...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:The evidence is conflicting regarding the effect of delays from the time of diagnosis to surgery on the survival in patients with hepatocellular carcinoma. We sought to investigate the impact of time to surgery on overall survival for patients who underwent curative resection for primary hepatocellular carci...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.09.022
更新日期：2020-02-01 00:00:00
abstract：:We performed spirometry on 114 morbidly obese patients considered for gastric bypass surgery to assess its efficacy as a preoperative screening test. One hundred eight subjects underwent surgery, and 61 patients returned for repeat spirometry 1 year later. The average preoperative forced vital capacity (FVC), forced e...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:Between 1969 and 1976, 174 patients were treated surgically for simultaneous carotid and coronary atherosclerosis. In 59 patients, staged carotid endarterectomy was performed a few days to 6 months prior to myocardial revascularization. Severe (more than 60% stenosis) coronary atherosclerosis affected a single vessel ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:This study analyzes trends in hospitalization and outcome for adult, elderly, and pediatric trauma victims in the Florida Trauma System (FTS) from 1991 to 2003, during which time the number of centers nearly doubled from 11 to 20. METHODS:Administrative data was queried for all admissions with at least one ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.01.012
更新日期：2006-07-01 00:00:00
abstract：:Earlier work has shown that morphine sulfate can produce a dose-related decrease in heart rate (HR) and cardiac output (CO) in isolated working rat hearts. This response is preventable with the use of the opiate receptor antagonist, naloxone hydrochloride. In this study, the stereospecificity of the opiate response wa...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:Breast milk has been shown to prevent gut-origin infections in neonates through undefined mechanisms. Putative protective factors in breast milk include immunoglobulin (Ig)A, IgG, and lactoferrin. We examined their role in bacterial translocation in neonatal rabbits. METHODS:IgA, IgG, and lactoferrin were i...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Surgical procedures suppress host antitumor defense mechanisms, which may increase the risk of metastatic tumor dissemination. We have evaluated the effects of the biologic response modifier polyadenylic-polyuridylic acid (PAPU) on natural cytotoxicity in patients with breast cancer undergoing operation. ME...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0039-6060(05)80370-8
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The benefit of removing the splenic lymph nodes in patients with proximal gastric cancer has been controversial. The purpose of our study was to investigate the importance of performing a splenic hilar lymph node dissection without splenectomy in patients undergoing total gastrectomy for gastric cancer. MET...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.07.053
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. METHODS:We studied 126 men undergoing AAA repair and compared them with 99 men undergoing...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that gadolinium ethoxybenzyl diethylenetriamine penta acetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging may be used to evaluate liver function. The aim of this study was to assess whether the signal intensity of Gd-EOB-DTPA magnetic resonance imaging may be used to predic...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.04.041
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Pediatric umbilical hernia repair is a common procedure that requires minimal tissue disruption. We examined variation in opioid prescription fills after repair of uncomplicated umbilical hernias to characterize the types and doses of medication used and persistent postsurgical use. METHODS:Using the Truven...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.10.029
更新日期：2019-04-01 00:00:00
abstract：:To test the hypothesis that nonprotein calorie intake and nitrogen intake are equally important in establishing positive nitrogen balance, weight gain, and serum protein response in the depleted primate treated with total parenteral nutrition (TPN), 10 adult male chair-adapted primates (Macaque fascicularis) were stud...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Fine-needle aspirations and cutting needle biopsies were performed on 415 patients with solitary thyroid nodules. All nodules were considered hypofunctioning by scintiscans. Specimens were adequate in 399 patients. Ten percent of these patients had thyroid cancers documented by thyroidectomies. Results from either or ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：:The findings of decreased adenosine triphosphate (ATP) levels in liver, kidney, and other tissues of animals in hemorrhagic shock were the rationale for previous experimental attempts to improve cell function by administration of fluids that contained high concentrations of ATP. The beneficial effects of this resuscit...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:T cells that receive T-cell antigen receptor signals but do not undergo mitosis become unresponsive to subsequent antigenic stimulation. This can be achieved by antigen presentation to T cells in the absence of critical costimulatory signals from antigen-presenting cells (APC) or in the presence of the antip...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic canc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.09.012
更新日期：2018-05-01 00:00:00
abstract：:Peripheral parenteral nutrition avoids the use of central lines and is a useful means of nutritional support for selected patients. Amino acids alone have been used for peripheral parenteral nutrition and have been shown to give near nitrogen equilibrium. The addition of small amounts of dextrose to amino acids furthe...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Differentiation between parathyroid hyperplasia and adenoma is difficult and based on the surgeon's skill. Microarrays and other sophisticated research tools generate information about differential gene expression in various tissues. Exploration of genes that express differentially in 1 tissue will enable id...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.128614
更新日期：2002-12-01 00:00:00
